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Pharmacogenomics Volume 25, 2024 - Issue 3
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Research Article

Workforce readiness for pharmacogenomics and key elements for sustainment within the Veterans Health Administration

Rebekah Ryanne Wu1 Division of General Internal Medicine, Precision Medicine Program, Department of Medicine, Duke University, Durham, NC27708, USA;2 Durham VA Medical Center, Durham, NC27705, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7655-3096
ORCID Icon,
Richelle Benevent3 IBM Consulting, Washington DC, WA20005, USA
,
Nina R Sperber1 Division of General Internal Medicine, Precision Medicine Program, Department of Medicine, Duke University, Durham, NC27708, USA;2 Durham VA Medical Center, Durham, NC27705, USA;4 Department of Population Health, Duke University, Durham, NC27708, USA
,
Jill S Bates2 Durham VA Medical Center, Durham, NC27705, USA;5 Department of Veterans Affairs, National Pharmacogenomics Program, Washington DC, WA20420, USA;6 Division of Practice Advancement & Clinical Education, Eschelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599, USA
,
Daniel Villa7 Titan Alpha, LLC, Chantilly, VA20151, USA
,
Dilhan Weeraratne3 IBM Consulting, Washington DC, WA20005, USA
,
Timothy A Burrell3 IBM Consulting, Washington DC, WA20005, USAORCID Iconhttps://orcid.org/0000-0001-7973-7803
ORCID Icon &
Deepak Voora1 Division of General Internal Medicine, Precision Medicine Program, Department of Medicine, Duke University, Durham, NC27708, USA;2 Durham VA Medical Center, Durham, NC27705, USA;5 Department of Veterans Affairs, National Pharmacogenomics Program, Washington DC, WA20420, USA;8 Department of Medicine, Division of Cardiology, Duke University, Durham, NC27708, USA
 show all
Pages 133-145 | Received 09 Oct 2023, Accepted 14 Feb 2024, Published online: 05 Mar 2024

References

  • RossS, KrebsK, PareG, MilaniL. Pharmacogenomics in stroke and cardiovascular disease: state of the art. Stroke 54(1), 270–278 (2023).
  • TalebiZ, SparreboomA, ColaceSI. Pharmacogenomics in cytotoxic chemotherapy of cancer. Methods Mol. Biol. 2547, 63–94 (2022).
  • ScudelerMM, ManochioC, BragaPinto AJ, SantosCirino HD, da SilvaCS, Rodrigues-SoaresF. Breast cancer pharmacogenetics: a systematic review. Pharmacogenomics 24(2), 107–122 (2023).
  • OslinDW, LynchKG, ShihMCet al. Effect of pharmacogenomic testing for drug–gene interactions on medication selection and remission of symptoms in major depressive disorder: the PRIME care randomized clinical trial. JAMA 328(2), 151–161 (2022).
  • SwenJJ, vander Wouden CH, MansonLEet al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 401(10374), 347–356 (2023).
  • RellingMV, KleinTE. CPIC: clinical pharmacogenetics implementation consortium of the pharmacogenomics research network. Clin. Pharmacol. Ther. 89(3), 464–467 (2011).
  • Clinical Pharmacogenetics Implementation Consortium Guidelines. https://cpicpgx.org/guidelines/ (Accessed 16 August 2023 ).
  • Dutch Pharmacogenetics Working Group Guidelines. www.knmp.nl/dossiers/farmacogenetica (Accessed 16 August 2023 ).
  • Chanfreau-CoffinierC, HullLE, LynchJAet al. Projected prevalence of actionable pharmacogenetic variants and level a drugs prescribed among US Veterans Health Administration Pharmacy users. JAMA Netw. Open 2(6), e195345 (2019).
  • MooreVR, GlassmanPA, AuA, GoodCB, LeadholmTC, CunninghamFE. Adverse drug reactions in the Veterans Affairs healthcare system: frequency, severity, and causative medications analyzed by patient age. Am. J. Health Syst. Pharm. 76(5), 312–319 (2019).
  • DongOM, BatesJ, Chanfreau-CoffinierCet al. Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program. Pharmacogenomics 22(3), 137–144 (2021).
  • EcclesMP, MittmanBS. Welcome to Implementation Science. Implemen. Sci. 1(1), 1 (2006).
  • DongOM, RobertsMC, WuRRet al. Evaluation of the Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program at initial test sites. Pharmacogenomics 22(17), 1121–1133 (2021).
  • WeinerBJ, LewisCC, StanickCet al. Psychometric assessment of three newly developed implementation outcome measures. Implemen. Sci. 12(1), 108 (2017).
  • ProctorE, SilmereH, RaghavanRet al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm. Policy Ment. Health 38(2), 65–76 (2011).
  • StecklerA, GoodmanRM, McLeroyKR, DavisS, KochG. Measuring the diffusion of innovative health promotion programs. Am. J. Health Promot. 6(3), 214–224 (1992).
  • RahawiS, NaikH, BlakeKVet al. Knowledge and attitudes on pharmacogenetics among pediatricians. J. Hum. Genet 65(5), 437–444 (2020).
  • OrlandoLA, SperberNR, VoilsCet al. Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network/’s Common Measures Working Group. Genet Med. 20(6), 655–663 (2018).
  • JohansenTaber KA, DickinsonBD. Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties. Pharmgenom. Pers. Med. 7, 145–162 (2014).
  • Dedoose Version 9.0.17, cloud application for managing, analyzing, and presenting qualitative and mixed method research data. SocioCultural Research Consultation, LLC (2021). www.dedoose.com
  • MeyerVM, BenjamensS, MoumniME, LangeJFM, PolRA. Global overview of response rates in patient and health care professional surveys in surgery: a systematic review. Ann. Surg. 275(1), e75–e81 (2022).
  • McLeodCC, KlabundeCN, WillisGB, StarkD. Health care provider surveys in the United States, 2000–2010: a review. Eval. Health Prof. 36(1), 106–126 (2013).
  • HaidarCE, PetryN, OxencisC, DouglasJS, HoffmanJM. ASHP statement on the pharmacist’s role in clinical pharmacogenomics. Am. J. Health Syst. Pharm. 79(8), 704–707 (2022).
  • WellsDL, PopishS, KayC, TorriseV, ChristopherMLD. VA academic detailing service: implementation and lessons learned. Fed. Pract. 33(5), 38–42 (2016).

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