Association Between Sleep Apnea Syndrome and Osteoarthritis: Insights from Bidirectional Mendelian Randomization and Bioinformatics Analysis

References

• Benjafield AV, Ayas NT, Eastwood PR. et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7(8):687–698. doi:10.1016/S2213-2600(19)30198-5
   PubMed Web of Science ®Google Scholar
• Shobatake R, Ota H, Takahashi N, et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci. 2022;23(21):1. doi:10.3390/ijms232112957
   Web of Science ®Google Scholar
• Taylor SS, Hughes JM, Coffman CJ, et al. Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and Hip osteoarthritis. BMC Musculoskelet Disord. 2018;19(1):79. doi:10.1186/s12891-018-1993-y
   PubMedGoogle Scholar
• Gaspar LS, Sousa C, Alvaro AR, et al. Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: an unexpectable link? Pharmacol Res. 2021;164:105369. doi:10.1016/j.phrs.2020.105369
   PubMed Web of Science ®Google Scholar
• Kanbay A, Kokturk O, Pihtili A, et al. Obstructive sleep apnea is a risk factor for osteoarthritis. Tuberk Toraks. 2018;66:304–311. doi:10.5578/tt.57403
   PubMedGoogle Scholar
• Diaz K, Faverio P, Hospenthal A, et al. Obstructive sleep apnea is associated with higher healthcare utilization in elderly patients. Ann Thorac Med. 2014;9(2):92–98. doi:10.4103/1817-1737.128854
   PubMed Web of Science ®Google Scholar
• Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014; 23:R89–98.
   PubMed Web of Science ®Google Scholar
• Richmond RC, Davey Smith G. Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med. 2022;12(1):1. doi:10.1101/cshperspect.a040501
   Web of Science ®Google Scholar
• Emdin CA, Khera AV, Kathiresan S. Mendelian Randomization. JAMA. 2017;318(19):1925–1926. doi:10.1001/jama.2017.17219
   PubMed Web of Science ®Google Scholar
• Orru V, Steri M, Sidore C, et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet. 2020;52(10):1036–1045. doi:10.1038/s41588-020-0684-4
   PubMed Web of Science ®Google Scholar
• Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039–1049. doi:10.1002/art.1780290816
   PubMed Web of Science ®Google Scholar
• Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45(4):422–427, 427e421–e422. doi:10.1038/ng.2528
   Web of Science ®Google Scholar
• Palmer TM, Lawlor DA, Harbord RM, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21(3):223–242. doi:10.1177/0962280210394459
   PubMed Web of Science ®Google Scholar
• Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017;32(5):377–389. doi:10.1007/s10654-017-0255-x
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–314. doi:10.1002/gepi.21965
   PubMed Web of Science ®Google Scholar
• Verbanck M, Chen CY, Neale B, et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–698. doi:10.1038/s41588-018-0099-7
   PubMed Web of Science ®Google Scholar
• Silva A, Mello MT, Serrao PR, et al. Influence of obstructive sleep apnea in the functional aspects of patients with osteoarthritis. J Clin Sleep Med. 2018;14(02):265–270. doi:10.5664/jcsm.6950
   PubMedGoogle Scholar
• Mukandala G, Tynan R, Lanigan S, et al. The effects of hypoxia and inflammation on synaptic signaling in the CNS. Brain Sci. 2016;6(1):1. doi:10.3390/brainsci6010006
   Web of Science ®Google Scholar
• Seixas AA, Gyamfi L, Newsome V, et al. Moderating effects of sleep duration on diabetes risk among cancer survivors: analysis of the national health interview survey in the USA. Cancer Manag Res. 2018;10:4575–4580. doi:10.2147/CMAR.S177428
   PubMed Web of Science ®Google Scholar
• Zychowski KE, Sanchez B, Pedrosa RP, et al. Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells. Atherosclerosis. 2016;254:59–66. doi:10.1016/j.atherosclerosis.2016.09.017
   PubMed Web of Science ®Google Scholar
• Maniaci A, Iannella G, Cocuzza S, et al. Oxidative stress and inflammation biomarker expression in obstructive sleep apnea patients. J Clin Med. 2021;10(2):1. doi:10.3390/jcm10020277
   Web of Science ®Google Scholar
• Alsharif IA, Abd-Elsalam RM, Amer MS, et al. Crataegus sinaica defatted methanolic extract ameliorated monosodium iodoacetate-induced oxidative stress andinhibited inflammation in a rat model of osteoarthritis. Res Pharm Sci. 2022;17(5):493–507. doi:10.4103/1735-5362.355209
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yang X, Li S, et al. sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-alpha and enhances their efficacy in alleviating inflammatory arthritis. Stem Cell Res Ther. 2021;12(1):535. doi:10.1186/s13287-021-02602-4
   PubMed Web of Science ®Google Scholar
• Schenker N, Chung DU, Burger H, et al. Safety and efficacy of excimer laser powered lead extractions in obese patients: a GALLERY subgroup analysis. J Clin Med. 2023;12(12):2. doi:10.3390/jcm12124096
   Web of Science ®Google Scholar
• Guo Q, Chen X, Chen J, et al. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-kappaB signaling pathway. Cell Death Dis. 2021;12(1):13. doi:10.1038/s41419-020-03341-9
   PubMed Web of Science ®Google Scholar
• Giesler A, Mukherjee M, Radford K, et al. Modulation of human airway smooth muscle biology by human adipocytes. Respir Res. 2018;19(1):33. doi:10.1186/s12931-018-0741-z
   PubMedGoogle Scholar
• Liao J, Chen J, Xu W, et al. Prevalence and associations of sarcopenia, obesity and sarcopenic obesity in end-stage knee osteoarthritis patients. J Health Popul Nutr. 2023;42(1):108. doi:10.1186/s41043-023-00438-7
   PubMed Web of Science ®Google Scholar
• da Silva NC, da Silva G, Onofri SMM, et al. Obstructive sleep apnea and orofacial myofunctional aspects in obesity. Sleep Breath. 2023;27(4):1351–1358. doi:10.1007/s11325-022-02738-4
   PubMed Web of Science ®Google Scholar
• Fiedorczuk P, Olszewska E, Polecka A, et al. Investigating the role of serum and plasma IL-6, IL-8, IL-10, TNF-alpha, CRP, and S100B concentrations in obstructive sleep apnea diagnosis. Int J Mol Sci. 2023;24(18):13875. doi:10.3390/ijms241813875
   PubMed Web of Science ®Google Scholar
• Luo Y, Zhang FR, Wu JL, et al. Efficacy of continuous positive airway pressure on TNF-alpha in obstructive sleep apnea patients: a meta-analysis. PLoS One. 2023;18:e0282172.
   PubMed Web of Science ®Google Scholar
• Kammermann JR, Kincaid SA, Rumph PF, et al. Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. Osteoarthritis Cartilage. 1996;4(1):23–34. doi:10.1016/S1063-4584(96)80004-5
   PubMed Web of Science ®Google Scholar
• Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 2010;18(11):1441–1447. doi:10.1016/j.joca.2010.08.016
   PubMed Web of Science ®Google Scholar
• Hussein MR, Fathi NA, El-Din AM, et al. Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations. Pathol Oncol Res. 2008;14(3):321–328. doi:10.1007/s12253-008-9016-1
   PubMed Web of Science ®Google Scholar
• Yi M, Zhao W, Fei Q, et al. Causal analysis between altered levels of interleukins and obstructive sleep apnea. Front Immunol. 2022;13:888644. doi:10.3389/fimmu.2022.888644
   PubMed Web of Science ®Google Scholar
• Huang YS, Guilleminault C, Hwang FM, et al. Inflammatory cytokines in pediatric obstructive sleep apnea. Medicine. 2016;95(41):e4944. doi:10.1097/MD.0000000000004944
   PubMed Web of Science ®Google Scholar
• Ni K, Zhao L, Wu J, et al. Th17/Treg balance in children with obstructive sleep apnea syndrome and the relationship with allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2015;79(9):1448–1454. doi:10.1016/j.ijporl.2015.06.026
   PubMed Web of Science ®Google Scholar
• Wu TJ, Chang SL, Lin CY, et al. IL-17 facilitates VCAM-1 production and monocyte adhesion in osteoarthritis synovial fibroblasts by suppressing miR-5701 synthesis. Int J Mol Sci. 2022;23(12). doi:10.3390/ijms23126804
   Web of Science ®Google Scholar
• Fang Y, Su J, Zhao C, et al. Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: a retrospective study. J Clin Lab Anal. 2023;37:e24499.
   PubMed Web of Science ®Google Scholar
• Li D, Xu N, Hou Y, et al. Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway. Mol Med. 2022;28(1):3. doi:10.1186/s10020-021-00427-8
   PubMed Web of Science ®Google Scholar
• Gkretsi V, Simopoulou T, Tsezou A. Lipid metabolism and osteoarthritis: lessons from atherosclerosis. Prog Lipid Res. 2011;50(2):133–140. doi:10.1016/j.plipres.2010.11.001
   PubMed Web of Science ®Google Scholar
• Kasasbeh E, Chi DS, Krishnaswamy G. Inflammatory aspects of sleep apnea and their cardiovascular consequences. South Med J. 2006;99(1):58–67; quiz 68–59, 81. doi:10.1097/01.smj.0000197705.99639.50
   Web of Science ®Google Scholar
• Su MS, Xu L, Xu K, et al. Association of T lymphocyte immune imbalance and IL-10 gene polymorphism with the risk of obstructive sleep apnea in children with obesity. Sleep Breath. 2017;21(4):929–937. doi:10.1007/s11325-017-1504-7
   PubMed Web of Science ®Google Scholar
• Yang J, Wang HX, Xie J, et al. DGK alpha and zeta activities control T(H)1 and T(H)17 cell differentiation. Front Immunol. 2019;10:3048. doi:10.3389/fimmu.2019.03048
   PubMed Web of Science ®Google Scholar
• Jaskiewicz L, Chmielewski G, Kuna J, et al. The role of sclerostin in rheumatic diseases: a review. J Clin Med. 2023;12(19):6248. doi:10.3390/jcm12196248
   PubMed Web of Science ®Google Scholar
• Chow YY, Chin KY. The role of inflammation in the pathogenesis of osteoarthritis. Mediators Inflamm. 2020;2020:8293921. doi:10.1155/2020/8293921
   PubMed Web of Science ®Google Scholar
• Yamazaki S, Tanaka Y, Araki H, et al. The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep. 2017;7(1):17402. doi:10.1038/s41598-017-17597-3
   PubMedGoogle Scholar
• Lin Z, Miao J, Zhang T, et al. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Aging Cell. 2021;20(2):e13306. doi:10.1111/acel.13306
   PubMed Web of Science ®Google Scholar
• Collins JA, Kim CJ, Coleman A, et al. Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice. Ann Rheum Dis. 2023;82(11):1464–1473. doi:10.1136/ard-2023-224385
   PubMed Web of Science ®Google Scholar
• Li X, Wang Z, Tong H, et al. Effects of COL8A1 on the proliferation of muscle-derived satellite cells. Cell Biol Int. 2018;42(9):1132–1140. doi:10.1002/cbin.10979
   PubMed Web of Science ®Google Scholar