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Journal of Inflammation Research Volume 17, 2024 - Issue
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ORIGINAL RESEARCH

Mendelian Randomization and Transcriptomic Analysis Reveal the Protective Role of NKT Cells in Sepsis

Qingxiang Liu1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5098-9254View further author information
ORCID Icon,
Haitao Liu2 School of Life Science, Fudan University, Shanghai, 200000, People’s Republic of ChinaView further author information
,
Zihan Hu1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0008-4096-4775View further author information
ORCID Icon,
Xing Zhou1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaView further author information
,
Kai Jin1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0006-8647-7783View further author information
ORCID Icon,
Yingzi Huang1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaView further author information
,
Wei Huang1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
&
Yi Yang1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaView further author information
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Pages 3159-3171 | Received 15 Jan 2024, Accepted 07 May 2024, Published online: 17 May 2024

References

  • Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet. 2020;10219(395):200–211. doi:10.1016/S0140-6736(19)32989-7
  • Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011;23(306):2594–2605. doi:10.1001/jama.2011.1829
  • Behar SM, Porcelli SA. CD1-restricted T cells in host defense to infectious diseases. Curr Top Microbiol Immunol. 2007;314:215–250. doi:10.1007/978-3-540-69511-0_9
  • Hammond KJ, Pelikan SB, Crowe NY, et al. NKT cells are phenotypically and functionally diverse. Eur J Immunol. 1999;11(29):3768–3781. doi:10.1002/(SICI)1521-4141(199911)29:11
  • Christaki E, Diza E, Giamarellos-Bourboulis EJ, et al. NK and NKT cell depletion alters the outcome of experimental pneumococcal pneumonia: relationship with regulation of interferon-gamma production. J Immunol Res. 2015;2015:532717. doi:10.1155/2015/532717
  • Hu CK, Venet F, Heffernan DS, et al. The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock. J Immunol. 2009;4(182):2467–2475. doi:10.4049/jimmunol.0801463
  • Birney E. Mendelian randomization. Cold Spring Harb Perspect Med. 2022;4(12). doi:10.1101/cshperspect.a041302
  • Harrison S, Dixon P, Jones HE, Davies AR, Howe LD, Davies NM. Long-term cost-effectiveness of interventions for obesity: a Mendelian randomisation study. PLoS Med. 2021;8(18):e1003725. doi:10.1371/journal.pmed.1003725
  • Wang C, Zhu D, Zhang D, et al. Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study. BMC Psychiatry. 2023;1(23). doi:10.1186/s12888-023-05081-4
  • Vallejo J, Cochain C, Zernecke A, Ley K. Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq. Cardiovasc Res. 2021;13(117):2537–2543. doi:10.1093/cvr/cvab260
  • Rosati E, Rios MG, Pogorelyy MV, et al. A novel unconventional T cell population enriched in Crohn’s disease. Gut. 2022;11(71):2194–2204. doi:10.1136/gutjnl-2021-325373
  • Wang Y, Zang F, Ye X, et al. Diversity of circulating NKT cells in defense against Carbapenem-Resistant Klebsiella pneumoniae infection. J Persona Med. 2022;12(12):2025. doi:10.3390/jpm12122025
  • Orru V, Steri M, Sidore C, et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet. 2020;10(52):1036–1045. doi:10.1038/s41588-020-0684-4
  • Auton A, Brooks LD, Durbin RM, et al. A global reference for human genetic variation. Nature. 2015;7571(526):68–74. doi:10.1038/nature15393
  • Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res. 2017;5(26):2333–2355. doi:10.1177/0962280215597579
  • Bowden J, Davey SG, Haycock PC, Burgess S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;4(40):304–314. doi:10.1002/gepi.21965
  • Greco MF, Minelli C, Sheehan NA, Thompson JR. Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med. 2015;21(34):2926–2940. doi:10.1002/sim.6522
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;8(315):801–810. doi:10.1001/jama.2016.0287
  • Stuart T, Butler A, Hoffman P, et al. Comprehensive integration of single-cell data. Cell. 2019;7(177):1888–1902. doi:10.1016/j.cell.2019.05.031
  • Qiu X, Hill A, Packer J, Lin D, Ma YA, Trapnell C. Single-cell mRNA quantification and differential analysis with Census. Nat Methods. 2017;3(14):309–315. doi:10.1038/nmeth.4150
  • Bravo GC, De Winter S, Hulselmans G, et al. SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks. Nat Methods. 2023. doi:10.1038/s41592-023-01938-4
  • Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;1(28):27–30. doi:10.1093/nar/28.1.27
  • Su Z, Huang Y, Gu X. Tissue-driven hypothesis with Gene Ontology (GO) analysis. Ann Biomed Eng. 2007;6(35):1088–1094. doi:10.1007/s10439-007-9269-y
  • Kim EY, Ner-Gaon H, Varon J, et al. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-gamma in NK cells. J Clin Invest. 2020;6(130):3238–3252. doi:10.1172/JCI128075

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