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Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells
Emma KelsallCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKView further author information
, Claire HarrisCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKView further author information
, Titash SenCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKView further author information
, Diane HattonCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKView further author information
, Sarah DunnCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKCorrespondence[email protected]
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& View further author information
Suzanne GibsonCell Culture and Fermentation Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Cambridge, UKCorrespondence[email protected]
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Article: 2242548
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Received 12 Apr 2023, Accepted 26 Jul 2023, Published online: 09 Aug 2023
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