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Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
Dario A. T. Cramera Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
, Vojtech Franca Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
, Anna-Katharina Heidenreichc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
, Michaela Hookc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
, Mahdi Adibzadehd Pharma Technical Development, F. Hoffmann-La Roche AG, Basel, SwitzerlandView further author information
, Dietmar Reuschc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
, Albert J. R. Hecka Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
& Markus Habergerc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyCorrespondence[email protected]
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Article: 2175312
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Received 10 Oct 2022, Accepted 29 Jan 2023, Published online: 17 Feb 2023
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