Bioinformatics Prediction and Experimental Validation of the Role of Macrophage Polarization and Ferroptosis in Gestational Diabetes Mellitus

References

• Russo LM, Nobles C, Ertel KA, et al. Physical activity interventions in pregnancy and risk of gestational diabetes mellitus: a systematic review and meta-analysis. Obstet Gynecol. 2015;125(3):576–582. doi:10.1097/aog.0000000000000691
   PubMed Web of Science ®Google Scholar
• Damm P, Houshmand-Oeregaard A, Kelstrup L, et al. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark. Diabetologia. 2016;59(7):1396–1399. doi:10.1007/s00125-016-3985-5
   PubMed Web of Science ®Google Scholar
• Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015;36(7):709–715. doi:10.1016/j.placenta.2015.04.006
   PubMed Web of Science ®Google Scholar
• Kleiblova P, Dostalova I, Bartlova M, et al. Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Mol Cell Endocrinol. 2010;314(1):150–156. doi:10.1016/j.mce.2009.08.002
   PubMed Web of Science ®Google Scholar
• Hamidzadeh K, Christensen SM, Dalby E, et al. Macrophages and the recovery from acute and chronic inflammation. Annu Rev Physiol. 2017;79(1):567–592. doi:10.1146/annurev-physiol-022516-034348
   PubMed Web of Science ®Google Scholar
• Mrizak I, Grissa O, Henault B, et al. Placental infiltration of inflammatory markers in gestational diabetic women. Gen Physiol Biophys. 2014;33(2):169–176. doi:10.4149/gpb_2013075
   PubMed Web of Science ®Google Scholar
• Bari MF, Weickert MO, Sivakumar K, et al. Elevated soluble CD163 in gestational diabetes mellitus: secretion from human placenta and adipose tissue. PLoS One. 2014;9(7):e101327. doi:10.1371/journal.pone.0101327
   PubMed Web of Science ®Google Scholar
• Schliefsteiner C, Peinhaupt M, Kopp S, et al. Human placental hofbauer cells maintain an anti-inflammatory m2 phenotype despite the presence of gestational diabetes mellitus. Front Immunol. 2017;8:888. doi:10.3389/fimmu.2017.00888
   PubMed Web of Science ®Google Scholar
• Huang X, Zha B, Zhang M, et al. Decreased monocyte count is associated with gestational diabetes mellitus development, macrosomia, and inflammation. J Clin Endocrinol Metab. 2022;107(1):192–204. doi:10.1210/clinem/dgab657
   PubMed Web of Science ®Google Scholar
• Ashkenazi A, Salvesen G. Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol. 2014;30(1):337–356. doi:10.1146/annurev-cellbio-100913-013226
   PubMedGoogle Scholar
• Tang D, Kang R, Berghe TV, et al. The molecular machinery of regulated cell death. Cell Res. 2019;29(5):347–364. doi:10.1038/s41422-019-0164-5
   PubMed Web of Science ®Google Scholar
• Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375(6586):1254–1261. doi:10.1126/science.abf0529
   PubMed Web of Science ®Google Scholar
• Kasture V, Sahay A, Joshi S. Cell death mechanisms and their roles in pregnancy related disorders. Adv Protein Chem Struct Biol. 2021;126:195–225. doi:10.1016/bs.apcsb.2021.01.006
   PubMed Web of Science ®Google Scholar
• Sun Y, Chen P, Zhai B, et al. The emerging role of ferroptosis in inflammation. Biomed Pharmacother. 2020;127:110108. doi:10.1016/j.biopha.2020.110108
   PubMed Web of Science ®Google Scholar
• Zhao Y, Gao Q, Li B, et al. Ferroptosis and its potential role in gestational diabetes mellitus: updated evidence from pathogenesis to therapy. Front Endocrinol. 2023;14:1177547. doi:10.3389/fendo.2023.1177547
   PubMed Web of Science ®Google Scholar
• Zheng Y, Hu Q, Wu J. Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity. Endocrine. 2022;75(3):781–793. doi:10.1007/s12020-021-02933-5
   PubMed Web of Science ®Google Scholar
• Han D, Jiang L, Gu X, et al. SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol. 2020;235(11):8839–8851. doi:10.1002/jcp.29727
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo F, Peng Y, et al. Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level. Front Endocrinol. 2021;12:679582. doi:10.3389/fendo.2021.679582
   PubMed Web of Science ®Google Scholar
• Stuart T, Butler A, Hoffman P, et al. Comprehensive integration of single-cell data. Cell. 2019;177(7):1888–902.e21. doi:10.1016/j.cell.2019.05.031
   PubMed Web of Science ®Google Scholar
• Korsunsky I, Millard N, Fan J, et al. Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods. 2019;16(12):1289–1296. doi:10.1038/s41592-019-0619-0
   PubMed Web of Science ®Google Scholar
• Binder AM, LaRocca J, Lesseur C, et al. Epigenome-wide and transcriptome-wide analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex. Clin Epigenetics. 2015;7(1):79. doi:10.1186/s13148-015-0116-y
   PubMedGoogle Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Wu T, Hu E, Xu S, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2(3):100141. doi:10.1016/j.xinn.2021.100141
   Web of Science ®Google Scholar
• Hanzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinf. 2013;14(1):7. doi:10.1186/1471-2105-14-7
   PubMed Web of Science ®Google Scholar
• Jensen LJ, Kuhn M, Stark M, et al. STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 2009;37(Database):D412–6. doi:10.1093/nar/gkn760
   PubMedGoogle Scholar
• Zeng D, Ye Z, Shen R, et al. IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures. Front Immunol. 2021;12:687975. doi:10.3389/fimmu.2021.687975
   PubMed Web of Science ®Google Scholar
• Garcia-Alonso L, Holland CH, Ibrahim MM, et al. Benchmark and integration of resources for the estimation of human transcription factor activities. Genome Res. 2019;29(8):1363–1375. doi:10.1101/gr.240663.118
   PubMed Web of Science ®Google Scholar
• Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using cellchat. Nat Commun. 2021;12(1):1088. doi:10.1038/s41467-021-21246-9
   PubMed Web of Science ®Google Scholar
• Hauet-Broere F, Wieten L, Guichelaar T, et al. Heat shock proteins induce T cell regulation of chronic inflammation. Ann Rheum Dis. 2006;65(Suppl 3):iii65–8. doi:10.1136/ard.2006.058495
   PubMedGoogle Scholar
• Corbalan JJ, Medina C, Jacoby A, et al. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects. Int J Nanomedicine. 2011;6:2821–2835. doi:10.2147/IJN.S25071
   PubMed Web of Science ®Google Scholar
• Bowers K, Yeung E, Williams MA, et al. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care. 2011;34(7):1557–1563. doi:10.2337/dc11-0134
   PubMed Web of Science ®Google Scholar
• Fernández-Cao JC, Aranda N, Ribot B, et al. Elevated iron status and risk of gestational diabetes mellitus: a systematic review and meta-analysis. Matern Child Nutr. 2017;13(4). doi:10.1111/mcn.12400
   PubMed Web of Science ®Google Scholar
• Hartling L, Dryden DM, Guthrie A, et al.; Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive services task force and the national institutes of health office of medical applications of research. Ann Intern Med. 2013;159(2):123–129. doi:10.7326/0003-4819-159-2-201307160-00661
   PubMed Web of Science ®Google Scholar
• Hedderson MM, Brown SD, Ehrlich SF, et al. A tailored letter based on electronic health record data improves gestational weight gain among women with gestational diabetes mellitus: the gestational diabetes’ effects on moms (gem) cluster-randomized controlled trial. Diabetes Care. 2018;41(7):1370–1377. doi:10.2337/dc17-1133
   PubMed Web of Science ®Google Scholar
• Group HSCR, Metzger BE, Lowe LP, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002. doi:10.1056/NEJMoa0707943
   PubMed Web of Science ®Google Scholar
• Schaefer-Graf UM, Pawliczak J, Passow D, et al. Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes. Diabetes Care. 2005;28(7):1745–1750. doi:10.2337/diacare.28.7.1745
   PubMed Web of Science ®Google Scholar
• Evangelista AF, Collares CV, Xavier DJ, et al. Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation. BMC Med Genomics. 2014;7(1):28. doi:10.1186/1755-8794-7-28
   PubMedGoogle Scholar
• Chen X, Kang R, Kroemer G, et al. Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021;218(6). doi:10.1084/jem.20210518
   Web of Science ®Google Scholar
• Li C, Xu MM, Wang K, et al. Macrophage polarization and meta-inflammation. Transl Res. 2018;191:29–44. doi:10.1016/j.trsl.2017.10.004
   PubMed Web of Science ®Google Scholar
• Theocharidis G, Thomas BE, Sarkar D, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13(1):181. doi:10.1038/s41467-021-27801-8
   PubMed Web of Science ®Google Scholar
• Louiselle AE, Niemiec SM, Zgheib C, et al. Macrophage polarization and diabetic wound healing. Transl Res. 2021;236:109–116. doi:10.1016/j.trsl.2021.05.006
   PubMed Web of Science ®Google Scholar
• Jia G, DeMarco VG, Sowers JR. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144–153. doi:10.1038/nrendo.2015.216
   PubMed Web of Science ®Google Scholar
• De Luccia TPB, Pendeloski KPT, Ono E, et al. Unveiling the pathophysiology of gestational diabetes: studies on local and peripheral immune cells. Scand J Immunol. 2020;91(4):e12860. doi:10.1111/sji.12860
   PubMed Web of Science ®Google Scholar
• Barke TL, Goldstein JA, Sundermann AC, et al. Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta. Am J Reprod Immunol. 2018;80(4):e13020. doi:10.1111/aji.13020
   PubMed Web of Science ®Google Scholar
• Sisino G, Bouckenooghe T, Aurientis S, et al. Diabetes during pregnancy influences hofbauer cells, a subtype of placental macrophages, to acquire a pro-inflammatory phenotype. Biochim Biophys Acta. 2013;1832(12):1959–1968. doi:10.1016/j.bbadis.2013.07.009
   PubMed Web of Science ®Google Scholar
• Pan X, Jin X, Wang J, et al. Placenta inflammation is closely associated with gestational diabetes mellitus. Am J Transl Res. 2021;13(5):4068–4079.
   PubMed Web of Science ®Google Scholar