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Case Report

Radiation-Induced Coronary Artery Disease During Immune Checkpoint Inhibitor Therapy: A Case Report

, & ORCID Icon
Pages 359-370 | Received 02 Apr 2023, Accepted 05 Jan 2024, Published online: 05 Feb 2024

References

  • Ravenholt RT . California chiropractors. An epidemiological study of causes of death among them and other characteristics. Calif. Med.101(5), 341–347 (1964).
  • Donnellan E , PhelanD, McCarthyCP, CollierP, DesaiM, GriffinB. Radiation-induced heart disease: a practical guide to diagnosis and management. Cleve. Clin. J. Med.83(12), 914–922 (2016).
  • Fajardo LF , StewartJR. Experimental radiation-induced heart disease. I. Light microscopic studies. Am. J. Pathol.59(2), 299–316 (1970).
  • Pedersen LN , SchifferW, MitchellJD, BergomC. Radiation-induced cardiac dysfunction: practical implications. Kardiol. Pol. 80(3), 256–265 (2022).
  • Garg A , KumarP. Dosimetric comparison of the heart and left anterior descending artery in patients with left breast cancer treated with three-dimensional conformal and intensity-modulated radiotherapy. Cureus14(1), e21108 (2022).
  • Pezner RD . Coronary artery disease and breast radiation therapy. Int. J. Radiat. Oncol. Biol. Phys.86(5), 816–818 (2013).
  • Darby SC , EwertzM, McgalePet al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N. Engl. J. Med.368(11), 987–998 (2013).
  • Lancellotti P , NkomoVT, BadanoLPet al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J. Am. Soc. Echocardiogr.26(9), 1013–1032 (2013).
  • Atkins KM , BittermanDS, ChaunzwaTLet al. Mean heart dose is an inadequate surrogate for left anterior descending coronary artery dose and the risk of major adverse cardiac events in lung cancer radiation therapy. Int. J. Radiat. Oncol. Biol. Phys.110(5), 1473–1479 (2021).
  • Atkins KM , RawalB, ChaunzwaTLet al. Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer. J. Am. Coll. Cardiol.73(23), 2976–2987 (2019).
  • van Nimwegen FA , SchaapveldM, CutterDJet al. Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma. J. Clin. Oncol.34(3), 235–43 (2016).
  • Van Nimwegen FA , SchaapveldM, JanusCPet al. Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern. Med.175(6), 1007–1017 (2015).
  • Al-Kindi SG , OliveiraGH. Prevalence of preexisting cardiovascular disease in patients with different types of cancer: the unmet need for onco-cardiology. Mayo Clin. Proc.91(1), 81–83 (2016).
  • Atkins KM , ChaunzwaTL, LambaNet al. Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non-small cell lung cancer. JAMA Oncol.7(2), 206–219 (2021).
  • Zhang Z , LiuX, ChenD, YuJ. Radiotherapy combined with immunotherapy: the dawn of cancer treatment. Signal Transduct. Target. Ther.7(1), 258 (2022).
  • Du S , ZhouL, AlexanderGSet al. PD-1 modulates radiation-induced cardiac toxicity through cytotoxic T lymphocytes. J. Thorac. Oncol.13(4), 510–520 (2018).
  • Yegya-Raman N , LeeSH, FriedesCet al. Cardiac radiation dose is associated with inferior survival but not cardiac events in patients with locally advanced non-small cell lung cancer in the era of immune checkpoint inhibitor consolidation. Radiother. Oncol.190, 110005 (2024).
  • Lyon AR , López-FernándezT, CouchLSet al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur. Heart J. Cardiovasc. Imaging23(10), e333–e465 (2022).
  • Saro H , Armenianet al. Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. JCO35, 893–911 (2017).
  • Lyon AR , YousafN, BattistiNML, MoslehiJ, LarkinJ. Immune checkpoint inhibitors and cardiovascular toxicity. Lancet Oncol.19(9), e447–e458 (2018).
  • Chang HM , MoudgilR, ScarabelliT, OkwuosaTM, YehETH. Cardiovascular complications of cancer therapy: best practices in diagnosis, prevention, and management: part 1. J. Am. Coll. Cardiol.70(20), 2536–2551 (2017).
  • Virmani R , FarbA, CarterAJ, JonesRM. Comparative pathology: radiation-induced coronary artery disease in man and animals. Semin. Interv. Cardiol. 3(3–4), 163–172 (1998).
  • Jaworski C , MarianiJA, WheelerG, KayeDM. Cardiac complications of thoracic irradiation. J. Am. Coll. Cardiol.61(23), 2319–2328 (2013).
  • Balanescu DV , DonisanT, DayahTet al. Refractory radiation-induced coronary artery disease: mapping the path and guiding treatment with optical coherence tomography. Int. J. Cardiovasc. Imaging35(5), 759–760 (2019).
  • Hussey P , WuI, JohnstonT. 2018 ACC/HRS/NASCI/SCAI/SCCT expert consensus document on optimal use of ionizing radiation in cardiovascular imaging: best practices for safety and effectiveness – a review for the cardiac anesthesiologist. J. Cardiothorac. Vasc. Anesth.33(11), 2902–2908 (2019).
  • Venkatesulu BP , MahadevanLS, AliruMLet al. Radiation-induced endothelial vascular injury: a review of possible mechanisms. JACC Basic Transl. Sci.3(4), 563–572 (2018).
  • Cuomo JR , JavaheriSP, SharmaGK, KapoorD, BermanAE, WeintraubNL. How to prevent and manage radiation-induced coronary artery disease. Heart104(20), 1647–1653 (2018).
  • Orzan F , BruscaA, ConteMR, PresbiteroP, FigliomeniMC. Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment. Br. Heart J.69(6), 496–500 (1993).
  • Om A , VetrovecGW. Coronary angioplasty of radiation-induced stenosis. Am. Heart J.125(4), 1164–1166 (1993).
  • McEniery PT , DorostiK, SchiavoneWA, PedrickTJ, SheldonWC. Clinical and angiographic features of coronary artery disease after chest irradiation. Am. J. Cardiol.60(13), 1020–1024 (1987).
  • Ruiz CR , Mesa-PabónM, SotoK, RománJH, López-CandalesA. Radiation-induced coronary artery disease in young patients. Heart Views19(1), 23–26 (2018).
  • Levine GN , BatesER, BlankenshipJCet al. 2011 ACCF/AHA/SCAI Guideline for percutaneous coronary intervention: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheter Cardiovasc. Interv.79(3), 453–495 (2012).
  • Gaya AM , AshfordRF. Cardiac complications of radiation therapy. Clin. Oncol. (R. Coll. Radiol.)17(3), 153–159 (2005).
  • Dezorzi C . Radiation-induced coronary artery disease and its treatment: a quick review of current evidence. Cardiol. Res. Pract.2018, 8367268 (2018).
  • Darby SC , CutterDJ, BoermaMet al. Radiation-related heart disease: current knowledge and future prospects. Int. J. Radiat. Oncol. Biol. Phys.76(3), 656–665 (2010).
  • Bradley JD , HuC, KomakiRRet al. Long-term results of NRG oncology RTOG 0617: standard-versus high-dose chemoradiotherapy with or without cetuximab for unresectable stage III non-small-cell lung cancer. J. Clin. Oncol.38(7), 706 (2020).
  • Lee SH , GengH, ArnoldJet al. Interpretable Machine Learning for Choosing Radiation Dose-volume Constraints on Cardio-pulmonary Substructures Associated with Overall Survival in NRG Oncology RTOG 0617. Int. J. Radiat. Oncol. Biol. Phys.117(5), 1270–1286 (2023).
  • Demirci S , NamJ, HubbsJL, NguyenT, MarksLB. Radiation-induced cardiac toxicity after therapy for breast cancer: interaction between treatment era and follow-up duration. Int. J. Radiat. Oncol. Biol. Phys.73(4), 980–987 (2009).
  • Rehammar JC , JensenMB, McGalePet al. Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977–2005. Radiother. Oncol.123(2), 299–305 (2017).
  • Yeboa DN , EvansSB. Contemporary breast radiotherapy and cardiac toxicity. Semin. Radiat. Oncol.26(1), 71–78 (2016).
  • Marks LB , YorkeED, JacksonAet al. Use of normal tissue complication probability models in the clinic. Int. J. Radiat. Oncol. Biol. Phys.76(Suppl. 3), S10–S19 (2010).
  • Brown KN , HussainK, RichardsJR. Radiation induced coronary artery disease. In: StatPearls.StatPearls Publishing, FL, USA (2022).
  • Task Force Members , MontalescotG, SechtemUet al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur. Heart J.34(38), 2949–3003 (2013).
  • Visseren FLJ , MachF, SmuldersYMet al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur. Heart J.42(34), 3227–3337 (2021).
  • Wei J , XuH, LiuY, LiB, ZhouF. Effect of captopril on radiation-induced TGF-β1 secretion in EA.Hy926 human umbilical vein endothelial cells. Oncotarget8(13), 20842–20850 (2017).
  • Wilkinson EL , SidawayJE, CrossMJ. Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. J. Cell. Physiol.233(1), 186–200 (2018).
  • O’Herron T , LaffertyJ. Prophylactic use of colchicine in preventing radiation induced coronary artery disease. Med. Hypotheses111, 58–60 (2018).
  • Annest LS , AndersonRP, LiW, HafermannMD. Coronary artery disease following mediastinal radiation therapy. J. Thorac. Cardiovasc. Surg.85(2), 257–263 (1983).
  • Veeragandham RS , GoldinMD. Surgical management of radiation-induced heart disease. Ann. Thorac. Surg.65(4), 1014–1019 (1998).
  • Schömig K , NdrepepaG, MehilliJ, PacheJ, KastratiA, SchömigA. Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement. Catheter Cardiovasc. Interv. 70(3), 359–365 (2007).
  • Caio G . Myocarditis with immune checkpoint blockade. N. Engl. J. Med.376(3), 291–292 (2017).
  • Johnson DB , BalkoJM, ComptonMLet al. Fulminant myocarditis with combination immune checkpoint blockade. N. Engl. J. Med.375(18), 1749–1755 (2016).
  • Grabie N , LichtmanAH, PaderaR. T cell checkpoint regulators in the heart. Cardiovasc. Res.115(5), 869–877 (2019).
  • Wang WX , SongZZ, ZhangYP. Cardiovascular toxicities associated with immune checkpoint inhibitors. Zhonghua Zhong Liu Za Zhi42(7), 609–613 (2020).
  • Grabie N , GotsmanI, DacostaRet al. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation116(18), 2062–2071 (2007).
  • Libby P , RidkerPM, HanssonGK. Progress and challenges in translating the biology of atherosclerosis. Nature473(7347), 317–325 (2011).
  • Zhao TX , MallatZ. Targeting the immune system in atherosclerosis: JACC state-of-the-art review. J. Am. Coll. Cardiol.73(13), 1691–1706 (2019).
  • Bu DX , TarrioM, Maganto-GarciaEet al. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler. Thromb. Vasc. Biol.31(5), 1100–1107 (2011).
  • Foks AC , KuiperJ. Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis. Br. J. Pharmacol.174(22), 3940–3955 (2017).
  • Gelsomino F , FiorentinoM, ZompatoriMet al. Programmed death-1 inhibition and atherosclerosis: can nivolumab vanish complicated atheromatous plaques? Ann. Oncol. 29(1), 284–286 (2018).
  • Cautela J , RoubyF, SalemJEet al. Acute coronary syndrome with immune checkpoint inhibitors: a proof-of-concept case and pharmacovigilance analysis of a life-threatening adverse event. Can. J. Cardiol.36(4), 476–481 (2020).
  • Son C , MoeyMYY, WalkerPR, NaqashAR, PeachMS, JuAW. Cardiac toxicity in patients with lung cancer receiving thoracic radiotherapy and immunotherapy. Front. Oncol.12, 1025455 (2022).
  • Calabretta R , HoellerC, PichlerVet al. Immune checkpoint inhibitor therapy induces inflammatory activity in large arteries. Circulation142(24), 2396–2398 (2020).
  • Newman JL , StoneJR. Immune checkpoint inhibition alters the inflammatory cell composition of human coronary artery atherosclerosis. Cardiovasc. Pathol. 43, 107148 (2019).
  • Drobni ZD , AlviRM, TaronJet al. Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque. Circulation142(24), 2299–2311 (2020).
  • Cheng Y , NieL, MaW, ZhengB. Early onset acute coronary artery occlusion after pembrolizumab in advanced non-small cell lung cancer: a case report. Cardiovasc. Toxicol. 21(8), 683–686 (2021).
  • Antonia SJ , VillegasA, DanielDet al. Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N. Engl. J. Med.377(20), 1919–1929 (2017).
  • Jabbour SK , LeeKH, FrostNet al. Pembrolizumab plus concurrent chemoradiation therapy in patients with unresectable, locally advanced, stage III non-small cell lung cancer: the phase 2 KEYNOTE-799 nonrandomized trial. JAMA Oncol.7(9), 1–9 (2021).

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