145
Views
1
CrossRef citations to date
0
Altmetric
CASE REPORT

Co-Occurring EGFR S645C and EGFR L858R in a Patient with Lung Adenocarcinoma Induced Primary Resistance to Osimertinib

, ORCID Icon, , , & ORCID Icon
Pages 79-84 | Received 20 Jul 2023, Accepted 29 Sep 2023, Published online: 09 Oct 2023

References

  • Shi Y, Au JS, Thongprasert S, et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol. 2014;9(2):154–162. doi:10.1097/JTO.0000000000000033
  • Yavuz BR, Tsai CJ, Nussinov R, Tuncbag N. Pan-cancer clinical impact of latent drivers from double mutations. Commun Biol. 2023;6(1):202. doi:10.1038/s42003-023-04519-5
  • Li M, Zhou CZ, Yang JJ, et al. The in cis compound EGFR mutations in Chinese advanced non-small cell lung cancer patients. Cancer Biol Ther. 2019;20(8):1097–1104. doi:10.1080/15384047.2019.1595280
  • Zhuang X, Zhao C, Li J, et al. Clinical features and therapeutic options in non-small cell lung cancer patients with concomitant mutations of EGFR, ALK, ROS1, KRAS or BRAF. Cancer Med. 2019;8(6):2858–2866. doi:10.1002/cam4.2183
  • Larsen AK, Ouaret D, El OK, Petitprez A. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther. 2011;131(1):80–90. doi:10.1016/j.pharmthera.2011.03.012
  • Socinski MA, Nishio M, Jotte RM, et al. IMpower150 final overall survival analyses for atezolizumab plus bevacizumab and chemotherapy in first-line metastatic nonsquamous NSCLC. J Thorac Oncol. 2021;16(11):1909–1924. doi:10.1016/j.jtho.2021.07.009
  • Lu S, Wu L, Jian H, et al. Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, Phase 3 trial. Lancet Oncol. 2022;23(9):1167–1179. doi:10.1016/S1470-2045(22)00382-5
  • Chen Y, Yang Z, Wang Y, et al. Pembrolizumab plus chemotherapy or anlotinib vs. pembrolizumab alone in patients with previously treated EGFR-mutant NSCLC. Front Oncol. 2021;11:671228. doi:10.3389/fonc.2021.671228
  • Morikawa K, Iinuma M, Shinozaki Y, Nishine H, Inoue T, Mineshita M. A case of advanced adenocarcinoma genetically confirmed with EGFR/BRAF co-mutation in both primary and metastatic lesions. Ther Adv Med Oncol. 2021;13:17588359211053420. doi:10.1177/17588359211053420
  • Wang S, Li M, Zhang J, et al. Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer. J Hematol Oncol. 2022;15(1):137. doi:10.1186/s13045-022-01355-8
  • Guo L, Chen Z, Xu C, et al. Intratumoral heterogeneity of EGFR-activating mutations in advanced NSCLC patients at the single-cell level. BMC Cancer. 2019;19(1):369. doi:10.1186/s12885-019-5555-y
  • Wu Q, Luo W, Li W, Wang T, Huang L, Xu F. First-generation EGFR-TKI plus chemotherapy versus EGFR-TKI alone as first-line treatment in advanced NSCLC with EGFR activating mutation: a systematic review and meta-analysis of randomized controlled trials. Front Oncol. 2021;11:598265. doi:10.3389/fonc.2021.598265
  • Miyauchi E, Morita S, Nakamura A, et al. Updated analysis of NEJ009: gefitinib-alone versus gefitinib plus chemotherapy for non-small-cell lung cancer with mutated EGFR. J Clin Oncol. 2022;40(31):3587–3592. doi:10.1200/JCO.21.02911
  • André F, Arnedos M, Baras AS; AACR Project GENIE Consortium. AACR Project GENIE: powering Precision Medicine through an International Consortium. Cancer Discov. 2017;7(8):818–831. doi:10.1158/2159-8290.CD-17-0151
  • Berger AH, Brooks AN, Wu X, et al. High-throughput phenotyping of lung cancer somatic mutations. Cancer Cell. 2016;30(2):214–228. doi:10.1016/j.ccell.2016.06.022
  • Ikeuchi H, Hirose T, Ikegami M, et al. Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model. Oncogene. 2022;41(17):2470–2479. doi:10.1038/s41388-022-02263-4
  • Luo J, Makhnin A, Tobi Y, et al. Erlotinib and trametinib in patients with EGFR-mutant lung adenocarcinoma and acquired resistance to a prior tyrosine kinase inhibitor. JCO Precis Oncol. 2021;5:55–64.
  • Eberlein CA, Stetson D, Markovets AA, et al. Acquired resistance to the mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models. Cancer Res. 2015;75(12):2489–2500. doi:10.1158/0008-5472.CAN-14-3167