Gastroprotective Effect of 2,3-Dimethylquinoxaline Against Indomethacin-Induced Gastric Ulcer in Rat

References

• Yekta RF, Amiri-Dashatan N, Koushki M, et al. A metabolomic study to identify potential tissue biomarkers for indomethacin-induced gastric ulcer in rats. Avicenna J Med Biotechnol. 2019;11(4):1.
   PubMedGoogle Scholar
• Zheng YF, Xie J-H, Xu Y-F, et al. Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats. Chem Biol Interact. 2014;222:27–36. doi:10.1016/j.cbi.2014.08.008
   PubMed Web of Science ®Google Scholar
• Boligon AA, de Freitas RB, de Brum TF, et al. Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats. Acta Pharm Sin B. 2014;4(5):358–367. doi:10.1016/j.apsb.2014.05.001
   PubMed Web of Science ®Google Scholar
• Taher MA, Nyeem MA, Ahammed MM, et al. Moringa oleifera (Shajna): the wonderful indigenous medicinal plant. Asian J Med Biol Res. 2017;3(1). doi:10.3329/ajmbr.v3i1.32032
   Google Scholar
• Sabiu S, Garuba T, Sunmonu T, et al. Indomethacin-induced gastric ulceration in rats: protective roles of Spondias mombin and Ficus exasperata. Toxicol Reports. 2015;2. doi:10.1016/j.toxrep.2015.01.002
   PubMedGoogle Scholar
• Tripathi K. Essentials of Medical Pharmacology; 2013.
   Google Scholar
• Mousa AM, El-Sammad NM, Hassan SK, et al. Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats. BMC Complement Altern Med. 2019;19(1). doi:10.1186/s12906-019-2760-9
   PubMed Web of Science ®Google Scholar
• Griffin MR, Scheiman JM. Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity. Am J Med. 2001;110(1 SUPPL. 1):S33–S37. doi:10.1016/s0002-9343(00)00634-3
   PubMedGoogle Scholar
• Chattopadhyay S, Adhikary B, Yadav SK, Roy K, Bandyopadhyay SK. Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evid Based Complement Altern Med. 2011;2011. doi:10.1155/2011/546560
   Web of Science ®Google Scholar
• Musumba C, Pritchard DM, Pirmohamed M. Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther. 2009;30(6):517–531. doi:10.1111/j.1365-2036.2009.04086.x
   PubMed Web of Science ®Google Scholar
• Suleyman H, Albayrak A, Bilici M, Cadirci E, Halici Z. Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation. 2010;33(4):224–234. doi:10.1007/s10753-009-9176-5
   PubMed Web of Science ®Google Scholar
• Yadav SK, Adhikary B, Chand S, Maity B, Bandyopadhyay SK, Chattopadhyay S. Molecular mechanism of indomethacin-induced gastropathy. Free Radic Biol Med. 2012;52(7):1175–1187. doi:10.1016/j.freeradbiomed.2011.12.023
   PubMed Web of Science ®Google Scholar
• Shaik RA, Eid BG. Piceatannol affects gastric ulcers induced by indomethacin: association of antioxidant, anti-inflammatory, and angiogenesis mechanisms in rats. Life. 2022;12(3):356. doi:10.3390/life12030356
   PubMedGoogle Scholar
• Liu L, Li J, Kundu JK, Surh YJ. Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1. Inflamm Res. 2014;63(12):1013–1021. doi:10.1007/s00011-014-0777-6
   PubMed Web of Science ®Google Scholar
• Jeong SO, Son Y, Lee JH, et al. Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells. Mol Med Rep. 2015;12(1):937–944. doi:10.3892/mmr.2015.3553
   PubMed Web of Science ®Google Scholar
• Molnar V, Matišić V, Kodvanj I, et al. Cytokines and chemokines involved in osteoarthritis pathogenesis. Int J Mol Sci. 2021;22(17):9208. doi:10.3390/ijms22179208
   PubMed Web of Science ®Google Scholar
• Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20(23):6008. doi:10.3390/ijms20236008
   PubMed Web of Science ®Google Scholar
• Abdallah IZA, Khattaba HAH, Heebab GH. Gastroprotective effect of Cordia Myxa L. fruit extract against indomethacin-induced gastric ulceration in rats. Life Sci J. 2011;8(3):1.
   Google Scholar
• Eraslan E, Tanyeli A, Güler MC, Kurt N, Yetim Z. Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacological Reports. 2020;72(4):984–991. doi:10.1007/s43440-019-00049-2
   PubMed Web of Science ®Google Scholar
• Abbas AM, Sakr HF. Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. J Physiol Biochem. 2013;69(3):527–537. doi:10.1007/s13105-013-0241-z
   PubMed Web of Science ®Google Scholar
• Kang JW, Yun N, Han HJ, et al. Protective effect of flos lonicerae against experimental gastric ulcers in rats: mechanisms of antioxidant and anti-inflammatory action. Evid Based Complement Altern Med. 2014;2014:1–11. doi:10.1155/2014/596920
   Web of Science ®Google Scholar
• El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats. Nutrition. 2016;32(7–8):849–854. doi:10.1016/j.nut.2016.01.010
   PubMed Web of Science ®Google Scholar
• Akah PA, Orisakwe OE, Gamaniel KS, Shittu A. Evaluation of Nigerian traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer. J Ethnopharmacol. 1998;62(2):123–127. doi:10.1016/S0378-8741(98)00060-9
   PubMed Web of Science ®Google Scholar
• Hawkins C, Hanks GW. The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs. A review of the literature. J Pain Sympt Manage. 2000;20(2):140–151. doi:10.1016/S0885-3924(00)00175-5
   PubMed Web of Science ®Google Scholar
• Peralta-Cruz J, Díaz-Fernández M, Ávila-Castro A, Ortegón-Reyna D, Ariza-Castolo A. An experimental and theoretical study of intramolecular regioselective oxidations of 6-substituted 2,3-dimethylquinoxaline derivatives. New J Chem. 2016;40(6):5501–5515. doi:10.1039/c5nj03282b
   Web of Science ®Google Scholar
• Kaleem M, Haque SE. Evaluation of cardioprotective role of vinpocetine in isoproterenol induced myocardial infarction in rats. J Pharm Res. 2015;9(7):408–414.
   Google Scholar
• Al KhalafA, AbdulrahmanAO, KaleemM, et al. Comparative analysis of the impact of urolithins on the composition of the gut microbiota in normal-diet fed rats. Nutr. 2021;13:3885. doi:10.3390/NU13113885
   Google Scholar
• Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008;135(1):41–60. doi:10.1053/j.gastro.2008.05.030
   PubMed Web of Science ®Google Scholar
• Shaker E, Mahmoud H, Mnaa S. Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camel thorn). Food Chem Toxicol. 2010;48(10):2785–2790. doi:10.1016/j.fct.2010.07.007
   PubMed Web of Science ®Google Scholar
• Lichtenberger LM. The hydrophobic barrier properties of gastrointestinal mucus. Ann Rev Physiol. 1995;57(1):565–583. doi:10.1146/annurev.ph.57.030195.003025
   PubMedGoogle Scholar
• Oluwabunmi I, Abiola T. Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats. Int J Appl Basic Med Res. 2015;5(1):41. doi:10.4103/2229-516x.149238
   PubMedGoogle Scholar
• Werawatganon D, Rakananurak N, Sallapant S, et al. Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats. World J Gastroenterol. 2014;20(48):18330. doi:10.3748/wjg.v20.i48.18330
   PubMed Web of Science ®Google Scholar
• Konturek PC, Duda A, Brzozowski T, et al. Activation of genes for superoxide dismutase, interleukin-1β, tumor necrosis factor-α, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury. Scand J Gastroenterol. 2000;35(5). doi:10.1080/003655200750023697
   Web of Science ®Google Scholar
• Lazzaroni M, Bianchi Porro G. Gastrointestinal side-effects of traditional non-steroidal anti-inflammatory drugs and new formulations. Aliment Pharmacol Ther. 2004;20(SUPPL.2):48–58. doi:10.1111/j.1365-2036.2004.02037.x
   PubMedGoogle Scholar
• Thong-Ngam D, Choochuai S, Patumraj S, Chayanupatkul M, Klaikeaw N. Curcumin prevents indomethacin-induced gastropathy in rats. World J Gastroenterol. 2012;18(13):1479. doi:10.3748/wjg.v18.i13.1479
   PubMed Web of Science ®Google Scholar
• Abood WN, Abdulla MA, Ismail S. Involvement of inflammatory mediators in the gastroprotective action of Phaleria macrocarpa against ethanol-induced gastric ulcer. World Appl Sci J. 2014;30(30 A). doi:10.5829/idosi.wasj.2014.30.icmrp.48
   Google Scholar
• AlKreathy HM, Alghamdi MK, Esmat A. Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: impact on oxidative, inflammatory, and angiogenic machineries. Saudi Pharm J. 2020;28(8):916–926. doi:10.1016/j.jsps.2020.06.012
   PubMed Web of Science ®Google Scholar
• Sun J, Shen X, Li Y, et al. Therapeutic potential to modify the mucus barrier in inflammatory bowel disease. Nutrients. 2016;8(1):44. doi:10.3390/nu8010044
   PubMed Web of Science ®Google Scholar
• Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn’t the stomach digest itself? Physiol Rev. 2008;88(4). doi:10.1152/physrev.00004.2008
   PubMed Web of Science ®Google Scholar
• Gilani SJ, Bin-Jumah MN, Al-Abbasi FA, et al. Protective effect of fustin against ethanol-activated gastric ulcer via downregulation of biochemical parameters in rats. ACS Omega. 2022;7(27):23245–23254. doi:10.1021/acsomega.2c01341
   PubMed Web of Science ®Google Scholar
• Suleyman H. The role of alpha-2 adrenergic receptors in anti-ulcer activity. Eurasian J Medi. 2012;44(1):43–45. doi:10.5152/eajm.2012.09
   PubMedGoogle Scholar
• Kisaoglu A, Ozogul B, Cetyn N, et al. The role of alpha-2 adrenergic receptors in the anti-ulcerative activity of famotidine and omeprazole in rats and its relationship with oxidant-antioxidant parameters. Int J Pharmacol. 2011;7(6):682–689. doi:10.3923/ijp.2011.682.689
   Google Scholar