250
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Associations Between Sleep Spindle Metrics, Age, Education and Executive Function in Young Adult and Middle-Aged Patients with Obstructive Sleep Apnea

, , , , , , , , & show all
Pages 1-15 | Received 19 Sep 2023, Accepted 18 Dec 2023, Published online: 05 Jan 2024

References

  • Senaratna CV, Perret JL, Lodge CJ, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev. 2017;34:70–81. doi:10.1016/j.smrv.2016.07.002
  • Cunningham J, Hunter M, Budgeon C, et al. The prevalence and comorbidities of obstructive sleep apnea in middle-aged men and women: the Busselton healthy ageing study. J Clin Sleep Med. 2021;17(10):2029–2039. doi:10.5664/jcsm.9378
  • Torres G, Sánchez-de-la-torre M, Barbé F. Relationship between osa and hypertension. Chest. 2015;148(3):824–832. doi:10.1378/chest.15-0136
  • Bradley TD, Floras JS. Obstructive sleep apnea and its cardiovascular consequences. Lancet. 2009;373(9657):82–93. doi:10.1016/S0140-6736(08)61622-0
  • Bubu OM, Andrade AG, Umasabor-Bubu OQ, et al. Obstructive sleep apnea, cognition and alzheimer’s disease: a systematic review integrating three decades of multidisciplinary research. Sleep Med Rev. 2020;50:101250. doi:10.1016/j.smrv.2019.101250
  • Beaudin AE, Raneri JK, Ayas NT, et al. Cognitive function in a sleep clinic cohort of patients with obstructive sleep apnea. Ann Am Thorac Soc. 2021;18(5):865–875. doi:10.1513/AnnalsATS.202004-313OC
  • Nemeth D, Csábi E, Janacsek K, Várszegi M, Mari Z. Intact implicit probabilistic sequence learning in obstructive sleep apnea. J Sleep Res. 2012;21(4):396–401. doi:10.1111/j.1365-2869.2011.00983.x
  • Stranks EK, Crowe SF. The cognitive effects of obstructive sleep apnea: an updated meta-analysis. Arch Clin Neuropsychol. 2016;31(2):186–193.
  • Bucks RS, Olaithe M, Eastwood P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology. 2013;18(1):61–70. doi:10.1111/j.1440-1843.2012.02255.x
  • Parnaudeau S, Bolkan SS, Kellendonk C. The mediodorsal thalamus: an essential partner of the prefrontal cortex for cognition. Biol Psychiatry. 2018;83(8):648–656. doi:10.1016/j.biopsych.2017.11.008
  • Halassa MM, Sherman SM. Thalamocortical circuit motifs: a general framework. Neuron. 2019;103(5):762–770. doi:10.1016/j.neuron.2019.06.005
  • Giraldo-Chica M, Rogers BP, Damon SM, Landman BA, Woodward ND. Prefrontal-thalamic anatomical connectivity and executive cognitive function in schizophrenia. Biol Psychiatry. 2018;83(6):509–517. doi:10.1016/j.biopsych.2017.09.022
  • Fernandez LMJ, Lüthi A. Sleep spindles: mechanisms and functions. Physiol Rev. 2020;100(2):805–868. doi:10.1152/physrev.00042.2018
  • Baran B, Karahanoğlu FI, Mylonas D, et al. Increased thalamocortical connectivity in schizophrenia correlates with sleep spindle deficits: evidence for a common pathophysiology. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(8):706–714. doi:10.1016/j.bpsc.2019.04.012
  • Carvalho DZ, Gerhardt GJ, Dellagustin G, et al. Loss of sleep spindle frequency deceleration in obstructive sleep apnea. Clin Neurophysiol. 2014;125(2):306–312. doi:10.1016/j.clinph.2013.07.005
  • Teh JZ, Grummitt L, Haroutonian C, et al. Overnight declarative memory consolidation and NREM sleep EEG oscillations in older adults with obstructive sleep apnea. Sleep. 2023;46(6):zsad087. doi:10.1093/sleep/zsad087
  • Shetty M, Perera A, Kadar M, et al. The effects of sleep-disordered breathing on sleep spindle activity in children and the relationship with sleep, behavior, and neurocognition. Sleep Med. 2023;101:468–477. doi:10.1016/j.sleep.2022.11.028
  • Djonlagic I, Mariani S, Fitzpatrick AL, et al. Macro and micro sleep architecture and cognitive performance in older adults. Nat Hum Behav. 2021;5(1):123–145. doi:10.1038/s41562-020-00964-y
  • Lafortune M, Gagnon JF, Martin N, et al. Sleep spindles and rapid eye movement sleep as predictors of next morning cognitive performance in healthy middle-aged and older participants. J Sleep Res. 2014;23(2):159–167. doi:10.1111/jsr.12108
  • Vermeulen MCM, Van der Heijden KB, Swaab H, Van Someren EJW. Sleep spindle characteristics and sleep architecture are associated with learning of executive functions in school-age children. J Sleep Res. 2019;28(1):e12779. doi:10.1111/jsr.12779
  • Joo EY, Jeon S, Kim ST, Lee JM, Hong SB. Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep. 2013;36(8):1153–1162. doi:10.5665/sleep.2876
  • Roy B, Sahib AK, Kang D, Aysola RS, Kumar R. Brain tissue integrity mapping in adults with obstructive sleep apnea using T1-weighted and T2-weighted images. Ther Adv Neurol Disord. 2022;15:17562864221137505. doi:10.1177/17562864221137505
  • Parker JL, Melaku YA, D’Rozario AL, et al. The association between obstructive sleep apnea and sleep spindles in middle-aged and older men: a community-based cohort study. Sleep. 2022;45(3):zsab282. doi:10.1093/sleep/zsab282
  • Parker JL, Appleton SL, Adams RJ, et al. The association between sleep spindles and cognitive function in middle-aged and older men from a community-based cohort study. Sleep Health. 2023;9(5):774–785. doi:10.1016/j.sleh.2023.03.007
  • Yeager BE, Bruss J, Duffau H, et al. Central precuneus lesions are associated with impaired executive function. Brain Struct Funct. 2022;227(9):3099–3108. doi:10.1007/s00429-022-02556-0
  • Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ. β-alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals. J Int Soc Sports Nutr. 2018;15(1):32. doi:10.1186/s12970-018-0238-7
  • Hwang JY, Kim N, Kim S, et al. Stroop task-related brain activity in patients with insomnia: changes after cognitive-behavioral therapy for insomnia. Behav Sleep Med. 2019;17(5):621–633. doi:10.1080/15402002.2018.1435546
  • D’Rozario AL, Dungan GC 2nd, Banks S, et al. An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing. Sleep Breath. 2015;19(2):607–615. doi:10.1007/s11325-014-1056-z
  • Ronneberger O, Fischer P, Brox T. U-net: convolutional networks for biomedical image segmentation. In: Navab N, Hornegger J, Wells W, Frangi A, editors. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. Lecture Notes in Computer Science. 9351. Cham: Springer; 2015. 234–241—.
  • Kaulen L, Schwabedal JTC, Schneider J, Ritter P, Bialonski S. Advanced sleep spindle identification with neural networks. Sci Rep. 2022;12(1):7686. doi:10.1038/s41598-022-11210-y
  • Yaffe K, Laffan AM, Harrison SL, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306(6):613–619. doi:10.1001/jama.2011.1115
  • Shieu MM, Dunietz GL, Paulson HL, Chervin RD, Braley TJ. The association between obstructive sleep apnea risk and cognitive disorders: a population-based study. J Clin Sleep Med. 2022;18(4):1177–1185. doi:10.5664/jcsm.9832
  • Olaithe M, Bucks RS, Hillman DR, Eastwood PR. Cognitive deficits in obstructive sleep apnea: insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation. Sleep Med Rev. 2018;38:39–49. doi:10.1016/j.smrv.2017.03.005
  • Crawford-Achour E, Dauphinot V, Martin MS, et al. Protective effect of long-term CPAP therapy on cognitive performance in elderly patients with severe osa: the proof study. J Clin Sleep Med. 2015;11(5):519–524. doi:10.5664/jcsm.4694
  • D’Rozario AL, Hoyos CM, Wong KKH, et al. Improvements in cognitive function and quantitative sleep electroencephalogram in obstructive sleep apnea after six months of continuous positive airway pressure treatment. Sleep. 2022;45(6):zsac013. doi:10.1093/sleep/zsac013
  • Taillard J, Sagaspe P, Berthomier C, et al. Non-REM sleep characteristics predict early cognitive impairment in an aging population. Front Neurol. 2019;10:197. doi:10.3389/fneur.2019.00197
  • Dunietz GL, Chervin RD, Burke JF, Conceicao AS, Braley TJ. Obstructive sleep apnea treatment and dementia risk in older adults. Sleep. 2021;44(9):zsab076. doi:10.1093/sleep/zsab076
  • Li Y, Owens RL, Sands S, et al. The effect of donepezil on arousal threshold and apnea-hypopnea index. a randomized, double-blind, cross-over study. Ann Am Thorac Soc. 2016;13(11):2012–2018. doi:10.1513/AnnalsATS.201605-384OC
  • Borghesani PR, Madhyastha TM, Aylward EH, et al. The association between higher order abilities, processing speed, and age are variably mediated by white matter integrity during typical aging. Neuropsychologia. 2013;51(8):1435–1444. doi:10.1016/j.neuropsychologia.2013.03.005
  • Hadar L, Trope Y, Ben-David BM. Aging impairs inhibitory control over incidental cues: a construal-level perspective. Psychol Sci. 2021;32(9):1442–1451. doi:10.1177/0956797621998316
  • Jia J, Wang F, Wei C, et al. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement. 2014;10(1):1–9. doi:10.1016/j.jalz.2013.01.012
  • Jia F, Li Y, Li M, Cao F. Subjective cognitive decline, cognitive reserve indicators, and the incidence of dementia. J Am Med Dir Assoc. 2021;22(7):1449–1455. doi:10.1016/j.jamda.2020.08.005
  • Olaithe M, Pushpanathan M, Hillman D, et al. Cognitive profiles in obstructive sleep apnea: a cluster analysis in sleep clinic and community samples. J Clin Sleep Med. 2020;16(9):1493–1505. doi:10.5664/jcsm.8564
  • Stern Y, Habeck C, Moeller J, S, et al. Brain networks associated with cognitive reserve in healthy young and old adults. Cereb Cortex. 2005;15(4):394–402. doi:10.1093/cercor/bhh142
  • Ferreira D, Machado A, Molina Y, et al. Cognitive variability during middle-age: possible association with neurodegeneration and cognitive reserve. Front Aging Neurosci. 2017;9:188. doi:10.3389/fnagi.2017.00188
  • Lavrencic LM, Richardson C, Harrison SL, et al. Is there a link between cognitive reserve and cognitive function in the oldest-old?. J Gerontol a Biol Sci Med Sci. 2018;73(4):499–505. doi:10.1093/gerona/glx140
  • Bonjean M, Baker T, Lemieux M, Timofeev I, Sejnowski T, Bazhenov M. Corticothalamic feedback controls sleep spindle duration in vivo. J Neurosci. 2011;31(25):9124–9134. doi:10.1523/JNEUROSCI.0077-11.2011
  • Pratt JA, Morris BJ. The thalamic reticular nucleus: a functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery. J Psychopharmacol. 2015;29(2):127–137. doi:10.1177/0269881114565805
  • Ferrarelli F, Tononi G. Reduced sleep spindle activity point to a TRN-MD thalamus-PFC circuit dysfunction in schizophrenia. Schizophr Res. 2017;180:36–43. doi:10.1016/j.schres.2016.05.023
  • Guadagni V, Byles H, Av T, et al. Association of sleep spindle characteristics with executive functioning in healthy sedentary middle-aged and older adults. J Sleep Res. 2021;30(2):e13037. doi:10.1111/jsr.13037