986
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Investigating the Impact of Kratom (Mitragyna speciosa) Use Upon Male Sexual Health

ORCID Icon, ORCID Icon, , , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 69-76 | Received 23 Sep 2022, Accepted 20 Jan 2023, Published online: 10 Feb 2023

References

  • Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa Korth). Addiction. 2008;103(6):1048–1050. doi:10.1111/j.1360-0443.2008.02209.x
  • Eastlack SC, Cornett EM, Kaye AD. Kratom-pharmacology, clinical implications, and outlook: a comprehensive review. Pain Ther. 2020;9(1):55–69. doi:10.1007/s40122-020-00151-x
  • Grundmann O. Patterns of Kratom use and health impact in the US-Results from an online survey. Drug Alcohol Depend. 2017;176:63–70. doi:10.1016/j.drugalcdep.2017.03.007
  • Covvey JR, Vogel SM, Peckham AM, Evoy KE. Prevalence and characteristics of self-reported kratom use in a representative US general population sample. J Addict Dis. 2020;38(4):506–513. doi:10.1080/10550887.2020.1788914
  • Kruegel AC, Gassaway MM, Kapoor A, et al. Synthetic and receptor signaling explorations of the Mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators. J Am Chem Soc. 2016;138(21):6754–6764. doi:10.1021/jacs.6b00360
  • Yamamoto LT, Horie S, Takayama H, et al. Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa. Gen Pharmacol. 1999;33(1):73–81. doi:10.1016/S0306-3623(98)00265-1
  • Matsumoto K, Horie S, Ishikawa H, et al. Antinociceptive effect of 7-hydroxymitragynine in mice: discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sci. 2004;74(17):2143–2155. doi:10.1016/j.lfs.2003.09.054
  • Kruegel AC, Uprety R, Grinnell SG, et al. 7-hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects. ACS Cent Sci. 2019;5(6):992–1001. doi:10.1021/acscentsci.9b00141
  • Matsumoto K, Horie S, Takayama H, et al. Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa. Life Sci. 2005;78(1):2–7. doi:10.1016/j.lfs.2004.10.086
  • Hsieh A, DiGiorgio L, Fakunle M, Sadeghi-Nejad H. Management strategies in opioid abuse and sexual dysfunction: a review of opioid-induced androgen deficiency. Sex Med Rev. 2018;6(4):618–623. doi:10.1016/j.sxmr.2018.04.003
  • Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer. 2004;100(4):851–858. doi:10.1002/cncr.20028
  • Rubinstein AL, Carpenter DM, Minkoff JR. Hypogonadism in men with chronic pain linked to the use of long-acting rather than short-acting opioids. Clin J Pain. 2013;29(10):840–845. doi:10.1097/AJP.0b013e31827c7b5d
  • Safarinejad MR, Asgari SA, Farshi A, et al. The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity. Reprod Toxicol. 2013;36:18–23. doi:10.1016/j.reprotox.2012.11.010
  • Martyn-St James M, Cooper K, Kaltenthaler E, et al. Tramadol for premature ejaculation: a systematic review and meta-analysis. BMC Urol. 2015;15:6. doi:10.1186/1471-2490-15-6
  • Ciocanel O, Power K, Eriksen A. Interventions to treat erectile dysfunction and premature ejaculation: an overview of systematic reviews. Sex Med. 2019;7(3):251–269. doi:10.1016/j.esxm.2019.06.001
  • Smith KE, Lawson T. Prevalence and motivations for kratom use in a sample of substance users enrolled in a residential treatment program. Drug Alcohol Depend. 2017;180:340–348. doi:10.1016/j.drugalcdep.2017.08.034
  • Nicewonder JA, Buros AF, Veltri CA, Grundmann O. Distinct kratom user populations across the United States: a regional analysis based on an online survey. Hum Psychopharmacol. 2019;34(5):e2709. doi:10.1002/hup.2709
  • Schimmel J, Amioka E, Rockhill K, et al. Prevalence and description of kratom (Mitragyna speciosa) use in the United States: a cross-sectional study. Addiction. 2020; 116(1):176–181.
  • Grundmann O, Babin JK, Henningfield JE, et al. Kratom use in the United States: a diverse and complex profile. Addiction. 2020;116:202–203. doi:10.1111/add.15173
  • Vicknasingam B, Narayanan S, Beng GT, Mansor SM. The informal use of ketum (Mitragyna speciosa) for opioid withdrawal in the northern states of Peninsular Malaysia and implications for drug substitution therapy. Int J Drug Policy. 2010;21(4):283–288. doi:10.1016/j.drugpo.2009.12.003
  • Ahmad K, Aziz Z. Mitragyna speciosa use in the northern states of Malaysia: a cross-sectional study. J Ethnopharmacol. 2012;141(1):446–450. doi:10.1016/j.jep.2012.03.009
  • Veltri C, Grundmann O. Current perspectives on the impact of Kratom use. Subst Abuse Rehabil. 2019;10:23–31. doi:10.2147/SAR.S164261
  • Saingam D, Assanangkornchai S, Geater AF, Balthip Q. Pattern and consequences of kratom (Mitragyna speciosa Korth.) use among male villagers in southern Thailand: a qualitative study. Int J Drug Policy. 2013;24(4):351–358. doi:10.1016/j.drugpo.2012.09.004
  • LaBryer L, Sharma R, Chaudhari KS, Talsania M, Scofield RH. Kratom, an emerging drug of abuse, Raises prolactin and causes secondary hypogonadism: case report. J Investig Med High Impact Case Rep. 2018;6:2324709618765022. doi:10.1177/2324709618765022
  • Singh DGO, Murugaiyah V, Rahim AB, Balasingam V. Improved sexual functioning of long-term daily users of Mitragyna speciosa (Korth). J Herb Med. 2019;19:100293.
  • Symonds T, Perelman MA, Althof S, et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol. 2007;52(2):565–573. doi:10.1016/j.eururo.2007.01.028
  • Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B. Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung. 1996;46(11):1029–1036.
  • Szkutnik-Fiedler D, Kus K, Balcerkiewicz M, et al. Concomitant use of tramadol and venlafaxine - evaluation of antidepressant-like activity and other behavioral effects in rats. Pharmacol Rep. 2012;64(6):1350–1358. doi:10.1016/S1734-1140(12)70932-5
  • Bar-Or D, Salottolo KM, Orlando A, Winkler JV, Tramadol OD. A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol. 2012;61(4):736–743. doi:10.1016/j.eururo.2011.08.039
  • Eggleston W, Stoppacher R, Suen K, Marraffa JM, Nelson LS. Kratom Use and Toxicities in the United States. Pharmacotherapy. 2019;39(7):775–777. doi:10.1002/phar.2280