Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives

References

• Cook WL, Tomlinson G, Donaldson M, et al. Falls and fall-related injuries in older dialysis patients. Clin J Am Soc Nephrol. 2006;1(6):1197–1204. doi:10.2215/cjn.01650506
   PubMed Web of Science ®Google Scholar
• Kutner NG, Zhang R, Huang Y, Wasse H. Falls among hemodialysis patients: potential opportunities for prevention? Clin Kidney J. 2014;7(3):257–263. doi:10.1093/ckj/sfu034
   PubMedGoogle Scholar
• Ren J, Zhang X, Lin H, Zeng JH. Influencing factors of fear of falling among glaucoma patients in west China: a cross-sectional study. Int J Ophthalmol. 2023;16(4):563–570. doi:10.18240/ijo.2023.04.10
   PubMed Web of Science ®Google Scholar
• Sakthivadivel V, Geetha J, Gaur A, Kaliappan A. Performance-Oriented mobility assessment test and timed up and go test as predictors of falls in the elderly - A cross-sectional study. J Family Med Prim Care. 2022;11(11):7294–7298. doi:10.4103/jfmpc.jfmpc_1294_22
   PubMedGoogle Scholar
• O’Loughlin JL, Robitaille Y, Boivin JF, Suissa S. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol. 1993;137(3):342–354. doi:10.1093/oxfordjournals.aje.a116681
   PubMed Web of Science ®Google Scholar
• Kistler BM, Khubchandani J, Jakubowicz G, Wilund K, Sosnoff J. Falls and fall-related injuries among US adults aged 65 or older with chronic kidney disease. Prev Chronic Dis. 2018;15:E82. doi:10.5888/pcd15.170518
   PubMedGoogle Scholar
• Kistler BM, Khubchandani J, Wiblishauser M, Wilund KR, Sosnoff JJ. Epidemiology of falls and fall-related injuries among middle-aged adults with kidney disease. Int Urol Nephrol. 2019;51(9):1613–1621. doi:10.1007/s11255-019-02148-8
   PubMed Web of Science ®Google Scholar
• Bortolussi-Courval É, Podymow T, Trinh E, et al. Electronic decision support for deprescribing in patients on hemodialysis: clinical research protocol for a prospective, controlled, quality improvement study. Can J Kidney Health Dis. 2023;10:20543581231165712. doi:10.1177/20543581231165712
   Google Scholar
• Aguilar A, Gifre L, Ureña-Torres P, et al. Pathophysiology of bone disease in chronic kidney disease: from basics to renal osteodystrophy and osteoporosis. Front Physiol. 2023;14:1177829. doi:10.3389/fphys.2023.1177829
   PubMed Web of Science ®Google Scholar
• Hall RK, Landerman LR, O’Hare AM, Anderson RA, Colón-Emeric CS. Chronic kidney disease and recurrent falls in nursing home residents: a retrospective cohort study. Geriatr Nurs. 2015;36(2):136–141. doi:10.1016/j.gerinurse.2014.12.012
   PubMed Web of Science ®Google Scholar
• Falcão L, Raimundo M, Fernandes S, et al. At least one hyperkalemia episode is associated with mortality and disease progression in stage 3 CKD patients. J Nephrol. 2023;36(9):2655–2656. doi:10.1007/s40620-023-01647-3
   PubMed Web of Science ®Google Scholar
• Gungor O, Ulu S, Hasbal NB, Anker SD, Kalantar‐Zadeh K. Effects of hormonal changes on sarcopenia in chronic kidney disease: where are we now and what can we do? J Cachexia Sarcopenia Muscle. 2021;12(6):1380–1392. doi:10.1002/jcsm.12839
   PubMed Web of Science ®Google Scholar
• Shen Y. Role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder: a narrative review. Medicine. 2023;102(14):e33477. doi:10.1097/md.0000000000033477
   PubMed Web of Science ®Google Scholar
• Liao Y, Zhang L, Peng Y, et al. Characteristics of accidental falls in the patients with chronic kidney diseases: a 14-year retrospective study and review. medRxiv. 2023;3:1.
   Google Scholar
• van der Velde N, Seppala LJ, Hartikainen S, et al. European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the world guidelines for falls prevention and management: implications and implementation. Eur Geriatr Med. 2023. doi:10.1007/s41999-023-00824-8
   Web of Science ®Google Scholar
• Novotna K, Zeiselova J, Stanickova B, Kovari M, Uher T, Janatova M. Interest in telerehabilitation among patients with mild to severe multiple sclerosis: results of the Czech Republic. Telemed J E Health. 2023. doi:10.1089/tmj.2023.0065
   PubMed Web of Science ®Google Scholar
• Bowling CB, Hall RK, Khakharia A, Franch HA, Plantinga LC. Serious fall injury history and adverse health outcomes after initiating hemodialysis among older U.S. ADULTS. J Gerontol a Biol Sci Med Sci. 2018;73(9):1216–1221. doi:10.1093/gerona/glx260
   PubMed Web of Science ®Google Scholar
• Kear T, Ulrich B. Patient Safety and patient safety culture in nephrology nurse practice settings: issues, solutions, and best practices. Nephrol Nurs J. 2015;42(2):113–22; quiz 123.
   PubMed Web of Science ®Google Scholar
• Shiomi K, Saito C, Nagai K, et al. Ratio of serum creatinine to cystatin C is related to leg strength in predialysis CKD patients. Clin Exp Nephrol. 2021;25(10):1079–1086. doi:10.1007/s10157-021-02050-7
   PubMed Web of Science ®Google Scholar
• Rampersad C, Brar R, Connelly K, et al. Association of physical activity and poor health outcomes in patients with advanced CKD. Am J Kidney Dis. 2021;78(3):391–398. doi:10.1053/j.ajkd.2020.12.018
   PubMed Web of Science ®Google Scholar
• Assimon MM, Flythe JE. Zolpidem versus trazodone initiation and the risk of fall-related fractures among individuals receiving maintenance hemodialysis. Clin J Am Soc Nephrol. 2020;16(1):88–97. doi:10.2215/cjn.10070620
   PubMed Web of Science ®Google Scholar
• Chao YT, Kuo FH, Lee YS, et al. Characteristics and outcome determinants of hospitalized older patients with cognitive dysfunction. Int J Environ Res Public Health. 2022;19:1.
   Web of Science ®Google Scholar
• Takase R, Nakata T, Aoki K, et al. The relationship between edema and body functions in patients with chronic kidney disease: a preliminary study. Cureus. 2022;14(7):e27118. doi:10.7759/cureus.27118
   PubMed Web of Science ®Google Scholar
• Dávalos-Yerovi V, Pérez-Sáez MJ, Faura-Vendrell A, et al. Association between GLIM-defined malnutrition and hospitalizations in kidney transplant candidates: a post hoc analysis of a cohort study. JPEN J Parenter Enteral Nutr. 2023;14. doi:10.1002/jpen.2532
   Google Scholar
• Cogley C, Carswell C, Bramham J, et al. Improving kidney care for people with severe mental health difficulties: a thematic analysis of twenty-two healthcare providers’ perspectives. Front Public Health. 2023;11:1225102. doi:10.3389/fpubh.2023.1225102
   PubMed Web of Science ®Google Scholar
• Krauss MJ, Nguyen SL, Dunagan WC, et al. Circumstances of patient falls and injuries in 9 hospitals in a Midwestern healthcare system. Infect Control Hosp Epidemiol. 2007;28(5):544–550. doi:10.1086/513725
   PubMed Web of Science ®Google Scholar
• Roberts RG, Kenny RA, Brierley EJ. Are elderly haemodialysis patients at risk of falls and postural hypotension? Int Urol Nephrol. 2003;35(3):415–421. doi:10.1023/b:urol.0000022866.07751.4a
   PubMedGoogle Scholar
• Gamboa JL, Roshanravan B, Towse T, et al. Skeletal muscle mitochondrial dysfunction is present in patients with CKD before initiation of maintenance hemodialysis. Clin J Am Soc Nephrol. 2020;15(7):926–936. doi:10.2215/cjn.10320819
   PubMed Web of Science ®Google Scholar
• Thome T, Kumar RA, Burke SK, et al. Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight. 2020;6:1.
   Web of Science ®Google Scholar
• Wang XH, Mitch WE, Price SR. Pathophysiological mechanisms leading to muscle loss in chronic kidney disease. Nat Rev Nephrol. 2022;18(3):138–152. doi:10.1038/s41581-021-00498-0
   PubMed Web of Science ®Google Scholar
• Karava V, Dotis J, Kondou A, Printza N. Malnutrition patterns in children with chronic kidney disease. Life. 2023;13:3.
   Google Scholar
• Zhao Y, Yi Y, Gu B, Wang H, Ma J, Guo Z. Echinacoside protects adenine-induced uremic rats from sciatic nerve damage by up-regulating α-Klotho. J Musculoskelet Neuronal Interact. 2021;21(3):413–421.
   PubMed Web of Science ®Google Scholar
• Tan RZ, Li JC, Zhu BW, et al. Neuropeptide Y protects kidney from acute kidney injury by inactivating M1 macrophages via the Y1R-NF-κB-Mincle-dependent mechanism. Int J Biol Sci. 2023;19(2):521–536. doi:10.7150/ijbs.80200
   PubMed Web of Science ®Google Scholar
• Korucu B, Erten YT, Yeter HH, et al. Hypothalamic energy regulatory peptides in chronic kidney disease. Ther Apher Dial. 2019;23(5):437–443. doi:10.1111/1744-9987.12798
   PubMed Web of Science ®Google Scholar
• Del Colle S, Morello F, Rabbia F, et al. Antihypertensive drugs and the sympathetic nervous system. J Cardiovasc Pharmacol. 2007;50(5):487–496. doi:10.1097/FJC.0b013e318135446c
   PubMed Web of Science ®Google Scholar
• Yildiz S, Heybeli C, Smith L, Soysal P, Kazancioglu R. The prevalence and clinical significance of loss of appetite in older patients with chronic kidney disease. Int Urol Nephrol. 2023;3. doi:10.1007/s11255-023-03540-1
   Google Scholar
• Ofori EK, Adekena CN, Boima V, et al. Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: an observational cross-sectional study. Health Sci Rep. 2023;6(1):e1053. doi:10.1002/hsr2.1053
   PubMedGoogle Scholar
• Collister D, Herrington G, Delgado L, et al. Patient views regarding cannabis use in chronic kidney disease and kidney failure: a survey study. Nephrol Dial Transplant. 2023;38(4):922–931. doi:10.1093/ndt/gfac226
   PubMed Web of Science ®Google Scholar
• Moussa O, Feng C, Wang JX, Li XS, Zhang FX, Tang XH. Safety and effectiveness of roxadustat in dialysis-dependent patients with renal anemia: a hospital-based cohort study. Cureus. 2022;14(4):e24427. doi:10.7759/cureus.24427
   PubMed Web of Science ®Google Scholar
• Silva MZC, Cederholm T, Gonzalez MC, Lindholm B, Avesani CM. GLIM in chronic kidney disease: what do we need to know? Clin Nutr. 2023;42(6):937–943. doi:10.1016/j.clnu.2023.04.019
   PubMed Web of Science ®Google Scholar
• Mirmohammadali SN, Gallant KMH, Biruete A. Oh, My Gut! New insights on the role of the gastrointestinal tract and the gut microbiome in chronic kidney disease-mineral and bone disorder. Curr Opin Nephrol Hypertens. 2024;33(2):226–230. doi:10.1097/mnh.0000000000000961
   PubMed Web of Science ®Google Scholar
• Jiang S, Fang J, Li W. Protein restriction for diabetic kidney disease. Cochrane Database Syst Rev. 2023;1(1):Cd014906. doi:10.1002/14651858.CD014906.pub2
   PubMedGoogle Scholar
• Spahia N, Rroji M, Barbullushi M, Spasovski G. The role of protein restriction in the progression of chronic kidney disease. Pril. 2023;44(2):53–63. doi:10.2478/prilozi-2023-0025
   PubMedGoogle Scholar
• Olivari V, Di Modica SM, Lidonnici MR, et al. A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease. Kidney Int. 2023;104(1):61–73. doi:10.1016/j.kint.2023.03.012
   PubMed Web of Science ®Google Scholar
• Hain D, Bednarski D, Cahill M, et al. Iron-deficiency anemia in CKD: a narrative review for the kidney care team. Kidney Med. 2023;5(8):100677. doi:10.1016/j.xkme.2023.100677
   PubMedGoogle Scholar
• Alvarenga L, Saldanha JF, Stockler-Pinto MB, Fouque D, Soulage CO, Mafra D. Effects of resveratrol on inflammation and oxidative stress induced by the uremic toxin indoxyl sulfate in Murine macrophage-like RAW 264.7. Biochimie. 2023;213:22–29. doi:10.1016/j.biochi.2023.05.001
   PubMed Web of Science ®Google Scholar
• Yang G, Tan L, Yao H, Xiong Z, Wu J, Huang X. Long-term effects of severe burns on the kidneys: research advances and potential therapeutic approaches. J Inflamm Res. 2023;16:1905–1921. doi:10.2147/JIR.S404983
   PubMed Web of Science ®Google Scholar
• Yang G, Waheed S, Wang C, Shekh M, Li Z, Wu J. Exosomes and Their bioengineering strategies in the cutaneous wound healing and related complications: current knowledge and future perspectives. review. Int J Bio Sci. 2023;19(5):1430–1454. doi:10.7150/ijbs.80430
   Google Scholar
• Zoccali C, Mallamaci F. Innate Immunity system in patients with cardiovascular and kidney disease. Circ Res. 2023;132(8):915–932. doi:10.1161/circresaha.122.321749
   PubMed Web of Science ®Google Scholar
• Bowling CB, Bromfield SG, Colantonio LD, et al. Association of reduced eGFR and albuminuria with serious fall injuries among older adults. Clin J Am Soc Nephrol. 2016;11(7):1236–1243. doi:10.2215/cjn.11111015
   PubMed Web of Science ®Google Scholar
• Koury MJ, Haase VH. Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD. Kidney Int. 2023;104(1):25–28. doi:10.1016/j.kint.2023.04.017
   PubMed Web of Science ®Google Scholar
• Mishina S, Waratani M, Onozawa S, Okumura H, Ito Y, Yasuda Y. A retrospective database analysis of erythropoiesis-stimulating agent treatment patterns and associated healthcare resource use in patients with non-dialysis-dependent chronic kidney disease-related anaemia in Japan. Nephrology. 2023;28(8):446–455. doi:10.1111/nep.14168
   PubMedGoogle Scholar
• Hassanein M, Arrigain S, Schold JD, et al. Dysnatremias, mortality, and kidney failure in CKD: findings From the Chronic Renal Insufficiency Cohort (CRIC) study. Kidney Med. 2022;4(12):100554. doi:10.1016/j.xkme.2022.100554
   PubMedGoogle Scholar
• Shin J, Lee CH. The roles of sodium and volume overload on hypertension in chronic kidney disease. Kidney Res Clin Pract. 2021;40(4):542–554. doi:10.23876/j.krcp.21.800
   PubMed Web of Science ®Google Scholar
• Jo SM. Understanding and treatment strategies of hypertension and hyperkalemia in chronic kidney disease. Electrolyte Blood Press. 2023;21(1):24–33. doi:10.5049/ebp.2023.21.1.24
   PubMedGoogle Scholar
• Chang HH, Chiang JH, Tsai CC, Chiu PF. Predicting hyperkalemia in patients with advanced chronic kidney disease using the XGBoost model. BMC Nephrol. 2023;24(1):169. doi:10.1186/s12882-023-03227-w
   PubMed Web of Science ®Google Scholar
• Pietribiasi M, Waniewski J, Leypoldt JK. Mathematical modelling of bicarbonate supplementation and acid-base chemistry in kidney failure patients on hemodialysis. PLoS One. 2023;18(2):e0282104. doi:10.1371/journal.pone.0282104
   PubMed Web of Science ®Google Scholar
• Tartaglione L, Rotondi S, Aucella F, et al. Parathyroidectomy and survival in a cohort of Italian dialysis patients: results of a multicenter, observational, prospective study. J Nephrol. 2023;23. doi:10.1007/s40620-023-01658-0
   Google Scholar
• Ionova TI, Buzanakov DM, Chernikov RA, et al. Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience. BMC Endocr Disord. 2023;23(1):87. doi:10.1186/s12902-023-01344-z
   PubMed Web of Science ®Google Scholar
• Carsote M, Nistor C. Forestalling hungry bone syndrome after parathyroidectomy in patients with primary and renal hyperparathyroidism. Diagnostics. 2023;13:11.
   Web of Science ®Google Scholar
• Echterdiek F, Ranke MB, Schwenger V, Heemann U, Latus J. Kidney disease and thyroid dysfunction: the chicken or egg problem. Pediatr Nephrol. 2022;37(12):3031–3042. doi:10.1007/s00467-022-05640-z
   PubMed Web of Science ®Google Scholar
• Rhee CM. Thyroid disease in end-stage renal disease. Curr Opin Nephrol Hypertens. 2019;28(6):621–630. doi:10.1097/mnh.0000000000000542
   PubMed Web of Science ®Google Scholar
• Drube J, Wan M, Bonthuis M, et al. Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease. Nat Rev Nephrol. 2019;15(9):577–589. doi:10.1038/s41581-019-0161-4
   PubMed Web of Science ®Google Scholar
• Wang Y, Ma W, Pu J, Chen F. Interrelationships between sarcopenia, bone turnover markers and low bone mineral density in patients on hemodialysis. Ren Fail. 2023;45(1):2200846. doi:10.1080/0886022x.2023.2200846
   PubMed Web of Science ®Google Scholar
• Ling J, Ng JKC, Chan JCN, Chow E. Use of continuous glucose monitoring in the assessment and management of patients with diabetes and chronic kidney disease. Front Endocrinol. 2022;13:869899. doi:10.3389/fendo.2022.869899
   PubMed Web of Science ®Google Scholar
• Long S, Hu L, Luo Y, Li Y, Ding F. Incidence and risk factors of falls in older adults after discharge: a prospective study. Int J Nurs Sci. 2023;10(1):23–29. doi:10.1016/j.ijnss.2022.12.010
   PubMed Web of Science ®Google Scholar
• Tanaka Y. Rheumatoid arthritis. Inflamm Regener. 2020;40(1):20. doi:10.1186/s41232-020-00133-8
   PubMed Web of Science ®Google Scholar
• Sullivan R, Hemsley B, Skinner I, Harding K. Hospital policies on falls in relation to patients with communication disability: a scoping review and content analysis. Aust Health Rev. 2023. doi:10.1071/ah22289
   Web of Science ®Google Scholar
• Bae S, Lee S, Park H, et al. Position statement: exercise guidelines for osteoporosis management and fall prevention in osteoporosis patients. J Bone Metab. 2023;30(2):149–165. doi:10.11005/jbm.2023.30.2.149
   PubMedGoogle Scholar
• Bennett PN, Bohm C, Yee-Moon Wang A, et al. An International survey of peritoneal dialysis exercise practices and perceptions. Kidney Int Rep. 2023;8(7):1389–1398. doi:10.1016/j.ekir.2023.04.024
   PubMed Web of Science ®Google Scholar
• Sharma B, Yadav DK. L-Carnitine and Chronic kidney disease: a comprehensive review on nutrition and health perspectives. J Pers Med. 2023;13(2).
   Web of Science ®Google Scholar
• Chang L, Tian R, Guo Z, et al. La dieta baja en proteínas suplementada con inulina reduce los niveles de toxinas unidas a proteínas en pacientes con enfermedad renal crónica en estadio 3b-5: un estudio controlado aleatorio [Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study]. Nutr Hosp. 2023. doi:10.20960/nh.04643
   PubMedGoogle Scholar
• Rhee CM, Wang AY, Biruete A, et al. Nutritional and dietary management of chronic kidney disease under conservative and preservative kidney care without dialysis. J Ren Nutr. 2023. doi:10.1053/j.jrn.2023.06.010
   Web of Science ®Google Scholar
• Torregrosa JV, Bover J, Rodríguez Portillo M, et al. Recommendations of the Spanish Society of Nephrology for the management of mineral and bone metabolism disorders in patients with chronic kidney disease: 2021 (SEN-MM). Nefrologia. 2023;43(Suppl 1):1–36. doi:10.1016/j.nefroe.2023.03.003
   PubMedGoogle Scholar
• Hao G, Lu W, Huang J, et al. Predialysis fluid overload linked with quality of sleep in patients undergoing hemodialysis. Sleep Med. 2018;51:140–147. doi:10.1016/j.sleep.2018.07.011
   PubMed Web of Science ®Google Scholar
• Lin HC, Chen MJ, Lee CH, Kung LC, Huang JT. Fall recognition based on an imu wearable device and fall verification through a smart speaker and the IoT. Sensors. 2023;23:12.
   Web of Science ®Google Scholar
• Fukaya K, Uchida M. Protection against impact with the ground using wearable airbags. Ind Health. 2008;46(1):59–65. doi:10.2486/indhealth.46.59
   PubMed Web of Science ®Google Scholar
• Tarbert RJ, Singhatat W. Real world evidence of wearable smartbelt for mitigation of fall impact in older adult care. IEEE J Transl Eng Health Med. 2023;11:247–251. doi:10.1109/jtehm.2023.3256893
   PubMedGoogle Scholar
• Botonis OK, Harari Y, Embry KR, et al. Wearable airbag technology and machine learned models to mitigate falls after stroke. J Neuroeng Rehabil. 2022;19(1):60. doi:10.1186/s12984-022-01040-4
   PubMed Web of Science ®Google Scholar
• Percy D, Phillips T, Torres F, Chaleunphonh M, Sung P. Effectiveness of virtual reality-based balance and gait in older adults with fear of movement: a systematic review and meta-analysis. Physiother Res Int. 2023;e2037. doi:10.1002/pri.2037
   PubMed Web of Science ®Google Scholar
• Martínez Montilla LA, López Cruces K, Calderón Erazo HS, et al. Effectiveness of virtual reality in balance training for fall prevention in older adults: systematic review. Sports Med Arthrosc Rev. 2023;31(2):41–48. doi:10.1097/jsa.0000000000000367
   PubMed Web of Science ®Google Scholar
• Zhao R, Zhao X, Guan J, Zhang C, Zhu K. The effect of virtual reality technology on anti-fall ability and bone mineral density of the elderly with osteoporosis in an elderly care institution. Eur J Med Res. 2023;28(1):204. doi:10.1186/s40001-023-01165-9
   PubMed Web of Science ®Google Scholar
• Bally ELS, Ye L, van Grieken A, et al. Factors associated with falls among hospitalized and community-dwelling older adults: the APPCARE study. Front Public Health. 2023;11:1180914. doi:10.3389/fpubh.2023.1180914
   PubMedGoogle Scholar
• Leal JC, Belo VS, Santos IM, Ferreira RV, de Melo SN, da Silva ES. Exergames in older adult community centers and nursing homes to improve balance and minimize the risk of falls in older adults: a systematic review and meta-analysis. Healthcare. 2023;11:13.
   Web of Science ®Google Scholar