Sevoflurane Alters Serum Metabolites in Elders and Aging Mice and Increases Inflammation in Hippocampus

References

• Needham MJ, Webb CE, Bryden DC. Postoperative cognitive dysfunction and dementia: what we need to know and do. Br J Anaesth. 2017;119(suppl_1):i115–i125. doi:10.1093/bja/aex354
   PubMed Web of Science ®Google Scholar
• Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014;111(8):119–125. doi:10.3238/arztebl.2014.0119
   PubMed Web of Science ®Google Scholar
• Tang X, Zhao Y, Zhou Z, et al. Resveratrol mitigates sevoflurane-induced neurotoxicity by the SIRT1-dependent regulation of BDNF expression in developing mice. Oxid Med Cell Longev. 2020;2020:9018624. doi:10.1155/2020/9018624
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhang Y, Wang H, Zhang X, Chen Y, Chen G. Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway. Int Immunopharmacol. 2023;116:109725. doi:10.1016/j.intimp.2023.109725
   PubMed Web of Science ®Google Scholar
• Eckenhoff RG, Johansson JS, Wei H, et al. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology. 2004;101(3):703–709. doi:10.1097/00000542-200409000-00019
   PubMed Web of Science ®Google Scholar
• Rutledge J, Oh H, Wyss-Coray T. Measuring biological age using omics data. Nat Rev Genet. 2022;23(12):715–727. doi:10.1038/s41576-022-00511-7
   PubMed Web of Science ®Google Scholar
• Wang R, Li B, Lam SM, Shui G. Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet Genomics. 2020;47(2):69–83. doi:10.1016/j.jgg.2019.11.009
   PubMed Web of Science ®Google Scholar
• Nielsen J. Systems biology of metabolism. Annu Rev Biochem. 2017;86(1):245–275. doi:10.1146/annurev-biochem-061516-044757
   PubMedGoogle Scholar
• Xu H, Wang J, Liu Y, et al. Development of a simultaneous quantification method for the gut microbiota-derived core nutrient metabolome in mice and its application in studying host-microbiota interaction. Anal Chim Acta. 2023;1251:341039. doi:10.1016/j.aca.2023.341039
   PubMed Web of Science ®Google Scholar
• Xie G, Wang L, Chen T, et al. A metabolite array technology for precision medicine. Anal Chem. 2021;93(14):5709–5717. doi:10.1021/acs.analchem.0c04686
   PubMed Web of Science ®Google Scholar
• Pang Z, Zhou G, Ewald J, et al. Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data. Nat Protoc. 2022;17(8):1735–1761. doi:10.1038/s41596-022-00710-w
   PubMed Web of Science ®Google Scholar
• Meng J, Moriyama M, Feld M, et al. New mechanism underlying IL-31-induced atopic dermatitis. J Allergy Clin Immunol. 2018;141(5):1677–1689 e8. doi:10.1016/j.jaci.2017.12.1002
   PubMed Web of Science ®Google Scholar
• Algahtani MM, Alshehri S, Alqarni SS, et al. Inhibition of ITK signaling causes amelioration in sepsis-associated neuroinflammation and depression-like state in mice. Int J Mol Sci. 2023;24(9):8101. doi:10.3390/ijms24098101
   PubMed Web of Science ®Google Scholar
• Kannan AK, Kim DG, August A, Bynoe MS. Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking. J Neurosci. 2015;35(1):221–233. doi:10.1523/JNEUROSCI.1957-14.2015
   PubMed Web of Science ®Google Scholar
• Miller ED, Dziedzic A, Saluk-Bijak J, Bijak M. A review of various antioxidant compounds and their potential utility as complementary therapy in multiple sclerosis. Nutrients. 2019;11(7):1528. doi:10.3390/nu11071528
   PubMed Web of Science ®Google Scholar
• Wang ZH, Feng Y, Hu Q, et al. Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice. J Cell Physiol. 2023;238(1):257–273. doi:10.1002/jcp.30923
   PubMed Web of Science ®Google Scholar
• Di Prisco S, Merega E, Lanfranco M, Casazza S, Uccelli A, Pittaluga A. Acute desipramine restores presynaptic cortical defects in murine experimental autoimmune encephalomyelitis by suppressing central CCL5 overproduction. Br J Pharmacol. 2014;171(9):2457–2467. doi:10.1111/bph.12631
   PubMed Web of Science ®Google Scholar
• Wang X, Deckert M, Xuan NT, et al. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-kappaB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol. 2013;126(5):711–724. doi:10.1007/s00401-013-1183-9
   PubMed Web of Science ®Google Scholar
• Cheng J, Zhang R, Xu Z, et al. Early glycolytic reprogramming controls microglial inflammatory activation. J Neuroinflammation. 2021;18(1):129. doi:10.1186/s12974-021-02187-y
   PubMed Web of Science ®Google Scholar
• Ruan N, Tribble J, Peterson AM, Jiang Q, Wang JQ, Chu X-P. Acid-sensing ion channels and mechanosensation. Int J Mol Sci. 2021;22(9):4810. doi:10.3390/ijms22094810
   PubMed Web of Science ®Google Scholar
• Malko P, Jiang LH. TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions. Redox Biol. 2020;37:101755. doi:10.1016/j.redox.2020.101755
   PubMed Web of Science ®Google Scholar
• Zhang W, Chen Y, Qin J, et al. Prolonged sevoflurane exposure causes abnormal synapse development and dysregulates beta-neurexin and neuroligins in the hippocampus in neonatal rats. J Affect Disord. 2022;312:22–29. doi:10.1016/j.jad.2022.05.115
   PubMed Web of Science ®Google Scholar
• Sun M, Xie Z, Zhang J, Leng Y. Mechanistic insight into sevoflurane-associated developmental neurotoxicity. Cell Biol Toxicol. 2022;38(6):927–943. doi:10.1007/s10565-021-09677-y
   PubMed Web of Science ®Google Scholar
• Liddelow SA, Barres BA. Reactive astrocytes: production, function, and therapeutic potential. Immunity. 2017;46(6):957–967. doi:10.1016/j.immuni.2017.06.006
   PubMed Web of Science ®Google Scholar
• Cenalmor A, Pascual E, Gil-Manso S, Correa-Rocha R, Suarez JR, Garcia-Alvarez I. Evaluation of anti-neuroinflammatory activity of isatin derivatives in activated microglia. Molecules. 2023;28(12):4882. doi:10.3390/molecules28124882
   PubMed Web of Science ®Google Scholar
• Medvedev A, Kopylov A, Buneeva O, et al. A neuroprotective dose of isatin causes multilevel changes involving the brain proteome: prospects for further research. Int J Mol Sci. 2020;21(11):4187. doi:10.3390/ijms21114187
   PubMed Web of Science ®Google Scholar
• Liddelow SA, Guttenplan KA, Clarke LE, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481–487. doi:10.1038/nature21029
   PubMed Web of Science ®Google Scholar
• Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017;2(7):e91229. doi:10.1172/jci.insight.91229
   PubMed Web of Science ®Google Scholar
• Guo S, Liu L, Wang C, Jiang Q, Dong Y, Tian Y. Repeated exposure to sevoflurane impairs the learning and memory of older male rats. Life Sci. 2018;192:75–83. doi:10.1016/j.lfs.2017.11.025
   PubMed Web of Science ®Google Scholar
• Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16(6):358–372. doi:10.1038/nrn3880
   PubMed Web of Science ®Google Scholar
• Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11(11):775–787. doi:10.1038/nri3086
   PubMed Web of Science ®Google Scholar
• Tang BL. Glucose, glycolysis, and neurodegenerative diseases. J Cell Physiol. 2020;235(11):7653–7662. doi:10.1002/jcp.29682
   PubMed Web of Science ®Google Scholar
• Wang YM, Liu HX, Fang NY. High glucose concentration impairs 5-PAHSA activity by inhibiting AMP-activated protein kinase activation and promoting nuclear factor-kappa-B-mediated inflammation. Front Pharmacol. 2018;9:1491. doi:10.3389/fphar.2018.01491
   PubMed Web of Science ®Google Scholar
• Ammini CV, Fernandez-Canon J, Shroads AL, et al. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. Biochem Pharmacol. 2003;66(10):2029–2038. doi:10.1016/j.bcp.2003.07.002
   PubMed Web of Science ®Google Scholar
• Burlina A, Giuliani A, Polo G, et al. Detection of 3-O-methyldopa in dried blood spots for neonatal diagnosis of aromatic L-amino-acid decarboxylase deficiency: the northeastern Italian experience. Mol Genet Metab. 2021;133(1):56–62. doi:10.1016/j.ymgme.2021.03.009
   PubMed Web of Science ®Google Scholar
• Lee ES, Chen H, King J, Charlton C. The role of 3-O-methyldopa in the side effects of L-dopa. Neurochem Res. 2008;33(3):401–411. doi:10.1007/s11064-007-9442-6
   PubMed Web of Science ®Google Scholar
• Asanuma M, Miyazaki I. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016;17(1):52. doi:10.1186/s12868-016-0289-0
   PubMedGoogle Scholar
• Zhang YZ, Du HZ, Liu HL, He QS, Xu Z. Isatin dimers and their biological activities. Arch Pharm. 2020;353(3):e1900299. doi:10.1002/ardp.201900299
   PubMed Web of Science ®Google Scholar
• Medvedev A, Igosheva N, Crumeyrolle-Arias M, Glover V. Isatin: role in stress and anxiety. Stress. 2005;8(3):175–183. doi:10.1080/10253890500342321
   PubMed Web of Science ®Google Scholar
• Brandao P, Marques C, Burke AJ, Pineiro M. The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules. Eur J Med Chem. 2021;211:113102. doi:10.1016/j.ejmech.2020.113102
   PubMed Web of Science ®Google Scholar