82
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Lysosome-Related Diagnostic Biomarkers for Pediatric Sepsis Integrated by Machine Learning

& ORCID Icon
Pages 5575-5583 | Received 25 Aug 2023, Accepted 21 Nov 2023, Published online: 23 Nov 2023

References

  • Qin Y, Caldino Bohn RI, Sriram A, et al. Refining empiric subgroups of pediatric sepsis using machine-learning techniques on observational data. Front Pediatr. 2023;11:1035576. doi:10.3389/fped.2023.1035576
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
  • Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49(11):e1063–e1143. doi:10.1097/CCM.0000000000005337
  • Wang F, Gómez-Sintes R, Boya P. Lysosomal membrane permeabilization and cell death. Traffic. 2018;19(12):918–931. doi:10.1111/tra.12613
  • Yambire KF, Rostosky C, Watanabe T, et al. Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. eLife. 2019;8. doi:10.7554/eLife.51031
  • Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene. 2008;27(50):6434–6451. doi:10.1038/onc.2008.310
  • Biasizzo M, Kopitar-Jerala N. Interplay between NLRP3 inflammasome and autophagy. Front Immunol. 2020;11:591803. doi:10.3389/fimmu.2020.591803
  • Chen L, Zhao Y, Lai D, et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis. 2018;9(6):597. doi:10.1038/s41419-018-0538-5
  • Tsujimoto K, Jo T, Nagira D, et al. The lysosomal ragulator complex activates NLRP3 inflammasome in vivo via HDAC6. EMBO J. 2023;42(1):e111389. doi:10.15252/embj.2022111389
  • Yang R, Zhang X. A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation. Front Cell Infect Microbiol. 2022;12:984835. doi:10.3389/fcimb.2022.984835
  • Peng J, Pan J, Wang H, Mo J, Lan L, Peng Y. Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1. J Neuroinflammation. 2022;19(1):87. doi:10.1186/s12974-022-02453-7
  • Liu Y, Wang D, Li T, et al. Melatonin: a potential adjuvant therapy for septic myopathy. Biomed Pharmacother. 2023;158:114209. doi:10.1016/j.biopha.2022.114209
  • Zhao Q, Gong Z, Wang J, et al. A zinc- and calcium-rich lysosomal nanoreactor rescues monocyte/macrophage dysfunction under sepsis. Adv. Sci. 2023;10(6):e2205097. doi:10.1002/advs.202205097
  • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550. doi:10.1073/pnas.0506580102
  • Weiss SL, Peters MJ, Alhazzani W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020;46(Suppl 1):10–67. doi:10.1007/s00134-019-05878-6
  • Zhang G. Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment. Front Immunol. 2022;13:975762. doi:10.3389/fimmu.2022.975762
  • Fan J, Shi S, Qiu Y, Liu M, Shu Q. Analysis of signature genes and association with immune cells infiltration in pediatric septic shock. Front Immunol. 2022;13:1056750. doi:10.3389/fimmu.2022.1056750
  • Gentles AJ, Newman AM, Liu CL, et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 2015;21(8):938–945. doi:10.1038/nm.3909
  • Lim PPC, Bondarev DJ, Edwards AM, Hoyen CM, Macias CG. The evolving value of older biomarkers in the clinical diagnosis of pediatric sepsis. Pediatr Res. 2023;93(4):789–796. doi:10.1038/s41390-022-02190-w
  • Germic N, Frangez Z, Yousefi S, Simon HU. Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation. Cell Death Differ. 2019;26(4):715–727. doi:10.1038/s41418-019-0297-6
  • Cai J, Li J, Zhou Y, et al. Staphylococcus aureus facilitates its survival in bovine macrophages by blocking autophagic flux. J Cell Mol Med. 2020;24(6):3460–3468. doi:10.1111/jcmm.15027
  • Iyer JK, Khurana T, Langer M, et al. Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun. 2010;78(6):2418–2428. doi:10.1128/IAI.00170-10
  • Wang X, Guo Z, Wang Z, et al. Diagnostic and predictive values of pyroptosis-related genes in sepsis. Front Immunol. 2023;14:1105399. doi:10.3389/fimmu.2023.1105399
  • Zhang WY, Chen ZH, An XX, et al. Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning. World J Pediatr. 2023;19(11):1094–1103. doi:10.1007/s12519-023-00717-7