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Bioscience, Biotechnology, and Biochemistry Volume 84, 2020 - Issue 12
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Biochemistry & Molecular Biology

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Tatsuro Kawamuraa RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, Saitama, Japan;b Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, GermanyView further author information
,
Yushi Futamurac Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, JapanView further author information
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Erchang Shangb Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, GermanyView further author information
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Makoto Muroia RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, Saitama, Japan;c Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, JapanView further author information
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Petra Janningb Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, GermanyView further author information
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Masayoshi Uenod Faculty of Science and Technology, Division of Molecular Science, Gunma University, Kiryu, Gunma, JapanView further author information
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Julian Wilkea RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, Saitama, Japan;b Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, Germany;e Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Dortmund, GermanyView further author information
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Shigeki Takedad Faculty of Science and Technology, Division of Molecular Science, Gunma University, Kiryu, Gunma, JapanView further author information
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Yasumitsu Kondohc Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, JapanView further author information
,
Slava Zieglerb Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, GermanyView further author information
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Nobumoto Watanabea RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, Saitama, JapanView further author information
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Herbert Waldmannb Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, Germany;e Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Dortmund, GermanyORCID Iconhttps://orcid.org/0000-0002-9606-7247View further author information
ORCID Icon &
Hiroyuki Osadaa RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN Center for Sustainable Resource Science, Saitama, Japan;c Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3606-4925View further author information
ORCID Icon show all
Pages 2484-2490 | Received 09 Jun 2020, Accepted 15 Aug 2020, Published online: 31 Aug 2020
Supplemental material

Table_S8._Proteomic_results_of_the_competition_pull-down_using_NPD9055-immobilized_photoaffinity_beads.xlsx

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Table_S7._Proteomic_results_of_the_competition_pull-down_using_affinity_probe_4__biological_replicate_2_.xlsx

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Table_S6._Proteomic_results_of_the_competition_pull-down_using_affinity_probe_4__biological_replicate_1_.xlsx

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Table_S4.NPD9055-induced_expression_change_and_subcellular_localization_of_each_protein_spot.xlsx

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Final_Kawamura_SI_BBB.docx

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