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Editorial

Selenium: The Emerging Element in the Medicinal Chemist’s Toolkit

, ORCID Icon & ORCID Icon
Pages 493-496 | Received 05 Feb 2024, Accepted 06 Feb 2024, Published online: 20 Feb 2024

References

  • Rayman MP . Selenium and human health. Lancet379(9822), 1256–1268 (2012).
  • Hou W , XuH. Incorporating selenium into heterocycles and natural products-from chemical properties to pharmacological activities. J. Med. Chem.65(6), 4436–4456 (2022).
  • Wrobel JK , PowerR, ToborekM. Biological activity of selenium: revisited. IUBMB Life68(2), 97–105 (2016).
  • Leszczynska G , CyprykM, GostynskiBet al. C5-substituted 2-selenouridines ensure efficient base pairing with guanosine; consequences for reading the NNG-3′ synonymous mRNA codons. Int. J. Mol. Sci.21(8), 2882 (2020).
  • Hou W , DongH, ZhangX, WangY, SuL, XuH. Selenium as an emerging versatile player in heterocycles and natural products modification. Drug Discov. Today27(8), 2268–2277 (2022).
  • Alhasan R , NasimMJ, JacobC, GaucherC. Selenoneine: a unique reactive selenium species from the blood of tuna with implications for human diseases. Curr. Pharmacol. Reports.5(3), 163–173 (2019).
  • Feng X , PanL, QianZet al. Discovery of selenium-containing STING agonists as orally available antitumor agents. J. Med. Chem.65(22), 15048–15065 (2022).
  • Rech TDST , RibeiroEH, CastroETet al. Antidepressant potential of a functionalized 3-selanyl benzo[b]furan compound in mice: focus on the serotonergic system. ACS Chem. Neurosci.14(6), 1181–1192 (2023).
  • Deng X , XieB, LiQet al. Discovery of novel bicyclic phenylselenyl-containing hybrids: an orally bioavailable, potential, and multiacting class of estrogen receptor modulators against endocrine-resistant breast cancer. J. Med. Chem.65(11), 7993–8010 (2022).
  • Pyka P , HaberekW, WięcekMet al. First-in-class selenium-containing potent serotonin receptor 5-HT 6 agents with a beneficial neuroprotective profile against Alzheimer’s disease. J. Med. Chem.67(2), 1580–1610 (2024).
  • Bijian K , WernicD, NivedhaAKet al. Novel aurora A and protein kinase C (α, β1, β2 and θ) multitarget inhibitors: impact of selenium atoms on the potency and selectivity. J. Med. Chem.65(4), 3134–3150 (2022).
  • Kayrouz CM , HuangJ, HauserN, SeyedsayamdostMR. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature610(7930), 199–204 (2022).
  • Beletskaya IP , AnanikovVP. Transition-metal-catalyzed C–S, C–Se and C–Te bond formations via cross-coupling and atom-economic addition reactions. achievements and challenges. Chem. Rev.122(21), 16110–16293 (2022).
  • Zhang X , ChengF, GuoJ, ZhengS, WangX, LiS. Enzymatic synthesis of organoselenium compounds via C-Se bond formation mediated by sulfur carrier proteins. Nat. Synth. doi: 10.1038/s44160-023-00477-2 (2024) (Online).
  • Hou W , DongH, YaoYet al. Clickable selenylation - a paradigm for seleno-medicinal chemistry. ChemMedChem.17(17), e202200324 (2022).
  • Amporndanai K , MengX, ShangWet al. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nat. Commun.12(1), 3061 (2021).
  • Xu H , GuY, ZhangSet al. A chemistry for incorporation of selenium into DNA-encoded libraries. Angew. Chem. Int. Ed.59(32), 13273–13280 (2020).
  • Xu H , WangY, DongHet al. Selenylation chemistry suitable for on-plate parallel and on-DNA library synthesis enabling high-throughput medicinal chemistry. Angew. Chem. Int. Ed.61(35), e202206516 (2022).
  • Zhou Z , GuY, WuLet al. Organo-Se BTSAs-enabled performance: from racemic and asymmetric synthesis to click chemistry application. Chem.9(11), 3335–3346 (2023).
  • Brenner S , LernerRA. Encoded combinatorial chemistry. Proc. Natl Acad. Sci. USA89(12), 5381–5383 (1992).
  • Ma P , ZhangS, HuangQet al. Evolution of chemistry and selection technology for DNA-encoded library. Acta Pharm. Sin. B.14(2), 492–516 (2024).

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