60
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro

, , , , , & ORCID Icon show all
Pages 2271-2284 | Received 09 Jan 2024, Accepted 09 Apr 2024, Published online: 14 Apr 2024

References

  • Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol. 2004;34(1):9–21. doi:10.1046/j.0906-6713.2002.003421.x
  • Zhao J, Birjandi AA, Ahmed M, Redhead Y, Olea JV, Sharpe P. Telocytes regulate macrophages in periodontal disease. Elife. 2022;3:11.
  • Novello S, Tricot-Doleux S, Novella A, Pellen-Mussi P, Jeanne S. Influence of periodontal ligament stem cell-derived conditioned medium on osteoblasts. Pharmaceutics. 2022;14(4):729. doi:10.3390/pharmaceutics14040729
  • Cheat B, Torrens C, Foda A, et al. NLRP3 Is involved in neutrophil mobilization in experimental periodontitis. Front Immunol. 2022;13:839929. doi:10.3389/fimmu.2022.839929
  • Li N, Xie L, Wu Y, et al. Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel with antibacterial and anti-inflammatory effects for periodontitis treatment. Mater Today Bio. 2022;16:100360. doi:10.1016/j.mtbio.2022.100360
  • Um S, Lee JH, Seo BM. TGF-beta2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells. Int J Oral Sci. 2018;10(3):29. doi:10.1038/s41368-018-0028-8
  • Chang Y, Hsiao YM, Hu CC, et al. Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection. Int J Mol Sci. 2020;21:8.
  • Bu T, Ren Y, Yu S, et al. A low-phenylalanine-containing whey protein hydrolysate stimulates osteogenic activity through the activation of p38/Runx2 signaling in osteoblast cells. Nutrients. 2022;14(15):3135. doi:10.3390/nu14153135
  • Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473(2):139–146. doi:10.1016/j.abb.2008.03.018
  • Lee HA, Park MH, Song Y, Na HS, Chung J. Role of Aggregatibacter actinomycetemcomitans-induced autophagy in inflammatory response. J Periodontol. 2020;91(12):1682–1693. doi:10.1002/JPER.19-0639
  • Nollet M, Santucci-Darmanin S, Breuil V, et al. Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy. 2014;10(11):1965–1977. doi:10.4161/auto.36182
  • Wang B, Khan S, Wang P, et al. A highly selective GSK-3beta Inhibitor CHIR99021 promotes osteogenesis by activating canonical and autophagy-mediated wnt signaling. Front Endocrinol. 2022;13:926622. doi:10.3389/fendo.2022.926622
  • Laha D, Deb M, Das H. KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy. Autophagy. 2019;15(12):2063–2075. doi:10.1080/15548627.2019.1596491
  • Onal M, Piemontese M, Xiong J, et al. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013;288(24):17432–17440. doi:10.1074/jbc.M112.444190
  • Piemontese M, Onal M, Xiong J, et al. Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage. Sci Rep. 2016;6(1):24262. doi:10.1038/srep24262
  • Fujiwara T, Ye S, Castro-Gomes T, et al. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight. 2016;1(17):e86330. doi:10.1172/jci.insight.86330
  • Yao Q, Chang BT, Chen R, et al. Research advances in pharmacology, safety, and clinical applications of Yunnan baiyao, a traditional Chinese medicine formula. Front Pharmacol. 2021;12:773185. doi:10.3389/fphar.2021.773185
  • Liu J, Cai M, Yan H, et al. Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus. Int J Med Sci. 2019;16(8):1078–1088. doi:10.7150/ijms.33723
  • Ren X, Zhu Y, Xie L, Zhang M, Gao L, He H. Yunnan Baiyao diminishes lipopolysaccharide-induced inflammation in osteoclasts. J Food Biochem. 2020;44(6):e13182. doi:10.1111/jfbc.13182
  • Li Y, Liu W, Zhao R, et al. Yunnan Baiyao inhibits periodontitis by suppressing the autophagic flux. Int Dent J. 2023;1:3.
  • Wang Y, Xia C, Chen Y, Jiang T, Hu Y, Gao Y. Resveratrol synergistically promotes BMP9-induced osteogenic differentiation of mesenchymal stem cells. Stem Cells Int. 2022;2022:8124085. doi:10.1155/2022/8124085
  • Hao Y, Ren Z, Yu L, et al. p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/beta-catenin axis. Aging Cell. 2022;21(8):e13677. doi:10.1111/acel.13677
  • Park SW, Kim J, Oh S, et al. PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation. Nucleic Acids Res. 2022;50(14):7856–7872. doi:10.1093/nar/gkac584
  • Kuo CH, Zhang BH, Huang SE, et al. Xanthine derivative KMUP-1 attenuates experimental periodontitis by reducing osteoclast differentiation and inflammation. Front Pharmacol. 2022;13:821492. doi:10.3389/fphar.2022.821492
  • Vicencio E, Cordero EM, Cortes BI, et al. Aggregatibacter actinomycetemcomitans induces autophagy in human junctional epithelium keratinocytes. Cells. 2020;9(5):1221. doi:10.3390/cells9051221
  • Momen-Heravi F, Friedman RA, Albeshri S, et al. Cell type-specific decomposition of gingival tissue transcriptomes. J Dent Res. 2021;100(5):549–556. doi:10.1177/0022034520979614
  • Ni K, Hua Y. Hydrogen sulfide exacerbated periodontal inflammation and induced autophagy in experimental periodontitis. Int Immunopharmacol. 2021;93:107399. doi:10.1016/j.intimp.2021.107399
  • Dang H, Chen W, Chen L, Huo X, Wang F. TPPU inhibits inflammation-induced excessive autophagy to restore the osteogenic differentiation potential of stem cells and improves alveolar ridge preservation. Sci Rep. 2023;13(1). doi:10.1038/s41598-023-28710-0
  • Gruber R. Osteoimmunology: inflammatory osteolysis and regeneration of the alveolar bone. J Clin Periodontol. 2019;46(Suppl 21):52–69. doi:10.1111/jcpe.13056
  • Hienz SA, Paliwal S, Ivanovski S. Mechanisms of Bone Resorption in Periodontitis. J Immunol Res. 2015;2015:615486. doi:10.1155/2015/615486
  • Ma Y, Qian Y, Chen Y, et al. Resveratrol modulates the inflammatory response in hPDLSCs via the NRF2/HO-1 and NF-kappaB pathways and promotes osteogenic differentiation. J Periodontal Res. 2023;3:1.
  • Tamura H, Maekawa T, Domon H, et al. Erythromycin restores osteoblast differentiation and osteogenesis suppressed by porphyromonas gingivalis lipopolysaccharide. Pharmaceuticals. 2023;16(2):303. doi:10.3390/ph16020303
  • Hirata N, Ichimaru R, Tominari T, et al. Beta-cryptoxanthin inhibits lipopolysaccharide-induced osteoclast differentiation and bone resorption via the suppression of inhibitor of NF-kappaB kinase activity. Nutrients. 2019;11(2):368. doi:10.3390/nu11020368
  • Mueller-Buehl AM, Tsai T, Hurst J, et al. Reduced retinal degeneration in an oxidative stress organ culture model through an iNOS-inhibitor. Biology. 2021;10(5):383. doi:10.3390/biology10050383
  • Baek I, Bello AB, Jeon J, et al. Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model. J Tissue Eng. 2022;13:20417314221116754. doi:10.1177/20417314221116754
  • Yasuda H, Shima N, Nakagawa N, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A. 1998;95(7):3597–3602. doi:10.1073/pnas.95.7.3597
  • Huang D, Zhao C, Li R, et al. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun. 2022;13(1):5338.
  • Kadriu B, Gold PW, Luckenbaugh DA, et al. Acute ketamine administration corrects abnormal inflammatory bone markers in major depressive disorder. Mol Psychiatry. 2018;23(7):1626–1631. doi:10.1038/mp.2017.109
  • Uenaka M, Yamashita E, Kikuta J, et al. Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nat Commun. 2022;13(1):1066. doi:10.1038/s41467-022-28673-2
  • Li Y, Su J, Sun W, Cai L, Deng Z. AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction. Int J Mol Med. 2018;41(5):2535–2544. doi:10.3892/ijmm.2018.3498
  • Yao W, Dai W, Jiang JX, Lane NE. Glucocorticoids and osteocyte autophagy. Bone. 2013;54(2):279–284. doi:10.1016/j.bone.2013.01.034
  • Liu J, Wang Y, Shi Q, et al. Mitochondrial DNA efflux maintained in gingival fibroblasts of patients with periodontitis through ROS/mPTP pathway. Oxid Med Cell Longev. 2022;2022:1000213. doi:10.1155/2022/1000213
  • Kang Y, Kong N, Ou M, et al. A novel cascaded energy conversion system inducing efficient and precise cancer therapy. Bioact Mater. 2023;20:663–676. doi:10.1016/j.bioactmat.2022.07.007
  • Liu C, Mo L, Niu Y, Li X, Zhou X, Xu X. The role of reactive oxygen species and autophagy in periodontitis and their potential linkage. Front Physiol. 2017;8:439. doi:10.3389/fphys.2017.00439
  • Greabu M, Giampieri F, Imre MM, et al. Autophagy, one of the main steps in periodontitis pathogenesis and evolution. Molecules. 2020;25(18):4338. doi:10.3390/molecules25184338