Identification of a Novel Target Implicated in Chronic Obstructive Sleep Apnea-Related Atrial Fibrillation by Integrative Analysis of Transcriptome and Proteome

References

• Chan MTV, Wang CY, Seet E, et al. Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major noncardiac surgery. JAMA. 2019;321(18):1788–1798. doi:10.1001/jama.2019.4783
   PubMed Web of Science ®Google Scholar
• Tavares L, Rodríguez-Mañero M, Kreidieh B, et al. Cardiac afferent denervation abolishes ganglionated plexi and sympathetic responses to apnea: implications for atrial fibrillation. Circ Arrhythm Electrophysiol. 2019;12(6):e006942. doi:10.1161/CIRCEP.118.006942
   PubMed Web of Science ®Google Scholar
• Guo Y, Xiaokereti J, Meng Q, et al. Low-level vagus nerve stimulation reverses obstructive sleep apnea-Related atrial fibrillation by ameliorating sympathetic hyperactivity and atrial myocyte injury. Front Physiol. 2021;11:620655. doi:10.3389/fphys.2020.620655
   PubMed Web of Science ®Google Scholar
• Zhang L, Guo Y, Xiaokereti J, et al. Ganglionated plexi ablation suppresses chronic obstructive sleep apnea-related atrial fibrillation by inhibiting cardiac autonomic hyperactivation. Front Physiol. 2021;12:640295. doi:10.3389/fphys.2021.640295
   PubMed Web of Science ®Google Scholar
• Lebkuchen A, Freitas LS, Cardozo KHM, et al. Advances and challenges in pursuing biomarkers for obstructive sleep apnea: implications for the cardiovascular risk. Trends Cardiovasc Med. 2021;31(4):242–249. doi:10.1016/j.tcm.2020.04.003
   PubMed Web of Science ®Google Scholar
• Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet. 2014;383(9918):736–747. doi:10.1016/S0140-6736(13)60734-5
   PubMed Web of Science ®Google Scholar
• Malhotra A, White DP. Obstructive sleep apnoea. Lancet. 2002;360(9328):237–245. doi:10.1016/S0140-6736(02)09464-3
   PubMed Web of Science ®Google Scholar
• Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American heart association. Circulation. 2021;144(3):e56–e67. doi:10.1161/CIR.0000000000000988
   PubMed Web of Science ®Google Scholar
• Chen W, Cai X, Yan H, Pan Y. Causal effect of obstructive sleep apnea on atrial fibrillation: a Mendelian randomization study. J Am Heart Assoc. 2021;10(23):e022560. doi:10.1161/JAHA.121.022560
   PubMed Web of Science ®Google Scholar
• Huang B, Liu H, Scherlag BJ, et al. Atrial fibrillation in obstructive sleep apnea: neural mechanisms and emerging therapies. Trends Cardiovasc Med. 2021;31(2):127–132. doi:10.1016/j.tcm.2020.01.006
   PubMed Web of Science ®Google Scholar
• Linz D, Linz B, Hohl M, Böhm M. Atrial arrhythmogenesis in obstructive sleep apnea: therapeutic implications. Sleep Med Rev. 2016;26:87–94. doi:10.1016/j.smrv.2015.03.003
   PubMed Web of Science ®Google Scholar
• Fein AS, Shvilkin A, Shah D, et al. Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation. J Am Coll Cardiol. 2013;62(4):300–305. doi:10.1016/j.jacc.2013.03.052
   PubMed Web of Science ®Google Scholar
• King A. Arrhythmias: CPAP with ablation reduces AF in OSA. Nat Rev Cardiol. 2013;10(7):364. doi:10.1038/nrcardio.2013.78
   PubMedGoogle Scholar
• Wilcox I, Chan KH, Dimitri H. Diagnosis and treatment of obstructive sleep apnea is key to achieving optimal results after catheter ablation of atrial fibrillation. J Am Coll Cardiol. 2014;63(6):607–608. doi:10.1016/j.jacc.2013.08.1650
   PubMed Web of Science ®Google Scholar
• Linz D, Ukena C, Mahfoud F, Neuberger HR, Böhm M. Atrial autonomic innervation: a target for interventional antiarrhythmic therapy? J Am Coll Cardiol. 2014;63(3):215–224. doi:10.1016/j.jacc.2013.09.020
   PubMed Web of Science ®Google Scholar
• Buckley U, Rajendran PS, Shivkumar K. Ganglionated plexus ablation for atrial fibrillation: just because we can, does that mean we should? Heart Rhythm. 2017;14(1):133–134. doi:10.1016/j.hrthm.2016.09.001
   PubMed Web of Science ®Google Scholar
• Baman JR, Passman RS. Atrial fibrillation. JAMA. 2021;325(21):2218. doi:10.1001/jama.2020.23700
   PubMed Web of Science ®Google Scholar
• Michaud GF, Stevenson WG. Atrial fibrillation. N Engl J Med. 2021;384(4):353–361. doi:10.1056/NEJMcp2023658
   PubMed Web of Science ®Google Scholar
• Dorian P, Angaran P. Atrial fibrillation. N Engl J Med. 2021;385(4):382–383.
   PubMed Web of Science ®Google Scholar
• Lip GY, Tse HF, Lane DA. Atrial fibrillation. Lancet. 2012;379:9816):648–661. doi:10.1016/S0140-6736(11)61514-6
   Web of Science ®Google Scholar
• Linz D, McEvoy RD, Cowie MR, et al. Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: a review. JAMA Cardiol. 2018;3(6):532–540. doi:10.1001/jamacardio.2018.0095
   PubMed Web of Science ®Google Scholar
• May AM, Van Wagoner DR, Mehra R. OSA and cardiac arrhythmogenesis: mechanistic insights. Chest. 2017;151(1):225–241. doi:10.1016/j.chest.2016.09.014
   PubMed Web of Science ®Google Scholar
• Rossi VA, Stradling JR, Kohler M. Effects of obstructive sleep apnoea on heart rhythm. Eur Respir J. 2013;41(6):1439–1451. doi:10.1183/09031936.00128412
   PubMed Web of Science ®Google Scholar
• Roche F. Arrhythmias and conduction disturbances in obstructive sleep apnoea: the heart of the problem? Eur Respir J. 2013;41(6):1244–1246. doi:10.1183/09031936.00030813
   PubMed Web of Science ®Google Scholar
• Bradley TD, Floras JS. Obstructive sleep apnoea and its cardiovascular consequences. Lancet. 2009;373:9657):82–93. doi:10.1016/S0140-6736(08)61622-0
   Web of Science ®Google Scholar
• Chugh A. Ganglionated plexus ablation in patients undergoing pulmonary vein isolation for paroxysmal atrial fibrillation: here we go again. J Am Coll Cardiol. 2013;62(24):2326–2328. doi:10.1016/j.jacc.2013.07.055
   PubMed Web of Science ®Google Scholar
• Hanna P, Buch E, Stavrakis S, et al. Neuroscientific therapies for atrial fibrillation. Cardiovasc Res. 2021;117(7):1732–1745. doi:10.1093/cvr/cvab172
   PubMed Web of Science ®Google Scholar
• Katritsis DG, Pokushalov E, Romanov A, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2013;62(24):2318–2325. doi:10.1016/j.jacc.2013.06.053
   PubMed Web of Science ®Google Scholar
• Driessen AHG, Berger WR, Krul SPJ, et al. Ganglion plexus ablation in advanced atrial fibrillation: the AFACT Study. J Am Coll Cardiol. 2016;68(11):1155–1165. doi:10.1016/j.jacc.2016.06.036
   PubMed Web of Science ®Google Scholar
• Michaud GF, Kumar S. Surgical ganglionic plexus ablation in atrial fibrillation: is all hope lost for the plexus? J Am Coll Cardiol. 2016;68(11):1166–1168. doi:10.1016/j.jacc.2016.07.731
   PubMed Web of Science ®Google Scholar
• Hanash S. Disease proteomics. Nature. 2003;422(6928):226–232.
   PubMed Web of Science ®Google Scholar
• Vogel C, Marcotte EM. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet. 2012;13(4):227–232. doi:10.1038/nrg3185
   PubMed Web of Science ®Google Scholar
• Assum I, Krause J, Scheinhardt MO, et al. Tissue-specific multi-omics analysis of atrial fibrillation. Nat Commun. 2022;13(1):441. doi:10.1038/s41467-022-27953-1
   PubMed Web of Science ®Google Scholar
• Wang B, Lunetta KL, Dupuis J, et al. Integrative omics approach to identifying genes associated with atrial fibrillation. Circ Res. 2020;126(3):350–360. doi:10.1161/CIRCRESAHA.119.315179
   PubMed Web of Science ®Google Scholar
• Kornej J, Hanger VA, Trinquart L, et al. New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation. Cardiovasc Res. 2021;117(7):1632–1644. doi:10.1093/cvr/cvab073
   PubMed Web of Science ®Google Scholar
• Mason FE, Pronto JRD, Alhussini K, Maack C, Voigt N. Cellular and mitochondrial mechanisms of atrial fibrillation. Basic Res Cardiol. 2020;115(6):72. doi:10.1007/s00395-020-00827-7
   PubMed Web of Science ®Google Scholar
• Pool L, Wijdeveld LFJM, de Groot NMS, et al. The role of mitochondrial dysfunction in atrial fibrillation: translation to druggable target and biomarker discovery. Int J Mol Sci. 2021;22(16):8463. doi:10.3390/ijms22168463
   PubMed Web of Science ®Google Scholar
• Fossier L, Panel M, Butruille L, et al. Enhanced mitochondrial calcium uptake suppresses atrial fibrillation associated with metabolic syndrome. J Am Coll Cardiol. 2022;80(23):2205–2219. doi:10.1016/j.jacc.2022.09.041
   PubMed Web of Science ®Google Scholar
• Voigt N, Maack C, Pronto JRD. Targeting mitochondrial calcium handling to treat atrial fibrillation. J Am Coll Cardiol. 2022;80(23):2220–2223. doi:10.1016/j.jacc.2022.09.043
   PubMed Web of Science ®Google Scholar
• Oropeza-Almazán Y, Blatter LA. Mitochondrial calcium uniporter complex activation protects against calcium alternans in atrial myocytes. Am J Physiol Heart Circ Physiol. 2020;319(4):873–881. doi:10.1152/ajpheart.00375.2020
   Web of Science ®Google Scholar
• Montaigne D, Marechal X, Lefebvre P, et al. Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops. J Am Coll Cardiol. 2013;62(16):1466–1473. doi:10.1016/j.jacc.2013.03.061
   PubMedGoogle Scholar
• Nafissi S, Saadat I, Farrashbandi H, Saadat M. Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia. Psychiatry Res. 2011;187(1–2):314–315. doi:10.1016/j.psychres.2010.11.024
   PubMed Web of Science ®Google Scholar
• James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacol Ther. 2017;170:166–180. doi:10.1016/j.pharmthera.2016.10.018
   PubMed Web of Science ®Google Scholar
• Blackburn AC, Matthaei KI, Lim C, et al. Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol. 2006;69(2):650–657. doi:10.1124/mol.105.018911
   PubMed Web of Science ®Google Scholar
• Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther. 2011;336(1):87–94. doi:10.1124/jpet.110.173195
   PubMed Web of Science ®Google Scholar
• Rezaei Z, Saadat I, Saadat M. Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder. Psychiatry Res. 2012;198(1):166–168. doi:10.1016/j.psychres.2011.09.002
   PubMed Web of Science ®Google Scholar
• Yang P, Zeng Q, Cao WC, et al. Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality. Environ Res. 2016;147:445–452. doi:10.1016/j.envres.2016.03.009
   PubMed Web of Science ®Google Scholar
• Lantum HB, Baggs RB, Krenitsky DM, Board PG, Anders MW. Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues. Drug Metab Dispos. 2002;30(6):616–625. doi:10.1124/dmd.30.6.616
   PubMed Web of Science ®Google Scholar
• Alaidaroos NYA, Alraies A, Waddington RJ, Sloan AJ, Moseley R. Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence. Stem Cell Res Ther. 2021;12(1):142. doi:10.1186/s13287-021-02209-9
   PubMed Web of Science ®Google Scholar
• Jahn SC, Smeltz MG, Hu Z, et al. Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration. Biochem Pharmacol. 2018;152:236–243. doi:10.1016/j.bcp.2018.04.001
   PubMed Web of Science ®Google Scholar
• Yang F, Li J, Deng H, et al. GSTZ1-1 deficiency activates NRF2/IGF1R axis in HCC via accumulation of oncometabolite succinylacetone. EMBO J. 2019;38(15):e101964. doi:10.15252/embj.2019101964
   PubMed Web of Science ®Google Scholar
• Board PG, Anders MW. Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1−/− mice. Drug Metab Rev. 2011;43(2):215–225. doi:10.3109/03602532.2010.549132
   PubMed Web of Science ®Google Scholar
• Li J, Wang Q, Yang Y, et al. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. J Exp Clin Cancer Res. 2019;38(1):438. doi:10.1186/s13046-019-1459-6
   PubMed Web of Science ®Google Scholar
• Wang Q, Bin C, Xue Q, et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death Dis. 2021;12(5):426. doi:10.1038/s41419-021-03718-4
   PubMed Web of Science ®Google Scholar