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ORIGINAL RESEARCH

Serum Zonula Occludens-1 and Claudin-5 Levels in Patients with Insomnia Disorder: A Pilot Study

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Pages 873-884 | Received 07 Jun 2023, Accepted 18 Oct 2023, Published online: 31 Oct 2023

References

  • Roth T. New developments for treating sleep disorders. J Clin Psychiatry. 2001;62(Suppl 10):3–4.
  • Morin CM, Benca R. Chronic insomnia. Lancet. 2012;379(9821):1129–1141. doi:10.1016/S0140-6736(11)60750-2
  • Edinger JD, Bonnet MH, Bootzin RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep. 2004;27(8):1567–1596. doi:10.1093/sleep/27.8.1567
  • Buysse DJ. Insomnia. JAMA. 2013;309(7):706–716. doi:10.1001/jama.2013.193
  • Perlis ML, Posner D, Riemann D, Bastien CH, Teel J, Thase M. Insomnia. Lancet. 2022;400(10357):1047–1060. doi:10.1016/S0140-6736(22)00879-0
  • Wang Z, Wang Z, Lu T, et al. The microbiota-gut-brain axis in sleep disorders. Sleep Med Rev. 2022;65:101691. doi:10.1016/j.smrv.2022.101691
  • Wagner-Skacel J, Dalkner N, Moerkl S, et al. Sleep and microbiome in psychiatric diseases. Nutrients. 2020;12(8):2198. doi:10.3390/nu12082198
  • Smith RP, Easson C, Lyle SM, et al. Gut microbiome diversity is associated with sleep physiology in humans. PLoS One. 2019;14(10):e0222394. doi:10.1371/journal.pone.0222394
  • Liu B, Lin W, Chen S, et al. Gut microbiota as an objective measurement for auxiliary diagnosis of insomnia disorder. Front Microbiol. 2019;10:1770. doi:10.3389/fmicb.2019.01770
  • Li Y, Zhang B, Zhou Y, et al. Gut microbiota changes and their relationship with inflammation in patients with acute and chronic insomnia. Nat Sci Sleep. 2020;12:895–905. doi:10.2147/NSS.S271927
  • Feng Y, Fu S, Li C, et al. Interaction of gut microbiota and brain function in patients with chronic insomnia: a Regional Homogeneity Study. Front Neurosci. 2021;15:804843. doi:10.3389/fnins.2021.804843
  • Chen Z, Feng Y, Li S, et al. Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency. Front Psychiatry. 2022;13:1050403. doi:10.3389/fpsyt.2022.1050403
  • Li Y, Hao Y, Fan F, Zhang B. The role of microbiome in insomnia, circadian disturbance and depression. Front Psychiatry. 2018;9:669. doi:10.3389/fpsyt.2018.00669
  • Shin C, Kim Y-K. Microbiota-gut-brain axis: pathophysiological mechanism in neuropsychiatric disorders. Adv Exp Med Biol. 2023;1411:17–37. doi:10.1007/978-981-19-7376-5_2
  • Wettschureck N, Strilic B, Offermanns S. Passing the vascular barrier: endothelial signaling processes controlling extravasation. Physiol Rev. 2019;99(3):1467–1525. doi:10.1152/physrev.00037.2018
  • Wasiak J, Gawlik-Kotelnicka O. Intestinal permeability and its significance in psychiatric disorders - A narrative review and future perspectives. Behav Brain Res. 2023;448:114459. doi:10.1016/j.bbr.2023.114459
  • Kealy J, Greene C, Campbell M. Blood-brain barrier regulation in psychiatric disorders. Neurosci Lett. 2020;726:133664. doi:10.1016/j.neulet.2018.06.033
  • Kadry H, Noorani B, Cucullo L. A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS. 2020;17(1):69. doi:10.1186/s12987-020-00230-3
  • Wang X, Ma L, Luo Y, et al. Increasing of blood brain barrier permeability and the association with depression and anxiety in systemic lupus erythematosus patients. Front Med. 2022;9:852835. doi:10.3389/fmed.2022.852835
  • Thal SC, Luh C, Schaible EV, et al. Volatile anesthetics influence blood-brain barrier integrity by modulation of tight junction protein expression in traumatic brain injury. PLoS One. 2012;7(12):e50752. doi:10.1371/journal.pone.0050752
  • Zhu JC, Si MY, Li YZ, et al. Circulating tight junction proteins mirror blood-brain barrier integrity in leukaemia central nervous system metastasis. Hematol Oncol. 2017;35(3):365–373. doi:10.1002/hon.2289
  • Wu H, Wang J, Teng T, et al. Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder. J Affect Disord. 2023;323:659–666. doi:10.1016/j.jad.2022.11.058
  • Kılıç F, Işık Ü, Kumbul Doğuç D. Serum Claudin-5, but not zonulin, may be associated with obsessive-compulsive disorder. Psychiatr Danub. 2022;34(2):273–278. doi:10.24869/psyd.2022.273
  • Kılıç F, Işık Ü, Demirdaş A, Doğuç DK, Bozkurt M. Serum zonulin and claudin-5 levels in patients with bipolar disorder. J Affect Disord. 2020;266:37–42. doi:10.1016/j.jad.2020.01.117
  • Usta A, Kılıç F, Demirdaş A, Ü I, Doğuç DK, Bozkurt M. Serum zonulin and claudin-5 levels in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2021;271(4):767–773. doi:10.1007/s00406-020-01152-9
  • Zhu N, Wei M, Yuan L, et al. Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission. Aging. 2022;14(8):3554–3568. doi:10.18632/aging.204029
  • Itoh M, Nagafuchi A, Yonemura S, Kitani-Yasuda T, Tsukita S, Tsukita S. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol. 1993;121(3):491–502. doi:10.1083/jcb.121.3.491
  • Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012;10(10):1096–1100. doi:10.1016/j.cgh.2012.08.012
  • Wells JM, Brummer RJ, Derrien M, et al. Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 2017;312(3):G171–G193. doi:10.1152/ajpgi.00048.2015
  • Assimakopoulos SF, Akinosoglou K, de Lastic A-L, Skintzi A, Mouzaki A, Gogos CA. The prognostic value of endotoxemia and intestinal barrier biomarker ZO-1 in bacteremic sepsis. Am J Med Sci. 2020;359(2):100–107. doi:10.1016/j.amjms.2019.10.006
  • Guo M, Du C, Li B, Yao R, Tang Y, Jiang Y, Liu H, Su H, Zhou Y, Wang L, Yang X, Zhou M, Yu W. Reducing particulates in indoor air can improve the circulation and cardiorespiratory health of old people: A randomized, double-blind crossover trial of air filtration. Sci Total Environ. 2021;798:149248.
  • Baglioni C, Regen W, Teghen A, et al. Sleep changes in the disorder of insomnia: a meta-analysis of polysomnographic studies. Sleep Med Rev. 2014;18(3):195–213. doi:10.1016/j.smrv.2013.04.001
  • Kazmierski R, Michalak S, Wencel-Warot A, Nowinski WL. Serum tight-junction proteins predict hemorrhagic transformation in ischemic stroke patients. Neurology. 2012;79(16):1677–1685. doi:10.1212/WNL.0b013e31826e9a83
  • Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, et al. PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex. Oncotarget. 2017;8(55):93382–93391. doi:10.18632/oncotarget.21850
  • Guo Y, Singh LN, Zhu Y, et al. Association of a functional Claudin-5 variant with schizophrenia in female patients with the 22q11.2 deletion syndrome. Schizophr Res. 2020;215:451–452. doi:10.1016/j.schres.2019.09.014
  • Greene C, Kealy J, Humphries MM, et al. Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. Mol Psychiatry. 2018;23(11):2156–2166. doi:10.1038/mp.2017.156
  • Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonté B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ. Social stress induces neurovascular pathology promoting depression. Nat Neurosci. 2017;20:1752–1760.
  • Aydoğan Avşar P, Ü I, Aktepe E, Kılıç F, Doğuç DK, Büyükbayram H. Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder. Int J Psychiatry Clin Pract. 2021;25(1):49–55. doi:10.1080/13651501.2020.1801754
  • Hurtado-Alvarado G, Domínguez-Salazar E, Pavon L, Velázquez-Moctezuma J, Gómez-González B. Blood-brain barrier disruption induced by chronic sleep loss: low-grade inflammation may be the link. J Immunol Res. 2016;2016:4576012. doi:10.1155/2016/4576012
  • Maki KA, Burke LA, Calik MW, et al. Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats. Physiol Genomics. 2020;52(7):280–292. doi:10.1152/physiolgenomics.00039.2020
  • Grosicki GJ, Riemann BL, Flatt AA, Valentino T, Lustgarten MS. Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: a pilot study. Sleep Med. 2020;73:76–81. doi:10.1016/j.sleep.2020.04.013
  • Szentirmai É, Millican NS, Massie AR, Kapás L. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Sci Rep. 2019;9(1):7035. doi:10.1038/s41598-019-43502-1
  • Yu L, Han X, Cen S, et al. Beneficial effect of GABA-rich fermented milk on insomnia involving regulation of gut microbiota. Microbiol Res. 2020;233:126409. doi:10.1016/j.micres.2020.126409
  • Fock E, Parnova R. Mechanisms of Blood-brain barrier protection by microbiota-derived short-chain fatty acids. Cells. 2023;12(4):657.
  • Cuddapah VA, Zhang SL, Sehgal A. Regulation of the blood-brain barrier by circadian rhythms and sleep. Trends Neurosci. 2019;42(7):500–510. doi:10.1016/j.tins.2019.05.001
  • Luo C, Zhang J, Pan J. One-year course and effects of insomnia in rural Chinese adolescents. Sleep. 2013;36(3):377–384. doi:10.5665/sleep.2454
  • Plante DT, Jensen JE, Schoerning L, Winkelman JW. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? Neuropsychopharmacology. 2012;37(6):1548–1557. doi:10.1038/npp.2012.4
  • Blake MJ, Trinder JA, Allen NB. Mechanisms underlying the association between insomnia, anxiety, and depression in adolescence: implications for behavioral sleep interventions. Clin Psychol Rev. 2018;63:25–40. doi:10.1016/j.cpr.2018.05.006
  • Zhao Y, Gan L, Ren L, Lin Y, Ma C, Lin X. Factors influencing the blood-brain barrier permeability. Brain Res. 2022;1788:147937. doi:10.1016/j.brainres.2022.147937
  • Hochman E, Taler M, Flug R, et al. Serum claudin-5 levels among patients with unipolar and bipolar depression in relation to the pro-inflammatory cytokine tumor necrosis factor-alpha levels. Brain Behav Immun. 2023;109:162–167. doi:10.1016/j.bbi.2023.01.015