Investigating the Role of BDNF in Insomnia: Current Insights

References

• Ananthakrishnan AN, Long MD, Martin CF, Sandler RS, Kappelman MD. Sleep disturbance and risk of active disease in patients with Crohn’s disease and ulcerative colitis. Clin Gastroenterol Hepatol. 2013;11(8):965–971. doi:10.1016/j.cgh.2013.01.021
   PubMed Web of Science ®Google Scholar
• Seo HM, Kim TL, Kim JS. The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study. Sleep. 2018;41(9). doi:10.1093/sleep/zsy111
   Web of Science ®Google Scholar
• Young KA, Munroe ME, Harley JB, et al. Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. Lupus. 2018;27(9):1524–1531. doi:10.1177/0961203318778368
   PubMed Web of Science ®Google Scholar
• Sang N, Gao RC, Zhang MY, Wu ZZ, Wu ZG, Wu GC. Causal relationship between sleep traits and risk of systemic lupus erythematosus: a two-sample Mendelian randomization study. Front Immunol. 2022;13:918749. doi:10.3389/fimmu.2022.918749
   PubMed Web of Science ®Google Scholar
• Serchov T, Clement HW, Schwarz MK, et al. Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a. Neuron. 2015;87(3):549–562. doi:10.1016/j.neuron.2015.07.010
   PubMed Web of Science ®Google Scholar
• Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487–504. doi:10.5664/jcsm.27286
   PubMed Web of Science ®Google Scholar
• Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016;5(4):780–784. doi:10.4103/2249-4863.201153
   PubMedGoogle Scholar
• Ditmer M, Gabryelska A, Turkiewicz S, Bialasiewicz P, Malecka-Wojciesko E, Sochal M. Sleep problems in chronic inflammatory diseases: prevalence, treatment, and new perspectives: a narrative review. J Clin Med. 2021;11(1):67. doi:10.3390/jcm11010067
   PubMed Web of Science ®Google Scholar
• Sochal M, Binienda A, Ditmer M, et al. Relation between symptoms of insomnia, depression, sleep quality, anti-tumor necrosis factor therapy and disrupted circadian clock genes’ expression in inflammatory bowel disease. Pol Arch Intern Med. 2023. doi:10.20452/pamw.16487
   Google Scholar
• Sochal M, Ditmer M, Binienda A, et al. Relation between selected sleep parameters, depression, anti-tumor necrosis factor therapy, and the brain-derived neurotrophic factor pathway in inflammatory bowel disease. Metabolites. 2023;13(3):450. doi:10.3390/metabo13030450
   PubMed Web of Science ®Google Scholar
• Harvey C-J, Gehrman P, Espie CA. Who is predisposed to insomnia: a review of familial aggregation, stress-reactivity, personality and coping style. Sleep Med Rev. 2014;18(3):237–247. doi:10.1016/j.smrv.2013.11.004
   PubMed Web of Science ®Google Scholar
• Kalmbach DA, Cuamatzi-Castelan AS, Tonnu CV, et al. Hyperarousal and sleep reactivity in insomnia: current insights. Nat Sci Sleep. 2018;10:193–201. doi:10.2147/nss.S138823
   PubMed Web of Science ®Google Scholar
• Spielman AJ, Caruso LS, Glovinsky PB. A behavioral perspective on insomnia treatment. Psychiatr Clin North Am. 1987;10(4):541–553. doi:10.1016/S0193-953X(18)30532-X
   PubMed Web of Science ®Google Scholar
• Haynes J, Talbert M, Fox S, Close E. Cognitive behavioral therapy in the treatment of insomnia. South Med J. 2018;111(2):75–80. doi:10.14423/smj.0000000000000769
   PubMed Web of Science ®Google Scholar
• Riemann D, Baglioni C, Bassetti C, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675–700. doi:10.1111/jsr.12594
   PubMed Web of Science ®Google Scholar
• Ballesio A, Zagaria A, Curti DG, et al. Peripheral brain-derived neurotrophic factor (BDNF) in insomnia: a systematic review and meta-analysis. Sleep Med Rev. 2023;67:101738. doi:10.1016/j.smrv.2022.101738
   PubMed Web of Science ®Google Scholar
• Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Review. Front Cell Neurosci. 2019;13. doi:10.3389/fncel.2019.00363
   PubMed Web of Science ®Google Scholar
• Sochal M, Ditmer M, Gabryelska A, Białasiewicz P. The role of brain-derived neurotrophic factor in immune-related diseases: a narrative review. J Clin Med. 2022;11(20):6023. doi:10.3390/jcm11206023
   PubMed Web of Science ®Google Scholar
• Chen SD, Wu CL, Hwang WC, Yang DI. More insight into BDNF against neurodegeneration: anti-apoptosis, anti-oxidation, and suppression of autophagy. Int J Mol Sci. 2017;18(3). doi:10.3390/ijms18030545
   Web of Science ®Google Scholar
• Rahmani M, Rahmani F, Rezaei N. The brain-derived neurotrophic factor: missing link between sleep deprivation, insomnia, and depression. Neurochem Res. 2020;45(2):221–231. doi:10.1007/s11064-019-02914-1
   PubMed Web of Science ®Google Scholar
• Molano J, Vaughn BV. Approach to insomnia in patients with dementia. Neurol Clin Pract. 2014;4(1):7–15. doi:10.1212/CPJ.0b013e3182a78edf
   PubMedGoogle Scholar
• Nutt D, Wilson S, Paterson L. Sleep disorders as core symptoms of depression. Dialogues Clin Neurosci. 2008;10(3):329–336. doi:10.31887/DCNS.2008.10.3/dnutt
   PubMedGoogle Scholar
• Gao L, Zhang Y, Sterling K, Song W. Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential. Transl Neurodegener. 2022;11(1):4. doi:10.1186/s40035-022-00279-0
   PubMed Web of Science ®Google Scholar
• Nazareth AM. BDNF, A focus to major depression. Open J Psychol. 2021;1(1):10–21.
   Google Scholar
• Rosenfeld RD, Zeni L, Haniu N, et al. Purification and identification of brain-derived neurotrophic factor from human serum. Protein Expr Purif. 1995;6(4):465–471. doi:10.1006/prep.1995.1062
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Turkiewicz S, Ditmer M, et al. BDNF and proBDNF serum protein levels in obstructive sleep apnea patients and their involvement in insomnia and depression symptoms. J Clin Med. 2022;11(23):7135. doi:10.3390/jcm11237135
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Sochal M. Evaluation of HIF-1 involvement in the BDNF and ProBDNF signaling pathways among obstructive sleep apnea patients. Int J Mol Sci. 2022;23(23):14876. doi:10.3390/ijms232314876
   PubMed Web of Science ®Google Scholar
• S-Y W, Pan B-S, Tsai S-F, et al. BDNF reverses aging-related microglial activation. J Neuroinflam. 2020;17(1):210. doi:10.1186/s12974-020-01887-1
   PubMed Web of Science ®Google Scholar
• Walsh EI, Smith L, Northey J, Rattray B, Cherbuin N. Towards an understanding of the physical activity-BDNF-cognition triumvirate: a review of associations and dosage. Ageing Res Rev. 2020;60:101044. doi:10.1016/j.arr.2020.101044
   PubMed Web of Science ®Google Scholar
• Causing CG, Gloster A, Aloyz R, et al. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron. 1997;18(2):257–267. doi:10.1016/S0896-6273(00)80266-4
   PubMed Web of Science ®Google Scholar
• Alonso M, Medina JH, Pozzo-Miller L. ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons. Learn Mem. 2004;11(2):172–178. doi:10.1101/lm.67804
   PubMed Web of Science ®Google Scholar
• Horch HW, Krüttgen A, Portbury SD, Katz LC. Destabilization of cortical dendrites and spines by BDNF. Neuron. 1999;23(2):353–364. doi:10.1016/s0896-6273(00)80785-0
   PubMed Web of Science ®Google Scholar
• Lom B, Cohen-Cory S. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J Neurosci. 1999;19(22):9928–9938. doi:10.1523/jneurosci.19-22-09928.1999
   PubMed Web of Science ®Google Scholar
• Niblock MM, Brunso-Bechtold JK, Riddle DR. Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex. J Neurosci. 2000;20(11):4165. doi:10.1523/JNEUROSCI.20-11-04165.2000
   PubMed Web of Science ®Google Scholar
• Kwon M, Fernández JR, Zegarek GF, Lo SB, Firestein BL. BDNF-promoted increases in proximal dendrites occur via CREB-dependent transcriptional regulation of cypin. J Neurosci. 2011;31(26):9735–9745. doi:10.1523/jneurosci.6785-10.2011
   PubMed Web of Science ®Google Scholar
• Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra TS. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci. 2000;3(4):323–329. doi:10.1038/73888
   PubMed Web of Science ®Google Scholar
• Pascual M, Climent E, Guerri C. BDNF induces glutamate release in cerebrocortical nerve terminals and in cortical astrocytes. NeuroReport. 2001;12(12):2673–2677. doi:10.1097/00001756-200108280-00017
   PubMed Web of Science ®Google Scholar
• Chen A, Xiong LJ, Tong Y, Mao M. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep. 2013;8(4):1011–1016. doi:10.3892/mmr.2013.1628
   PubMed Web of Science ®Google Scholar
• Caldeira MV, Melo CV, Pereira DB, et al. Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons. J Biol Chem. 2007;282(17):12619–12628. doi:10.1074/jbc.M700607200
   PubMed Web of Science ®Google Scholar
• Lin SY, Wu K, Levine ES, Mount HT, Suen PC, Black IB. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res Mol Brain Res. 1998;55(1):20–27. doi:10.1016/s0169-328x(97)00349-5
   PubMedGoogle Scholar
• Suen P-C, Wu K, Levine ES, et al. Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-d-aspartate receptor subunit 1. Proc Natl Acad Sci. 1997;94(15):8191–8195. doi:10.1073/pnas.94.15.8191
   PubMed Web of Science ®Google Scholar
• Almeida RD, Manadas BJ, Melo CV, et al. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ. 2005;12(10):1329–1343. doi:10.1038/sj.cdd.4401662
   PubMed Web of Science ®Google Scholar
• Porcher C, Medina I, Gaiarsa JL. Mechanism of BDNF modulation in GABAergic synaptic transmission in healthy and disease brains. Front Cell Neurosci. 2018;12:273. doi:10.3389/fncel.2018.00273
   PubMed Web of Science ®Google Scholar
• Song J, Kim E, Kim C-H, Song H-T, Lee JE. The role of orexin in post-stroke inflammation, cognitive decline, and depression. Molecular Brain. 2015;8(1):16. doi:10.1186/s13041-015-0106-1
   PubMedGoogle Scholar
• Guo Y, Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 2012;318(16):2004–2013. doi:10.1016/j.yexcr.2012.04.015
   PubMed Web of Science ®Google Scholar
• Erman MK. Sleep architecture and its relationship to insomnia. J Clin Psychiatry. 2001;62(Suppl 10):9–17.
   PubMedGoogle Scholar
• Yetton BD, McDevitt EA, Cellini N, Shelton C, Mednick SC. Quantifying sleep architecture dynamics and individual differences using big data and Bayesian networks. PLoS One. 2018;13(4):e0194604. doi:10.1371/journal.pone.0194604
   PubMed Web of Science ®Google Scholar
• Drake CL, Roehrs T, Roth T. Insomnia causes, consequences, and therapeutics: an overview. Depress Anxiety. 2003;18(4):163–176. doi:10.1002/da.10151
   PubMed Web of Science ®Google Scholar
• Moline M, Murphy P, Pinner K, et al. 0369 effect of lemborexant on sleep architecture in older adults with insomnia disorder. Sleep. 2019;42(Supplement_1):A150–A150. doi:10.1093/sleep/zsz067.368
   Google Scholar
• Watson AJ, Henson K, Dorsey SG, Frank MG. The truncated TrkB receptor influences mammalian sleep. Am J Physiol Regul Integr Comp Physiol. 2015;308(3):R199–R207. doi:10.1152/ajpregu.00422.2014
   PubMed Web of Science ®Google Scholar
• Garner JM, Chambers J, Barnes AK, Datta S. Changes in brain-derived neurotrophic factor expression influence sleep-wake activity and homeostatic regulation of rapid eye movement sleep. Sleep. 2018;41(2). doi:10.1093/sleep/zsx194
   PubMed Web of Science ®Google Scholar
• Henechowicz TL, Chen JL, Cohen LG, Thaut MH, Li Z. The prevalence of the Val66Met polymorphism in musicians: possible evidence for compensatory neuroplasticity from a pilot study. PLoS One. 2021;16(6):e0245107. doi:10.1371/journal.pone.0245107
   PubMed Web of Science ®Google Scholar
• Greene RW, Frank MG. Slow wave activity during sleep: functional and therapeutic implications. Neuroscientist. 2010;16(6):618–633. doi:10.1177/1073858410377064
   PubMed Web of Science ®Google Scholar
• Mongrain V, Warby SC. Determinants of cortical synchrony. Sleep. 2012;35(3):309–310. doi:10.5665/sleep.1680
   PubMed Web of Science ®Google Scholar
• Monteiro BC, Monteiro S, Candida M, et al. Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: a critical review. Clin Pract Epidemiol Ment Health. 2017;13(1):213–219. doi:10.2174/1745017901713010213
   PubMedGoogle Scholar
• Kushikata T, Kubota T, Fang J, Krueger JM. Neurotrophins 3 and 4 enhance non-rapid eye movement sleep in rabbits. Neurosci Lett. 2003;346(3):161–164. doi:10.1016/s0304-3940(03)00564-0
   PubMed Web of Science ®Google Scholar
• Faraguna U, Vyazovskiy VV, Nelson AB, Tononi G, Cirelli C. A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci. 2008;28(15):4088–4095. doi:10.1523/jneurosci.5510-07.2008
   PubMed Web of Science ®Google Scholar
• Muheim CM, Singletary KG, Frank MG. A chemical-genetic investigation of BDNF-NtrkB signaling in mammalian sleep. Sleep. 2022;45(2). doi:10.1093/sleep/zsab237
   PubMed Web of Science ®Google Scholar
• Kaczmarski P, Sochal M, Strzelecki D, Białasiewicz P, Gabryelska A. Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea. Review. Front Neurosci. 2023;17. doi:10.3389/fnins.2023.1213971
   PubMed Web of Science ®Google Scholar
• Reddy S, Reddy V, Sharma S. Physiology, circadian rhythm. In: StatPearls. StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.; 2023.
   Google Scholar
• Gabryelska A, Turkiewicz S, Karuga FF, Sochal M, Strzelecki D, Białasiewicz P. Disruption of circadian rhythm genes in obstructive sleep apnea patients—possible mechanisms involved and clinical implication. Int J Mol Sci. 2022;23(2):709. doi:10.3390/ijms23020709
   PubMed Web of Science ®Google Scholar
• Reid KJ, Zee PC. Chapter 41 - circadian disorders of the sleep–wake cycle. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 5th ed. W.B. Saunders; 2011:470–482.
   Google Scholar
• Sack RL, Auckley D, Auger RR, et al. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep. 2007;30(11):1460–1483. doi:10.1093/sleep/30.11.1460
   PubMed Web of Science ®Google Scholar
• Archer SN, Carpen JD, Gibson M, et al. Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder. Sleep. 2010;33(5):695–701. doi:10.1093/sleep/33.5.695
   PubMed Web of Science ®Google Scholar
• Semenova NV, Madaeva IM, Bairova TI, et al. 3111T/C clock gene polymorphism in women with insomnia. Bull Exp Biol Med. 2017;163(4):461–464. doi:10.1007/s10517-017-3828-5
   PubMed Web of Science ®Google Scholar
• Charrier A, Olliac B, Roubertoux P, Tordjman S. Clock genes and altered sleep-wake rhythms: their role in the development of psychiatric disorders. Int J Mol Sci. 2017;18(5):938. doi:10.3390/ijms18050938
   PubMed Web of Science ®Google Scholar
• Wickwire EM, Geiger-Brown J, Scharf SM, Drake CL. Shift work and shift work sleep disorder: clinical and organizational perspectives. Chest. 2017;151(5):1156–1172. doi:10.1016/j.chest.2016.12.007
   PubMed Web of Science ®Google Scholar
• Liang FQ, Sohrabji F, Miranda R, Earnest B, Earnest D. Expression of brain-derived neurotrophic factor and its cognate receptor, TrkB, in the rat suprachiasmatic nucleus. Exp Neurol. 1998;151(2):184–193. doi:10.1006/exnr.1998.6804
   PubMed Web of Science ®Google Scholar
• D’Agostino Y, Frigato E, Noviello TMR, et al. Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience. 2022;25(4):104054. doi:10.1016/j.isci.2022.104054
   PubMed Web of Science ®Google Scholar
• Cain SW, Chang AM, Vlasac I, et al. Circadian rhythms in plasma brain-derived neurotrophic factor differ in men and women. J Biol Rhythms. 2017;32(1):75–82. doi:10.1177/0748730417693124
   PubMed Web of Science ®Google Scholar
• Piccinni A, Marazziti D, Del Debbio A, et al. Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: an analysis of sex differences. Chronobiol Int. 2008;25(5):819–826. doi:10.1080/07420520802387773
   PubMed Web of Science ®Google Scholar
• Choi SW, Bhang S, Ahn JH. Diurnal variation and gender differences of plasma brain-derived neurotrophic factor in healthy human subjects. Psychiatry Res. 2011;186(2–3):427–430. doi:10.1016/j.psychres.2010.07.028
   PubMed Web of Science ®Google Scholar
• Begliuomini S, Lenzi E, Ninni F, et al. Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm. J Endocrinol. 2008;197(2):429–435. doi:10.1677/joe-07-0376
   PubMed Web of Science ®Google Scholar
• Miranda-Riestra A, Estrada-Reyes R, Torres-Sanchez ED, Carreño-García S, Ortiz GG, Benítez-King GM. A neurotrophic factor? Molecules. 2022;27(22):7742. doi:10.3390/molecules27227742
   PubMed Web of Science ®Google Scholar
• Shokri-Mashhadi N, Darand M, Rouhani MH, Yahay M, Feltham BA, Saraf-Bank S. Effects of melatonin supplementation on BDNF concentrations and depression: a systematic review and meta-analysis of randomized controlled trials. Behav Brain Res. 2023;436:114083. doi:10.1016/j.bbr.2022.114083
   PubMed Web of Science ®Google Scholar
• Otsuka Y, Itani O, Matsumoto Y, Kaneita Y. Associations between coping strategies and insomnia: a longitudinal study of Japanese workers. Sleep. 2022;45(2). doi:10.1093/sleep/zsab244
   PubMed Web of Science ®Google Scholar
• Kowalczuk K, Krajewska-Kułak E, Sobolewski M. Relationships between sleep problems and stress coping strategies adopted by nurses including socio-occupational factors. Front Psychiatry. 2021;12:660776. doi:10.3389/fpsyt.2021.660776
   PubMed Web of Science ®Google Scholar
• Serafin LI, Fukowska M, Zyskowska D, Olechowska J, Czarkowska-Pączek B. Impact of stress and coping strategies on insomnia among Polish novice nurses who are employed in their field while continuing their education: a cross-sectional study. BMJ Open. 2021;11(12):e049787. doi:10.1136/bmjopen-2021-049787
   PubMed Web of Science ®Google Scholar
• Soehner AM, Harvey AG. Prevalence and functional consequences of severe insomnia symptoms in mood and anxiety disorders: results from a nationally representative sample. Sleep. 2012;35(10):1367–1375. doi:10.5665/sleep.2116
   PubMed Web of Science ®Google Scholar
• Neckelmann D, Mykletun A, Dahl AA. Chronic insomnia as a risk factor for developing anxiety and depression. Sleep. 2007;30(7):873–880. doi:10.1093/sleep/30.7.873
   PubMed Web of Science ®Google Scholar
• Cano G, Mochizuki T, Saper CB. Neural circuitry of stress-induced insomnia in rats. J Neurosci. 2008;28(40):10167–10184. doi:10.1523/jneurosci.1809-08.2008
   PubMed Web of Science ®Google Scholar
• Dressle RJ, Riemann D. Hyperarousal in insomnia disorder: current evidence and potential mechanisms. J Sleep Res. 2023;e13928. doi:10.1111/jsr.13928
   PubMed Web of Science ®Google Scholar
• Riemann D, Spiegelhalder K, Feige B, et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev. 2010;14(1):19–31. doi:10.1016/j.smrv.2009.04.002
   PubMed Web of Science ®Google Scholar
• Sudheimer KD, O’Hara R, Spiegel D, et al. Cortisol, cytokines, and hippocampal volume interactions in the elderly. Original Research. Front Aging Neurosci. 2014;6. doi:10.3389/fnagi.2014.00153
   PubMed Web of Science ®Google Scholar
• Hall BS, Moda RN, Liston C. Glucocorticoid mechanisms of functional connectivity changes in stress-related neuropsychiatric disorders. Neurobiol Stress. 2015;1:174–183. doi:10.1016/j.ynstr.2014.10.008
   PubMedGoogle Scholar
• Jeanneteau F, Chao MV. Are BDNF and glucocorticoid activities calibrated? Neuroscience. 2013;239:173–195. doi:10.1016/j.neuroscience.2012.09.017
   PubMed Web of Science ®Google Scholar
• Dressle RJ, Feige B, Spiegelhalder K, et al. HPA axis activity in patients with chronic insomnia: a systematic review and meta-analysis of case–control studies. Sleep Med Rev. 2022;62:101588. doi:10.1016/j.smrv.2022.101588
   PubMed Web of Science ®Google Scholar
• Jeanneteau F, Borie A, Chao MV, Garabedian MJ. Bridging the gap between brain-derived neurotrophic factor and glucocorticoid effects on brain networks. Neuroendocrinology. 2019;109(3):277–284. doi:10.1159/000496392
   PubMed Web of Science ®Google Scholar
• Suri D, Vaidya VA. Glucocorticoid regulation of brain-derived neurotrophic factor: relevance to hippocampal structural and functional plasticity. Neuroscience. 2013;239:196–213. doi:10.1016/j.neuroscience.2012.08.065
   PubMed Web of Science ®Google Scholar
• Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuro Psychopharmacol Biol Psychiatry. 2012;39(1):112–119. doi:10.1016/j.pnpbp.2012.05.018
   PubMed Web of Science ®Google Scholar
• Naert G, Ixart G, Maurice T, Tapia-Arancibia L, Givalois L. Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol Cell Neurosci. 2011;46(1):55–66. doi:10.1016/j.mcn.2010.08.006
   PubMed Web of Science ®Google Scholar
• Ambrus L, Lindqvist D, Träskman-Bendz L, Å W. Hypothalamic–pituitary–adrenal axis hyperactivity is associated with decreased brain-derived neurotrophic factor in female suicide attempters. Nordic J Psychiatry. 2016;70(8):575–581. doi:10.1080/08039488.2016.1184310
   PubMed Web of Science ®Google Scholar
• Onen Sertoz O, Tolga Binbay I, Koylu E, Noyan A, Yildirim E, Elbi Mete H. The role of BDNF and HPA axis in the neurobiology of burnout syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1459–1465. doi:10.1016/j.pnpbp.2008.05.001
   PubMed Web of Science ®Google Scholar
• Suliman S, Hemmings S, Seedat S. Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Original Research. Front Integrat Neurosci. 2013;7. doi:10.3389/fnint.2013.00055
   PubMedGoogle Scholar
• Baik J-H. Stress and the dopaminergic reward system. Exp Mol Med. 2020;52(12):1879–1890. doi:10.1038/s12276-020-00532-4
   PubMed Web of Science ®Google Scholar
• Rosenblum M. Substance abuse and insomnia. Minn Med. 2017;100(3):38–39.
   PubMedGoogle Scholar
• Furihata R, Saitoh K, Otsuki R, et al. Association between reduced serum BDNF levels and insomnia with short sleep duration among female hospital nurses. Sleep Med. 2020;68:167–172. doi:10.1016/j.sleep.2019.12.011
   PubMed Web of Science ®Google Scholar
• Giese M, Unternährer E, Hüttig H, et al. BDNF: an indicator of insomnia? Mol Psychiatry. 2014;19(2):151–152. doi:10.1038/mp.2013.10
   PubMed Web of Science ®Google Scholar
• Gabryelska A, Turkiewicz S, Ditmer M, Sochal M. Neurotrophins in the neuropathophysiology, course, and complications of obstructive sleep apnea—a narrative review. Int J Mol Sci. 2023;24(3):1808. doi:10.3390/ijms24031808
   PubMed Web of Science ®Google Scholar
• Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol. 2008;11(8):1169–1180. doi:10.1017/S1461145708009309
   PubMed Web of Science ®Google Scholar
• Fan TT, Chen WH, Shi L, et al. Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role. Sleep. 2019;42(1). doi:10.1093/sleep/zsy192
   Web of Science ®Google Scholar
• Sanchez-Garcia S, Moreno-Tamayo K, Ramirez-Aldana R, et al. Insomnia impairs both the Pro-BDNF and the BDNF levels similarly to older adults with cognitive decline: an exploratory study. Int J Mol Sci. 2023;24(8):7387. doi:10.3390/ijms24087387
   PubMed Web of Science ®Google Scholar
• Satyanarayanan SK, Chien YC, Chang JP, et al. Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety. Brain Behav Immun. 2020;85:142–151. doi:10.1016/j.bbi.2019.03.003
   PubMed Web of Science ®Google Scholar
• Zhang P, Li YX, Zhang ZZ, et al. Astroglial mechanisms underlying chronic insomnia disorder: a clinical study. Nat Sci Sleep. 2020;12:693–704. doi:10.2147/nss.S263528
   PubMed Web of Science ®Google Scholar
• Mikoteit T, Brand S, Eckert A, Holsboer-Trachsler E, Beck J. Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity. J Psychiatr Res. 2019;110:103–109. doi:10.1016/j.jpsychires.2018.12.020
   PubMed Web of Science ®Google Scholar
• Deuschle M, Schredl M, Wisch C, et al. Serum brain-derived neurotrophic factor (BDNF) in sleep-disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities. J Sleep Res. 2018;27(1):73–77. doi:10.1111/jsr.12577
   PubMed Web of Science ®Google Scholar
• Schmitt K, Holsboer-Trachsler E, Eckert A. BDNF in sleep, insomnia, and sleep deprivation. Ann Med. 2016;48(1–2):42–51. doi:10.3109/07853890.2015.1131327
   PubMed Web of Science ®Google Scholar
• Xue J, Li H, Xu Z, et al. Paradoxical sleep deprivation aggravates and prolongs incision-induced pain hypersensitivity via BDNF signaling-mediated descending facilitation in rats. Neurochem Res. 2018;43(12):2353–2361. doi:10.1007/s11064-018-2660-2
   PubMed Web of Science ®Google Scholar
• Musazzi L, Treccani G, Popoli M. Functional and structural remodeling of glutamate synapses in prefrontal and frontal cortex induced by behavioral stress. Front Psychiatry. 2015;6:60. doi:10.3389/fpsyt.2015.00060
   PubMed Web of Science ®Google Scholar
• Cunha C, Brambilla R, Thomas KL. A simple role for BDNF in learning and memory? Front Mol Neurosci. 2010;3:1. doi:10.3389/neuro.02.001.2010
   PubMed Web of Science ®Google Scholar
• Frank L, Ventimiglia R, Anderson K, Lindsay RM, Rudge JS. BDN F down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. Eur J Neurosci. 1996;8(6):1220–1230. doi:10.1111/j.1460-9568.1996.tb01290.x
   PubMed Web of Science ®Google Scholar
• Bellesi M, de Vivo L, Chini M, Gilli F, Tononi G, Cirelli C. Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex. J Neurosci. 2017;37(21):5263–5273. doi:10.1523/jneurosci.3981-16.2017
   PubMed Web of Science ®Google Scholar
• Khalaji A, Behnoush AH, Shobeiri P, Saeedian B, Teixeira AL, Rezaei N. Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath. 2023;27(3):829–841. doi:10.1007/s11325-022-02707-x
   PubMed Web of Science ®Google Scholar
• Nordahl H, Havnen A, Hansen B, Ost LG, Kvale G. Sleep disturbances in treatment-seeking OCD-patients: changes after concentrated exposure treatment. Scand J Psychol. 2018;59(2):186–191. doi:10.1111/sjop.12417
   PubMed Web of Science ®Google Scholar
• Plante DT, Jensen JE, Winkelman JW. The role of GABA in primary insomnia. Sleep. 2012;35(6):741–742. doi:10.5665/sleep.1854
   PubMed Web of Science ®Google Scholar
• Morgan PT, Pace-Schott EF, Mason GF, et al. Cortical GABA levels in primary insomnia. Sleep. 2012;35(6):807–814. doi:10.5665/sleep.1880
   PubMed Web of Science ®Google Scholar
• Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) administration on stress and sleep in humans: a systematic review. Front Neurosci. 2020;14:923. doi:10.3389/fnins.2020.00923
   PubMed Web of Science ®Google Scholar
• Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y. Histamine: neural circuits and new medications. Sleep. 2019;42(1):zsy183. doi:10.1093/sleep/zsy183
   PubMed Web of Science ®Google Scholar
• Mormile R, Mazzei G, Vittori G, de Michele M, Squarcia U. Insomnia and shift-work sleep disorder: a crosstalk between glutamate excitotoxicity and decreased GABAergic neurotransmission? Sleep Biol Rhythms. 2012;10(4):340–341. doi:10.1111/j.1479-8425.2012.00574.x
   Web of Science ®Google Scholar
• Wang R, Reddy PH. Role of glutamate and NMDA receptors in Alzheimer’s disease. J Alzheimers Dis. 2017;57(4):1041–1048. doi:10.3233/jad-160763
   PubMed Web of Science ®Google Scholar
• He S, Zhang X, Glutamate QS. Glutamate transporters, and circadian rhythm sleep disorders in neurodegenerative diseases. ACS Chem Neurosci. 2019;10(1):175–181. doi:10.1021/acschemneuro.8b00419
   PubMed Web of Science ®Google Scholar
• Novati A, Hulshof HJ, Granic I, Meerlo P. Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicity. J Sleep Res. 2012;21(1):3–9. doi:10.1111/j.1365-2869.2011.00932.x
   PubMed Web of Science ®Google Scholar
• Gotoh K, Masaki T, Chiba S, et al. Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior. J Neurochem. 2013;125(4):588–598. doi:10.1111/jnc.12213
   PubMed Web of Science ®Google Scholar
• Ren J, Chen Y, Fang X, et al. Correlation of Orexin-A and brain-derived neurotrophic factor levels in metabolic syndrome and cognitive impairment in schizophrenia treated with clozapine. Neurosci Letters. 2022;782:136695. doi:10.1016/j.neulet.2022.136695
   PubMed Web of Science ®Google Scholar
• Mogavero MP, Silvani A, Lanza G, DelRosso LM, Ferini-Strambi L, Ferri R. Targeting orexin receptors for the treatment of insomnia: from physiological mechanisms to current clinical evidence and recommendations. Nat Sci Sleep. 2023;15:17–38. doi:10.2147/nss.S201994
   PubMed Web of Science ®Google Scholar
• Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24(12):726–731. doi:10.1016/s0166-2236(00)02002-6
   PubMed Web of Science ®Google Scholar
• Wang Z-J, Liu J-F. The molecular basis of insomnia: implication for therapeutic approaches. Drug Dev Res. 2016;77(8):427–436. doi:10.1002/ddr.21338
   PubMed Web of Science ®Google Scholar
• Palagini L, Geoffroy PA, Gehrman PR, Miniati M, Gemignani A, Riemann D. Potential genetic and epigenetic mechanisms in insomnia: a systematic review. J Sleep Res. 2023;e13868. doi:10.1111/jsr.13868
   PubMed Web of Science ®Google Scholar
• Stein MB, McCarthy MJ, Chen CY, et al. Genome-wide analysis of insomnia disorder. Mol Psychiatry. 2018;23(11):2238–2250. doi:10.1038/s41380-018-0033-5
   PubMed Web of Science ®Google Scholar
• Palagini L, Drake CL, Gehrman P, Meerlo P, Riemann D. Early-life origin of adult insomnia: does prenatal-early-life stress play a role? Sleep Med. 2015;16(4):446–456. doi:10.1016/j.sleep.2014.10.013
   PubMed Web of Science ®Google Scholar
• Van Someren EJW. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 2021;101(3):995–1046. doi:10.1152/physrev.00046.2019
   PubMed Web of Science ®Google Scholar
• Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. 2011;68(5):444–454. doi:10.1001/archgenpsychiatry.2010.189
   PubMed Web of Science ®Google Scholar
• Palagini L, Biber K, Riemann D. The genetics of insomnia--evidence for epigenetic mechanisms? Sleep Med Rev. 2014;18(3):225–235. doi:10.1016/j.smrv.2013.05.002
   PubMed Web of Science ®Google Scholar
• Hamet P, Tremblay J. Genetics of the sleep-wake cycle and its disorders. Metabolism. 2006;55:S7–S12. doi:10.1016/j.metabol.2006.07.006
   PubMed Web of Science ®Google Scholar
• Wang ZJ, Liu JF. The molecular basis of insomnia: implication for therapeutic approaches. Drug Dev Res. 2016;77(8):427–436. doi:10.1002/ddr.21338
   PubMed Web of Science ®Google Scholar
• Sammallahti S, Koopman-Verhoeff ME, Binter A-C, et al. Longitudinal associations of DNA methylation and sleep in children: a meta-analysis. Clin Epigenet. 2022;14(1):83. doi:10.1186/s13148-022-01298-4
   PubMed Web of Science ®Google Scholar
• Koopman-Verhoeff ME, Mulder RH, Saletin JM, et al. Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study. J Child Psychol Psychiatry. 2020;61(10):1061–1069. doi:10.1111/jcpp.13252
   PubMed Web of Science ®Google Scholar
• Ancelin M-L, Jaussent I, Ritchie K, Besset A, Ryan J, Dauvilliers Y. Brain-derived neurotrophic factor (BDNF) variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults. J Sleep Res. 2023;32(4):e13838. doi:10.1111/jsr.13838
   PubMed Web of Science ®Google Scholar
• Lahtinen A, Puttonen S, Vanttola P, et al. A distinctive DNA methylation pattern in insufficient sleep. Sci Rep. 2019;9(1):1193. doi:10.1038/s41598-018-38009-0
   PubMed Web of Science ®Google Scholar
• Peter CE, Antony JB, Mark F, Janet P, Clive M, John EJG. Sleep disturbance and daytime sleepiness predict vascular dementia. J Epidemiol Community Health. 2011;65(9):820. doi:10.1136/jech.2009.100503
   PubMed Web of Science ®Google Scholar
• Elder GJ, Lazar AS, Alfonso-Miller P, Taylor JP. Sleep disturbances in Lewy body dementia: a systematic review. Int J Geriatr Psychiatry. 2022;37(10). doi:10.1002/gps.5814
   PubMedGoogle Scholar
• Lloret MA, Cervera-Ferri A, Nepomuceno M, Monllor P, Esteve D, Lloret A. Is sleep disruption a cause or consequence of Alzheimer’s disease? Reviewing its possible role as a biomarker. Int J Mol Sci. 2020;21(3):1168. doi:10.3390/ijms21031168
   PubMed Web of Science ®Google Scholar
• Shen Y, Lv QK, Xie WY, et al. Circadian disruption and sleep disorders in neurodegeneration. Transl Neurodegener. 2023;12(1):8. doi:10.1186/s40035-023-00340-6
   PubMed Web of Science ®Google Scholar
• Johnson KA, Fox NC, Sperling RA, Klunk WE. Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(4):a006213. doi:10.1101/cshperspect.a006213
   PubMed Web of Science ®Google Scholar
• Leerssen J, Blanken TF, Pozzi E, et al. Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group. Transl Psychiatry. 2020;10(1):425. doi:10.1038/s41398-020-01109-5
   PubMed Web of Science ®Google Scholar
• Cechova K, Angelucci F, Markova H, et al. Ratio of serum proBDNF to BDNF and its association with cognitive performance and brain morphometry in mild cognitive impairment. Alzheimer’s Dementia. 2020;16(S6):e046340. doi:10.1002/alz.046340
   Google Scholar