New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage

References

• Feigin VL, Lawes CM, Bennett DA, et al. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8(4):355–369. doi:10.1016/S1474-4422(09)70025-0
   PubMed Web of Science ®Google Scholar
• Wilkinson DA, Pandey AS, Thompson BG, Keep RF, Hua Y, Xi G. Injury mechanisms in acute intracerebral hemorrhage. Neuropharmacology. 2018;134:240–248. doi:10.1016/j.neuropharm.2017.09.033
   PubMed Web of Science ®Google Scholar
• Ren H, Han R, Chen X, et al. Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update. J Cereb Blood Flow Metab. 2020;40(9):1752–1768. doi:10.1177/0271678X20923551
   PubMed Web of Science ®Google Scholar
• Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11(8):720–731. doi:10.1016/S1474-4422(12)70104-7
   PubMed Web of Science ®Google Scholar
• Kearns KN, Ironside N, Park MS, et al. Neuroprotective therapies for spontaneous intracerebral hemorrhage. Neurocrit Care. 2021;35(3):862–886. doi:10.1007/s12028-021-01311-3
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang Y, Wang J, Anne Stetler R, Yang QW. Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. Progr Neurobiol. 2014;115:25–44. doi:10.1016/j.pneurobio.2013.11.003
   PubMed Web of Science ®Google Scholar
• Shao Z, Tu S, Shao A. Pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage. Front Pharmacol. 2019;10:1079. doi:10.3389/fphar.2019.01079
   PubMed Web of Science ®Google Scholar
• Zhang W, Wu Q, Hao S, Chen S. The hallmark and crosstalk of immune cells after intracerebral hemorrhage: immunotherapy perspectives. Front Neurosci. 2022;16:1117999. doi:10.3389/fnins.2022.1117999
   PubMed Web of Science ®Google Scholar
• Zhu H, Wang Z, Yu J, et al. Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage. Progr Neurobiol. 2019;178:101610. doi:10.1016/j.pneurobio.2019.03.003
   PubMed Web of Science ®Google Scholar
• Lan X, Han X, Li Q, Yang QW, Wang J. Modulators of microglial activation and polarization after intracerebral haemorrhage. Nat Rev Neurol. 2017;13(7):420–433. doi:10.1038/nrneurol.2017.69
   PubMed Web of Science ®Google Scholar
• Xiong XY, Liu L, Yang QW. Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. Progr Neurobiol. 2016;142:23–44. doi:10.1016/j.pneurobio.2016.05.001
   PubMed Web of Science ®Google Scholar
• Fumagalli S, Perego C, Pischiutta F, Zanier ER, De Simoni MG. The ischemic environment drives microglia and macrophage function. Front Neurol. 2015;6:81. doi:10.3389/fneur.2015.00081
   PubMed Web of Science ®Google Scholar
• Shtaya A, Bridges LR, Esiri MM, et al. Rapid neuroinflammatory changes in human acute intracerebral hemorrhage. Ann Clin Transl Neurol. 2019;6(8):1465–1479. doi:10.1002/acn3.50842
   PubMed Web of Science ®Google Scholar
• Aronowski J, Hall CE. New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies. Neurological Res. 2005;27(3):268–279. doi:10.1179/016164105X25225
   PubMed Web of Science ®Google Scholar
• Guo Y, Dai W, Zheng Y, et al. Mechanism and regulation of microglia polarization in intracerebral hemorrhage. Molecules. 2022;27(20):7080. doi:10.3390/molecules27207080
   PubMed Web of Science ®Google Scholar
• He Y, Gao Y, Zhang Q, Zhou G, Cao F, Yao S. IL-4 switches microglia/macrophage M1/M2 polarization and alleviates neurological damage by modulating the JAK1/STAT6 pathway following ICH. Neuroscience. 2020;437:161–171. doi:10.1016/j.neuroscience.2020.03.008
   PubMed Web of Science ®Google Scholar
• Xi Z, Xu C, Chen X, et al. Protocatechuic acid suppresses microglia activation and facilitates M1 to M2 phenotype switching in intracerebral hemorrhage mice. J Stroke Cerebrovascular Dis. 2021;30(6):105765. doi:10.1016/j.jstrokecerebrovasdis.2021.105765
   PubMed Web of Science ®Google Scholar
• Wang C, Kong L, Kim S, et al. The role of IL-7 and IL-7R in cancer pathophysiology and immunotherapy. Int J Mol Sci. 2022;23(18):10412. doi:10.3390/ijms231810412
   PubMed Web of Science ®Google Scholar
• Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. 2002;99(11):3892–3904. doi:10.1182/blood.V99.11.3892
   PubMed Web of Science ®Google Scholar
• Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signalling. 2002;14(4):317–325. doi:10.1016/S0898-6568(01)00245-5
   PubMed Web of Science ®Google Scholar
• Seol MA, Kim JH, Oh K, et al. Interleukin-7 contributes to the invasiveness of prostate cancer cells by promoting epithelial-mesenchymal transition. Sci Rep. 2019;9(1):6917. doi:10.1038/s41598-019-43294-4
   PubMedGoogle Scholar
• Silva A, Almeida ARM, Cachucho A, et al. Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood. 2021;138(12):1040–1052. doi:10.1182/blood.2019000553
   PubMed Web of Science ®Google Scholar
• Alderson MR, Tough TW, Ziegler SF, Grabstein KH. Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med. 1991;173(4):923–930. doi:10.1084/jem.173.4.923
   PubMed Web of Science ®Google Scholar
• Fritzell S, Eberstål S, Sandén E, Visse E, Darabi A, Siesjö P. IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models. J Neuroimmunol. 2013;258(1–2):91–95. doi:10.1016/j.jneuroim.2013.02.017
   PubMed Web of Science ®Google Scholar
• Belarif L, Danger R, Kermarrec L, et al. IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease. J Clin Invest. 2019;129(5):1910–1925. doi:10.1172/JCI121668
   PubMed Web of Science ®Google Scholar
• Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 receptor signaling differentially affects effector CD4+ T cell subsets involved in experimental autoimmune encephalomyelitis. J Iimmunol. 2015;195(5):1974–1983. doi:10.4049/jimmunol.1403135
   PubMed Web of Science ®Google Scholar
• Wei D, Chen X, Xu J, He W. Identification of molecular subtypes of ischaemic stroke based on immune-related genes and weighted co-expression network analysis. Iet Syst Biol. 2023;17(2):58–69. doi:10.1049/syb2.12059
   PubMed Web of Science ®Google Scholar
• Zhang B, Zhang Y, Xiong L, et al. CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases. J Exp Med. 2022;219(2):e20211191. doi:10.1084/jem.20211191
   PubMed Web of Science ®Google Scholar
• Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nature Methods. 2015;12(5):453–457. doi:10.1038/nmeth.3337
   PubMed Web of Science ®Google Scholar
• Chen Z, Huang A, Sun J, Jiang T, Qin -FX-F, Wu A. Inference of immune cell composition on the expression profiles of mouse tissue. Sci Rep. 2017;7(1):40508. doi:10.1038/srep40508
   PubMedGoogle Scholar
• Shen W, Song Z, Zhong X, et al. Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta. 2022;1(3):e36. doi:10.1002/imt2.36
   Google Scholar
• Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols. 2009;4(1):44–57. doi:10.1038/nprot.2008.211
   PubMed Web of Science ®Google Scholar
• Sherman BT, Hao M, Qiu J, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216–W221. doi:10.1093/nar/gkac194
   PubMed Web of Science ®Google Scholar
• Franz M, Rodriguez H, Lopes C, et al. GeneMANIA update 2018. Nucleic Acids Res. 2018;46(W1):W60–W64. doi:10.1093/nar/gky311
   PubMed Web of Science ®Google Scholar
• Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-Seq data. BMC Bioinf. 2013;14(1):7. doi:10.1186/1471-2105-14-7
   PubMed Web of Science ®Google Scholar
• Sticht C, De La Torre C, Parveen A, Gretz N, Campbell M. miRWalk: an online resource for prediction of microRNA binding sites. PLoS One. 2018;13(10):e0206239. doi:10.1371/journal.pone.0206239
   PubMed Web of Science ®Google Scholar
• Rynkowski MA, Kim GH, Komotar RJ, et al. A mouse model of intracerebral hemorrhage using autologous blood infusion. Nature Protocols. 2008;3(1):122–128. doi:10.1038/nprot.2007.513
   PubMed Web of Science ®Google Scholar
• O’Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A. The JAK-STAT pathway: impact on human disease and therapeutic intervention. Ann Rev Med. 2015;66(1):311–328. doi:10.1146/annurev-med-051113-024537
   PubMedGoogle Scholar
• Nie H, Hu Y, Guo W, et al. miR-331-3p inhibits inflammatory response after intracerebral hemorrhage by directly targeting NLRP6. Biomed Res Int. 2020;2020:6182464. doi:10.1155/2020/6182464
   PubMed Web of Science ®Google Scholar
• Wang M, Ye X, Hu J, et al. NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice. J Neuroinflammation. 2020;17(1):364. doi:10.1186/s12974-020-02015-9
   PubMed Web of Science ®Google Scholar
• Kathirvelu B, Carmichael ST. Intracerebral hemorrhage in mouse models: therapeutic interventions and functional recovery. Metab Brain Dis. 2015;30(2):449–459. doi:10.1007/s11011-014-9559-7
   PubMed Web of Science ®Google Scholar
• Li W, Li L, Li W, et al. Spleen associated immune-response mediates brain-heart interaction after intracerebral hemorrhage. Exp Neurol. 2020;327:113209. doi:10.1016/j.expneurol.2020.113209
   PubMed Web of Science ®Google Scholar
• Shao A, Zhu Z, Li L, Zhang S, Zhang J. Emerging therapeutic targets associated with the immune system in patients with intracerebral haemorrhage (ICH): from mechanisms to translation. EBioMedicine. 2019;45:615–623. doi:10.1016/j.ebiom.2019.06.012
   PubMed Web of Science ®Google Scholar
• Elton TS, Selemon H, Elton SM, Parinandi NL. Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013;532(1):1–12. doi:10.1016/j.gene.2012.12.009
   PubMed Web of Science ®Google Scholar
• Shirjang S, Mansoori B, Mohammadi A, et al. miR-330 regulates colorectal cancer oncogenesis by targeting BACH1. Adv Pharm Bull. 2020;10(3):444–451. doi:10.34172/apb.2020.054
   PubMed Web of Science ®Google Scholar
• Zhao J, Ou SL, Wang WY, Yan C, Chi LX. MicroRNA-1907 enhances atherosclerosis-associated endothelial cell apoptosis by suppressing Bcl-2. Am J Transl Res. 2017;9(7):3433–3442.
   PubMed Web of Science ®Google Scholar
• Zhou M, Wang X, Shi Y, et al. Deficiency of ITGAM attenuates experimental abdominal aortic aneurysm in mice. J Am Heart Assoc. 2021;10(7):e019900. doi:10.1161/JAHA.120.019900
   PubMed Web of Science ®Google Scholar
• Shiokawa R, Otani N, Kajimoto R, et al. Glibenclamide attenuates brain edema associated with microglia activation after intracerebral hemorrhage. Neurochirurgie. 2022;68(6):589–594. doi:10.1016/j.neuchi.2022.07.009
   PubMed Web of Science ®Google Scholar
• Shen X, Qiu Y, Wight AE, Kim H-J, Cantor H. Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain. Proc Natl Acad Sci USA. 2022;119(8):e2116241119. doi:10.1073/pnas.2116241119
   PubMed Web of Science ®Google Scholar
• Wlodarczyk A, Holtman IR, Krueger M, et al. A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. 2017;36(22):3292–3308. doi:10.15252/embj.201696056
   PubMed Web of Science ®Google Scholar
• Wlodarczyk A, Løbner M, Cédile O, Owens T. Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response. J Neuroinflammation. 2014;11(1):57. doi:10.1186/1742-2094-11-57
   PubMedGoogle Scholar
• Grainger JR, Wohlfert EA, Fuss IJ, et al. Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nature Med. 2013;19(6):713–721. doi:10.1038/nm.3189
   PubMed Web of Science ®Google Scholar
• Yao Y, Tsirka SE. The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage. Glia. 2012;60(6):908–918. doi:10.1002/glia.22323
   PubMed Web of Science ®Google Scholar
• Hammond MD, Taylor RA, Mullen MT, et al. CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci. 2014;34(11):3901–3909. doi:10.1523/JNEUROSCI.4070-13.2014
   PubMed Web of Science ®Google Scholar
• Lan X, Han X, Li Q, et al. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain Behav Immun. 2017;61:326–339. doi:10.1016/j.bbi.2016.12.012
   PubMed Web of Science ®Google Scholar
• Li Q, Lan X, Han X, Wang J. Expression of Tmem119/Sall1 and Ccr2/CD69 in FACS-sorted microglia- and monocyte/macrophage-enriched cell populations after intracerebral hemorrhage. Front Cell Neurosci. 2018;12:520. doi:10.3389/fncel.2018.00520
   PubMed Web of Science ®Google Scholar
• Greaves P, Gribben JG. The role of B7 family molecules in hematologic malignancy. Blood. 2013;121(5):734–744. doi:10.1182/blood-2012-10-385591
   PubMed Web of Science ®Google Scholar
• Ma L, Shen X, Gao Y, et al. Blocking B7-1/CD28 pathway diminished long-range brain damage by regulating the immune and inflammatory responses in a mouse model of intracerebral hemorrhage. Neurochem Res. 2016;41(7):1673–1683. doi:10.1007/s11064-016-1883-3
   PubMed Web of Science ®Google Scholar
• Yang Z, Yu A, Liu Y, et al. Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage. Int Immunopharmacol. 2014;22(2):522–525. doi:10.1016/j.intimp.2014.06.037
   PubMed Web of Science ®Google Scholar
• Zhou K, Zhong Q, Wang Y-C, et al. RETRACTED: regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis. J Cereb Blood Flow Metab. 2017;37(3):967–979. doi:10.1177/0271678X16648712
   PubMed Web of Science ®Google Scholar
• Wang H-C, Lin W-C, Yang T-M, et al. The association between symptomatic delayed cerebral infarction and serum adhesion molecules in aneurysmal subarachnoid hemorrhage. Neurosurgery. 2011;68(6):1611–1617. doi:10.1227/NEU.0b013e318210c871
   PubMed Web of Science ®Google Scholar
• Jiang Q, Li WQ, Aiello FB, et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev. 2005;16:513–533.
   PubMed Web of Science ®Google Scholar
• Chen Z, S-j K, Chamberlain ND, et al. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis. J Immunol. 2013;190(10):5256–5266. doi:10.4049/jimmunol.1201675
   PubMed Web of Science ®Google Scholar
• Pickens SR, Chamberlain ND, Volin MV, et al. Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis. Arthritis Rheumatol. 2011;63:2884–2893.
   PubMedGoogle Scholar
• S-j K, Chang HJ, Volin MV, et al. Macrophages are the primary effector cells in IL-7-induced arthritis. Cell Mol Immunol. 2020;17(7):728–740. doi:10.1038/s41423-019-0235-z
   PubMed Web of Science ®Google Scholar
• Bao C, Wang B, Yang F, Chen L. Blockade of interleukin-7 receptor shapes macrophage alternative activation and promotes functional recovery after spinal cord injury. Neuroscience. 2018;371:518–527. doi:10.1016/j.neuroscience.2017.10.022
   PubMed Web of Science ®Google Scholar
• Yuan X, Wu Q, Wang P, et al. Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury. Biochem Biophys Res Commun. 2019;514(3):1023–1029. doi:10.1016/j.bbrc.2019.04.159
   PubMed Web of Science ®Google Scholar