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ORIGINAL RESEARCH

Comprehensive Nomograms Using Routine Biomarkers Beyond Eosinophil Levels: Enhancing Predictability of Corticosteroid Treatment Outcomes in AECOPD

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Pages 1511-1526 | Received 02 Dec 2023, Accepted 28 Feb 2024, Published online: 07 Mar 2024

References

  • Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease; 2023. Available from: https://goldcopd.org/2023-gold-reports-2/. Accessed April 20, 2023.
  • Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018;391(10131):1706–1717. doi:10.1016/S0140-6736(18)30841-9
  • Walters JA, Tan DJ, White CJ, Gibson PG, Wood-Baker R, Walters EH. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;9:CD001288.
  • Waljee AK, Rogers MA, Lin P, et al. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ. 2017;357:j1415. doi:10.1136/bmj.j1415
  • Papi A, Vestbo J, Fabbri L, et al. Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet. 2018;391(10125):1076–1084. doi:10.1016/S0140-6736(18)30206-X
  • Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671–1680. doi:10.1056/NEJMoa1713901
  • Bafadhel M, Peterson S, De Blas MA, et al. Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials. Lancet Respir Med. 2018;6(2):117–126. doi:10.1016/S2213-2600(18)30006-7
  • Siddiqui SH, Guasconi A, Vestbo J, et al. Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192(4):523–525. doi:10.1164/rccm.201502-0235LE
  • Pascoe S, Locantore N, Dransfield MT, Barnes NC, Pavord ID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3(6):435–442. doi:10.1016/S2213-2600(15)00106-X
  • Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184(6):662–671. doi:10.1164/rccm.201104-0597OC
  • Bafadhel M, Davies L, Calverley PM, Aaron SD, Brightling CE, Pavord ID. Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis. Eur Respir J. 2014;44(3):789–791. doi:10.1183/09031936.00062614
  • Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012;186(1):48–55. doi:10.1164/rccm.201108-1553OC
  • Sivapalan P, Lapperre TS, Janner J, et al. Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial. Lancet Respir Med. 2019;7(8):699–709. doi:10.1016/S2213-2600(19)30176-6
  • Li J, Liang L, Feng L, et al. The prognostic value of blood eosinophil level in AECOPD is influenced by corticosteroid treatment during hospitalization. J Inflamm Res. 2023;16:3233–3243. doi:10.2147/JIR.S421605
  • Liu T, Xiang ZJ, Hou XM, Chai JJ, Yang YL, Zhang XT. Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Ther Adv Chronic Dis. 2021;12:20406223211028768. doi:10.1177/20406223211028768
  • Wang JM, Han MK, Labaki WW. Chronic obstructive pulmonary disease risk assessment tools: is one better than the others? Curr Opin Pulm Med. 2022;28(2):99–108. doi:10.1097/MCP.0000000000000833
  • Nuñez A, Marras V, Harlander M, et al. Clinical and spirometric variables are better predictors of COPD exacerbations than routine blood biomarkers. Respir Med. 2020;171:106091. doi:10.1016/j.rmed.2020.106091
  • Halner A, Beer S, Pullinger R, Bafadhel M, Russell REK, Demidenko E. Predicting treatment outcomes following an exacerbation of airways disease. PLoS One. 2021;16(8):e0254425. doi:10.1371/journal.pone.0254425
  • Yu X, Zhu GP, Cai TF, Zheng JY. Establishment of risk prediction model and risk score for in-hospital mortality in patients with AECOPD. Clin Respir J. 2020;14(11):1090–1098. doi:10.1111/crj.13246
  • Gomez-Rosero JA, Caceres-Galvis C, Ascuntar J, Atencia C, Vallejo CE, Jaimes F. Biomarkers as a Prognostic Factor in COPD Exacerbation: a Cohort Study. COPD. 2021;18(3):325–332. doi:10.1080/15412555.2021.1922370
  • Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Respir J. 2008;32(4):962–969. doi:10.1183/09031936.00012408
  • Peng JC, Nie F, Li YJ, Xu QY, Xing SP, Gao Y. Prognostic nutritional index as a predictor of 30-day mortality among patients admitted to intensive care unit with acute exacerbation of chronic obstructive pulmonary disease: a single-center retrospective cohort study. Med Sci Monit. 2022;28:e934687. doi:10.12659/MSM.934687
  • Baldemir R, Cirik MO. Practical parameters that can be used for nutritional assessment in patients hospitalized in the intensive care unit with the diagnosis of chronic obstructive pulmonary disease: prognostic nutritional index, neutrophil-to-lymphocyte, platelet-to-lymphocyte, and lymphocyte-to-monocyte ratio. Medicine. 2022;101(24):e29433. doi:10.1097/MD.0000000000029433
  • Peng JC, Gong WW, Wu Y, Yan TY, Jiang XY. Development and validation of a prognostic nomogram among patients with acute exacerbation of chronic obstructive pulmonary disease in intensive care unit. BMC Pulm Med. 2022;22(1):306. doi:10.1186/s12890-022-02100-0
  • Chen L, Chen LJ, Zheng H, Wu SY, Wang SB. Emergency admission parameters for predicting in-hospital mortality in patients with acute exacerbations of chronic obstructive pulmonary disease with hypercapnic respiratory failure. BMC Pulm Med. 2021;21:1.
  • Hu WP, Lhamo T, Liu D, et al. Development of a nomogram to predict the risk of 30-day re-exacerbation for patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease. J Chronic Obstruct Pulmon Dis. 2019;16(2):160–167. doi:10.1080/15412555.2019.1606187
  • Sakamoto Y, Yamauchi Y, Yasunaga H, et al. Development of a nomogram for predicting in-hospital mortality of patients with exacerbation of chronic obstructive pulmonary disease. Int J Chronic Obstr. 2017;12:1605–1611. doi:10.2147/COPD.S129714
  • Zhao Q, Li J, Liang L. Establishment and application of the data quality control system of an electronic medical record-based big data platform for respiratory diseases. J Med Inform. 2022;7(43):55–60.
  • Mathioudakis AG, Abroug F, Agusti A, et al. ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations. Eur Respir J. 2022;59(5):2102006. doi:10.1183/13993003.02006-2021
  • Suehs CM, Zysman M, Chenivesse C, et al. Prioritising outcomes for evaluating eosinophil-guided corticosteroid therapy among patients with acute COPD exacerbations requiring hospitalisation: a Delphi consensus study. BMJ Open. 2020;10(7):e035811. doi:10.1136/bmjopen-2019-035811
  • Liang L, Li C, Shen Y, Rong H, Jing H, Tong Z. Long-term trends in hospitalization and outcomes in adult patients with exacerbation of chronic obstructive pulmonary disease in Beijing, China, from 2008 to 2017. Int J Chron Obstruct Pulmon Dis. 2020;15:1155–1164. doi:10.2147/COPD.S238006
  • Breiman L, Fridman JH, Olshen RA, Stone CJ. Classification and Regression Trees. 1st ed. New York: Routledge; 1984.
  • Steyerberg EW, Harrell FE, Borsboom GJ, Eijkemans MJ, Vergouwe Y, Habbema JD. Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol. 2001;54(8):774–781. doi:10.1016/S0895-4356(01)00341-9
  • Trubiano JA, Vogrin S, Chua KYL, et al. Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med. 2020;180(5):745–752. doi:10.1001/jamainternmed.2020.0403
  • Gong Y, Sun H. Relationship between blood eosinophils and systemic corticosteroid therapy in COPD exacerbation. Int J Gen Med. 2022;15:7459–7466. doi:10.2147/IJGM.S383940
  • Mao Y, Qian Y, Sun X, Li N, Huang H. Eosinopenia predicting long-term mortality in hospitalized acute exacerbation of COPD patients with community-acquired pneumonia-A Retrospective Analysis. Int J Chron Obstruct Pulmon Dis. 2021;16:3551–3559. doi:10.2147/COPD.S347948
  • Pu J, Yi Q, Luo Y, et al. Blood eosinophils and clinical outcomes in inpatients with acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study. Int J Chronic Obstr. 2023;18:169–179. doi:10.2147/COPD.S396311
  • MacDonald MI, Osadnik CR, Bulfin L, et al. Low and high blood eosinophil counts as biomarkers in hospitalized acute exacerbations of COPD. Chest. 2019;156(1):92–100. doi:10.1016/j.chest.2019.02.406
  • Barnes PJ. Endo-phenotyping of COPD patients. Expert Rev Respir Med. 2021;15(1):27–37. doi:10.1080/17476348.2020.1804364
  • Li L, Zhao N, Ma X, et al. Personalized variable vs fixed-dose systemic corticosteroid therapy in hospitalized patients with acute exacerbations of COPD: a prospective, multicenter, randomized, open-label clinical trial. Chest. 2021;160(5):1660–1669. doi:10.1016/j.chest.2021.05.024
  • Mathioudakis AG, Janssens W, Sivapalan P, et al. Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits. Thorax. 2020;75(6):520–527. doi:10.1136/thoraxjnl-2019-214484
  • Benson VS, Hartl S, Barnes N, Galwey N, Van Dyke MK, Kwon N. Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis. Eur Respir J. 2022;59:1. doi:10.1183/13993003.04590-2020
  • Colak Y, Afzal S, Nordestgaard BG, Marott JL, Lange P. Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen General Population Study. Eur Respir J. 2018;52(2):2. doi:10.1183/13993003.00616-2018
  • Barnes PJ, Ito K, Adcock IM. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet. 2004;363(9410):731–733. doi:10.1016/S0140-6736(04)15650-X
  • Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27. doi:10.1016/j.jaci.2016.05.011
  • Kerkhof M, Sonnappa S, Postma DS, et al. Blood eosinophil count and exacerbation risk in patients with COPD. Eur Respir J. 2017;50:1.
  • Han MK, Quibrera PM, Carretta EE, et al. Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017;5(8):619–626. doi:10.1016/S2213-2600(17)30207-2
  • Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009;33(5):1165–1185. doi:10.1183/09031936.00128008
  • Huang D, He DX, Gong LJ, et al. A prediction model for hospital mortality in patients with severe community-acquired pneumonia and chronic obstructive pulmonary disease. Respir Res. 2022;23(1). doi:10.1186/s12931-022-02181-9
  • Prins HJ, Duijkers R, van der Valk P, et al. CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions. Eur Respir J. 2019;53:5. doi:10.1183/13993003.02014-2018
  • Wang C, Zhou J, Wang J, et al. Progress in the mechanism and targeted drug therapy for COPD. Signal Transduct Target Ther. 2020;5(1):248. doi:10.1038/s41392-020-00345-x
  • Lesourd BM. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997;66(2):478S–484S. doi:10.1093/ajcn/66.2.478S
  • Reed RM, Iacono A, DeFilippis A, Eberlein M, Girgis RE, Jones S. Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol. J Heart Lung Transplant. 2011;30(6):674–678. doi:10.1016/j.healun.2010.12.010
  • Esteve E, Ricart W, Fernandez-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005;24(1):16–31. doi:10.1016/j.clnu.2004.08.004
  • Luo Z, Zhang W, Chen L, Xu N. Prognostic value of neutrophil: lymphocyte and platelet: lymphocyte ratios for 28-day mortality of patients with AECOPD. Int J Gen Med. 2021;14:2839–2848. doi:10.2147/IJGM.S312045
  • Yao CY, Liu XL, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chronic Obstr. 2017;12:2285–2290. doi:10.2147/COPD.S141760
  • Eriksson O, Mohlin C, Nilsson B, Ekdahl KN. The human platelet as an innate immune cell: interactions between activated platelets and the complement system. Front Immunol. 2019;10:10. doi:10.3389/fimmu.2019.00010
  • Melki I, Tessandier N, Zufferey A, Boilard E. Platelet microvesicles in health and disease. Platelets. 2017;28(3):214–221. doi:10.1080/09537104.2016.1265924
  • Mallah H, Ball S, Sekhon J, Parmar K, Nugent K. Platelets in chronic obstructive pulmonary disease: an update on pathophysiology and implications for antiplatelet therapy. Respir Med. 2020;3:171.
  • Lefrancais E, Looney MR. Platelet biogenesis in the lung circulation. Physiology. 2019;34(6):392–401. doi:10.1152/physiol.00017.2019
  • David B, Bafadhel M, Koenderman L, De Soyza A. Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait. Thorax. 2021;76(2):188–195. doi:10.1136/thoraxjnl-2020-215167
  • Cabrera López C, Sánchez Santos A, Lemes Castellano A, et al. Eosinophil subtypes in adults with asthma and adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2023;208(2):155–162. doi:10.1164/rccm.202301-0149OC
  • Freeman CM, Curtis JL, Hastie AT. Finding the right biological: eosinophil subset differences in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2023;208(2):121–123. doi:10.1164/rccm.202305-0811ED
  • Cui Y, Zhang W, Ma Y, Zhan Z, Chen Y. Stability of blood eosinophils in acute exacerbation of chronic obstructive pulmonary disease and its relationship to clinical outcomes: a prospective cohort study. Respir Res. 2021;22(1). doi:10.1186/s12931-021-01888-5
  • Zhang Y, Liang L-R, Zhang S, et al. Blood eosinophilia and its stability in hospitalized COPD exacerbations are associated with lower risk of all-cause mortality. Int J Chronic Obstr. 2020;15:1123–1134. doi:10.2147/COPD.S245056
  • Schumann DM, Tamm M, Kostikas K, Stolz D. Stability of the Blood Eosinophilic Phenotype in Stable and Exacerbated COPD. Chest. 2019;156(3):456–465. doi:10.1016/j.chest.2019.04.012