The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain

References

• Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1–32. doi:10.1146/annurev.neuro.051508.135531
   PubMed Web of Science ®Google Scholar
• Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10(4):287–333. doi:10.1016/j.ejpain.2005.06.009
   PubMed Web of Science ®Google Scholar
• Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–2097. doi:10.1016/S0140-6736(21)00393-7
   PubMed Web of Science ®Google Scholar
• Afolalu EF, Ramlee F, Tang NKY. Effects of sleep changes on pain-related health outcomes in the general population: a systematic review of longitudinal studies with exploratory meta-analysis. Sleep Med Rev. 2018;39:82–97. doi:10.1016/j.smrv.2017.08.001
   PubMed Web of Science ®Google Scholar
• Nissen A, Hynek KA, Scales D, Hilden PK, Straiton M. Chronic pain, mental health and functional impairment in adult refugees from Syria resettled in Norway: a cross-sectional study. BMC Psychiatry. 2022;22(1):571. doi:10.1186/s12888-022-04200-x
   PubMed Web of Science ®Google Scholar
• Blyth FM, Noguchi N. Chronic musculoskeletal pain and its impact on older people. Best Pract Res Clin Rheumatol. 2017;31(2):160–168. doi:10.1016/j.berh.2017.10.004
   PubMed Web of Science ®Google Scholar
• Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97–111. doi:10.1053/smrv.2002.0186
   PubMed Web of Science ®Google Scholar
• Shin DS, Jeong BY. Older female farmers and modeling of occupational hazards, wellbeing, and sleep-related problems on musculoskeletal pains. Int J Environ Res Public Health. 2022;19(12):7274. doi:10.3390/ijerph19127274
   PubMed Web of Science ®Google Scholar
• Alghadir AH, Khan M, Alshehri MM, Alqahtani AS, Aldaihan M. In hypertensive individuals, sleep time and sleep efficiency did not affect the number of angina episodes: a cross-sectional study. Sci Rep. 2022;12(1):16290. doi:10.1038/s41598-022-20255-y
   PubMed Web of Science ®Google Scholar
• Jolly T, Vadukapuram R, Trivedi C, et al. Risk of suicide in patients with major depressive disorder and comorbid chronic pain disorder: an insight from national inpatient sample data. Pain Physician. 2022;25(6):419–425.
   PubMed Web of Science ®Google Scholar
• Lazaridou A, Paschali M, Zgierska AE, Garland EL, Edwards RR. Exploring the relationship between endogenous pain modulation, pain intensity, and depression in patients using opioids for chronic low back pain. Clin J Pain. 2022;38(10):595–600. doi:10.1097/AJP.0000000000001063
   PubMed Web of Science ®Google Scholar
• Krause AJ, Prather AA, Wager TD, Lindquist MA, Walker MP. The pain of sleep loss: a brain characterization in humans. J Neurosci. 2019;39(12):2291–2300. doi:10.1523/JNEUROSCI.2408-18.2018
   PubMed Web of Science ®Google Scholar
• Chang JR, Fu SN, Li X, et al. The differential effects of sleep deprivation on pain perception in individuals with or without chronic pain: a systematic review and meta-analysis. Sleep Med Rev. 2022;66:101695. doi:10.1016/j.smrv.2022.101695
   PubMed Web of Science ®Google Scholar
• Staffe AT, Bech MW, Clemmensen SLK, Nielsen HT, Larsen DB, Petersen KK. Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants. PLoS One. 2019;14(12):e0225849. doi:10.1371/journal.pone.0225849
   PubMed Web of Science ®Google Scholar
• Schrimpf M, Liegl G, Boeckle M, Leitner A, Geisler P, Pieh C. The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis. Sleep Med. 2015;16(11):1313–1320. doi:10.1016/j.sleep.2015.07.022
   PubMed Web of Science ®Google Scholar
• Li Q, Zhu ZY, Lu J, et al. Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain. Acta Neuropathol Commun. 2019;7(1):217. doi:10.1186/s40478-019-0868-2
   PubMed Web of Science ®Google Scholar
• Stump PR, Dalben Gda S. Mechanisms and clinical management of pain. Braz Oral Res. 2012;26(Suppl 1):115–119. doi:10.1590/S1806-83242012000700017
   PubMedGoogle Scholar
• Pricope CV, Tamba BI, Stanciu GD, et al. The roles of imaging biomarkers in the management of chronic neuropathic pain. Int J Mol Sci. 2022;23(21):13038. doi:10.3390/ijms232113038
   PubMed Web of Science ®Google Scholar
• Zimmer Z, Fraser K, Grol-Prokopczyk H, Zajacova A. A global study of pain prevalence across 52 countries: examining the role of country-level contextual factors. Pain. 2022;163(9):1740–1750. doi:10.1097/j.pain.0000000000002557
   PubMed Web of Science ®Google Scholar
• Giovannini S, Coraci D, Brau F, et al. Neuropathic pain in the elderly. Diagnostics. 2021;11(4):613. doi:10.3390/diagnostics11040613
   Web of Science ®Google Scholar
• Simon KC, Nadel L, Payne JD. The functions of sleep: a cognitive neuroscience perspective. Proc Natl Acad Sci U S A. 2022;119(44):e2201795119. doi:10.1073/pnas.2201795119
   PubMed Web of Science ®Google Scholar
• Barbato G. REM sleep: an unknown indicator of sleep quality. Int J Environ Res Public Health. 2021;18(24):12976. doi:10.3390/ijerph182412976
   PubMed Web of Science ®Google Scholar
• Helfrich-Förster C. Sleep in insects. Annu Rev Entomol. 2018;63(1):69–86. doi:10.1146/annurev-ento-020117-043201
   PubMedGoogle Scholar
• Weigend S, Holst SC, Treyer V, et al. Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle. Sleep. 2019;42(11). doi:10.1093/sleep/zsz161
   PubMed Web of Science ®Google Scholar
• Hasegawa E, Miyasaka A, Sakurai K, Cherasse Y, Li Y, Sakurai T. Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science. 2022;375(6584):994–1000. doi:10.1126/science.abl6618
   PubMed Web of Science ®Google Scholar
• Oikonomou G, Altermatt M, Zhang RW, et al. The serotonergic raphe promote sleep in zebrafish and mice. Neuron. 2019;103(4):686–701.e8. doi:10.1016/j.neuron.2019.05.038
   PubMed Web of Science ®Google Scholar
• Cespuglio R. Serotonin: its place today in sleep preparation, triggering or maintenance. Sleep Med. 2018;49:31–39. doi:10.1016/j.sleep.2018.05.034
   PubMed Web of Science ®Google Scholar
• Kjaerby C, Andersen M, Hauglund N, et al. Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine. Nat Neurosci. 2022;25(8):1059–1070. doi:10.1038/s41593-022-01102-9
   PubMed Web of Science ®Google Scholar
• Mitchell HA, Weinshenker D. Good night and good luck: norepinephrine in sleep pharmacology. Biochem Pharmacol. 2010;79(6):801–809. doi:10.1016/j.bcp.2009.10.004
   PubMed Web of Science ®Google Scholar
• McCarter SJ, Hagen PT, St Louis EK, et al. Physiological markers of sleep quality: a scoping review. Sleep Med Rev. 2022;64:101657. doi:10.1016/j.smrv.2022.101657
   PubMed Web of Science ®Google Scholar
• Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99(3):1325–1380. doi:10.1152/physrev.00010.2018
   PubMed Web of Science ®Google Scholar
• Sateia MJ. International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014;146(5):1387–1394. doi:10.1378/chest.14-0970
   PubMed Web of Science ®Google Scholar
• Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR. Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30(3):274–280.
   PubMed Web of Science ®Google Scholar
• Jansson-Fröjmark M, Boersma K. Bidirectionality between pain and insomnia symptoms: a prospective study. Br J Health Psychol. 2012;17(2):420–431. doi:10.1111/j.2044-8287.2011.02045.x
   PubMedGoogle Scholar
• Lautenbacher S, Kundermann B, Krieg JC. Sleep deprivation and pain perception. Sleep Med Rev. 2006;10(5):357–369. doi:10.1016/j.smrv.2005.08.001
   PubMed Web of Science ®Google Scholar
• Habib G, Khazin F, Artul S, Aloisi AM. The effect of medical cannabis on pain level and quality of sleep among rheumatology clinic outpatients. Pain Res Manag. 2021;2021:1756588. doi:10.1155/2021/1756588
   PubMedGoogle Scholar
• Leys LJ, Chu KL, Xu J, et al. Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats. Pain. 2013;154(7):1092–1102. doi:10.1016/j.pain.2013.03.019
   PubMed Web of Science ®Google Scholar
• Cardis R, Lecci S, Fernandez LM, et al. Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain. Elife. 2021;10. doi:10.7554/eLife.65835
   PubMed Web of Science ®Google Scholar
• Alexandre C, Latremoliere A, Ferreira A, et al. Decreased alertness due to sleep loss increases pain sensitivity in mice. Nat Med. 2017;23(6):768–774. doi:10.1038/nm.4329
   PubMed Web of Science ®Google Scholar
• Chen S, Xie Y, Li Y, et al. Sleep deprivation and recovery sleep affect healthy male resident’s pain sensitivity and oxidative stress markers: the medial prefrontal cortex may play a role in sleep deprivation model. Front Mol Neurosci. 2022;15:937468. doi:10.3389/fnmol.2022.937468
   PubMed Web of Science ®Google Scholar
• Nosek K, Leppert W, Puchała Ł, Łoń K. Efficacy and safety of topical morphine: a narrative review. Pharmaceutics. 2022;14(7):1499. doi:10.3390/pharmaceutics14071499
   PubMed Web of Science ®Google Scholar
• Sanchez GA, Jutkiewicz EM, Ingram S, Smrcka AV. Coincident regulation of PLCβ signaling by Gq-coupled and μ-opioid receptors opposes opioid-mediated antinociception. Mol Pharmacol. 2022;102(6):269–279. doi:10.1124/molpharm.122.000541
   PubMedGoogle Scholar
• Roeckel LA, Utard V, Reiss D, et al. Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide. Sci Rep. 2017;7(1):10406. doi:10.1038/s41598-017-11120-4
   PubMed Web of Science ®Google Scholar
• Leppä M, Korvenoja A, Carlson S, et al. Acute opioid effects on human brain as revealed by functional magnetic resonance imaging. Neuroimage. 2006;31(2):661–669. doi:10.1016/j.neuroimage.2005.12.019
   PubMed Web of Science ®Google Scholar
• Higginbotham JA, Markovic T, Massaly N, Morón JA. Endogenous opioid systems alterations in pain and opioid use disorder. Front Syst Neurosci. 2022;16:1014768. doi:10.3389/fnsys.2022.1014768
   PubMed Web of Science ®Google Scholar
• Bai X, Batallé G, Balboni G, Pol O. Hydrogen sulfide increases the analgesic effects of µ- and Δ-opioid receptors during neuropathic pain: pathways implicated. Antioxidants. 2022;11(7):1321. doi:10.3390/antiox11071321
   Web of Science ®Google Scholar
• Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464–475. doi:10.1111/jdi.13401
   PubMed Web of Science ®Google Scholar
• Celik M, Labuz D, Henning K, et al. Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides. Brain Behav Immun. 2016;57:227–242. doi:10.1016/j.bbi.2016.04.018
   PubMed Web of Science ®Google Scholar
• Robertson RV, Crawford LS, Meylakh N, et al. Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: a 7-Tesla functional magnetic resonance imaging study. Neuroimage. 2022;259:119408. doi:10.1016/j.neuroimage.2022.119408
   PubMed Web of Science ®Google Scholar
• Presto P, Neugebauer V. Sex differences in CGRP regulation and function in the amygdala in a rat model of neuropathic pain. Front Mol Neurosci. 2022;15:928587. doi:10.3389/fnmol.2022.928587
   PubMed Web of Science ®Google Scholar
• Zhu Y, Sun M, Liu P, Shao W, Xiong M, Xu B. Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala. Korean J Pain. 2022;35(4):423–432. doi:10.3344/kjp.2022.35.4.423
   PubMed Web of Science ®Google Scholar
• Skinner GO, Damasceno F, Gomes A, de Almeida OM. Increased pain perception and attenuated opioid antinociception in paradoxical sleep-deprived rats are associated with reduced tyrosine hydroxylase staining in the periaqueductal gray matter and are reversed by L-dopa. Pharmacol Biochem Behav. 2011;99(1):94–99. doi:10.1016/j.pbb.2011.04.009
   PubMed Web of Science ®Google Scholar
• Smith MT, Mun CJ, Remeniuk B, et al. Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic. Sci Rep. 2020;10(1):20121. doi:10.1038/s41598-020-76934-1
   PubMed Web of Science ®Google Scholar
• Tomim DH, Pontarolla FM, Bertolini JF, et al. The pronociceptive effect of paradoxical sleep deprivation in rats: evidence for a role of descending pain modulation mechanisms. Mol Neurobiol. 2016;53(3):1706–1717. doi:10.1007/s12035-014-9059-0
   PubMed Web of Science ®Google Scholar
• Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014;34(2):566–573. doi:10.1523/JNEUROSCI.4128-13.2014
   PubMed Web of Science ®Google Scholar
• Ueno T, Tomita J, Tanimoto H, et al. Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci. 2012;15(11):1516–1523. doi:10.1038/nn.3238
   PubMed Web of Science ®Google Scholar
• Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001;21(5):1787–1794. doi:10.1523/JNEUROSCI.21-05-01787.2001
   PubMed Web of Science ®Google Scholar
• Moderie C, Carrier J, Dang-Vu TT. Les troubles du sommeil chez les patients atteints d'un trouble neurocognitif [Sleep disorders in patients with a neurocognitive disorder]. Encephale. 2022;48(3):325–334. French. doi:10.1016/j.encep.2021.08.014
   PubMedGoogle Scholar
• Li C, Liu S, Lu X, Tao F. Role of descending dopaminergic pathways in pain modulation. Curr Neuropharmacol. 2019;17(12):1176–1182. doi:10.2174/1570159X17666190430102531
   PubMed Web of Science ®Google Scholar
• Edwards S, Callicoatte CN, Barattini AE, et al. Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain. Neuropharmacology. 2022;208:108976. doi:10.1016/j.neuropharm.2022.108976
   PubMed Web of Science ®Google Scholar
• Li C, Sugam JA, Lowery-Gionta EG, et al. Mu opioid receptor modulation of dopamine neurons in the periaqueductal gray/dorsal raphe: a role in regulation of pain. Neuropsychopharmacology. 2016;41(8):2122–2132. doi:10.1038/npp.2016.12
   PubMed Web of Science ®Google Scholar
• Taylor NE, Pei J, Zhang J, et al. The Role of glutamatergic and dopaminergic neurons in the periaqueductal gray/dorsal raphe: separating analgesia and anxiety. eNeuro. 2019;6(1):ENEURO.0018–18.2019. doi:10.1523/ENEURO.0018-18.2019
   PubMed Web of Science ®Google Scholar
• Lau BK, Winters BL, Vaughan CW. Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway. Br J Pharmacol. 2020;177(10):2320–2332. doi:10.1111/bph.14982
   PubMed Web of Science ®Google Scholar
• Fu YT, Mao CJ, Ma LJ, et al. Pain correlates with sleep disturbances in parkinson’s disease patients. Pain Pract. 2018;18(1):29–37. doi:10.1111/papr.12578
   PubMed Web of Science ®Google Scholar
• Thompson T, Gallop K, Correll CU, et al. Pain perception in Parkinson’s disease: a systematic review and meta-analysis of experimental studies. Ageing Res Rev. 2017;35:74–86. doi:10.1016/j.arr.2017.01.005
   PubMed Web of Science ®Google Scholar
• Asakura W, Matsumoto K, Ohta H, Watanabe H. REM sleep deprivation decreases apomorphine-induced stimulation of locomotor activity but not stereotyped behavior in mice. Gen Pharmacol. 1992;23(3):337–341. doi:10.1016/0306-3623(92)90092-X
   PubMedGoogle Scholar
• Vanini G. Nucleus accumbens: a novel forebrain mechanism underlying the increase in pain sensitivity caused by rapid eye movement sleep deprivation. Pain. 2018;159(1):5–6. doi:10.1097/j.pain.0000000000001073
   PubMed Web of Science ®Google Scholar
• Sardi NF, Tobaldini G, Morais RN, Fischer L. Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors. Pain. 2018;159(1):75–84. doi:10.1097/j.pain.0000000000001066
   PubMed Web of Science ®Google Scholar
• Kato T, Mitsukura Y, Yoshida K, Mimura M, Takata N, Tanaka KF. Oscillatory population-level activity of dorsal raphe serotonergic neurons is inscribed in sleep structure. J Neurosci. 2022;42(38):7244–7255. doi:10.1523/JNEUROSCI.2288-21.2022
   PubMed Web of Science ®Google Scholar
• Vaseghi S, Arjmandi-Rad S, Eskandari M, Ebrahimnejad M, Kholghi G, Zarrindast MR. Modulating role of serotonergic signaling in sleep and memory. Pharmacol Rep. 2022;74(1):1–26. doi:10.1007/s43440-021-00339-8
   PubMed Web of Science ®Google Scholar
• Zant JC, Leenaars CH, Kostin A, Van Someren EJ, Porkka-Heiskanen T. Increases in extracellular serotonin and dopamine metabolite levels in the basal forebrain during sleep deprivation. Brain Res. 2011;1399:40–48. doi:10.1016/j.brainres.2011.05.008
   PubMed Web of Science ®Google Scholar
• Azizi H, Hwang J, Suen V, et al. Sleep deprivation induces changes in 5-HT actions and 5-HT(1A) receptor expression in the rat hippocampus. Neurosci Lett. 2017;655:151–155. doi:10.1016/j.neulet.2017.06.053
   PubMed Web of Science ®Google Scholar
• Zhao X, Ozols AB, Meyers KT, et al. Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Mol Psychiatry. 2022;27(3):1599–1610. doi:10.1038/s41380-021-01390-w
   PubMed Web of Science ®Google Scholar
• Ye H, Ji M, Wang C, et al. Integrated functional neuroimaging, monoamine neurotransmitters, and behavioral score on depressive tendency in intensive care unit medical staffs induced by sleep deprivation after night shift work. Front Psychiatry. 2022;13:848709. doi:10.3389/fpsyt.2022.848709
   PubMed Web of Science ®Google Scholar
• Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011;13(2):211. doi:10.1186/ar3306
   PubMed Web of Science ®Google Scholar
• Li CJ, Zhang LG, Liu LB, et al. Inhibition of spinal 5-HT3 receptor and spinal dorsal horn neuronal excitability alleviates hyperalgesia in a rat model of parkinson’s disease. Mol Neurobiol. 2022;59(12):7253–7264. doi:10.1007/s12035-022-03034-8
   PubMed Web of Science ®Google Scholar
• Chuck AJ, Swannell AJ, House AO, Pownall R. The effects of dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology. 2000;39(12):1425–1427. doi:10.1093/rheumatology/39.12.1425
   PubMed Web of Science ®Google Scholar
• Kim W, Chung Y, Choi S, Min BI, Kim SK. Duloxetine protects against oxaliplatin-induced neuropathic pain and spinal neuron hyperexcitability in rodents. Int J Mol Sci. 2017;18(12). doi:10.3390/ijms18122626
   Web of Science ®Google Scholar
• Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update. Int J Mol Sci. 2021;22(8):3891. doi:10.3390/ijms22083891
   PubMed Web of Science ®Google Scholar
• Wei H, Ma A, Wang YX, Pertovaara A. Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation. Pharmacol Res. 2008;57(6):469–475. doi:10.1016/j.phrs.2008.05.007
   PubMed Web of Science ®Google Scholar
• Thompson KI, Chau M, Lorenzetti MS, Hill LD, Fins AI, Tartar JL. Acute sleep deprivation disrupts emotion, cognition, inflammation, and cortisol in young healthy adults. Front Behav Neurosci. 2022;16:945661. doi:10.3389/fnbeh.2022.945661
   PubMed Web of Science ®Google Scholar
• Hunt CA, Smith MT, Mun CJ, Irwin MR, Finan PH. Trait positive affect buffers the association between experimental sleep disruption and inflammation. Psychoneuroendocrinology. 2021;129:105240. doi:10.1016/j.psyneuen.2021.105240
   PubMed Web of Science ®Google Scholar
• Irwin MR, Olmstead R, Kruse J, Breen EC, Haque R. Association of interleukin-8 and risk of incident and recurrent depression in long-term breast cancer survivors. Brain Behav Immun. 2022;105:131–138. doi:10.1016/j.bbi.2022.07.003
   PubMed Web of Science ®Google Scholar
• Raff H, Phillips J, Simpson P, Weisman SJ, Hainsworth KR. Interaction of chronic pain, obesity and time of day on cortisol in female human adolescents. Stress. 2022;25(1):331–336. doi:10.1080/10253890.2022.2142778
   PubMed Web of Science ®Google Scholar
• Fahmawi A, Khalifeh M, Alzoubi KH, Rababa’h AM. The effects of acute and chronic sleep deprivation on the immune profile in the rat. Curr Mol Pharmacol. 2022.
   Web of Science ®Google Scholar
• Dykstra-Aiello C, Koh KMS, Nguyen J, Xue M, Roy S, Krueger JM. A wake-like state in vitro induced by transmembrane TNF/soluble TNF receptor reverse signaling. Brain Behav Immun. 2021;94:245–258. doi:10.1016/j.bbi.2021.01.036
   PubMed Web of Science ®Google Scholar
• Oles V, Koh KMS, Dykstra-Aiello CJ, et al. Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice. J Appl Physiol. 2020;128(6):1506–1522. doi:10.1152/japplphysiol.00839.2019
   PubMed Web of Science ®Google Scholar
• Chennaoui M, Gomez-Merino D, Drogou C, et al. Effects of exercise on brain and peripheral inflammatory biomarkers induced by total sleep deprivation in rats. J Inflamm. 2015;12(1):56. doi:10.1186/s12950-015-0102-3
   Google Scholar
• Zielinski MR, Krueger JM. Sleep and innate immunity. Front Biosci. 2011;3(2):632–642.
   Google Scholar
• Smith C, Trageser KJ, Wu H, et al. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Transl Psychiatry. 2021;11(1):52. doi:10.1038/s41398-020-01189-3
   PubMed Web of Science ®Google Scholar
• Aghelan Z, Karima S, Khazaie H, et al. Interleukin-1α and tumor necrosis factor α as an inducer for reactive-oxygen-species-mediated NOD-like receptor protein 1/NOD-like receptor protein 3 inflammasome activation in mononuclear blood cells from individuals with chronic insomnia disorder. Eur J Neurol. 2022;29(12):3647–3657. doi:10.1111/ene.15540
   PubMed Web of Science ®Google Scholar
• Krueger JM, Clinton JM, Winters BD, et al. Involvement of cytokines in slow wave sleep. Prog Brain Res. 2011;193:39–47.
   PubMed Web of Science ®Google Scholar
• Hou J, Shen Q, Wan X, Zhao B, Wu Y, Xia Z. REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. Behav Brain Res. 2019;364:167–176. doi:10.1016/j.bbr.2019.01.038
   PubMed Web of Science ®Google Scholar
• Krueger JM, Obál FJ, Fang J, Kubota T, Taishi P. The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci. 2001;933:211–221. doi:10.1111/j.1749-6632.2001.tb05826.x
   PubMed Web of Science ®Google Scholar
• Kawasaki Y, Zhang L, Cheng JK, Ji RR. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci. 2008;28(20):5189–5194. doi:10.1523/JNEUROSCI.3338-07.2008
   PubMed Web of Science ®Google Scholar
• Cao H, Zhang YQ. Spinal glial activation contributes to pathological pain states. Neurosci Biobehav Rev. 2008;32(5):972–983. doi:10.1016/j.neubiorev.2008.03.009
   PubMed Web of Science ®Google Scholar
• Moalem G, Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev. 2006;51(2):240–264. doi:10.1016/j.brainresrev.2005.11.004
   PubMedGoogle Scholar
• Reeve AJ, Patel S, Fox A, Walker K, Urban L. Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain. 2000;4(3):247–257. doi:10.1053/eujp.2000.0177
   PubMed Web of Science ®Google Scholar
• Ma D, Wang X, Liu X, et al. Macrophage infiltration initiates RIP3/MLKL-dependent necroptosis in paclitaxel-induced neuropathic pain. Mediators Inflamm. 2022;2022:1567210. doi:10.1155/2022/1567210
   PubMed Web of Science ®Google Scholar
• Rakhshandeh H, Pourbagher-Shahri AM, Hasanpour M, Iranshahi M, Forouzanfar F. Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats. Metab Brain Dis. 2022;37(8):2839–2852. doi:10.1007/s11011-022-01094-2
   PubMed Web of Science ®Google Scholar
• Ishikawa T, Miyagi M, Kamoda H, et al. Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. Spine. 2013;38(1):11–16. doi:10.1097/BRS.0b013e3182610fa9
   PubMed Web of Science ®Google Scholar
• Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007;30(9):1145–1152. doi:10.1093/sleep/30.9.1145
   PubMed Web of Science ®Google Scholar
• Hirotsu C, Pedroni MN, Berro LF, Tufik S, Andersen ML. Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats. Sci Rep. 2018;8(1):13837. doi:10.1038/s41598-018-32276-7
   PubMedGoogle Scholar
• Dai Y, Liu S, Chen J, Liu L, Zhou C, Zuo Y. Microglial responses and pain behaviors are exacerbated by chronic sleep deprivation in rats with chronic pain via neuroinflammatory pathways. Neuroscience. 2022;503:83–94. doi:10.1016/j.neuroscience.2022.09.004
   PubMed Web of Science ®Google Scholar
• Soya S, Sakurai T. Evolution of Orexin Neuropeptide system: structure and function. Front Neurosci. 2020;14:691. doi:10.3389/fnins.2020.00691
   PubMed Web of Science ®Google Scholar
• Inutsuka A, Yamanaka A. The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions. Front Endocrinol. 2013;4:18. doi:10.3389/fendo.2013.00018
   PubMedGoogle Scholar
• Xiang X, Chen Y, Li KX, et al. Neuroanatomical basis for the orexinergic modulation of anesthesia arousal and pain control. Front Cell Neurosci. 2022;16:891631. doi:10.3389/fncel.2022.891631
   PubMed Web of Science ®Google Scholar
• McAlpine CS, Kiss MG, Rattik S, et al. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019;566(7744):383–387. doi:10.1038/s41586-019-0948-2
   PubMed Web of Science ®Google Scholar
• Gao XB, Horvath TL. From molecule to behavior: hypocretin/orexin revisited from a sex-dependent perspective. Endocr Rev. 2022;43(4):743–760. doi:10.1210/endrev/bnab042
   PubMed Web of Science ®Google Scholar
• Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98(4):437–451. doi:10.1016/S0092-8674(00)81973-X
   PubMed Web of Science ®Google Scholar
• Beuckmann CT, Sinton CM, Williams SC, et al. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci. 2004;24(18):4469–4477. doi:10.1523/JNEUROSCI.5560-03.2004
   PubMed Web of Science ®Google Scholar
• Sutcliffe JG, de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J Neurosci Res. 2000;62(2):161–168. doi:10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1
   PubMed Web of Science ®Google Scholar
• Xu A, Sakurai E, Kuramasu A, et al. Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats. J Pharmacol Sci. 2010;114(4):444–453. doi:10.1254/jphs.10177FP
   PubMed Web of Science ®Google Scholar
• Alakuijala A, Sarkanen T, Partinen M. Hypocretin-1 levels associate with fragmented sleep in patients with narcolepsy type 1. Sleep. 2016;39(5):1047–1050. doi:10.5665/sleep.5750
   PubMed Web of Science ®Google Scholar
• Murphy P, Moline M, Mayleben D, et al. Lemborexant, A Dual Orexin Receptor Antagonist (DORA) for the treatment of insomnia disorder: results from a Bayesian, Adaptive, Randomized, Double-Blind, Placebo-Controlled Study. J Clin Sleep Med. 2017;13(11):1289–1299. doi:10.5664/jcsm.6800
   PubMed Web of Science ®Google Scholar
• Hoever P, Dorffner G, Beneš H, et al. Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial. Clin Pharmacol Ther. 2012;91(6):975–985. doi:10.1038/clpt.2011.370
   PubMed Web of Science ®Google Scholar
• Roth T, Black J, Cluydts R, et al. Dual orexin receptor antagonist, almorexant, in elderly patients with primary insomnia: a Randomized, Controlled Study. Sleep. 2017;40(2). doi:10.1093/sleep/zsw034
   Web of Science ®Google Scholar
• Black J, Pillar G, Hedner J, et al. Efficacy and safety of almorexant in adult chronic insomnia: a randomized placebo-controlled trial with an active reference. Sleep Med. 2017;36:86–94. doi:10.1016/j.sleep.2017.05.009
   PubMed Web of Science ®Google Scholar
• Robinson CL, Supra R, Downs E, et al. Daridorexant for the treatment of insomnia. Health Psychol Res. 2022;10(3):37400. doi:10.52965/001c.37400
   PubMed Web of Science ®Google Scholar
• Ghalebandi S, Zareie F, Askari K, Yuzugulen J, Haghparast A. Intra-CA1 injection of orexin receptors antagonism attenuates the stress-induced analgesia in a rat acute pain model. Behav Brain Res. 2022;423:113785. doi:10.1016/j.bbr.2022.113785
   PubMed Web of Science ®Google Scholar
• Shakerinava P, Sayarnezhad A, Karimi-Haghighi S, Mesgar S, Haghparast A. Antagonism of the orexin receptors in the ventral tegmental area diminished the stress-induced analgesia in persistent inflammatory pain. Neuropeptides. 2022;96:102291. doi:10.1016/j.npep.2022.102291
   PubMed Web of Science ®Google Scholar
• Mobarakeh JI, Takahashi K, Sakurada S, et al. Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and −2) in mice. Peptides. 2005;26(5):767–777. doi:10.1016/j.peptides.2005.01.001
   PubMed Web of Science ®Google Scholar
• den Boon FS, Sarabdjitsingh RA. Circadian and ultradian patterns of HPA-axis activity in rodents: significance for brain functionality. Best Pract Res Clin Endocrinol Metab. 2017;31(5):445–457. doi:10.1016/j.beem.2017.09.001
   PubMed Web of Science ®Google Scholar
• Spiga F, Walker JJ, Terry JR, Lightman SL. HPA axis-rhythms. Compr Physiol. 2014;4(3):1273–1298.
   PubMed Web of Science ®Google Scholar
• Balbo M, Leproult R, Van Cauter E. Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity. Int J Endocrinol. 2010;2010:759234. doi:10.1155/2010/759234
   PubMed Web of Science ®Google Scholar
• Nollet M, Wisden W, Franks NP. Sleep deprivation and stress: a reciprocal relationship. Interface Focus. 2020;10(3):20190092. doi:10.1098/rsfs.2019.0092
   PubMed Web of Science ®Google Scholar
• Sgoifo A, Buwalda B, Roos M, Costoli T, Merati G, Meerlo P. Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats. Psychoneuroendocrinology. 2006;31(2):197–208. doi:10.1016/j.psyneuen.2005.06.009
   PubMed Web of Science ®Google Scholar
• Russell AL, Miller L, Yi H, Keil R, Handa RJ, Wu TJ. Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses. BMC Neurosci. 2021;22(1):5. doi:10.1186/s12868-020-00607-y
   PubMed Web of Science ®Google Scholar
• Galbo H, Kall L. Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study. Arthritis Res Ther. 2016;18(1):174. doi:10.1186/s13075-016-1072-4
   PubMedGoogle Scholar
• Rosenberg H, Halman S, Yadav K. Polymyalgia rheumatica. CMAJ. 2021;193(46):E1770. doi:10.1503/cmaj.210541
   PubMed Web of Science ®Google Scholar
• Kreiner F, Langberg H, Galbo H. Increased muscle interstitial levels of inflammatory cytokines in polymyalgia rheumatica. Arthritis Rheum. 2010;62(12):3768–3775. doi:10.1002/art.27728
   PubMedGoogle Scholar
• Wang S, Lim G, Zeng Q, et al. Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. J Neurosci. 2004;24(39):8595–8605. doi:10.1523/JNEUROSCI.3058-04.2004
   PubMed Web of Science ®Google Scholar
• Le Coz GM, Anton F, Hanesch U. Glucocorticoid-mediated enhancement of glutamatergic transmission may outweigh anti-inflammatory effects under conditions of neuropathic pain. PLoS One. 2014;9(3):e91393. doi:10.1371/journal.pone.0091393
   PubMed Web of Science ®Google Scholar
• Chiu GS, Freund GG. Modulation of neuroimmunity by adenosine and its receptors: metabolism to mental illness. Metabolism. 2014;63(12):1491–1498. doi:10.1016/j.metabol.2014.09.003
   PubMed Web of Science ®Google Scholar
• Gvilia I, Suntsova N, Kostin A, et al. The role of adenosine in the maturation of sleep homeostasis in rats. J Neurophysiol. 2017;117(1):327–335. doi:10.1152/jn.00675.2016
   PubMed Web of Science ®Google Scholar
• Basheer R, Bauer A, Elmenhorst D, Ramesh V, McCarley RW. Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain. Neuroreport. 2007;18(18):1895–1899. doi:10.1097/WNR.0b013e3282f262f6
   PubMed Web of Science ®Google Scholar
• Blanco-Centurion C, Xu M, Murillo-Rodriguez E, et al. Adenosine and sleep homeostasis in the Basal forebrain. J Neurosci. 2006;26(31):8092–8100. doi:10.1523/JNEUROSCI.2181-06.2006
   PubMed Web of Science ®Google Scholar
• Hao JW, Qiao WL, Li Q, et al. A1 adenosine receptor activation inhibits P2X3 receptor-mediated ATP currents in rat dorsal root ganglion neurons. Mol Neurobiol. 2022;59(11):7025–7035. doi:10.1007/s12035-022-03019-7
   PubMed Web of Science ®Google Scholar
• Martins DF, Mazzardo-Martins L, Cidral-Filho FJ, Stramosk J, Santos AR. Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. Phys Ther. 2013;93(3):401–412. doi:10.2522/ptj.20120226
   PubMed Web of Science ®Google Scholar
• Yamaoka G, Horiuchi H, Morino T, Miura H, Ogata T. Different analgesic effects of adenosine between postoperative and neuropathic pain. J Orthop Sci. 2013;18(1):130–136. doi:10.1007/s00776-012-0302-0
   PubMed Web of Science ®Google Scholar
• Hambrecht-Wiedbusch VS, Gabel M, Liu LJ, Imperial JP, Colmenero AV, Vanini G. Preemptive caffeine administration blocks the increase in postoperative pain caused by previous sleep loss in the rat: a potential role for preoptic adenosine A2A receptors in sleep-pain interactions. Sleep. 2017;40(9). doi:10.1093/sleep/zsx116
   PubMed Web of Science ®Google Scholar