107
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Identification of Key Genes for Pyroptosis-Induced Salivary Gland Inflammation in Sjogren’s Syndrome Based on Microarray Data and Immunohistochemistry Analysis

, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, & ORCID Icon show all
Pages 5865-5879 | Received 11 Aug 2023, Accepted 28 Nov 2023, Published online: 05 Dec 2023

References

  • Mavragani CP, Moutsopoulos HM. Sjögren’s syndrome: old and new therapeutic targets. J Autoimmun. 2020;110:102364.
  • Seror R, Nocturne G, Mariette X. Current and future therapies for primary Sjögren syndrome. Nature Rev Rheumatol. 2021;17(8):475–486.
  • Luppi F, Sebastiani M, Sverzellati N, Cavazza A, Salvarani C, Manfredi A. Lung complications of Sjogren syndrome. Eur Respir Rev. 2020;29(157):200021.
  • Davies K, Ng WF. Autonomic nervous system dysfunction in primary Sjögren’s syndrome. Front Immunol. 2021;12:702505.
  • Atzeni F, Gozza F, Cafaro G, Perricone C, Bartoloni E. Cardiovascular Involvement in Sjögren’s syndrome. Front Immunol. 2022;13:879516.
  • Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 2021;6(1):128.
  • You R, He X, Zeng Z, Zhan Y, Xiao Y, Xiao R. Pyroptosis and its role in autoimmune disease: a potential therapeutic target. Front Immunol. 2022;13:841732.
  • Ge G, Bai J, Wang Q, et al. Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway. Sci Chin Life Sci. 2022;65(3):588–603.
  • Zhuang L, Luo X, Wu S, et al. Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis. Cell Death Discovery. 2022;8(1):379.
  • Baldini C, Rossi C, Ferro F, et al. The P2X7 receptor-inflammasome complex has a role in modulating the inflammatory response in primary Sjögren’s syndrome. J Intern Med. 2013;274(5):480–489.
  • Li N, Li L, Wu M, et al. Integrated bioinformatics and validation reveal potential biomarkers associated with progression of primary Sjögren’s syndrome. Front Immunol. 2021;12:697157.
  • Chen L, Lu D, Yu K, et al. Bioinformatics analysis for identification of key genes in salivary gland and the potential of a combination of biomarkers for the diagnosis of SS. J Inflamm Res. 2021;14:4143–4153.
  • Oyelakin A, Horeth E, Song EC, et al. Transcriptomic and network analysis of minor salivary glands of patients with primary Sjögren’s syndrome. Front Immunol. 2020;11:606268.
  • Luo J, Liao X, Zhang L, et al. Transcriptome sequencing reveals potential roles of ICOS in Primary Sjögren’s syndrome. Front Cell Dev Biol. 2020;8:592490.
  • Cheng X, Yan J, Liu Y, Wang J, Taubert S. eVITTA: a web-based visualization and inference toolbox for transcriptome analysis. Nucleic Acids Res. 2021;49(W1):W207–w215.
  • Franceschini A, Szklarczyk D, Frankild S, et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41(Database issue):D808–815.
  • Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011;27(3):431–432.
  • Warde-Farley D, Donaldson SL, Comes O, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38(Web Server issue):W214–220.
  • Kim J, Sun D, Ozl R, et al. A validated method of labial minor salivary gland biopsy for the diagnosis of Sjogren’s syndrome. Laryngoscope. 2016;126(9):2041–2046.
  • Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome: a Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis Rheumatol. 2017;69(1):35–45.
  • Manfrè V, Cafaro G, Riccucci I, et al. One year in review 2020: comorbidities, diagnosis and treatment of primary Sjögren’s syndrome. Clin Exp Rheumatol. 2020;38(4):10–22.
  • Dela Cruz A, Kartha V, Tilston-Lunel A, et al. Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations. Sci Rep. 2021;11(1):11154.
  • Tseng YC, Yang HY, Lin WT, et al. Salivary dysbiosis in Sjögren’s syndrome and a commensal-mediated immunomodulatory effect of salivary gland epithelial cells. NPJ Biofilms Microbiomes. 2021;7(1):21.
  • Katsiougiannis S, Stergiopoulos A, Moustaka K, et al. Salivary gland epithelial cell in Sjögren’s syndrome: metabolic shift and altered mitochondrial morphology toward an innate immune cell function. J Autoimmun. 2023;136:103014.
  • Tang Y, Zhou Y, Wang X, et al. The role of epithelial cells in the immunopathogenesis of Sjögren’s syndrome. J Leukoc Biol. 2023. doi:10.1093/jleuko/qiad049
  • Colafrancesco S, Barbati C, Priori R, et al. Maladaptive autophagy in the pathogenesis of autoimmune epithelitis in Sjögren’s syndrome. Arthritis Rheumatol. 2022;74(4):654–664.
  • Cao T, Zhou J, Liu Q, et al. Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren’s syndrome via JAK/STAT1-mediated inhibition of system Xc(). Free Radic Biol Med. 2023;205:116–128.
  • Pontarini E, Sciacca E, Grigoriadou S, et al. NKp30 receptor upregulation in salivary glands of Sjögren’s syndrome characterizes Ectopic lymphoid structures and is restricted by rituximab treatment. Front Immunol. 2021;12:706737.
  • Vakrakou AG, Boiu S, Ziakas PD, Xingi E, Boleti H, Manoussakis MN. Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren’s syndrome fueled by inflammagenic DNA accumulations. J Autoimmun. 2018;91:23–33.
  • Hong SM, Lee J, Jang SG, et al. Type I interferon increases inflammasomes associated pyroptosis in the salivary glands of patients with primary Sjögren’s syndrome. Immun net. 2020;20(5):e39.
  • Khalafalla MG, Woods LT, Camden JM, et al. P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292(40):16626–16637.
  • Cuello C, Palladinetti P, Tedla N, et al. Chemokine expression and leucocyte infiltration in Sjögren’s syndrome. Br J Rheumatol. 1998;37(7):779–783.
  • Kobayashi M, Kawano S, Hatachi S, et al. Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren’s syndrome. J Rheumatol. 2005;32(11):2156–2163.
  • Aziz KE, McCluskey PJ, Wakefield D. Pattern of adhesion molecule expression in labial salivary glands from patients with primary Sjögren’s syndrome. Ocul Immunol Inflamm. 1995;3(4):221–236.
  • Alexopoulou L. Nucleic acid-sensing toll-like receptors: important players in Sjögren’s syndrome. Front Immunol. 2022;13:980400.
  • Roescher N, Vosters JL, Alsaleh G, et al. Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren’s syndrome as a proof of concept. Mol Ther. 2014;22(4):821–827.
  • Vakrakou AG, Svolaki IP, Evangelou K, Gorgoulis VG, Manoussakis MN. Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren’s syndrome. J Autoimmun. 2020;108:102381.
  • Kong R, Sun L, Li H, Wang D. The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease. Autoimmunity. 2022;55(1):1–7.
  • Zhong X, Zeng H, Zhou Z, et al. Structural mechanisms for regulation of GSDMB pore-forming activity. Nature. 2023;616(7957):598–605.
  • Johns CE, Galam L. Guanylate Binding Protein 1 (GBP1): a Key Protein in Inflammatory Pyroptosis. Cell Biochem Biophys. 2022;80(2):295–299.
  • Yao Q, Song Z, Wang B, Qin Q, Zhang JA. Identifying Key Genes and functionally enriched pathways in Sjögren’s syndrome by weighted gene co-expression network analysis. Front Genetics. 2019;10:1142.
  • Fisch D, Bando H, Clough B, et al. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO j. 2019;38(13):e100926.
  • Alpert S, Kang HI, Weissman I, Fox RI. Expression of granzyme A in salivary gland biopsies from patients with primary Sjögren’s syndrome. Arthritis Rheum. 1994;37(7):1046–1054.
  • Jia Y, Cui R, Wang C, et al. Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. Redox Bio. 2020;32:101534.
  • Zhang WJ, Chen SJ, Zhou SC, Wu SZ, Wang H. Inflammasomes and Fibrosis. Front Immunol. 2021;12:643149.
  • Ren C, Chen J, Che Q, et al. IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway. Immunobiology. 2023;228(3):152382.