Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment

References

• Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. Lancet. 2021;397(10281):1301–1315. doi:10.1016/s0140-6736(20)32549-6
   PubMed Web of Science ®Google Scholar
• Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA. 2020;323(19):1945–1960. doi:10.1001/jama.2020.4006
   PubMed Web of Science ®Google Scholar
• Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6):1475. doi:10.3390/ijms20061475
   PubMed Web of Science ®Google Scholar
• Ko SH, Chi CC, Yeh ML, Wang SH, Tsai YS, Hsu MY. Lifestyle changes for treating psoriasis. Cochrane Database Syst Rev. 2019;7(7):CD011972. doi:10.1002/14651858.CD011972.pub2
   PubMed Web of Science ®Google Scholar
• Ghoreschi K, Balato A, Enerbäck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet. 2021;397(10275):754–766. doi:10.1016/S0140-6736(21)00184-7
   PubMed Web of Science ®Google Scholar
• Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu Rev Immunol. 2014;32:227–255. doi:10.1146/annurev-immunol-032713-120225
   PubMed Web of Science ®Google Scholar
• Conrad C, Gilliet M. Psoriasis: from pathogenesis to targeted therapies. Clin Rev Allergy Immunol. 2018;54(1):102–113. doi:10.1007/s12016-018-8668-1
   PubMed Web of Science ®Google Scholar
• Armstrong AW, Puig L, Joshi A, et al. Comparison of biologics and oral treatments for plaque psoriasis: a meta-analysis. JAMA Dermatol. 2020;156(3):258–269. doi:10.1001/jamadermatol.2019.4029
   PubMed Web of Science ®Google Scholar
• Reich K, Armstrong AW, Langley RG, et al. Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis (ECLIPSE): results from a Phase 3, randomised controlled trial. Lancet. 2019;394(10201):831–839. doi:10.1016/S0140-6736(19)31773-8
   PubMed Web of Science ®Google Scholar
• Lambert SA, Jolma A, Campitelli LF, et al. The human transcription factors. Cell. 2018;172(4):650–665. doi:10.1016/j.cell.2018.01.029
   PubMed Web of Science ®Google Scholar
• Calissi G, Lam EWF, Link W. Therapeutic strategies targeting FOXO transcription factors. Nat Rev Drug Discov. 2021;20(1):21–38. doi:10.1038/s41573-020-0088-2
   PubMed Web of Science ®Google Scholar
• Zhang Z, Xu L, Xu X. The role of transcription factor 7-like 2 in metabolic disorders. Obes Rev. 2021;22(5):e13166. doi:10.1111/obr.13166
   PubMed Web of Science ®Google Scholar
• Kanno Y, Vahedi G, Hirahara K, Singleton K, O’Shea JJ. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol. 2012;30:707–731. doi:10.1146/annurev-immunol-020711-075058
   PubMed Web of Science ®Google Scholar
• Gege C. RORγt inhibitors as potential back-ups for the Phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345. Expert Opin Ther Pat. 2017;27(1):1–8. doi:10.1080/13543776.2017.1262350
   PubMed Web of Science ®Google Scholar
• Biswas PS, Gupta S, Chang E, et al. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest. 2010;120(9):3280–3295. doi:10.1172/JCI42856
   PubMed Web of Science ®Google Scholar
• Wu T, Hu E, Xu S, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2(3):100141. doi:10.1016/j.xinn.2021.100141
   Web of Science ®Google Scholar
• Satija R, Farrell JA, Gennert D, Schier AF, Regev A. Spatial reconstruction of single-cell gene expression data. Nat Biotechnol. 2015;33(5):495–502. doi:10.1038/nbt.3192
   PubMed Web of Science ®Google Scholar
• Korsunsky I, Millard N, Fan J, et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods. 2019;16(12):1289–1296. doi:10.1038/s41592-019-0619-0
   PubMed Web of Science ®Google Scholar
• Li M, Zhang X, Ang KS, et al. DISCO: a database of deeply integrated human Single-Cell Omics data. Nucleic Acids Res. 2022;50(D1):D596–D602. doi:10.1093/nar/gkab1020
   PubMed Web of Science ®Google Scholar
• Zou Z, Long X, Zhao Q, et al. A single-cell transcriptomic atlas of human skin aging. Dev Cell. 2021;56(3):383–397.e8. doi:10.1016/j.devcel.2020.11.002
   PubMed Web of Science ®Google Scholar
• Merleev A, Ji-Xu A, Toussi A, et al. Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI Insight. 2022;7(16):e141193. doi:10.1172/jci.insight.141193
   PubMed Web of Science ®Google Scholar
• Aibar S, González-Blas CB, Moerman T, et al. SCENIC: single-cell regulatory network inference and clustering. Nat Methods. 2017;14(11):1083–1086. doi:10.1038/nmeth.4463
   PubMed Web of Science ®Google Scholar
• Baran Y, Bercovich A, Sebe-Pedros A, et al. MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions. Genome Biol. 2019;20(1):206. doi:10.1186/s13059-019-1812-2
   PubMed Web of Science ®Google Scholar
• Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJM. Using networks to measure similarity between genes: association index selection. Nat Methods. 2013;10(12):1169–1176. doi:10.1038/nmeth.2728
   PubMed Web of Science ®Google Scholar
• Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12(1):1088. doi:10.1038/s41467-021-21246-9
   PubMed Web of Science ®Google Scholar
• Kuleshov MV, Jones MR, Rouillard AD, et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 2016;44(W1):W90–W97. doi:10.1093/nar/gkw377
   PubMed Web of Science ®Google Scholar
• Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: a comprehensive review. Clin Rev Allergy Immunol. 2016;50(3):377–389. doi:10.1007/s12016-016-8535-x
   PubMed Web of Science ®Google Scholar
• Kim J, Krueger JG. Highly effective new treatments for psoriasis target the IL-23/Type 17 T cell autoimmune axis. Annu Rev Med. 2017;68:255–269. doi:10.1146/annurev-med-042915-103905
   PubMed Web of Science ®Google Scholar
• Gaffen SL, Jain R, Garg AV, Cua DJ. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol. 2014;14(9):585–600. doi:10.1038/nri3707
   PubMed Web of Science ®Google Scholar
• Hou Y, Zhu L, Tian H, et al. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018;9(12):1027–1038. doi:10.1007/s13238-018-0505-z
   PubMed Web of Science ®Google Scholar
• Ravipati A, Nolan S, Alphonse M, et al. IL-6R/Signal transducer and activator of transcription 3 signaling in keratinocytes rather than in T cells induces psoriasis-like dermatitis in mice. J Invest Dermatol. 2022;142(4):1126–1135.e4. doi:10.1016/j.jid.2021.09.012
   PubMed Web of Science ®Google Scholar
• Albanesi C, Madonna S, Gisondi P, Girolomoni G. The Interplay between keratinocytes and immune cells in the pathogenesis of psoriasis. Front Immunol. 2018;9:1549. doi:10.3389/fimmu.2018.01549
   PubMed Web of Science ®Google Scholar
• Novoszel P, Holcmann M, Stulnig G, et al. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells. EMBO Mol Med. 2021;13(4):e12409. doi:10.15252/emmm.202012409
   PubMed Web of Science ®Google Scholar
• Bernhagen J, Krohn R, Lue H, et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13(5):587–596. doi:10.1038/nm1567
   PubMed Web of Science ®Google Scholar
• Jankauskas SS, Wong DWL, Bucala R, Djudjaj S, Boor P. Evolving complexity of MIF signaling. Cell Signalling. 2019;57:76–88. doi:10.1016/j.cellsig.2019.01.006
   PubMed Web of Science ®Google Scholar
• Gesser B, Rasmussen MK, Raaby L, et al. Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. Inflamm Res. 2011;60(7):643–653. doi:10.1007/s00011-011-0316-7
   PubMed Web of Science ®Google Scholar
• Negishi H, Taniguchi T, Yanai H. The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) transcription factor family. Cold Spring Harb Perspect Biol. 2018;10(11):a028423. doi:10.1101/cshperspect.a028423
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol. 2001;19:623–655. doi:10.1146/annurev.immunol.19.1.623
   PubMed Web of Science ®Google Scholar
• Tang S, Jiang W, Xu P, et al. Integrated bioinformatic analysis of key biomarkers and signalling pathways in psoriasis. Scott Med J. 2022;67(1):7–17. doi:10.1177/00369330221078993
   PubMed Web of Science ®Google Scholar
• Raposo RA, Gupta R, Abdel-Mohsen M, et al. Antiviral gene expression in psoriasis. J Eur Acad Dermatol Venereol. 2015;29(10):1951–1957. doi:10.1111/jdv.13091
   PubMed Web of Science ®Google Scholar
• Guo H, Zhang J, Zhang X, et al. SCARB2/LIMP-2 regulates IFN production of plasmacytoid dendritic cells by mediating endosomal translocation of TLR9 and nuclear translocation of IRF7. J Immunol. 2015;194(10):4737–4749. doi:10.4049/jimmunol.1402312
   PubMed Web of Science ®Google Scholar
• Honda K, Ohba Y, Yanai H, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature. 2005;434(7036):1035–1040. doi:10.1038/nature03547
   PubMed Web of Science ®Google Scholar
• Zhu H, Lou F, Yin Q, et al. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease. EMBO Mol Med. 2017;9(5):589–604. doi:10.15252/emmm.201607027
   PubMed Web of Science ®Google Scholar
• Morell M, Varela N, Castillejo-López C, et al. SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model. EBioMedicine. 2022;76:103808. doi:10.1016/j.ebiom.2021.103808
   PubMed Web of Science ®Google Scholar