Associations of Gut and Circulating Microbiota with Circulating Vitamin D₃, Type I Interferon, and Systemic Inflammation in Chronic Spontaneous Urticaria Patients

References

• Sánchez-Borges M, Ansotegui IJ, Baiardini I, et al. The challenges of chronic urticaria part 1: epidemiology, immunopathogenesis, comorbidities, quality of life, and management. World Allergy Organ J. 2021;14(6):100533. doi:10.1016/j.waojou.2021.100533
   PubMed Web of Science ®Google Scholar
• Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734–766. doi:10.1111/all.15090
   PubMed Web of Science ®Google Scholar
• Song Y, Dan K, Yao Z, Yang X, Chen B, Hao F. Altered gut microbiota in H1-antihistamine-resistant chronic spontaneous urticaria associates with systemic inflammation. Front Cell Infect Microbiol. 2022;12:831489. doi:10.3389/fcimb.2022.831489
   PubMed Web of Science ®Google Scholar
• Asero R, Ferrer M, Kocaturk E, Maurer M. Chronic spontaneous urticaria: the role and relevance of autoreactivity, autoimmunity, and autoallergy. J Allergy Clin Immunol Pract. 2023;11(8):2302–2308. doi:10.1016/j.jaip.2023.02.022
   PubMed Web of Science ®Google Scholar
• Nabavizadeh SH, Alyasin S, Esmaeilzadeh H, Mosavat F, Ebrahimi N. The effect of vitamin D add-on therapy on the improvement of quality of life and clinical symptoms of patients with chronic spontaneous urticaria. Asian. Pac J Allergy Immunol. 2023;41(2):150–157.
   PubMed Web of Science ®Google Scholar
• Yang Z, Yanghui B, Hao F, Chen B. Advances in vitamin D3 signaling and interferon response in diseases. J Chongqing Med Univ. 2023;48(11):1296–1301.
   Google Scholar
• Futata E, Azor M, Dos Santos J, et al. Impaired IFN-α secretion by plasmacytoid dendritic cells induced by TLR9 activation in chronic idiopathic urticaria. Br J Dermatol. 2011;164(6):1271–1279. doi:10.1111/j.1365-2133.2010.10198.x
   PubMed Web of Science ®Google Scholar
• Wirusanti NI, Baldridge MT, Harris VC. Microbiota regulation of viral infections through interferon signaling. Trends Microbiol. 2022;30(8):778–792. doi:10.1016/j.tim.2022.01.007
   PubMed Web of Science ®Google Scholar
• Chen B, Chen C, Yanghui B, Song H, Hao F. Progress of gut microbiota in the modulation of interferon response in viral and neoplastic diseases. Chin J Infect Dis. 2023;5:351–357.
   Google Scholar
• Chen B, Song Y, Yang X, Yang J, Hao F. Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU. J Leukoc Biol. 2023;113(5):461–470. doi:10.1093/jleuko/qiad025
   PubMed Web of Science ®Google Scholar
• Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–1414. doi:10.1111/all.13397
   PubMed Web of Science ®Google Scholar
• Wang Y, Dan K, Xue X, Chen B, Chen C. Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells. Gut Pathog. 2022;14(1):8. doi:10.1186/s13099-022-00481-5
   PubMed Web of Science ®Google Scholar
• Tomaszewska K, Słodka A, Tarkowski B, Zalewska-Janowska A. Neuro-immuno-psychological aspects of chronic urticaria. J Clin Med. 2023;12(9):3134. doi:10.3390/jcm12093134
   PubMed Web of Science ®Google Scholar
• Kaplan A, Lebwohl M, Giménez-Arnau AM, Hide M, Armstrong AW, Maurer M. Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances. Allergy. 2023;78(2):389–401. doi:10.1111/all.15603
   PubMed Web of Science ®Google Scholar
• Murdaca G, Allegra A, Tonacci A, Musolino C, Ricciardi L, Gangemi S. Mast cells and vitamin D status: a clinical and biological link in the onset of allergy and bone diseases. Biomedicines. 2022;10(8):1877. doi:10.3390/biomedicines10081877
   PubMed Web of Science ®Google Scholar
• Tsai TY, Huang YC. Vitamin D deficiency in patients with chronic and acute urticaria: a systematic review and meta-analysis. J Am Acad Dermatol. 2018;79(3):573–575. doi:10.1016/j.jaad.2018.02.033
   PubMed Web of Science ®Google Scholar
• Tuchinda P, Kulthanan K, Chularojanamontri L, Arunkajohnsak S, Sriussadaporn S. Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy. 2018;8:51. doi:10.1186/s13601-018-0234-7
   PubMed Web of Science ®Google Scholar
• Mohamed AA, Hussein MS, Salah EM, et al. Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients. J DermatolTreat. 2022;33(1):427–432. doi:10.1080/09546634.2020.1762838
   Google Scholar
• Grzanka A, Machura E, Mazur B, et al. Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria. J Inflamm. 2014;11(1):2. doi:10.1186/1476-9255-11-2
   Google Scholar
• Zhao JW, Ping JD, Wang YF, et al. Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1α pathway in chronic spontaneous urticaria. Clin Immunol. 2020;215:108444. doi:10.1016/j.clim.2020.108444
   PubMed Web of Science ®Google Scholar
• Newmark H, Dantoft W, Ghazal P. Evolutionary origin of the interferon-immune metabolic axis: the sterol-vitamin D link. Front Immunol. 2017;8:62. doi:10.3389/fimmu.2017.00062
   PubMed Web of Science ®Google Scholar
• Suzuki T, Tatsuno K, Ito T, Sakabe JI, Funakoshi A, Tokura Y. Distinctive downmodulation of plasmacytoid dendritic cell functions by vitamin D3 analogue calcipotriol. J. Dermatol Sci. 2016;84(1):71–79. doi:10.1016/j.jdermsci.2016.06.003
   PubMed Web of Science ®Google Scholar
• Postal M, Vivaldo JF, Fernandez-Ruiz R, Paredes JL, Appenzeller S, Niewold TB. Type I interferon in the pathogenesis of systemic lupus erythematosus. Curr Opin Immunol. 2020;67:87–94. doi:10.1016/j.coi.2020.10.014
   PubMed Web of Science ®Google Scholar
• Tversky JR, Le TV, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT. Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9. Clin Exp Allergy. 2008;38(5):781–788. doi:10.1111/j.1365-2222.2008.02954.x
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Shimabukuro-Demoto S, Tsutsui H, Toyama-Sorimachi N, Schmidt-Supprian M. Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis. PLoS Biol. 2019;17(11):e3000530. doi:10.1371/journal.pbio.3000530
   PubMed Web of Science ®Google Scholar
• Krišto M, Lugović-Mihić L, Muñoz M, et al. Gut microbiome composition in patients with chronic urticaria: a review of current evidence and data. Life. 2023;13(1):152. doi:10.3390/life13010152
   PubMedGoogle Scholar
• Malaguarnera L. Vitamin D and microbiota: two sides of the same coin in the immunomodulatory aspects. Int Immunopharmacol. 2020;79:106112. doi:10.1016/j.intimp.2019.106112
   PubMed Web of Science ®Google Scholar
• Bashir M, Prietl B, Tauschmann M, et al. Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. Eur J Nutr. 2016;55(4):1479–1489. doi:10.1007/s00394-015-0966-2
   PubMed Web of Science ®Google Scholar
• Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab. 2013;98(7):2944–2951. doi:10.1210/jc.2012-4262
   PubMed Web of Science ®Google Scholar
• Akimbekov NS, Digel I, Sherelkhan DK, Lutfor AB, Razzaque MS. Vitamin D and the host-gut microbiome: a brief overview. Acta Histochem Cytochem. 2020;53(3):33–42. doi:10.1267/ahc.20011
   PubMed Web of Science ®Google Scholar
• Tschurtschenthaler M, Wang J, Fricke C, et al. Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration. Gut. 2014;63(12):1921–1931. doi:10.1136/gutjnl-2013-305863
   PubMed Web of Science ®Google Scholar
• Stefan KL, Kim MV, Iwasaki A, Kasper DL. Commensal microbiota modulation of natural resistance to virus infection. Cell. 2020;183(5):1312–1324.e10. doi:10.1016/j.cell.2020.10.047
   PubMed Web of Science ®Google Scholar
• Antunes KH, Fachi JL, de Paula R, et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat Commun. 2019;10(1):3273. doi:10.1038/s41467-019-11152-6
   PubMed Web of Science ®Google Scholar
• Castillo DJ, Rifkin RF, Cowan DA, Potgieter M. The healthy human blood microbiome: fact or fiction? Front Cell Infect Microbiol. 2019;9:148. doi:10.3389/fcimb.2019.00148
   PubMed Web of Science ®Google Scholar
• Panaiotov S, Hodzhev Y, Tsafarova B, Tolchkov V, Kalfin R. Culturable and non-culturable blood microbiota of healthy individuals. Microorganisms. 2021;9(7):1464. doi:10.3390/microorganisms9071464
   PubMed Web of Science ®Google Scholar
• Tsafarova B, Hodzhev Y, Yordanov G, Tolchkov V, Kalfin R, Panaiotov S. Morphology of blood microbiota in healthy individuals assessed by light and electron microscopy. Front Cell Infect Microbiol. 2023;12:1091341. doi:10.3389/fcimb.2022.1091341
   PubMed Web of Science ®Google Scholar