Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives

References

• Chen H, Han Z, Luo Q, et al. Radiotherapy modulates tumor cell fate decisions: a review. Radiat Oncol. 2022;17(1):196. doi:10.1186/s13014-022-02171-7
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi:10.1038/s41419-020-2298-2
   PubMed Web of Science ®Google Scholar
• Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107–125. doi:10.1038/s41422-020-00441-1
   PubMed Web of Science ®Google Scholar
• Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 2022;22(7):381–396. doi:10.1038/s41568-022-00459-0
   PubMed Web of Science ®Google Scholar
• Wang K, Chen XZ, Wang YH, et al. Emerging roles of ferroptosis in cardiovascular diseases. Cell Death Discov. 2022;8(1):394. doi:10.1038/s41420-022-01183-2
   PubMed Web of Science ®Google Scholar
• Wang J, Liu Y, Wang Y, Sun L. The cross-link between ferroptosis and kidney diseases. Oxid Med Cell Longev. 2021;2021:6654887. doi:10.1155/2021/6654887
   PubMed Web of Science ®Google Scholar
• Zhang Y, Huang X, Qi B, et al. Ferroptosis and musculoskeletal diseases: “Iron maiden” cell death may be a promising therapeutic target. Front Immunol. 2022;13:972753. doi:10.3389/fimmu.2022.972753
   PubMed Web of Science ®Google Scholar
• Gulec S, Anderson GJ, Collins JF. Mechanistic and regulatory aspects of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol. 2014;307(4):G397–G409. doi:10.1152/ajpgi.00348.2013
   PubMed Web of Science ®Google Scholar
• Huang L, Bian M, Zhang J, Jiang L. Iron metabolism and ferroptosis in peripheral nerve injury. Oxid Med Cell Longev. 2022;2022:5918218. doi:10.1155/2022/5918218
   PubMed Web of Science ®Google Scholar
• Anderson GJ, Frazer DM. Current understanding of iron homeostasis. Am J Clin Nutr. 2017;106(Suppl 6):1559S–1566S. doi:10.3945/ajcn.117.155804
   PubMed Web of Science ®Google Scholar
• Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009;23(3):95–104. doi:10.1016/j.blre.2008.08.001
   PubMed Web of Science ®Google Scholar
• Ward DM, Kaplan J. Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012;1823(9):1426–1433. doi:10.1016/j.bbamcr.2012.03.004
   PubMed Web of Science ®Google Scholar
• Kawabata H. Transferrin and transferrin receptors update. Free Radic Biol Med. 2019;133:46–54. doi:10.1016/j.freeradbiomed.2018.06.037
   PubMed Web of Science ®Google Scholar
• Capelletti MM, Manceau H, Puy H, Peoc’h K. Ferroptosis in liver diseases: an overview. Int J Mol Sci. 2020;21(14):4908. doi:10.3390/ijms21144908
   PubMed Web of Science ®Google Scholar
• DeGregorio-Rocasolano N, Marti-Sistac O, Ponce J, et al. Iron-loaded transferrin (tf) is detrimental whereas iron-free tf confers protection against brain ischemia by modifying blood tf saturation and subsequent neuronal damage. Redox Biol. 2018;15:143–158. doi:10.1016/j.redox.2017.11.026
   PubMed Web of Science ®Google Scholar
• Lei P, Bai T, Sun Y. Mechanisms of ferroptosis and relations with regulated cell death: a review. Front Physiol. 2019;10:139. doi:10.3389/fphys.2019.00139
   PubMed Web of Science ®Google Scholar
• Morales M, Xue X. Targeting iron metabolism in cancer therapy. Theranostics. 2021;11(17):8412–8429. doi:10.7150/thno.59092
   PubMed Web of Science ®Google Scholar
• Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013;13(5):342–355. doi:10.1038/nrc3495
   PubMed Web of Science ®Google Scholar
• Santana-Codina N, Gikandi A, Mancias JD. The role of ncoa4-mediated ferritinophagy in ferroptosis. Adv Exp Med Biol. 2021;1301:41–57.
   PubMed Web of Science ®Google Scholar
• Billesbolle CB, Azumaya CM, Kretsch RC, et al. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020;586(7831):807–811. doi:10.1038/s41586-020-2668-z
   PubMed Web of Science ®Google Scholar
• Harayama T, Riezman H. Understanding the diversity of membrane lipid composition. Nat Rev Mol Cell Biol. 2018;19(5):281–296. doi:10.1038/nrm.2017.138
   PubMed Web of Science ®Google Scholar
• Lei G, Mao C, Yan Y, Zhuang L, Gan B. Ferroptosis, radiotherapy, and combination therapeutic strategies. Protein Cell. 2021;12(11):836–857. doi:10.1007/s13238-021-00841-y
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, et al. Acsl4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–98. doi:10.1038/nchembio.2239
   PubMed Web of Science ®Google Scholar
• Reed A, Ichu TA, Milosevich N, et al. Lpcat3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis. ACS Chem Biol. 2022;17(6):1607–1618. doi:10.1021/acschembio.2c00317
   PubMed Web of Science ®Google Scholar
• Chen X, Li J, Kang R, Klionsky DJ, Tang D. Ferroptosis: machinery and regulation. Autophagy. 2021;17(9):2054–2081. doi:10.1080/15548627.2020.1810918
   PubMed Web of Science ®Google Scholar
• Liang D, Minikes AM, Jiang X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell. 2022;82(12):2215–2227. doi:10.1016/j.molcel.2022.03.022
   PubMed Web of Science ®Google Scholar
• Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266–282. doi:10.1038/s41580-020-00324-8
   PubMed Web of Science ®Google Scholar
• Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A. 2016;113(34):E4966–E4975. doi:10.1073/pnas.1603244113
   PubMed Web of Science ®Google Scholar
• Maiorino M, Conrad M, Ursini F. Gpx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues. Antioxid Redox Signal. 2018;29(1):61–74. doi:10.1089/ars.2017.7115
   PubMed Web of Science ®Google Scholar
• Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter slc7a11/xct at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun. 2018;38(1):12. doi:10.1186/s40880-018-0288-x
   PubMed Web of Science ®Google Scholar
• Parker JL, Deme JC, Kolokouris D, et al. Molecular basis for redox control by the human cystine/glutamate antiporter system xc(). Nat Commun. 2021;12(1):7147. doi:10.1038/s41467-021-27414-1
   PubMed Web of Science ®Google Scholar
• Koppula P, Zhuang L, Gan B. Cystine transporter slc7a11/xct in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599–620. doi:10.1007/s13238-020-00789-5
   PubMed Web of Science ®Google Scholar
• Liu X, Olszewski K, Zhang Y, et al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020;22(4):476–486. doi:10.1038/s41556-020-0496-x
   PubMed Web of Science ®Google Scholar
• Wang Y, Hekimi S. Understanding ubiquinone. Trends Cell Biol. 2016;26(5):367–378. doi:10.1016/j.tcb.2015.12.007
   PubMed Web of Science ®Google Scholar
• Elguindy MM, Nakamaru-Ogiso E. Apoptosis-inducing factor (AIF) and its family member protein, AMID, are rotenone-sensitive NADH: ubiquinone oxidoreductases (NDH-2). J Biol Chem. 2015;290(34):20815–20826. doi:10.1074/jbc.M115.641498
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The coq oxidoreductase fsp1 acts parallel to gpx4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. doi:10.1038/s41586-019-1705-2
   PubMed Web of Science ®Google Scholar
• Doll S, Freitas FP, Shah R, et al. Fsp1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693–698. doi:10.1038/s41586-019-1707-0
   PubMed Web of Science ®Google Scholar
• Kraft VAN, Bezjian CT, Pfeiffer S, et al. Gtp cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci. 2020;6(1):41–53. doi:10.1021/acscentsci.9b01063
   PubMed Web of Science ®Google Scholar
• Thony B, Auerbach G, Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J. 2000;347(Pt 1):1–16. doi:10.1042/bj3470001
   PubMed Web of Science ®Google Scholar
• Soula M, Weber RA, Zilka O, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol. 2020;16(12):1351–1360. doi:10.1038/s41589-020-0613-y
   PubMed Web of Science ®Google Scholar
• Hu Q, Wei W, Wu D, et al. Blockade of gch1/bh4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol. 2022;10:810327. doi:10.3389/fcell.2022.810327
   PubMed Web of Science ®Google Scholar
• Wei X, Yi X, Zhu XH, Jiang DS, Lloret A. Posttranslational modifications in ferroptosis. Oxid Med Cell Longev. 2020;2020:8832043. doi:10.1155/2020/8832043
   PubMed Web of Science ®Google Scholar
• Luo Y, Gao X, Zou L, Lei M, Feng J, Hu Z. Bavachin induces ferroptosis through the stat3/p53/slc7a11 axis in osteosarcoma cells. Oxid Med Cell Longev. 2021;2021:1783485. doi:10.1155/2021/1783485
   PubMed Web of Science ®Google Scholar
• Zeng C, Lin J, Zhang K, et al. Sharpin promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/slc7a11/gpx4 signaling. Cancer Sci. 2022;113(11):3766–3775. doi:10.1111/cas.15531
   PubMed Web of Science ®Google Scholar
• Jiang L, Kon N, Li T, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57–62. doi:10.1038/nature14344
   PubMed Web of Science ®Google Scholar
• Wang SJ, Li D, Ou Y, et al. Acetylation is crucial for p53-mediated ferroptosis and tumor suppression. Cell Rep. 2016;17(2):366–373. doi:10.1016/j.celrep.2016.09.022
   PubMed Web of Science ®Google Scholar
• Ma XH, Liu JH, Liu CY, et al. Alox15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Signal Transduct Target Ther. 2022;7(1):288. doi:10.1038/s41392-022-01090-z
   PubMed Web of Science ®Google Scholar
• Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med. 2019;133:162–168. doi:10.1016/j.freeradbiomed.2018.05.074
   PubMed Web of Science ®Google Scholar
• Suzuki S, Venkatesh D, Kanda H, et al. Gls2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma. Cancer Res. 2022;82(18):3209–3222. doi:10.1158/0008-5472.CAN-21-3914
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang C, Wang J, Hu W, Feng Z. The regulation of ferroptosis by tumor suppressor p53 and its pathway. Int J Mol Sci. 2020;21(21):8387. doi:10.3390/ijms21218387
   PubMed Web of Science ®Google Scholar
• Tarangelo A, Magtanong L, Bieging-Rolett KT, et al. P53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep. 2018;22(3):569–575. doi:10.1016/j.celrep.2017.12.077
   PubMed Web of Science ®Google Scholar
• Xie Y, Zhu S, Song X, et al. The tumor suppressor p53 limits ferroptosis by blocking dpp4 activity. Cell Rep. 2017;20(7):1692–1704. doi:10.1016/j.celrep.2017.07.055
   PubMed Web of Science ®Google Scholar
• Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Modulating nrf2 in disease: timing is everything. Annu Rev Pharmacol Toxicol. 2019;59(1):555–575. doi:10.1146/annurev-pharmtox-010818-021856
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Chen R, et al. Activation of the p62-keap1-nrf2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173–184. doi:10.1002/hep.28251
   PubMed Web of Science ®Google Scholar
• Cheng H, Wang P, Wang N, et al. Neuroprotection of nrf2 against ferroptosis after traumatic brain injury in mice. Antioxidants. 2023;12(3):731. doi:10.3390/antiox12030731
   Web of Science ®Google Scholar
• Dong H, Xia Y, Jin S, et al. Nrf2 attenuates ferroptosis-mediated iir-ali by modulating tert and slc7a11. Cell Death Dis. 2021;12(11):1027. doi:10.1038/s41419-021-04307-1
   PubMed Web of Science ®Google Scholar
• Dang R, Wang M, Li X, et al. Edaravone ameliorates depressive and anxiety-like behaviors via sirt1/nrf2/ho-1/gpx4 pathway. J Neuroinflammation. 2022;19(1):41. doi:10.1186/s12974-022-02400-6
   PubMed Web of Science ®Google Scholar
• Cano M, Datta S, Wang L, et al. Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction. Aging Cell. 2021;20(8):e13444. doi:10.1111/acel.13444
   PubMed Web of Science ®Google Scholar
• Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of nrf2/ho-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221–3247. doi:10.1007/s00018-016-2223-0
   PubMed Web of Science ®Google Scholar
• Rochette L, Zeller M, Cottin Y, Vergely C. Redox functions of heme oxygenase-1 and biliverdin reductase in diabetes. Trends Endocrinol Metab. 2018;29(2):74–85. doi:10.1016/j.tem.2017.11.005
   PubMed Web of Science ®Google Scholar
• Tang Z, Ju Y, Dai X, et al. Ho-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biol. 2021;43:101971. doi:10.1016/j.redox.2021.101971
   PubMed Web of Science ®Google Scholar
• Lin SC, Hardie DG. AMPK: sensing glucose as well as cellular energy status. Cell Metab. 2018;27(2):299–313. doi:10.1016/j.cmet.2017.10.009
   PubMed Web of Science ®Google Scholar
• Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121–135. doi:10.1038/nrm.2017.95
   PubMed Web of Science ®Google Scholar
• Song X, Zhu S, Chen P, et al. AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity. Curr Biol. 2018;28(15):2388–2399 e5. doi:10.1016/j.cub.2018.05.094
   PubMed Web of Science ®Google Scholar
• Liu MY, Li HM, Wang XY, et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. Free Radic Biol Med. 2022;182:219–231. doi:10.1016/j.freeradbiomed.2022.03.002
   PubMed Web of Science ®Google Scholar
• Zhao Y, Li M, Yao X, et al. Hcar1/mct1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications. Cell Rep. 2020;33(10):108487. doi:10.1016/j.celrep.2020.108487
   PubMed Web of Science ®Google Scholar
• Wang X, Chen X, Zhou W, et al. Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways. Acta Pharm Sin B. 2022;12(2):708–722. doi:10.1016/j.apsb.2021.10.005
   PubMed Web of Science ®Google Scholar
• Lu Q, Yang L, Xiao JJ, et al. Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. Free Radic Biol Med. 2023;195:89–102. doi:10.1016/j.freeradbiomed.2022.12.088
   PubMed Web of Science ®Google Scholar
• Lee H, Zandkarimi F, Zhang Y, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020;22(2):225–234. doi:10.1038/s41556-020-0461-8
   PubMed Web of Science ®Google Scholar
• Hunkeler M, Hagmann A, Stuttfeld E, et al. Structural basis for regulation of human acetyl-coa carboxylase. Nature. 2018;558(7710):470–474. doi:10.1038/s41586-018-0201-4
   PubMed Web of Science ®Google Scholar
• Wu J, Minikes AM, Gao M, et al. Intercellular interaction dictates cancer cell ferroptosis via nf2-yap signalling. Nature. 2019;572(7769):402–406. doi:10.1038/s41586-019-1426-6
   PubMed Web of Science ®Google Scholar
• Gao R, Kalathur RKR, Coto-Llerena M, et al. Yap/taz and atf4 drive resistance to sorafenib in hepatocellular carcinoma by preventing ferroptosis. EMBO Mol Med. 2021;13(12):e14351. doi:10.15252/emmm.202114351
   PubMed Web of Science ®Google Scholar
• Magesh S, Cai D. Roles of yap/taz in ferroptosis. Trends Cell Biol. 2022;32(9):729–732. doi:10.1016/j.tcb.2022.05.005
   PubMed Web of Science ®Google Scholar
• Ma S, Meng Z, Chen R, Guan KL. The hippo pathway: biology and pathophysiology. Annu Rev Biochem. 2019;88(1):577–604. doi:10.1146/annurev-biochem-013118-111829
   PubMedGoogle Scholar
• Piccolo S, Dupont S, Cordenonsi M. The biology of yap/taz: hippo signaling and beyond. Physiol Rev. 2014;94(4):1287–1312. doi:10.1152/physrev.00005.2014
   PubMed Web of Science ®Google Scholar
• Sun T, Chi JT. Regulation of ferroptosis in cancer cells by yap/taz and hippo pathways: the therapeutic implications. Genes Dis. 2021;8(3):241–249. doi:10.1016/j.gendis.2020.05.004
   PubMed Web of Science ®Google Scholar
• Yang WH, Chi JT. Hippo pathway effectors yap/taz as novel determinants of ferroptosis. Mol Cell Oncol. 2020;7(1):1699375. doi:10.1080/23723556.2019.1699375
   PubMed Web of Science ®Google Scholar
• Yang WH, Huang Z, Wu J, Ding CC, Murphy SK, Chi JT. A taz-angptl4-nox2 axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer. Mol Cancer Res. 2020;18(1):79–90. doi:10.1158/1541-7786.MCR-19-0691
   PubMed Web of Science ®Google Scholar
• Rozycki M, Bialik JF, Speight P, et al. Myocardin-related transcription factor regulates nox4 protein expression: linking cytoskeletal organization to redox state. J Biol Chem. 2016;291(1):227–243. doi:10.1074/jbc.M115.674606
   PubMed Web of Science ®Google Scholar
• Yang WH, Ding CC, Sun T, et al. The hippo pathway effector taz regulates ferroptosis in renal cell carcinoma. Cell Rep. 2019;28(10):2501–2508 e4. doi:10.1016/j.celrep.2019.07.107
   PubMed Web of Science ®Google Scholar
• Hua H, Kong Q, Zhang H, Wang J, Luo T, Jiang Y. Targeting mtor for cancer therapy. J Hematol Oncol. 2019;12(1):71. doi:10.1186/s13045-019-0754-1
   PubMed Web of Science ®Google Scholar
• Alzahrani AS. Pi3k/akt/mtor inhibitors in cancer: at the bench and bedside. Semin Cancer Biol. 2019;59:125–132. doi:10.1016/j.semcancer.2019.07.009
   PubMed Web of Science ®Google Scholar
• Yi J, Zhu J, Wu J, Thompson CB, Jiang X. Oncogenic activation of pi3k-akt-mtor signaling suppresses ferroptosis via srebp-mediated lipogenesis. Proc Natl Acad Sci U S A. 2020;117(49):31189–31197. doi:10.1073/pnas.2017152117
   PubMed Web of Science ®Google Scholar
• Chen H, Qi Q, Wu N, et al. Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer. Redox Biol. 2022;55:102426. doi:10.1016/j.redox.2022.102426
   PubMed Web of Science ®Google Scholar
• Han D, Jiang L, Gu X, et al. SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol. 2020;235(11):8839–8851. doi:10.1002/jcp.29727
   PubMed Web of Science ®Google Scholar
• Zhang Y, Swanda RV, Nie L, et al. Mtorc1 couples cyst(e)ine availability with gpx4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12(1):1589. doi:10.1038/s41467-021-21841-w
   PubMed Web of Science ®Google Scholar
• Buckwalter JA, Cooper RR. Bone structure and function. Instr Course Lect. 1987;36:27–48.
   PubMedGoogle Scholar
• Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiol Rev. 2022;102(1):379–410. doi:10.1152/physrev.00043.2020
   PubMed Web of Science ®Google Scholar
• Cui J, Shibata Y, Zhu T, Zhou J, Zhang J. Osteocytes in bone aging: advances, challenges, and future perspectives. Ageing Res Rev. 2022;77:101608. doi:10.1016/j.arr.2022.101608
   PubMed Web of Science ®Google Scholar
• Ponzetti M, Rucci N. Osteoblast differentiation and signaling: established concepts and emerging topics. Int J Mol Sci. 2021;22(13). doi:10.3390/ijms22136651
   PubMed Web of Science ®Google Scholar
• Sommerfeldt DW, Rubin CT. Biology of bone and how it orchestrates the form and function of the skeleton. Eur Spine J. 2001;10(Suppl 2):S86–S95. doi:10.1007/s005860100283
   PubMedGoogle Scholar
• Boyce BF. Advances in the regulation of osteoclasts and osteoclast functions. J Dent Res. 2013;92(10):860–867. doi:10.1177/0022034513500306
   PubMed Web of Science ®Google Scholar
• Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-osteoclast communication and bone homeostasis. Cells. 2020;9(9):2073. doi:10.3390/cells9092073
   PubMed Web of Science ®Google Scholar
• Armas LA, Recker RR. Pathophysiology of osteoporosis: new mechanistic insights. Endocrinol Metab Clin North Am. 2012;41(3):475–486. doi:10.1016/j.ecl.2012.04.006
   PubMed Web of Science ®Google Scholar
• Gao Z, Chen Z, Xiong Z, Liu X. Ferroptosis - a new target of osteoporosis. Exp Gerontol. 2022;165:111836. doi:10.1016/j.exger.2022.111836
   PubMed Web of Science ®Google Scholar
• Guggenbuhl P, Filmon R, Mabilleau G, Basle MF, Chappard D. Iron inhibits hydroxyapatite crystal growth in vitro. Metabolism. 2008;57(7):903–910. doi:10.1016/j.metabol.2008.02.004
   PubMed Web of Science ®Google Scholar
• Li Z, Li D, Chen R, Gao S, Xu Z, Li N. Cell death regulation: a new way for natural products to treat osteoporosis. Pharmacol Res. 2023;187:106635. doi:10.1016/j.phrs.2022.106635
   PubMed Web of Science ®Google Scholar
• Lin Z, He H, Wang M, Liang J. microRNA-130a controls bone marrow mesenchymal stem cell differentiation towards the osteoblastic and adipogenic fate. Cell Prolif. 2019;52(6):e12688. doi:10.1111/cpr.12688
   PubMed Web of Science ®Google Scholar
• Komori T. Whole aspect of runx2 functions in skeletal development. Int J Mol Sci. 2022;23(10):5776. doi:10.3390/ijms23105776
   PubMed Web of Science ®Google Scholar
• Balogh E, Tolnai E, Nagy B, et al. Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin. Biochim Biophys Acta. 2016;1862(9):1640–1649. doi:10.1016/j.bbadis.2016.06.003
   PubMed Web of Science ®Google Scholar
• Lan D, Qi S, Yao C, et al. Quercetin protects rat bmscs from oxidative stress via ferroptosis. J Mol Endocrinol. 2022;69(3):401–413. doi:10.1530/JME-22-0086
   PubMed Web of Science ®Google Scholar
• Messer JG, Kilbarger AK, Erikson KM, Kipp DE. Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone. 2009;45(5):972–979. doi:10.1016/j.bone.2009.07.073
   PubMed Web of Science ®Google Scholar
• Jiang Z, Wang H, Qi G, Jiang C, Chen K, Yan Z. Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: an in vitro and in vivo study. IUBMB Life. 2022;74(11):1052–1069. doi:10.1002/iub.2656
   PubMed Web of Science ®Google Scholar
• Ma H, Wang X, Zhang W, et al. Melatonin suppresses ferroptosis induced by high glucose via activation of the nrf2/ho-1 signaling pathway in type 2 diabetic osteoporosis. Oxid Med Cell Longev. 2020;2020:9067610. doi:10.1155/2020/9067610
   PubMed Web of Science ®Google Scholar
• Xu P, Lin B, Deng X, Huang K, Zhang Y, Wang N. Vdr activation attenuates osteoblastic ferroptosis and senescence by stimulating the nrf2/gpx4 pathway in age-related osteoporosis. Free Radic Biol Med. 2022;193(Pt 2):720–735. doi:10.1016/j.freeradbiomed.2022.11.013
   PubMedGoogle Scholar
• Jin C, Tan K, Yao Z, et al. A novel anti-osteoporosis mechanism of VK2: interfering with ferroptosis via AMPK/SIRT1 pathway in type 2 diabetic osteoporosis. J Agric Food Chem. 2023;71(6):2745–2761. doi:10.1021/acs.jafc.2c05632
   PubMedGoogle Scholar
• Tian Q, Wu S, Dai Z, et al. Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway. PeerJ. 2016;4:e2611. doi:10.7717/peerj.2611
   PubMed Web of Science ®Google Scholar
• Wang B, Zhan Y, Yan L, Hao D. How zoledronic acid improves osteoporosis by acting on osteoclasts. Front Pharmacol. 2022;13:961941. doi:10.3389/fphar.2022.961941
   PubMed Web of Science ®Google Scholar
• Ma J, Wang A, Zhang H, et al. Iron overload induced osteocytes apoptosis and led to bone loss in hepcidin(-/-) mice through increasing sclerostin and rankl/opg. Bone. 2022;164:116511. doi:10.1016/j.bone.2022.116511
   PubMed Web of Science ®Google Scholar
• Yang J, Dong D, Luo X, Zhou J, Shang P, Zhang H. Iron overload-induced osteocyte apoptosis stimulates osteoclast differentiation through increasing osteocytic rankl production in vitro. Calcif Tissue Int. 2020;107(5):499–509. doi:10.1007/s00223-020-00735-x
   PubMed Web of Science ®Google Scholar
• Ni S, Yuan Y, Qian Z, et al. Hypoxia inhibits rankl-induced ferritinophagy and protects osteoclasts from ferroptosis. Free Radic Biol Med. 2021;169:271–282. doi:10.1016/j.freeradbiomed.2021.04.027
   PubMed Web of Science ®Google Scholar
• Reid IR, Billington EO. Drug therapy for osteoporosis in older adults. Lancet. 2022;399(10329):1080–1092. doi:10.1016/S0140-6736(21)02646-5
   PubMed Web of Science ®Google Scholar
• Yang Y, Lin Y, Wang M, et al. Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis. Bone Res. 2022;10(1):26. doi:10.1038/s41413-022-00198-w
   PubMed Web of Science ®Google Scholar
• Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet. 2015;386(9991):376–387. doi:10.1016/S0140-6736(14)60802-3
   PubMed Web of Science ®Google Scholar
• Charlier E, Deroyer C, Ciregia F, et al. Chondrocyte dedifferentiation and osteoarthritis (oa). Biochem Pharmacol. 2019;165:49–65. doi:10.1016/j.bcp.2019.02.036
   PubMed Web of Science ®Google Scholar
• Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I. Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol. 2018;71–72:40–50. doi:10.1016/j.matbio.2018.05.008
   PubMed Web of Science ®Google Scholar
• Miao Y, Chen Y, Xue F, et al. Contribution of ferroptosis and gpx4’s dual functions to osteoarthritis progression. EBioMedicine. 2022;76:103847. doi:10.1016/j.ebiom.2022.103847
   PubMed Web of Science ®Google Scholar
• Xu C, Ni S, Xu N, et al. Theaflavin-3,3’-digallate inhibits erastin-induced chondrocytes ferroptosis via the nrf2/gpx4 signaling pathway in osteoarthritis. Oxid Med Cell Longev. 2022;2022:3531995. doi:10.1155/2022/3531995
   PubMed Web of Science ®Google Scholar
• Zhang S, Xu J, Si H, Wu Y, Zhou S, Shen B. The role played by ferroptosis in osteoarthritis: evidence based on iron dyshomeostasis and lipid peroxidation. Antioxidants. 2022;11(9):1668. doi:10.3390/antiox11091668
   Web of Science ®Google Scholar
• Liu H, Deng Z, Yu B, et al. Identification of slc3a2 as a potential therapeutic target of osteoarthritis involved in ferroptosis by integrating bioinformatics, clinical factors and experiments. Cells. 2022;11(21):3430. doi:10.3390/cells11213430
   PubMed Web of Science ®Google Scholar
• Yao X, Sun K, Yu S, et al. Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 2021;27:33–43. doi:10.1016/j.jot.2020.09.006
   PubMed Web of Science ®Google Scholar
• Yan J, Feng G, Ma L, Chen Z, Jin Q. Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis. J Orthop Surg Res. 2022;17(1):333. doi:10.1186/s13018-022-03225-y
   PubMed Web of Science ®Google Scholar
• Yi D, Yu H, Lu K, et al. AMPK signaling in energy control, cartilage biology, and osteoarthritis. Front Cell Dev Biol. 2021;9:696602. doi:10.3389/fcell.2021.696602
   PubMed Web of Science ®Google Scholar
• Wan Y, Shen K, Yu H, Fan W. Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. Free Radic Biol Med. 2023;196:108–120. doi:10.1016/j.freeradbiomed.2023.01.006
   PubMed Web of Science ®Google Scholar
• Zhou X, Zheng Y, Sun W, et al. D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a hif-2alpha-dependent manner. Cell Prolif. 2021;54(11):e13134. doi:10.1111/cpr.13134
   PubMed Web of Science ®Google Scholar
• Ma S, Dubin AE, Zhang Y, et al. A role of piezo1 in iron metabolism in mice and humans. Cell. 2021;184(4):969–982 e13. doi:10.1016/j.cell.2021.01.024
   PubMed Web of Science ®Google Scholar
• Wang S, Li W, Zhang P, et al. Mechanical overloading induces gpx4-regulated chondrocyte ferroptosis in osteoarthritis via piezo1 channel facilitated calcium influx. J Adv Res. 2022;41:63–75. doi:10.1016/j.jare.2022.01.004
   PubMed Web of Science ®Google Scholar
• Tong L, Yu H, Huang X, et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches. Bone Res. 2022;10(1):60. doi:10.1038/s41413-022-00226-9
   PubMed Web of Science ®Google Scholar
• Gong Z, Wang Y, Li L, Li X, Qiu B, Hu Y. Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway. Food Chem Toxicol. 2023;174:113644. doi:10.1016/j.fct.2023.113644
   PubMed Web of Science ®Google Scholar
• Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z. Targeting mir-10a-5p/il-6r axis for reducing il-6-induced cartilage cell ferroptosis. Exp Mol Pathol. 2021;118:104570. doi:10.1016/j.yexmp.2020.104570
   PubMed Web of Science ®Google Scholar
• Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038. doi:10.1016/S0140-6736(16)30173-8
   PubMed Web of Science ®Google Scholar
• Ogilvie-Harris DJ, Fornaiser VL. Synovial iron deposition in osteoarthritis and rheumatoid arthritis. J Rheumatol. 1980;7(1):30–36.
   PubMed Web of Science ®Google Scholar
• Chen Y, Xu W, Yang H, et al. Serum levels of hepcidin in rheumatoid arthritis and its correlation with disease activity and anemia: a meta-analysis. Immunol Invest. 2021;50(2–3):243–258. doi:10.1080/08820139.2020.1742731
   PubMed Web of Science ®Google Scholar
• Cylwik B, Gruszewska E, Gindzienska-Sieskiewicz E, Kowal-Bielecka O, Chrostek L. Serum profile of transferrin isoforms in rheumatoid arthritis treated with biological drugs. Clin Biochem. 2019;74:31–35. doi:10.1016/j.clinbiochem.2019.10.005
   PubMed Web of Science ®Google Scholar
• Elsheemy MS, Hasanin AH, Mansour A, Mehrez SI, Abdel-Bary M. Etanercept improved anemia and decreased hepcidin gene expression in a rat model of rheumatoid arthritis. Biomed Pharmacother. 2019;112:108740. doi:10.1016/j.biopha.2019.108740
   PubMed Web of Science ®Google Scholar
• Fan XX, Xu MZ, Leung EL, Jun C, Yuan Z, Liu L. Ros-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria. Nanomicro Lett. 2020;12(1):76. doi:10.1007/s40820-020-0410-x
   PubMed Web of Science ®Google Scholar
• Xie Z, Hou H, Luo D, An R, Zhao Y, Qiu C. Ros-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: a covert clue for potential therapy. Inflammation. 2021;44(1):35–47. doi:10.1007/s10753-020-01338-2
   PubMed Web of Science ®Google Scholar
• Bustamante MF, Garcia-Carbonell R, Whisenant KD, Guma M. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2017;19(1):110. doi:10.1186/s13075-017-1303-3
   PubMed Web of Science ®Google Scholar
• Chang S, Tang M, Zhang B, Xiang D, Li F. Ferroptosis in inflammatory arthritis: a promising future. Front Immunol. 2022;13:955069. doi:10.3389/fimmu.2022.955069
   PubMed Web of Science ®Google Scholar
• Liu P, Wang W, Li Z, et al. Ferroptosis: a new regulatory mechanism in osteoporosis. Oxid Med Cell Longev. 2022;2022:2634431. doi:10.1155/2022/2634431
   PubMed Web of Science ®Google Scholar
• Ling H, Li M, Yang C, et al. Glycine increased ferroptosis via sam-mediated gpx4 promoter methylation in rheumatoid arthritis. Rheumatology. 2022;61(11):4521–4534. doi:10.1093/rheumatology/keac069
   PubMed Web of Science ®Google Scholar
• Wu J, Feng Z, Chen L, et al. Tnf antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models. Nat Commun. 2022;13(1):676. doi:10.1038/s41467-021-27948-4
   PubMed Web of Science ®Google Scholar
• Cheng Q, Chen M, Liu M, et al. Semaphorin 5a suppresses ferroptosis through activation of pi3k-akt-mtor signaling in rheumatoid arthritis. Cell Death Dis. 2022;13(7):608. doi:10.1038/s41419-022-05065-4
   PubMed Web of Science ®Google Scholar
• Ooi M, Hibbs S, Chen FE. The safety of modern intravenous iron infusions in patients with rheumatoid arthritis - a review of the literature. Hematology. 2020;25(1):108–111. doi:10.1080/16078454.2020.1730557
   PubMed Web of Science ®Google Scholar
• Luo H, Zhang R. Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the xc-/gpx4 axis. Exp Ther Med. 2021;21(1):72. doi:10.3892/etm.2020.9504
   PubMed Web of Science ®Google Scholar
• Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, Alipour B. Effects of coenzyme q10 supplementation on inflammatory cytokines (tnf-alpha, il-6) and oxidative stress in rheumatoid arthritis patients: a randomized controlled trial. Arch Med Res. 2015;46(7):527–533. doi:10.1016/j.arcmed.2015.08.006
   PubMed Web of Science ®Google Scholar
• Hu J, Zhang R, Chang Q, et al. P53: a regulator of ferroptosis induced by galectin-1 derived peptide 3 in mh7a cells. Front Genet. 2022;13:920273. doi:10.3389/fgene.2022.920273
   PubMed Web of Science ®Google Scholar
• Xiang J, Chen H, Lin Z, Chen J, Luo L. Identification and experimental validation of ferroptosis-related gene slc2a3 is involved in rheumatoid arthritis. Eur J Pharmacol. 2023;943:175568. doi:10.1016/j.ejphar.2023.175568
   PubMed Web of Science ®Google Scholar
• Sonou T, Ohya M, Yashiro M, et al. Magnesium prevents phosphate-induced vascular calcification via trpm7 and pit-1 in an aortic tissue culture model. Hypertens Res. 2017;40(6):562–567. doi:10.1038/hr.2016.188
   PubMed Web of Science ®Google Scholar
• Schappe MS, Szteyn K, Stremska ME, et al. Chanzyme trpm7 mediates the ca(2+) influx essential for lipopolysaccharide-induced toll-like receptor 4 endocytosis and macrophage activation. Immunity. 2018;48(1):59–74 e5. doi:10.1016/j.immuni.2017.11.026
   PubMed Web of Science ®Google Scholar
• Zhou R, Chen Y, Li S, et al. Trpm7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the pkcalpha-nox4 axis. Redox Biol. 2022;55:102411. doi:10.1016/j.redox.2022.102411
   PubMed Web of Science ®Google Scholar
• Ritter J, Bielack SS. Osteosarcoma. Ann Oncol. 2010;21(Suppl 7):vii320–vii325. doi:10.1093/annonc/mdq276
   PubMed Web of Science ®Google Scholar
• Chen C, Xie L, Ren T, Huang Y, Xu J, Guo W. Immunotherapy for osteosarcoma: fundamental mechanism, rationale, and recent breakthroughs. Cancer Lett. 2021;500:1–10. doi:10.1016/j.canlet.2020.12.024
   PubMed Web of Science ®Google Scholar
• Liu J, Hong M, Li Y, Chen D, Wu Y, Hu Y. Programmed cell death tunes tumor immunity. Front Immunol. 2022;13:847345. doi:10.3389/fimmu.2022.847345
   PubMed Web of Science ®Google Scholar
• Shi Y, Gong M, Deng Z, et al. Tirapazamine suppress osteosarcoma cells in part through slc7a11 mediated ferroptosis. Biochem Biophys Res Commun. 2021;567:118–124. doi:10.1016/j.bbrc.2021.06.036
   PubMed Web of Science ®Google Scholar
• Liu J, Lou C, Zhen C, Wang Y, Shang P, Lv H. Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blockage in k7m2 osteosarcoma cells. Metallomics. 2022;14(5). doi:10.1093/mtomcs/mfac027
   Web of Science ®Google Scholar
• Xu Z, Chen L, Wang C, Zhang L, Xu W. microRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4. Free Radic Res. 2021;55(11–12):1119–1129. doi:10.1080/10715762.2021.2024816
   PubMed Web of Science ®Google Scholar
• Chen M, Jiang Y, Sun Y. Kdm4a-mediated histone demethylation of slc7a11 inhibits cell ferroptosis in osteosarcoma. Biochem Biophys Res Commun. 2021;550:77–83. doi:10.1016/j.bbrc.2021.02.137
   PubMed Web of Science ®Google Scholar
• Wen RJ, Dong X, Zhuang HW, et al. Baicalin induces ferroptosis in osteosarcomas through a novel nrf2/xct/gpx4 regulatory axis. Phytomedicine. 2023;116:154881. doi:10.1016/j.phymed.2023.154881
   PubMed Web of Science ®Google Scholar
• Jiacong H, Qirui Y, Haonan L, Yichang S, Yan C, Keng C. Zoledronic acid induces ferroptosis by upregulating por in osteosarcoma. Med Oncol. 2023;40(5):141. doi:10.1007/s12032-023-01988-w
   PubMed Web of Science ®Google Scholar
• Lv H, Zhen C, Liu J, Shang P. Beta-phenethyl isothiocyanate induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the MAPK signaling pathway. Oxid Med Cell Longev. 2020;2020:5021983. doi:10.1155/2020/5021983
   PubMed Web of Science ®Google Scholar
• Lv HH, Zhen CX, Liu JY, Shang P. Peitc triggers multiple forms of cell death by gsh-iron-ros regulation in k7m2 murine osteosarcoma cells. Acta Pharmacol Sin. 2020;41(8):1119–1132. doi:10.1038/s41401-020-0376-8
   PubMed Web of Science ®Google Scholar
• Lin H, Chen X, Zhang C, et al. Ef24 induces ferroptosis in osteosarcoma cells through hmox1. Biomed Pharmacother. 2021;136:111202. doi:10.1016/j.biopha.2020.111202
   PubMed Web of Science ®Google Scholar
• Velletri T, Xie N, Wang Y, et al. P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development. Cell Death Dis. 2016;7(1):e2015. doi:10.1038/cddis.2015.367
   PubMedGoogle Scholar
• Wang L, Pan S. The regulatory effects of p53 on the typical and atypical ferroptosis in the pathogenesis of osteosarcoma: a systematic review. Front Genet. 2023;14:1154299. doi:10.3389/fgene.2023.1154299
   PubMed Web of Science ®Google Scholar
• Liu Q, Wang K. The induction of ferroptosis by impairing stat3/nrf2/gpx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin. Cell Biol Int. 2019;43(11):1245–1256. doi:10.1002/cbin.11121
   PubMed Web of Science ®Google Scholar
• Li X, Liu J. Fancd2 inhibits ferroptosis by regulating the jak2/stat3 pathway in osteosarcoma. BMC Cancer. 2023;23(1):179. doi:10.1186/s12885-023-10626-7
   PubMed Web of Science ®Google Scholar
• Zhang W, Lyu P, Andreev D, Jia Y, Zhang F, Bozec A. Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma. Front Cell Dev Biol. 2022;10:974851. doi:10.3389/fcell.2022.974851
   PubMed Web of Science ®Google Scholar
• Fu J, Li T, Yang Y, et al. Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors. Biomaterials. 2021;268:120537. doi:10.1016/j.biomaterials.2020.120537
   PubMed Web of Science ®Google Scholar
• Jiang R, He S, Gong H, et al. Identification of atg7 as a regulator of proferroptosis and oxidative stress in osteosarcoma. Oxid Med Cell Longev. 2022;2022:8441676. doi:10.1155/2022/8441676
   PubMed Web of Science ®Google Scholar
• Yang L, Liu J, Liu S. Clinical significance and immune landscape of a novel ferroptosis-related prognosis signature in osteosarcoma. BMC Cancer. 2023;23(1):229. doi:10.1186/s12885-023-10688-7
   PubMed Web of Science ®Google Scholar
• Jiang M, Jike Y, Gan F, et al. Verification of ferroptosis subcluster-associated genes related to osteosarcoma and exploration of immune targeted therapy. Oxid Med Cell Longev. 2022;2022:9942014. doi:10.1155/2022/9942014
   PubMed Web of Science ®Google Scholar
• Wang X, Xia G, Xiao S, et al. A ferroptosis-related gene signature associated with immune landscape and therapeutic response in osteosarcoma. Front Oncol. 2022;12:1024915. doi:10.3389/fonc.2022.1024915
   PubMed Web of Science ®Google Scholar
• Liu X, Du S, Wang S, Ye K. Ferroptosis in osteosarcoma: a promising future. Front Oncol. 2022;12:1031779. doi:10.3389/fonc.2022.1031779
   PubMed Web of Science ®Google Scholar
• Zhang F, Yan Y, Cai Y, et al. Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications. Front Cell Dev Biol. 2023;11:1112751. doi:10.3389/fcell.2023.1112751
   PubMed Web of Science ®Google Scholar