Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

Shufang Liua Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USAView further author information

Sara C. Humphreysa Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USAView further author information

Kevin D. Cooka Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USAView further author information

Kip P. Connera Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USAView further author information

Ana R. Correiab Therapeutic Discovery, Amgen, Thousand Oaks, CA, USAView further author information

Alex W. Jacobitzc Process Development, Amgen Inc, Thousand Oaks, CA, USAView further author information

Melissa Yangb Therapeutic Discovery, Amgen, Thousand Oaks, CA, USAView further author information

Ronya Primackd Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA, USAView further author information

Marcus Sotod Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA, USAView further author information

Rupa Padakic Process Development, Amgen Inc, Thousand Oaks, CA, USAView further author information

Mariusz Lubomirskie Global Biostatistical Science, Amgen Inc, Thousand Oaks, CA, USAView further author information

Richard Smitha Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USAView further author information

Marissa Mockb Therapeutic Discovery, Amgen, Thousand Oaks, CA, USAView further author information

Veena A. Thomasa Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USACorrespondence[email protected]

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