Serum Proteomic Analysis Revealed Biomarkers for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps Pathophysiology

References

• Scadding GK, Scadding GW. Biologics for chronic rhinosinusitis with nasal polyps (CRSwNP). J Allergy Clin Immunol. 2022;149:895–897. doi:10.1016/j.jaci.2021.10.029
   PubMed Web of Science ®Google Scholar
• Gelardi M, Bocciolini C, Notargiacomo M, et al. Chronic rhinosinusitis with nasal polyps: how to identify eligible patients for biologics in clinical practice. Acta Otorhinolaryngol Ital. 2022;42:75–81. doi:10.14639/0392-100X-N1699
   PubMed Web of Science ®Google Scholar
• Xie S, Zhang C, Xie Z, et al. Serum metabolomics identifies uric acid as a possible novel biomarker for predicting recurrence of chronic rhinosinusitis with nasal polyps. Rhinology. 2023;61:541–551. doi:10.4193/Rhin23.236
   PubMedGoogle Scholar
• Xu X, Seet JE, Yap QV, et al. Latent class analysis of structured histopathology in prognosticating surgical outcomes of chronic rhinosinusitis with nasal polyps in Singapore. Rhinology. 2023;61:358–367. doi:10.4193/Rhin22.455
   PubMed Web of Science ®Google Scholar
• Sedaghat AR, Singerman KM, Phillips KM. Discordance of chronic rhinosinusitis disease control between EPOS guidelines and patient perspectives identifies utility of patient-rated control assessment. Rhinology. 2022;60:444–452. doi:10.4193/Rhin22.160
   PubMed Web of Science ®Google Scholar
• Fokkens WJ, Viskens AS, Backer V, et al. EPOS/EUFOREA update on indication and evaluation of biologics in chronic rhinosinusitis with nasal polyps 2023. Rhinology. 2023;61:194–202. doi:10.4193/Rhin22.489
   PubMed Web of Science ®Google Scholar
• La Mantia I, Ragusa M, Grigaliute E, et al. Sensibility, specificity, and accuracy of the sinonasal outcome test 8 (SNOT-8) in patients with chronic rhinosinusitis (CRS): a cross-sectional cohort study. Europ Archiv Oto Rhin Laryngol. 2023;280:3259–3264. doi:10.1007/s00405-023-07855-8
   PubMed Web of Science ®Google Scholar
• Abbas EE, Li C, Xie A, et al. Distinct clinical pathology and microbiota in chronic rhinosinusitis with nasal polyps endotypes. Laryngoscope. 2021;131:E34–E44.
   PubMed Web of Science ®Google Scholar
• Wu PW, Chiu CH, Huang YL, et al. Tissue eosinophilia and computed tomography features in paediatric chronic rhinosinusitis with nasal polyps requiring revision surgery. Rhinology. 2023;61:246–254.
   Web of Science ®Google Scholar
• Maspero JF, Katelaris CH, Busse WW, et al. Dupilumab efficacy in uncontrolled, moderate-to-severe asthma with self-reported chronic rhinosinusitis. J Aller Clin Immunol Pract. 2020;8:527–539.e529. doi:10.1016/j.jaip.2019.07.016
   PubMed Web of Science ®Google Scholar
• Jo S, Lee SH, Jo HR, et al. Eosinophil-derived TGFβ1 controls the new bone formation in chronic rhinosinusitis with nasal polyps. Rhinology. 2023;61:338–347. doi:10.4193/Rhin22.439
   PubMed Web of Science ®Google Scholar
• Lou H, Zhang N, Bachert C, et al. Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement. Int Forum Allergy Rhinol. 2018;8:1218–1225. doi:10.1002/alr.22214
   PubMed Web of Science ®Google Scholar
• Dayon L, Cominetti O, Affolter M. Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications. Expert Rev Proteomics. 2022;19:131–151. doi:10.1080/14789450.2022.2070477
   PubMed Web of Science ®Google Scholar
• Utkarsh K, Kumar A, Khan A, et al. Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer. Genes Dis. 2023;10:1005–1018. doi:10.1016/j.gendis.2022.07.004
   PubMed Web of Science ®Google Scholar
• Zhao Y, Xue Q, Wang M, et al. Evolution of mass spectrometry instruments and techniques for blood proteomics. J Proteome Res. 2023;22:1009–1023. doi:10.1021/acs.jproteome.3c00102
   PubMedGoogle Scholar
• Deutsch EW, Omenn GS, Sun Z, et al. Advances and utility of the human plasma proteome. J Proteome Res. 2021;20:5241–5263. doi:10.1021/acs.jproteome.1c00657
   PubMed Web of Science ®Google Scholar
• Tremlett H, Dai DL, Hollander Z, et al. Serum proteomics in multiple sclerosis disease progression. J Proteomics. 2015;118:2–11. doi:10.1016/j.jprot.2015.02.018
   PubMed Web of Science ®Google Scholar
• Astradsson T, Sellberg F, Ehrsson YT, et al. Serum proteomics in patients with head and neck cancer: peripheral blood immune response to treatment. Int J Mol Sci. 2022;23:6304. doi:10.3390/ijms23116304
   PubMed Web of Science ®Google Scholar
• Brunner PM, Suarez-Farinas M, He H, et al. The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. Sci Rep. 2017;7:8707. doi:10.1038/s41598-017-09207-z
   PubMed Web of Science ®Google Scholar
• Hu C, Dai Z, Xu J, et al. Proteome Profiling Identifies Serum Biomarkers in Rheumatoid Arthritis. Front Immunol. 2022;13:865425. doi:10.3389/fimmu.2022.865425
   PubMed Web of Science ®Google Scholar
• Mayo S, Benito-Leon J, Pena-Bautista C, et al. Recent evidence in epigenomics and proteomics biomarkers for early and minimally invasive diagnosis of alzheimer’s and parkinson’s diseases. Curr Neuropharmacol. 2021;19:1273–1303. doi:10.2174/1570159X19666201223154009
   PubMed Web of Science ®Google Scholar
• Zhou G, Wei P, Lan J, et al. TMT-based quantitative proteomics analysis and potential serum protein biomarkers for systemic lupus erythematosus. Clin Chim Acta. 2022;534:43–49. doi:10.1016/j.cca.2022.06.031
   PubMed Web of Science ®Google Scholar
• Geyer PE, Voytik E, Treit PV, et al. Plasma proteome profiling to detect and avoid sample-related biases in biomarker studies. EMBO Mol Med. 2019;11:e10427.
   PubMed Web of Science ®Google Scholar
• Zainal NHM, Abas R, Mohamad Asri SF. Childhood allergy disease, early diagnosis, and the potential of salivary protein biomarkers. Mediators Inflamm. 2021;2021:9198249. doi:10.1155/2021/9198249
   PubMed Web of Science ®Google Scholar
• Dyball S, Rodziewicz M, Mendoza-Pinto C, et al. Predicting progression from undifferentiated connective tissue disease to definite connective tissue disease: a systematic review and meta-analysis. Autoimmun Rev. 2022;21:103184. doi:10.1016/j.autrev.2022.103184
   PubMed Web of Science ®Google Scholar
• Kao SS, Bassiouni A, Ramezanpour M, et al. Scoping review of chronic rhinosinusitis proteomics. Rhinology. 2020;58:418–429. doi:10.4193/Rhin20.034
   PubMed Web of Science ®Google Scholar
• Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50:1–12. doi:10.4193/Rhino12.000
   PubMed Web of Science ®Google Scholar
• Greguric T, Prokopakis E, Vlastos I, et al. Imaging in chronic rhinosinusitis: a systematic review of MRI and CT diagnostic accuracy and reliability in severity staging. J Neuroradiol. 2021;48:277–281. doi:10.1016/j.neurad.2021.01.010
   PubMed Web of Science ®Google Scholar
• Yu J, Hu C, Dai Z, et al. Dipeptidyl peptidase 4 as a potential serum biomarker for disease activity and treatment response in rheumatoid arthritis. Int Immunopharmacol. 2023;119:110203. doi:10.1016/j.intimp.2023.110203
   PubMed Web of Science ®Google Scholar
• Chen CL, Yao Y, Pan L, et al. Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes. J Allergy Clin Immunol. 2020;146:677–681. doi:10.1016/j.jaci.2020.02.010
   PubMed Web of Science ®Google Scholar
• Wang T, Chen Y, Gao R, et al. Overexpression of AXL on macrophages associates with disease severity and recurrence in chronic rhinosinusitis with nasal polyps. Int Immunopharmacol. 2023;121:110449. doi:10.1016/j.intimp.2023.110449
   PubMed Web of Science ®Google Scholar
• Wang C, Zhang L. Determining a cut-off value for eosinophilic chronic rhinosinusitis. Rhinology. 2022;60:318–319. doi:10.4193/Rhin22.090
   PubMed Web of Science ®Google Scholar
• Tsai PC, Lee TJ, Chang PH, et al. Role of serum eosinophil cationic protein in distinct endotypes of chronic rhinosinusitis. Rhinology. 2023;2023:1.
   Google Scholar
• Zhang H, Xie S, Fan R, et al. Elevated ALCAM expression associated with endotypes and postoperative recurrence in chronic rhinosinusitis with nasal polyps. J Inflamm Res. 2022;15:1063–1077. doi:10.2147/JIR.S350609
   PubMed Web of Science ®Google Scholar
• Zhu KZ, He C, Li Z, et al. Development and multicenter validation of a novel radiomics-based model for identifying eosinophilic chronic rhinosinusitis with nasal polyps. Rhinology. 2023;61:132–143. doi:10.4193/Rhin22.361
   PubMed Web of Science ®Google Scholar
• Xie S, Zhang H, Liu Y, et al. The role of serum metabolomics in distinguishing chronic rhinosinusitis with nasal polyp phenotypes. Front Mol Biosci. 2020;7:593976. doi:10.3389/fmolb.2020.593976
   PubMed Web of Science ®Google Scholar
• Liang Y, Xie R, Xiong X, et al. Alterations of nasal microbiome in eosinophilic chronic rhinosinusitis. J Allergy Clin Immunol. 2023;151:1286–1295.e1282. doi:10.1016/j.jaci.2022.11.031
   PubMed Web of Science ®Google Scholar
• Wang J, Yang Y, Guo J, et al. The tissue lymphocyte-to-eosinophil ratio predicted long-term recurrence of eosinophilic CRSwNP. Am J Rhinol Allergy. 2023;37:563–570. doi:10.1177/19458924231179615
   PubMed Web of Science ®Google Scholar
• Pappa E, Vougas K, Zoidakis J, et al. Proteomic advances in salivary diagnostics. Bioch Bioph Acta Prote Prot. 2020;1868:140494. doi:10.1016/j.bbapap.2020.140494
   PubMed Web of Science ®Google Scholar
• Kessel C, Lavric M, Weinhage T, et al. Serum biomarkers confirming stable remission in inflammatory bowel disease. Sci Rep. 2021;11:6690. doi:10.1038/s41598-021-86251-w
   PubMed Web of Science ®Google Scholar
• Bakker DS, Nierkens S, Knol EF, et al. Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers. J Allergy Clin Immunol. 2021;147:189–198. doi:10.1016/j.jaci.2020.04.062
   PubMed Web of Science ®Google Scholar
• Diorio C, Shraim R, Myers R, et al. Comprehensive serum proteome profiling of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome patients with B-Cell ALL receiving CAR T19. Clin Cancer Res. 2022;28:3804–3813. doi:10.1158/1078-0432.CCR-22-0822
   PubMed Web of Science ®Google Scholar
• Ribeiro Vitorino T, Ferraz Do Prado A, Bruno de Assis Cau S, et al. MMP-2 and its implications on cardiac function and structure: interplay with inflammation in hypertension. Biochem Pharmacol. 2023;215:115684. doi:10.1016/j.bcp.2023.115684
   PubMed Web of Science ®Google Scholar
• Wang X, Sima Y, Zhao Y, et al. Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors. J Allergy Clin Immunol. 2023;151:458–468. doi:10.1016/j.jaci.2022.10.010
   PubMed Web of Science ®Google Scholar
• Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010;141:52–67. doi:10.1016/j.cell.2010.03.015
   PubMed Web of Science ®Google Scholar
• Jia R, Li T, Wang N. Long noncoding RNA HOTAIR functions as ceRNA to regulate MMP2 in paraquat induced lung epithelial-mesenchymal transition. Toxicology. 2021;461:152891. doi:10.1016/j.tox.2021.152891
   PubMed Web of Science ®Google Scholar
• Corry DB, Kiss A, Song LZ, et al. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J. 2004;18:995–997. doi:10.1096/fj.03-1412fje
   PubMed Web of Science ®Google Scholar
• Kuwabara Y, Kobayashi T, D’Alessandro-Gabazza CN, et al. Role of matrix metalloproteinase-2 in eosinophil-mediated airway remodeling. Front Immunol. 2018;9:2163. doi:10.3389/fimmu.2018.02163
   PubMed Web of Science ®Google Scholar
• Janulaityte I, Januskevicius A, Rimkunas A, et al. Asthmatic eosinophils alter the gene expression of extracellular matrix proteins in airway smooth muscle cells and pulmonary fibroblasts. Int J Mol Sci. 2022;23:4086. doi:10.3390/ijms23084086
   PubMed Web of Science ®Google Scholar
• Mori S, Pawankar R, Ozu C, et al. Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in allergic nasal mucosa. Allergy Asthma Immunol Res. 2012;4:231–239. doi:10.4168/aair.2012.4.4.231
   PubMed Web of Science ®Google Scholar
• Rimkunas A, Januskevicius A, Vasyle E, et al. Blood inflammatory-like and lung resident-like eosinophils affect migration of airway smooth muscle cells and their ECM-related proliferation in asthma. Int J Mol Sci. 2023;25:24. doi:10.3390/ijms25010024
   PubMedGoogle Scholar
• Pan X, Zhang Y, Wang C, et al. Evaluation of nasal symptoms to distinguish eosinophilic from noneosinophilic nasal polyps based on peripheral blood. Allergy Asthma Proc. 2021;42:214–221. doi:10.2500/aap.2021.42.210004
   PubMed Web of Science ®Google Scholar
• Wang C, Zhou ML, Liu YC, et al. The roles of autophagy, mitophagy, and the Akt/mTOR pathway in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Immunol Res. 2022;2022:2273121. doi:10.1155/2022/2273121
   PubMed Web of Science ®Google Scholar
• Zhu Z, Wang W, Zhang X, et al. Nasal fluid cytology and cytokine profiles of eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Rhinology. 2020;58:314–322. doi:10.4193/Rhin19.275
   PubMed Web of Science ®Google Scholar
• Shi LL, Ma J, Deng YK, et al. Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps. Allergy. 2021;76:497–509. doi:10.1111/all.14287
   PubMed Web of Science ®Google Scholar
• Abdelaziz MH, Abdelwahab SF, Wan J, et al. Alternatively activated macrophages; a double-edged sword in allergic asthma. J Transl Med. 2020;18:18. doi:10.1186/s12967-019-02169-y
   PubMed Web of Science ®Google Scholar
• Sokulsky LA, Goggins B, Sherwin S, et al. GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation. Clin Exp Allergy. 2020;50:609–624. doi:10.1111/cea.13582
   PubMed Web of Science ®Google Scholar
• Lee SH, Chaves MM, Kamenyeva O, et al. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Sci Immunol. 2020;2020:5.
   Google Scholar
• Peterson S, Poposki JA, Nagarkar DR, et al. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012;129:119–127. doi:10.1016/j.jaci.2011.08.021
   PubMed Web of Science ®Google Scholar
• Yao Y, Wang ZC, Liu JX, et al. Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rh. 2017;7:963–972. doi:10.1002/alr.21984
   PubMed Web of Science ®Google Scholar