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ORIGINAL RESEARCH

Integrated Analysis Identified TGFBI as a Biomarker of Disease Severity and Prognosis Correlated with Immune Infiltrates in Patients with Sepsis

ORCID Icon, , & ORCID Icon
Pages 2285-2298 | Received 21 Dec 2023, Accepted 26 Mar 2024, Published online: 14 Apr 2024

References

  • Russell J. Management of sepsis. New Engl J Med. 2006;355(16):1699–1713. doi:10.1056/NEJMra043632
  • Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580–637. doi:10.1097/CCM.0b013e31827e83af
  • Gilbert J. Sepsis care bundles: a work in progress. Lancet Respir Med. 2018;6(11):821–823. doi:10.1016/s2213-2600(18)30362-x
  • Cecconi M, Evans L, Levy M, et al. Sepsis and septic shock. Lancet. 2018;392(10141):75–87. doi:10.1016/s0140-6736(18)30696-2
  • Scicluna B, Wiewel M, van Vught L, et al. Molecular biomarker to assist in diagnosing abdominal sepsis upon ICU admission. Am J Respir Crit Care Med. 2018;197(8):1070–1073. doi:10.1164/rccm.201707-1339LE
  • Mikacenic C, Price B, Harju-Baker S, et al. A two-biomarker model predicts mortality in the critically ill with sepsis. Am J Respir Crit Care Med. 2017;196(8):1004–1011. doi:10.1164/rccm.201611-2307OC
  • Downes KJ, Fitzgerald JC, Weiss SL. Utility of procalcitonin as a biomarker for sepsis in children. J Clin Microbiol. 2020;58(7). doi:10.1128/jcm.01851-19
  • Donadello K, Scolletta S, Covajes C, et al. suPAR as a prognostic biomarker in sepsis. BMC Med. 2012;10(2). doi:10.1186/1741-7015-10-2
  • Faix JD. Biomarkers of sepsis. Critical Rev Clin Lab Sci. 2013;50(1):23–36. doi:10.3109/10408363.2013.764490
  • Póvoa P, Teixeira-Pinto AM, Carneiro AH. C-reactive protein, an early marker of community-acquired sepsis resolution: a multi-center prospective observational study. Critical Care. 2011;15(4):R169. doi:10.1186/cc10313
  • Salluh JI, Lisboa T. C-reactive protein in community-acquired sepsis: you can teach new tricks to an old dog. Critical Care. 2011;15(5):186. doi:10.1186/cc10301
  • Molano Franco D, Arevalo-Rodriguez I, Roqué IFM, et al. Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults. Cochrane Database Syst Rev. 2019;4(4):Cd011811. doi:10.1002/14651858.CD011811.pub2
  • de Matos Morawski F, Dias GBM, Sousa KAP, et al. Chitosan/genipin modified electrode for voltammetric determination of interleukin-6 as a biomarker of sepsis. Int J Biol Macromol. 2023;224:1450–1459. doi:10.1016/j.ijbiomac.2022.10.232
  • Yang K, Fan M. Lactate induces vascular permeability via disruption of ve-cadherin in endothelial cells during sepsis. Int J Med. 2022;8(17):eabm8965. doi:10.1126/sciadv.abm8965
  • Puskarich MA, Trzeciak S, Shapiro NI, et al. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest. 2013;143(6):1548–1553. doi:10.1378/chest.12-0878
  • Haynes A, Ruda F, Oliver J, et al. Syndecan 1 shedding contributes to pseudomonas aeruginosa sepsis. Infect Immun. 2005;73(12):7914–7921. doi:10.1128/iai.73.12.7914-7921.2005
  • Cox D. Sepsis - it is all about the platelets. Front Immunol. 2023;14:1210219. doi:10.3389/fimmu.2023.1210219
  • Szklarczyk D, Kirsch R, Koutrouli M, et al. The string database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638–D646. doi:10.1093/nar/gkac1000
  • Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.1239303
  • Venet F, Monneret G. Advances in the understanding and treatment of sepsis-induced immunosuppression. Nat Rev Nephrol. 2018;14(2):121–137. doi:10.1038/nrneph.2017.165
  • Iskander K, Osuchowski M, Stearns-Kurosawa D, et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013;93(3):1247–1288. doi:10.1152/physrev.00037.2012
  • Catton EA, Bonsor DA, Herrera C, et al. Human ceacam1 is targeted by a streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Pathogenesis. 2023;14(1):2275. doi:10.1038/s41467-023-37732-1
  • Karampela I, Christodoulatos GS, Dalamaga M. The role of adipose tissue and adipokines in sepsis: inflammatory and metabolic considerations, and the obesity paradox. Current Obesity Rep. 2019;8(4):434–457. doi:10.1007/s13679-019-00360-2
  • Huang D, Yan H. Methyltransferase like 7b is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization. Bioengineered. 2022;13(5):11753–11766. doi:10.1080/21655979.2022.2068892
  • Nakazawa N, Yokobori T, Turtoi A, et al. Aso author reflections: high stromal tgfbi is a useful predictive marker for nivolumab in non-small cell lung cancer. Ann Surg Oncol. 2020;27(3):943–944. doi:10.1245/s10434-019-08057-5
  • Fico F, Santamaria-Martínez A. Tgfbi modulates tumour hypoxia and promotes breast cancer metastasis. Mol Oncol. 2020;14(12):3198–3210. doi:10.1002/1878-0261.12828
  • Steitz A, Steffes A, Finkernagel F, et al. Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (tgfbi) and tenascin c. Cell Death Dis. 2020;11(4):249. doi:10.1038/s41419-020-2438-8
  • Shah J, Shao G, Hei T, et al. Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR. BMC Cancer. 2008;8:284. doi:10.1186/1471-2407-8-284
  • Skonier J, Neubauer M, Madisen L, et al. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol. 1992;11(7):511–522. doi:10.1089/dna.1992.11.511
  • Ween MP, Oehler MK, Ricciardelli C. Transforming growth factor-beta-induced protein (tgfbi)/(βig-h3): a matrix protein with dual functions in ovarian cancer. Int J Mol Sci. 2012;13(8):10461–10477. doi:10.3390/ijms130810461
  • Mosher DF, Johansson MW, Gillis ME, et al. Periostin and tgf-β-induced protein: two peas in a pod? Crit. Rev. Biochem. Mol. Biol. 2015;50(5):427–439. doi:10.3109/10409238.2015.1069791
  • Thapa N, Lee BH, Kim IS. Tgfbip/betaig-h3 protein: a versatile matrix molecule induced by tgf-beta. Int J Biochem Cell Biol. 2007;39(12):2183–2194. doi:10.1016/j.biocel.2007.06.004
  • Tumbarello DA, Andrews MR, Brenton JD. Sparc regulates transforming growth factor beta induced (tgfbi) extracellular matrix deposition and paclitaxel response in ovarian cancer cells. PLoS One. 2016;11(9):e0162698. doi:10.1371/journal.pone.0162698
  • Sun J, Ge X, Wang Y, et al. Usf2 knockdown downregulates thbs1 to inhibit the tgf-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury. Pharmacol Res. 2022;176:105962. doi:10.1016/j.phrs.2021.105962
  • de Pablo R, Monserrat J, Reyes E, et al. Sepsis-induced acute respiratory distress syndrome with fatal outcome is associated to increased serum transforming growth factor beta-1 levels. Eur J Internal Med. 2012;23(4):358–362. doi:10.1016/j.ejim.2011.10.001
  • Marie C, Cavaillon JM, Losser MR. Elevated levels of circulating transforming growth factor-beta 1 in patients with the sepsis syndrome. Ann Internal Med. 1996;125(6):520–521. doi:10.7326/0003-4819-125-6-199609150-00034
  • Lee SG, Chae J, Woo SM, et al. Tgfbi remodels adipose metabolism by regulating the notch-1 signaling pathway. Exp Mol Med. 2023;55(3):520–531. doi:10.1038/s12276-023-00947-9
  • Ruiz M, Toupet K, Maumus M, et al. Tgfbi secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles. Biomaterials. 2020;226:119544. doi:10.1016/j.biomaterials.2019.119544
  • Nielsen NS, Poulsen ET, Lukassen MV, et al. Biochemical mechanisms of aggregation in tgfbi-linked corneal dystrophies. Prog Retinal Eye Res. 2020;77:100843. doi:10.1016/j.preteyeres.2020.100843
  • Han B, Cai H, Chen Y, et al. The role of tgfbi (βig-h3) in gastrointestinal tract tumorigenesis. Mol Cancer. 2015;14:64. doi:10.1186/s12943-015-0335-z
  • Pajares MJ, Agorreta J, Salvo E, et al. Tgfbi expression is an independent predictor of survival in adjuvant-treated lung squamous cell carcinoma patients. Br. J. Cancer. 2014;110(6):1545–1551. doi:10.1038/bjc.2014.33
  • Rudra-Ganguly N, Lowe C, Mattie M, et al. Discoidin domain receptor 1 contributes to tumorigenesis through modulation of tgfbi expression. PLoS One. 2014;9(11):e111515. doi:10.1371/journal.pone.0111515
  • Wen G, Partridge MA, Li B, et al. Tgfbi expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells. Cancer Lett. 2011;308(1):23–32. doi:10.1016/j.canlet.2011.04.010
  • Calaf GM, Echiburú-Chau C, Zhao YL, et al. Bigh3 protein expression as a marker for breast cancer. IntJ Mol Med. 2008;21(5):561–568.
  • Seok Y, Lee WK, Park JY, et al. Tgfbi promoter methylation is associated with poor prognosis in lung adenocarcinoma patients. Mol Cells. 2019;42(2):161–165. doi:10.14348/molcells.2018.0322
  • Cheng Y, He C, Wang M, et al. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduction Targeted Therapy. 2019;4:62. doi:10.1038/s41392-019-0095-0
  • Nam JO, Son HN, Jun E, et al. Fas1 domain protein inhibits vegf165-induced angiogenesis by targeting the interaction between vegfr-2 and αvβ3 integrin. Molecular Cancer Res. 2012;10(8):1010–1020. doi:10.1158/1541-7786.mcr-11-0600
  • Nam JO, Jeong HW, Lee BH, et al. Regulation of tumor angiogenesis by fastatin, the fourth fas1 domain of betaig-h3, via alphavbeta3 integrin. Cancer Res. 2005;65(10):4153–4161. doi:10.1158/0008-5472.can-04-2705
  • Ahmed AA, Mills AD, Ibrahim AE, et al. The extracellular matrix protein tgfbi induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 2007;12(6):514–527. doi:10.1016/j.ccr.2007.11.014
  • Nummela P, Lammi J, Soikkeli J, et al. Transforming growth factor beta-induced (tgfbi) is an anti-adhesive protein regulating the invasive growth of melanoma cells. Am J Pathol. 2012;180(4):1663–1674. doi:10.1016/j.ajpath.2011.12.035
  • Lecker L, Berlato C, Maniati E, et al. Tgfbi production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer. Cancer Res. 2021;81(22):5706–5719. doi:10.1158/0008-5472.can-21-0536
  • Annunziato F, Cosmi L, Liotta F, et al. Type 17 t helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol. 2009;5(6):325–331. doi:10.1038/nrrheum.2009.80
  • Merino C, Martínez F, Cardemil F, et al. Absolute eosinophils count as a marker of mortality in patients with severe sepsis and septic shock in an intensive care unit. J Crit Care. 2012;27(4):394–399. doi:10.1016/j.jcrc.2011.10.010
  • Rubio I, Osuchowski M, Shankar-Hari M, et al. Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infect Dis. 2019;19(12):e422–e436. doi:10.1016/s1473-3099(19)30567-5
  • van der Poll T, Shankar-Hari M, Wiersinga W. The immunology of sepsis. Immunity. 2021;54(11):2450–2464. doi:10.1016/j.immuni.2021.10.012
  • Sweeney T, Shidham A, Wong H, et al. A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set. Sci, trans med. 2015;7(287):287ra271. doi:10.1126/scitranslmed.aaa5993
  • Peng P, Zhu H, Liu D, et al. Tgfbi secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-src-stat3 signaling. Theranostics. 2022;12(9):4221–4236. doi:10.7150/thno.69605