IL-6 Gene Polymorphism Predicts PEGylated IFN-α Treatment Response in Hepatitis B Surface Antigen-Positive Chronic Hepatitis B Patients

References

• Nannini P , SokalEM. Hepatitis B: changing epidemiology and interventions. Arch. Dis. Child.102(7), 676–680 (2017).
   PubMed Web of Science ®Google Scholar
• Polaris Observatory Collaborators . Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol. Hepatol.3(6), 383–403 (2018).
   PubMed Web of Science ®Google Scholar
• Liu CJ , ChenPJ. Changing epidemiology of liver disease in Asia: dual infection of HBV and HCV. Liver Int.42(9), 1945–1954 (2022).
   PubMed Web of Science ®Google Scholar
• Sun J , HouJL. Management of chronic hepatitis B: experience from China. J. Viral Hepat.17(Suppl. 1), 10–17 (2010).
   PubMed Web of Science ®Google Scholar
• Wang FS . Current status and prospects of studies on human genetic alleles associated with hepatitis B virus infection. World J. Gastroenterol.9(4), 641–644 (2003).
   PubMed Web of Science ®Google Scholar
• Tang LSY , CovertE , WilsonE , KottililS. Chronic hepatitis B infection: a review. JAMA319(17), 1802–1813 (2018).
   PubMed Web of Science ®Google Scholar
• Jiang Y , HanQ , ZhaoH , ZhangJ. The mechanisms of HBV-induced hepatocellular carcinoma. J. Hepatocell. Carcinoma8, 435–450 (2021).
   PubMed Web of Science ®Google Scholar
• Fanning GC , ZoulimF , HouJ , BertolettiA. Therapeutic strategies for hepatitis B virus infection: towards a cure. Nat. Rev. Drug Discov.18(11), 827–844 (2019).
   PubMed Web of Science ®Google Scholar
• Zheng K , ZhangAM. Correlations between genetic polymorphism of IFN-lambda family gene and HBV infection, virus replication and clearance. Sheng Wu Gong Cheng Xue Bao38(3), 893–902 (2022).
   PubMedGoogle Scholar
• Ispiroglu M , BahceciogluIH , DemirelU , YalnizM. Impact of interleukin 28B rs12979860 C/T polymorphism on severity of disease and response to treatment in hepatitis delta. J. Infect. Dev. Ctries11(1), 58–64 (2017).
   PubMed Web of Science ®Google Scholar
• Abbas Z , YakoobJ , UmerMA , AbbasM , HamidS. Interferon lambda-3 polymorphism and response to pegylated interferon in patients with hepatitis D. Antivir. Ther.20(5), 529–533 (2015).
   PubMed Web of Science ®Google Scholar
• Wang L , ZouZQ , WangK. Clinical relevance of HLA gene variants in HBV infection. J. Immunol. Res.2016, 9069375 (2016).
   PubMed Web of Science ®Google Scholar
• Ben Dhifallah I , AyouniK , NajjarGet al. Interleukin IL-1B gene polymorphism in Tunisian patients with chronic hepatitis B infection: association with replication levels. Microbiol. Immunol.64(7), 512–519 (2020).
   PubMed Web of Science ®Google Scholar
• Ben Dhifallah I , AyouniK , JmelHet al. Strong association of functional polymorphism in IL-12B with susceptibility to chronic hepatitis B in Tunisia. J. Med. Virol.93(8), 4949–4956 (2021).
   PubMed Web of Science ®Google Scholar
• Nie G , XieCL , CaoYJet al. Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk. Genet. Mol. Res.15(2), doi:10.4238/gmr.15028255 (2016).
   Web of Science ®Google Scholar
• Popko K , GorskaE , DemkowU. Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance. Eur. J. Med. Res.15(Suppl. 2), 123–127 (2010).
   PubMedGoogle Scholar
• Katkam SK , RajasekharL , KumaraswamiK , KutalaVK. Association of IL-6 -174 G>C polymorphism with the risk of SLE among south Indians: evidence from case–control study and meta-analysis. Lupus26(14), 1491–1501 (2017).
   PubMed Web of Science ®Google Scholar
• Lan T , ChangL , WuL , YuanYF. IL-6 plays a crucial role in HBV infection. J. Clin. Transl. Hepatol.3(4), 271–276 (2015).
   PubMedGoogle Scholar
• Ito H . IL-6 and Crohn’s disease. Current drug targets. Curr. Drug Targets Inflamm. Allergy2(2), 125–130 (2003).
   PubMedGoogle Scholar
• Ogata A , KatoY , HigaS , YoshizakiK. IL-6 inhibitor for the treatment of rheumatoid arthritis: a comprehensive review. Mod. Rheumatol.29(2), 258–267 (2019).
   PubMed Web of Science ®Google Scholar
• Yang JR , WangJ , LiHM , GaoS , FanYC , WangK. IL-6 promoter hypomethylation acts as a diagnostic biomarker in hepatitis B virus-associated hepatocellular carcinoma. Front. Oncol.12, 746643 (2022).
   PubMed Web of Science ®Google Scholar
• Lv H , PanZ , HuSet al. [Relationship between CD4+CD25+Treg cells, Th17 cells and IL-6 and the prognosis of hepatitis B virus-related acute-on-chronic liver failure: a meta-analysis]. Zhonghua Gan Zang Bing Za Zhi22(7), 493–498 (2014).
   PubMedGoogle Scholar
• Schmidt-Arras D , Rose-JohnS. IL-6 pathway in the liver: from physiopathology to therapy. J. Hepatol.64(6), 1403–1415 (2016).
   PubMed Web of Science ®Google Scholar
• Yin Z , MaT , LinYet al. IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. J. Cell. Biochem.119(11), 9419–9432 (2018).
   PubMed Web of Science ®Google Scholar
• Lu S , WangY , WangYet al. The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk. J. Cell. Mol. Med.24(11), 6191–6207 (2020).
   PubMed Web of Science ®Google Scholar
• Wang F , WeiF , LiuHet al. Association of the IL-6 rs1800796 SNP with concentration/dose ratios of tacrolimus and donor liver function after transplantation. Immunol. Invest.50(8), 939–948 (2021).
   PubMed Web of Science ®Google Scholar
• Li M , ZhuoY , XuY , ChenH , ChengZ , ZhouL. Genetic association of interleukin-6 polymorphism (rs1800796) with chronic hepatitis B virus infection in Chinese Han population. Viral Immunol.34(4), 267–272 (2021).
   PubMed Web of Science ®Google Scholar
• Lu Y , PengJ , WangC , ZhuY , WangF , SunZ. IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection. Clin. Lab.60(11), 1903–1907 (2014).
   PubMed Web of Science ®Google Scholar
• Sarmati L , MalagninoV. HBV infection in HIV-driven immune suppression. Viruses11(11), 1077 (2019).
   PubMed Web of Science ®Google Scholar
• Li Q , SunB , ZhuoYet al. Interferon and interferon-stimulated genes in HBV treatment. Front. Immunol.13, 1034968 (2022).
   PubMed Web of Science ®Google Scholar
• Van Buuren N , RamirezR , TurnerSet al. Characterization of the liver immune microenvironment in liver biopsies from patients with chronic HBV infection. JHEP Rep.4(1), 100388 (2022).
   PubMedGoogle Scholar
• Wang YX , NiklaschM , LiuTet al. Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication. J. Hepatol.72(5), 865–876 (2020).
   PubMed Web of Science ®Google Scholar
• Qi X , LiF , ZhangYet al. STAT4 genetic polymorphism significantly affected HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients receiving Peginterferon-alpha therapy: a prospective cohort study in China. J. Med. Virol.94(9), 4449–4458 (2022).
   PubMed Web of Science ®Google Scholar
• Fateh A , AghasadeghiMR , KeyvaniHet al. High resolution melting curve assay for detecting rs12979860 IL28B polymorphisms involved in response of Iranian patients to chronic hepatitis C treatment. Asian Pac. J. Cancer Prev.16(5), 1873–1880 (2015).
   PubMedGoogle Scholar
• Madan K , BatraY , JhaJKet al. Clinical relevance of HBV DNA load in patients with chronic hepatitis B infection. Trop. Gastroenterol.29(2), 84–90 (2008).
   PubMedGoogle Scholar
• Romanelli RG , StasiC. Recent advancements in diagnosis and therapy of liver cirrhosis. Curr. Drug Targets17(15), 1804–1817 (2016).
   PubMed Web of Science ®Google Scholar
• Shang H , HuY , GuoHet al. Using machine learning models to predict HBeAg seroconversion in CHB patients receiving pegylated interferon-alpha monotherapy. J. Clin. Lab. Anal.36(11), e24667 (2022).
   PubMed Web of Science ®Google Scholar