Drug Design, Development and Therapy, Volume 12, Issue (2018)

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Drug Design, Development and Therapy, Volume 12, Issue (2018)

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Original Research

Article
RETRACTED ARTICLE: Development of a nanoliposomal formulation of erlotinib for lung cancer and in vitro/in vivo antitumoral evaluation
Xiao Zhou, Hui Tao & Kai-Hu Shi
Pages: 1-8
Published online: 18 Dec 2017
AbstractforRETRACTED ARTICLE: Development of a nanoliposomal formulation of erlotinib for lung cancer and in vitro/in vivo antitumoral evaluation | PDF (5.4 MB)
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Open Access

Review

Review Article
HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience
Frank Dellanna, David Goldsmith, Andriy Krendyukov, Andreas Seidl, Nadja Höbel & Christian Combe
Pages: 9-14
Published online: 18 Dec 2017
AbstractforHX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience | Full Text | References | PDF (471 KB)
  • 107 Views
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Open Access

Original Research

Article
Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model
Kayleigh Wong, Guy Trudel & Odette Laneuville
Pages: 15-24
Published online: 21 Dec 2017
AbstractforIntra-articular collagenase injection increases range of motion in a rat knee flexion contracture model | Full Text | References | PDF (1.3 MB)
  • 150 Views
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Open Access

Review

Review Article
Leishmaniasis in humans: drug or vaccine therapy?
Masoud Ghorbani & Ramin Farhoudi
Pages: 25-40
Published online: 22 Dec 2017
AbstractforLeishmaniasis in humans: drug or vaccine therapy? | Full Text | References | PDF (369.2 KB)
  • 524 Views
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Open Access

Original Research

Article
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil
Sheng Zhu, Yu-Hui Yang, Rong-Wei Gao, Ran Li, Yu-Zhen Zou, Lei Feng & Bo Zhang
Pages: 41-45
Published online: 27 Dec 2017
AbstractforClinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil | Full Text | References | PDF (260.5 KB)
  • 64 Views
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Open Access
Article
Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice
Guoyin Zheng, Fengfeng Mo, Chen Ling, Hao Peng, Wei Gu, Min Li & Zhe Chen
Pages: 47-55
Published online: 28 Dec 2017
AbstractforPortulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice | Full Text | References | PDF (1.2 MB)
  • 187 Views
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Open Access
Article
The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation
Ning Chen, Xiao-yan Yang, Chang-e Guo, Xin-ning Bi, Jian-hua Chen, Hong-ying Chen, Hong-pin Li, Hong-ying Lin & Yu-jie Zhang
Pages: 57-65
Published online: 28 Dec 2017
AbstractforThe oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation | Full Text | References | PDF (1.4 MB)
  • 97 Views
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Open Access
Article
Quantitative assessment of the effects of chitosan intervention on blood pressure control
Haohai Huang, Ying Zou & Honggang Chi
Pages: 67-75
Published online: 28 Dec 2017
AbstractforQuantitative assessment of the effects of chitosan intervention on blood pressure control | Full Text | References | PDF (613.2 KB)
  • 120 Views
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Open Access
Article
Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway
Chuanjing Fu, Qi Wang, Xiaofu Zhai & Juemin Gao
Pages: 77-84
Published online: 05 Jan 2018
AbstractforSinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway | Full Text | References | PDF (1.7 MB)
  • 75 Views
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Open Access

Research Letter

Article
Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro
Christine Pierrot, Xiguang Zhang, Gigliola Zhangi, Aline Fréville, Angelita Rebollo & Jamal Khalife
Pages: 85-88
Published online: 09 Jan 2018
First Page PreviewforPeptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro | Full Text | References | PDF (517.3 KB)
  • 86 Views
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Open Access

Original Research

Article
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway
Hongxia Zhang, Yanlan Yang, Yanqin Wang, Baodong Wang & Rongshan Li
Pages: 89-98
Published online: 09 Jan 2018
AbstractforRenal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway | Full Text | References | PDF (2.2 MB)
  • 103 Views
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Open Access
Article
Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis
Gulixian Mahemuti, Hui Zhang, Jing Li, Nueramina Tieliwaerdi & Lili Ren
Pages: 99-120
Published online: 10 Jan 2018
AbstractforEfficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis | Full Text | References | PDF (3.8 MB)
  • 491 Views
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Open Access

Review

Review Article
Natural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism
Jian Li, Haiyang Yu, Sijian Wang, Wei Wang, Qian Chen, Yanmin Ma, Yi Zhang & Tao Wang
Pages: 121-135
Published online: 10 Jan 2018
AbstractforNatural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism | Full Text | References | PDF (15.8 MB)
  • 168 Views
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Open Access

Original Research

Article
Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway
Yuanyuan Han, Xuxia Wang, Dan Ma, Xiaoxiao Wu, Panpan Yang & Jun Zhang
Pages: 137-148
Published online: 11 Jan 2018
AbstractforIpriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway | Full Text | References | PDF (3 MB)
  • 118 Views
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Open Access
Article
Biological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs
Isnatin Miladiyah, Jumina Jumina, Sofia Mubarika Haryana & Mustofa Mustofa
Pages: 149-158
Published online: 15 Jan 2018
AbstractforBiological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs | Full Text | References | PDF (784.6 KB)
  • 551 Views
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Open Access
Article
Diminishing the side effect of mitomycin C by using pH-sensitive liposomes: in vitro characterization and in vivo pharmacokinetics
Yi-Ping Fang, Pei-Yu Hu & Yaw-Bin Huang
Pages: 159-169
Published online: 15 Jan 2018
AbstractforDiminishing the side effect of mitomycin C by using pH-sensitive liposomes: in vitro characterization and in vivo pharmacokinetics | Full Text | References | PDF (2.4 MB)
  • 124 Views
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Open Access
Article
Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation
Yonghao Feng, Long Chen, Qiong Luo, Men Wu, Yinghui Chen & Xiaohong Shi
Pages: 171-177
Published online: 17 Jan 2018
AbstractforInvolvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation | Full Text | References | PDF (1 MB)
  • 182 Views
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Open Access
Article
Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
Salim M Bastaki, Yousef M Abdulrazzaq, Mohamed Shafiullah, Małgorzata Więcek, Katarzyna Kieć-Kononowicz & Bassem Sadek
Pages: 179-194
Published online: 19 Jan 2018
AbstractforAnticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice | Full Text | References | PDF (1 MB)
  • 84 Views
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Open Access

Review

Review Article
Bispecific antibodies: design, therapy, perspectives
Sergey E Sedykh, Victor V Prinz, Valentina N Buneva & Georgy A Nevinsky
Pages: 195-208
Published online: 22 Jan 2018
AbstractforBispecific antibodies: design, therapy, perspectives | Full Text | References | PDF (918.7 KB)
  • 1858 Views
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Open Access
Review Article
Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma
Izak Faiena, Amy L Cummings, Anna M Crosetti, Allan J Pantuck, Karim Chamie & Alexandra Drakaki
Pages: 209-215
Published online: 23 Jan 2018
AbstractforDurvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma | Full Text | References | PDF (664.2 KB)
  • 167 Views
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Open Access

Original Research

Article
The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials
Tzu-Lin Yeh, Pei-Ching Shih, Shu-Jung Liu, Chao-Hsu Lin, Jui-Ming Liu, Wei-Te Lei & Chien-Yu Lin
Pages: 217-230
Published online: 25 Jan 2018
AbstractforThe influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (1.3 MB)
  • 229 Views
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Open Access
Article
Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin
Dehua Liao, Yujin Guo, Daxiong Xiang, Ruili Dang, Pengfei Xu, Hualin Cai, Lizhi Cao & Pei Jiang
Pages: 231-239
Published online: 30 Jan 2018
AbstractforDysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin | Full Text | References | PDF (2.9 MB)
  • 103 Views
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Open Access

Review

Review Article
Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data
Kendall Liner, Celeste Brown & Laura Y McGirt
Pages: 241-254
Published online: 31 Jan 2018
AbstractforClinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data | Full Text | References | PDF (338.2 KB)
  • 110 Views
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Original Research

Article
Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity
Shaimaa Ahmed, Thirumala Govender, Inamullah Khan, Nisar ur Rehman, Waqar Ali, Syed Muhammad Hassan Shah, Shahzeb Khan, Zahid Hussain, Riaz Ullah & Mansour S Alsaid
Pages: 255-269
Published online: 05 Feb 2018
AbstractforExperimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity | Full Text | References | PDF (1.8 MB)
  • 204 Views
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Open Access
Article
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Arne Reimers, Jon Andsnes Berg, Margrete Larsen Burns, Eylert Brodtkorb, Svein I Johannessen & Cecilie Johannessen Landmark
Pages: 271-280
Published online: 08 Feb 2018
AbstractforReference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines | Full Text | References | PDF (292.1 KB)
  • 236 Views
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Open Access

Review

Review Article
Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
Raffaela Zaffini, Giovanni Gotte & Marta Menegazzi
Pages: 281-293
Published online: 12 Feb 2018
AbstractforAsthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach | Full Text | References | PDF (708.7 KB)
  • 91 Views
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Open Access

Original Research

Article
Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients
Ho Joong Choi, Dong Goo Kim, Bong Jun Kwak, Jae Hyun Han, Tae Ho Hong & Young Kyoung You
Pages: 295-301
Published online: 13 Feb 2018
AbstractforComparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients | Full Text | References | PDF (654 KB)
  • 108 Views
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Open Access
Article
RETRACTED ARTICLE: Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity
Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Hani S Faidah, Muhammad Khurram, Muhammad Usman Amin, Abdul Haseeb & Maria Kakar
Pages: 303-312
Published online: 14 Feb 2018
AbstractforRETRACTED ARTICLE: Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity | PDF (1.9 MB)
  • 661 Views
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Open Access

Review

Review Article
Review of deutetrabenazine: a novel treatment for chorea associated with Huntington’s disease
Marissa Dean & Victor W Sung
Pages: 313-319
Published online: 15 Feb 2018
AbstractforReview of deutetrabenazine: a novel treatment for chorea associated with Huntington’s disease | Full Text | References | PDF (251.9 KB)
  • 582 Views
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Open Access
Review Article
Abemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2− advanced breast cancer
Silvia Paola Corona & Daniele Generali
Pages: 321-330
Published online: 16 Feb 2018
AbstractforAbemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2− advanced breast cancer | Full Text | References | PDF (384.4 KB)
  • 600 Views
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Open Access

Original Research

Article
Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects
Yu Kyong Kim, Kwang-Hee Shin, Jeffrey Alderman, Kyung-Sang Yu, In-Jin Jang & SeungHwan Lee
Pages: 331-337
Published online: 19 Feb 2018
AbstractforPharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects | Full Text | References | PDF (591.9 KB)
  • 100 Views
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Open Access
Article
Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy
Yuting Peng, Xiongze Zhang, Miaoling Li, Bing Liu, Lan Mi, Chengguo Zuo & Feng Wen
Pages: 339-345
Published online: 19 Feb 2018
AbstractforShort-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy | Full Text | References | PDF (383.8 KB)
  • 64 Views
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Open Access

Letter

Letter
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials
Iulian Alecu, Tsveta Milenkova & Simon R Turner
Pages: 347-348
Published online: 21 Feb 2018
CitationforRisk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials | Full Text | References | PDF (193 KB)
  • 95 Views
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Open Access

Original Research

Article
Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride
Muhammad Rouf Akram, Mahmood Ahmad, Asad Abrar, Rai Muhammad Sarfraz & Asif Mahmood
Pages: 349-364
Published online: 21 Feb 2018
AbstractforFormulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride | Full Text | References | PDF (3.1 MB)
  • 473 Views
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Open Access

Review

Review Article
Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis
Nongsak Chanasumon, Tueboon Sriphojanart & Poonkiat Suchonwanit
Pages: 365-372
Published online: 22 Feb 2018
AbstractforTherapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis | Full Text | References | PDF (385.7 KB)
  • 329 Views
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Original Research

Article
Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells
Xiaowen Zhang & Nan Wu
Pages: 373-381
Published online: 23 Feb 2018
AbstractforFasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells | Full Text | References | PDF (2.4 MB)
  • 76 Views
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Open Access
Article
RETRACTED ARTICLE: A novel ocular delivery of brinzolamide based on gellan gum: in vitro and in vivo evaluation
Jingfen Sun & Zhengshen Zhou
Pages: 383-389
Published online: 23 Feb 2018
AbstractforRETRACTED ARTICLE: A novel ocular delivery of brinzolamide based on gellan gum: in vitro and in vivo evaluation | PDF (1.6 MB)
  • 79 Views
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Open Access

Corrigendum

Correction
The role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials [Corrigendum]
Page: 391
Published online: 27 Feb 2018
CitationforThe role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials [Corrigendum] | Full Text | PDF (139.5 KB)
  • 56 Views
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Open Access

Original Research

Article
Integration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells
Yanhong Yang, Na Zhang, Kundong Li, Juan Chen, Lang Qiu & Jufeng Zhang
Pages: 393-408
Published online: 28 Feb 2018
AbstractforIntegration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells | Full Text | References | PDF (4.1 MB)
  • 129 Views
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Open Access
Article
Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?
Ebru Celik Kavak, Funda Gulcu Bulmus, Ozgur Bulmus, Salih Burcin Kavak & Nevin Kocaman
Pages: 409-415
Published online: 28 Feb 2018
AbstractforMagnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model? | Full Text | References | PDF (5.3 MB)
  • 101 Views
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Open Access

Review

Review Article
Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis
Tianyi Xia, Sang Zhu, Yan Wen, Shouhong Gao, Mingming Li, Xia Tao, Feng Zhang & Wansheng Chen
Pages: 417-428
Published online: 28 Feb 2018
AbstractforRisk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis | Full Text | References | PDF (948.5 KB)
  • 149 Views
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Open Access

Original Research

Article
Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation
Tom Ottoboni, Mary Rose Keller, Matt Cravets, Neil Clendeninn & Barry Quart
Pages: 429-435
Published online: 01 Mar 2018
AbstractforBioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation | Full Text | References | PDF (1.8 MB)
  • 181 Views
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Open Access
Article
Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis
Ling-Yun Liu, Yang Liu, Mei-Yan Wu, Yan-Yan Sun & Fu-Zhe Ma
Pages: 437-444
Published online: 02 Mar 2018
AbstractforEfficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis | Full Text | References | PDF (506.3 KB)
  • 109 Views
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Open Access
Article
Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis
Hua-feng Zhang, Chen-guang Wang, Hui Li, Yu-ting Huang & Zhi-jun Li
Pages: 445-453
Published online: 05 Mar 2018
AbstractforIntra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis | Full Text | References | PDF (469.1 KB)
  • 252 Views
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Open Access
Article
Combined application of tenuigenin and β-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer’s disease
Wenguang Chang & Junfang Teng
Pages: 455-462
Published online: 05 Mar 2018
AbstractforCombined application of tenuigenin and β-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer’s disease | Full Text | References | PDF (824.8 KB)
  • 79 Views
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Open Access
Article
Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis
Shu Yang, Zhihua Xing, Tao Liu, Jing Zhou, Qinghua Liang, Tao Tang, Hanjin Cui, Weijun Peng, Xingui Xiong & Yang Wang
Pages: 463-473
Published online: 06 Mar 2018
AbstractforSynovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis | Full Text | References | PDF (1.9 MB)
  • 112 Views
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Open Access
Article
Combination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer: a meta-analysis of randomized controlled trials
Jiamin Jin, Chunbo Teng & Tao Li
Pages: 475-480
Published online: 07 Mar 2018
AbstractforCombination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer: a meta-analysis of randomized controlled trials | Full Text | References | PDF (590.4 KB)
  • 87 Views
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Open Access
Article
Development of controlled release silicone adhesive-based mupirocin patch demonstrates antibacterial activity on live rat skin against Staphylococcus aureus
Sheba R David, Nurafiqah Malek, Abdul Hanif Mahadi, Srikumar Chakravarthi & Rajan Rajabalaya
Pages: 481-494
Published online: 08 Mar 2018
AbstractforDevelopment of controlled release silicone adhesive-based mupirocin patch demonstrates antibacterial activity on live rat skin against Staphylococcus aureus | Full Text | References | PDF (2.3 MB)
  • 232 Views
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Article
Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2
Weon Sup Lee, Sang Ryeol Shim, Seon Young Lee, Jin San Yoo & Sung Kweon Cho
Pages: 495-504
Published online: 08 Mar 2018
AbstractforPreclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2 | Full Text | References | PDF (814.5 KB)
  • 110 Views
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Article
Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
Kamil Kuca, Jana Zdarova Karasova, Ondrej Soukup, Jiri Kassa, Eva Novotna, Vendula Sepsova, Anna Horova, Jaroslav Pejchal, Martina Hrabinova, Eva Vodakova, Daniel Jun, Eugenie Nepovimova, Martin Valis & Kamil Musilek
Pages: 505-512
Published online: 09 Mar 2018
AbstractforDevelopment of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings | Full Text | References | PDF (1,008.1 KB)
  • 80 Views
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Article
Inhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo
Jiayang He, Ping Fang, Xiang Zheng, Chenchen Wang, Tenghui Liu, Bowen Zhang, Jian Wen & Ren-ai Xu
Pages: 513-519
Published online: 09 Mar 2018
AbstractforInhibitory effect of celecoxib on agomelatine metabolism in vitro and in vivo | Full Text | References | PDF (671 KB)
  • 88 Views
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Review

Review Article
Can dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis
Zhipeng Zhu, Hongmei Zhou, Yunjian Ni, Cheng Wu, Caijun Zhang & Xiaoyan Ling
Pages: 521-531
Published online: 12 Mar 2018
AbstractforCan dexmedetomidine reduce atrial fibrillation after cardiac surgery? A systematic review and meta-analysis | Full Text | References | PDF (1.4 MB)
  • 140 Views
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Open Access

Retraction

Retraction
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction]
Page: 533
Published online: 13 Mar 2018
CitationforInvolvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum] [Retraction] | Full Text | PDF (149 KB)
  • 57 Views
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Original Research

Article
Enhanced gastric therapeutic effects of Brucea javanica oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study
Yue Zhang, Liying Zhang, Qi Zhang, Xitong Zhang, Tong Zhang & Bing Wang
Pages: 535-544
Published online: 13 Mar 2018
AbstractforEnhanced gastric therapeutic effects of Brucea javanica oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study | Full Text | References | PDF (2.8 MB)
  • 154 Views
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Open Access
Article
Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects
Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Sookie La, Hyun-Ju Kim, Seungil Cho, Young-Ran Yoon, Dong Heon Yang & Hae Won Lee
Pages: 545-553
Published online: 14 Mar 2018
AbstractforPharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects | Full Text | References | PDF (580 KB)
  • 366 Views
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Article
Effect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin
Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana & Kok-Yong Chin
Pages: 555-564
Published online: 16 Mar 2018
AbstractforEffect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin | Full Text | References | PDF (1.1 MB)
  • 124 Views
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Article
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
Ming Hu, Fangming Li & Weidong Wang
Pages: 565-573
Published online: 16 Mar 2018
AbstractforVitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway | Full Text | References | PDF (5.6 MB)
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Article
Bioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers
Javier Martínez González, Mayte Monreal, Ignacio Ayani Almagia, Jordi Llaudó Garín, Lourdes Ochoa Díaz de Monasterioguren & Ibón Gutierro Adúriz
Pages: 575-582
Published online: 19 Mar 2018
AbstractforBioequivalence of a biosimilar enoxaparin sodium to Clexane® after single 100 mg subcutaneous dose: results of a randomized, double-blind, crossover study in healthy volunteers | Full Text | References | PDF (980.1 KB)
  • 322 Views
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Article
The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
Li Zhang, Mengxi Liu, Chaocheng Lu, Dandan Ren, Guoqing Fan, Chang Liu, Mengjiao Liu, Gang Shu, Guangneng Peng, Zhixiang Yuan, Zhijun Zhong, Wei Zhang & Hualin Fu
Pages: 583-589
Published online: 19 Mar 2018
AbstractforThe hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability | Full Text | References | PDF (897.9 KB)
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Review

Review Article
Tendinopathy: injury, repair, and current exploration
Kelsey Lipman, Chenchao Wang, Kang Ting, Chia Soo & Zhong Zheng
Pages: 591-603
Published online: 20 Mar 2018
AbstractforTendinopathy: injury, repair, and current exploration | Full Text | References | PDF (875.6 KB)
  • 454 Views
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Review Article
Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer
Ilaria Colombo, Stephanie Lheureux & Amit Manulal Oza
Pages: 605-617
Published online: 21 Mar 2018
AbstractforRucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer | Full Text | References | PDF (478.2 KB)
  • 240 Views
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Review Article
Benralizumab in the treatment of severe asthma: design, development and potential place in therapy
Corrado Pelaia, Alessandro Vatrella, Andrea Bruni, Rosa Terracciano & Girolamo Pelaia
Pages: 619-628
Published online: 21 Mar 2018
AbstractforBenralizumab in the treatment of severe asthma: design, development and potential place in therapy | Full Text | References | PDF (2 MB)
  • 249 Views
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Original Research

Article
Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway
Hefan He, Weifeng Liu, Yingying Zhou, Yibin Liu, Peiqing Weng, Yasong Li & Huangde Fu
Pages: 629-638
Published online: 23 Mar 2018
AbstractforSevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway | Full Text | References | PDF (6.1 MB)
  • 101 Views
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Article
The role of propranolol as a radiosensitizer in gastric cancer treatment
Xinhua Liao, Prakash Chaudhary, Guanglin Qiu, Xiangming Che & Lin Fan
Pages: 639-645
Published online: 28 Mar 2018
AbstractforThe role of propranolol as a radiosensitizer in gastric cancer treatment | Full Text | References | PDF (2.1 MB)
  • 212 Views
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Clinical Trial Report

Article
Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study
Sultan Keles & Ozlem Kocaturk
Pages: 647-653
Published online: 28 Mar 2018
AbstractforComparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study | Full Text | References | PDF (588.1 KB)
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Corrigendum

Correction
Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro [Corrigendum]
Page: 655
Published online: 29 Mar 2018
CitationforPeptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro [Corrigendum] | Full Text | PDF (145.8 KB)
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Original Research

Article
The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation
Elham Bagheri, Fatemeh Hajiaghaalipour, Shaik Nyamathulla & Nur’Ain Salehen
Pages: 657-671
Published online: 29 Mar 2018
AbstractforThe apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation | Full Text | References | PDF (2.6 MB)
  • 187 Views
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Article
Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model
Kenzo Iizuka, Cheng Jin, Kokoro Eshima, Mei Hua Hong, Kiyoshi Eshima & Masakazu Fukushima
Pages: 673-683
Published online: 29 Mar 2018
AbstractforAnticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model | Full Text | References | PDF (2.6 MB)
  • 115 Views
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Article
Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs
Kristofer F Nilsson, Waldemar Goździk, Claes Frostell, Stanisław Zieliński, Marzena Zielińska, Kornel Ratajczak, Piotr Skrzypczak, Sylwia Rodziewicz, Johanna Albert & Lars E Gustafsson
Pages: 685-694
Published online: 29 Mar 2018
AbstractforOrganic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs | Full Text | References | PDF (873.5 KB)
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Article
Hot-water extract of the branches of Hovenia dulcis Thunb. (Rhamnaceae) ameliorates low-fiber diet-induced constipation in rats
Chul-Yung Choi, Seung-Sik Cho & In-Soo Yoon
Pages: 695-703
Published online: 03 Apr 2018
AbstractforHot-water extract of the branches of Hovenia dulcis Thunb. (Rhamnaceae) ameliorates low-fiber diet-induced constipation in rats | Full Text | References | PDF (1.1 MB)
  • 123 Views
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Article
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis
Michele Grasso, Marco de Vincentiis, Griselda Agolli, Francesco Cilurzo & Raffaele Grasso
Pages: 705-709
Published online: 03 Apr 2018
AbstractforThe effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis | Full Text | References | PDF (493.6 KB)
  • 149 Views
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Article
Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection
Chun-Woong Park, Hyo-Jung Lee, Dong-Won Oh, Ji-Hyun Kang, Chang-Soo Han & Dong-Wook Kim
Pages: 711-719
Published online: 05 Apr 2018
AbstractforPreparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection | Full Text | References | PDF (998.1 KB)
  • 320 Views
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Article
Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
Juan Wang, Handong Wang, Kangjian Sun, Xiaoliang Wang, Hao Pan, Jianhong Zhu, Xiangjun Ji & Xiang Li
Pages: 721-733
Published online: 03 Apr 2018
AbstractforChrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway | Full Text | References | PDF (5.7 MB)
  • 217 Views
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Article
The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial
Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Heshu Sulaiman Rahman & Abdullah Rasedee
Pages: 735-742
Published online: 05 Apr 2018
AbstractforThe efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial | Full Text | References | PDF (1.1 MB)
  • 336 Views
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Article
Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
Lei Lyu, Lu-qi Huang, Tao Huang, Wei Xiang, Jing-dong Yuan & Chuan-hua Zhang
Pages: 743-756
Published online: 05 Apr 2018
AbstractforCell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis | Full Text | References | PDF (1.7 MB)
  • 104 Views
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Article
Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations
Can Wang, Qing-ping Shi, Feng Ding, Xiao-dong Jiang, Wei Tang, Mei-Ling Yu & Jian-Hua Zhu
Pages: 757-767
Published online: 05 Apr 2018
AbstractforReevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations | Full Text | References | PDF (544.7 KB)
  • 95 Views
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Article
Upregulation of vascular endothelial growth factor receptor-1 contributes to sevoflurane preconditioning-mediated cardioprotection
Bin Qian, Yang Yang, Yusheng Yao, Yanling Liao & Ying Lin
Pages: 769-776
Published online: 06 Apr 2018
AbstractforUpregulation of vascular endothelial growth factor receptor-1 contributes to sevoflurane preconditioning-mediated cardioprotection | Full Text | References | PDF (2.7 MB)
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Review

Review Article
Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas
Jun Gong, Jessica Yan, Charles Forscher & Andrew Hendifar
Pages: 777-786
Published online: 06 Apr 2018
AbstractforAldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas | Full Text | References | PDF (288.8 KB)
  • 148 Views
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Original Research

Article
Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians
Jieon Lee, Su-jin Rhee, SeungHwan Lee & Kyung-Sang Yu
Pages: 787-794
Published online: 06 Apr 2018
AbstractforEvaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians | Full Text | References | PDF (547.8 KB)
  • 115 Views
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Article
Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation
Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi & Nurzalina Abdul Karim Khan
Pages: 795-813
Published online: 09 Apr 2018
AbstractforTransethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation | Full Text | References | PDF (4.5 MB)
  • 923 Views
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Article
Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers
Hyungsub Kim, Hee Youn Choi, Yo-Han Kim, Kyun-Seop Bae, Jina Jung, Hankil Son & Hyeong-Seok Lim
Pages: 815-821
Published online: 11 Apr 2018
AbstractforPharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers | Full Text | References | PDF (511.7 KB)
  • 217 Views
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Article
Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction
Hengwen Chen, Yan Dong, Xuanhui He, Jun Li & Jie Wang
Pages: 823-836
Published online: 12 Apr 2018
AbstractforPaeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction | Full Text | References | PDF (7.8 MB)
  • 94 Views
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Article
Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia
Hui Xue, Wenping Xiang, Yichuan Yu, Guorong Liu, Yi Chong & Jiying Zhou
Pages: 837-843
Published online: 12 Apr 2018
AbstractforRandomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia | Full Text | References | PDF (944.8 KB)
  • 74 Views
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Article
Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway
Jinwei Liang, Shanhu Wu, Wenxi Xie & Hefan He
Pages: 845-853
Published online: 16 Apr 2018
AbstractforKetamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway | Full Text | References | PDF (4.7 MB)
  • 264 Views
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Article
Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection
Li-Juan Zhi, Li Wang, Xing-Kai Chen, Xiao-Ying Zhai, Li Wen, Lei Dong, Evelyne Jacqz-Aigrain, Zhong-Ren Shi & Wei Zhao
Pages: 855-862
Published online: 17 Apr 2018
AbstractforPopulation pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection | Full Text | References | PDF (947.9 KB)
  • 86 Views
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Article
Lymphoma-targeted treatment using a folic acid-decorated vincristine-loaded drug delivery system
Lei Qiu, Chao Dong & Xuan Kan
Pages: 863-872
Published online: 17 Apr 2018
AbstractforLymphoma-targeted treatment using a folic acid-decorated vincristine-loaded drug delivery system | Full Text | References | PDF (1.7 MB)
  • 163 Views
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Article
Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway
Shaoren Zhang, Yuqing Mao & Xiaoming Fan
Pages: 873-885
Published online: 18 Apr 2018
AbstractforInhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway | Full Text | References | PDF (3.8 MB)
  • 119 Views
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Article
Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury
Siyang Xiao, Wenxin Zhang, Hongjin Chen, Bo Fang, Yinda Qiu, Xianxin Chen, Lingfeng Chen, Sheng Shu, Yali Zhang, Yunjie Zhao, Zhiguo Liu & Guang Liang
Pages: 887-899
Published online: 19 Apr 2018
AbstractforDesign, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury | Full Text | References | PDF (1.6 MB)
  • 163 Views
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Review

Review Article
Theoretical overview of clinical and pharmacological aspects of the use of etelcalcetide in diabetic patients undergoing hemodialysis
Jianzhen Ye, Guangrui Deng & Feng Gao
Pages: 901-909
Published online: 19 Apr 2018
AbstractforTheoretical overview of clinical and pharmacological aspects of the use of etelcalcetide in diabetic patients undergoing hemodialysis | Full Text | References | PDF (283.9 KB)
  • 89 Views
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Original Research

Article
Attenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells
Yizhou Zeng, Xiaofang Tian, Quan Wang, Weiyang He, Jing Fan & Xin Gou
Pages: 911-920
Published online: 19 Apr 2018
AbstractforAttenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells | Full Text | References | PDF (2.1 MB)
  • 87 Views
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Article
Chitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer
Haijun Shen, Fang Li, Dongxia Wang, Zhihan Yang, Chunfang Yao, Yang Ye & Xiaona Wang
Pages: 921-934
Published online: 19 Apr 2018
AbstractforChitosan–alginate BSA-gel-capsules for local chemotherapy against drug-resistant breast cancer | Full Text | References | PDF (3.7 MB)
  • 236 Views
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Article
Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet
Sang-In Park, Su-Hak Heo, Gihwan Kim, Seokhoon Chang, Keon-Hyoung Song, Min-Gul Kim, Eun-Heui Jin, JaeWoo Kim, SeungHwan Lee & Jang Hee Hong
Pages: 935-942
Published online: 20 Apr 2018
AbstractforComparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet | Full Text | References | PDF (825.5 KB)
  • 404 Views
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Article
Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts
Wei Chen, Jing Ju, Yehong Yang, Hao Wang, Wenjie Chen, Xuelan Zhao, Hongying Ye & Yu Zhang
Pages: 943-954
Published online: 20 Apr 2018
AbstractforAstragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts | Full Text | References | PDF (3.9 MB)
  • 90 Views
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Article
Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of Edgeworthia gardneri
Manjiao Zhuang, Honghong Qiu, Ping Li, Lihua Hu, Yayu Wang & Lei Rao
Pages: 955-966
Published online: 23 Apr 2018
AbstractforIslet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of Edgeworthia gardneri | Full Text | References | PDF (4.2 MB)
  • 136 Views
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Article
A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis
Xi-xi Xu, Jian-ping Bi, Li Ping, Ping Li & Fei Li
Pages: 967-979
Published online: 24 Apr 2018
AbstractforA network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis | Full Text | References | PDF (2.3 MB)
  • 143 Views
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Article
The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
Yayi He, Sangtian Liu, Jane Mattei, Paul A Bunn Jr, Caicun Zhou & Daniel Chan
Pages: 981-986
Published online: 24 Apr 2018
AbstractforThe combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC | Full Text | References | PDF (445.9 KB)
  • 139 Views
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Article
Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
Keivan Sadrerafi, Emilia O Mason & Mark W Lee Jr
Pages: 987-995
Published online: 24 Apr 2018
AbstractforClickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors | Full Text | References | PDF (625.1 KB)
  • 88 Views
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Article
4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5
Jing Ju, Nan Wang, Jiali Wang, Fanrong Wu, Jinfang Ge & Feihu Chen
Pages: 997-1008
Published online: 27 Apr 2018
Abstractfor4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5 | Full Text | References | PDF (7.8 MB)
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Review

Review Article
Advances in the drug therapies of acute myeloid leukemia (except acute wpromyelocytic leukemia)
Min Lin & Baoan Chen
Pages: 1009-1017
Published online: 30 Apr 2018
AbstractforAdvances in the drug therapies of acute myeloid leukemia (except acute wpromyelocytic leukemia) | Full Text | References | PDF (252.2 KB)
  • 99 Views
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Original Research

Article
Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7
Yasmine M Mandour, Ulrike Breitinger, Chunlong Ma, Jun Wang, Frank M Boeckler, Hans-Georg Breitinger & Darius P Zlotos
Pages: 1019-1031
Published online: 30 Apr 2018
AbstractforSymmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7 | Full Text | References | PDF (1.9 MB)
  • 71 Views
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Review

Review Article
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy
Jeffrey D Jenks, Helmut JF Salzer, Juergen Prattes, Robert Krause, Dieter Buchheidt & Martin Hoenigl
Pages: 1033-1044
Published online: 30 Apr 2018
AbstractforSpotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy | Full Text | References | PDF (355.2 KB)
  • 288 Views
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Article
Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese
Yewon Choi, Seonghae Yoon, Kyoko Matsumoto, Yoshiyasu Ohta, SeungHwan Lee, Kyung-Sang Yu & In-Jin Jang
Pages: 1045-1051
Published online: 30 Apr 2018
AbstractforPharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese | Full Text | References | PDF (465 KB)
  • 82 Views
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Article
Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells
Menaga Subramaniam, Su Ki Liew, Lionel LA In, Khalijah Awang, Niyaz Ahmed & Noor Hasima Nagoor
Pages: 1053-1063
Published online: 01 May 2018
AbstractforInactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells | Full Text | References | PDF (1.2 MB)
  • 73 Views
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Article
Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening
Swati Singh, Garima Khare, Ritika Kar Bahal, Prahlad C Ghosh & Anil K Tyagi
Pages: 1065-1079
Published online: 01 May 2018
AbstractforIdentification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening | Full Text | References | PDF (2.6 MB)
  • 162 Views
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Research Article

Article
Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload
Dijiong Wu, Xiaowen Wen, Wenbin Liu, Huijin Hu, Baodong Ye & Yuhong Zhou
Pages: 1081-1091
Published online: 03 May 2018
AbstractforComparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload | Full Text | References | PDF (7.8 MB)
  • 127 Views
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Clinical Trial Report

Article
Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β2-agonists in patients with atopic asthma
Eric D Bateman, Christopher O’Brien, Paul Rugman, Sally Luke, Stefan Ivanov & Mohib Uddin
Pages: 1093-1106
Published online: 04 May 2018
AbstractforEfficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β2-agonists in patients with atopic asthma | Full Text | References | PDF (730.9 KB)
  • 79 Views
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Original Research

Article
Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler: a Calu-3 model
Lyné van Rensburg, Johann M van Zyl & Johan Smith
Pages: 1107-1118
Published online: 04 May 2018
AbstractforDeposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler: a Calu-3 model | Full Text | References | PDF (1.4 MB)
  • 139 Views
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Article
Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from Murraya koenigii (L) Spreng
Behnam Kamalidehghan, Soudeh Ghafouri-Fard, Elahe Motevaseli & Fatemeh Ahmadipour
Pages: 1119-1133
Published online: 04 May 2018
AbstractforInhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from Murraya koenigii (L) Spreng | Full Text | References | PDF (5.3 MB)
  • 215 Views
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Article
Identification of novel drug targets in bovine respiratory disease: an essential step in applying biotechnologic techniques to develop more effective therapeutic treatments
Meena Kishore Sakharkar, Karthic Rajamanickam, Ramesh Chandra, Haseeb A Khan, Abdullah S Alhomida & Jian Yang
Pages: 1135-1146
Published online: 07 May 2018
AbstractforIdentification of novel drug targets in bovine respiratory disease: an essential step in applying biotechnologic techniques to develop more effective therapeutic treatments | Full Text | References | PDF (3.2 MB)
  • 87 Views
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Review

Review Article
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
Dmitrij A Sychev, Ghulam Md Ashraf, Andrey A Svistunov, Maksim L Maksimov, Vadim V Tarasov, Vladimir N Chubarev, Vitalij A Otdelenov, Natal’ja P Denisenko, George E Barreto & Gjumrakch Aliev
Pages: 1147-1156
Published online: 08 May 2018
AbstractforThe cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo | Full Text | References | PDF (558.9 KB)
  • 228 Views
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Original Research

Article
Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects
Minkyung Oh, Jong-Lyul Ghim, Sung-Eun Park, Eun-Young Kim & Jae-Gook Shin
Pages: 1157-1164
Published online: 08 May 2018
AbstractforPharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects | Full Text | References | PDF (495.5 KB)
  • 180 Views
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Open Access
Article
Traditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats
Kou-Toung Chung, Chih-Hsiang Hsu, Ching-Lung Lin, Sheue-Er Wang & Chung-Hsin Wu
Pages: 1165-1171
Published online: 08 May 2018
AbstractforTraditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats | Full Text | References | PDF (1.1 MB)
  • 214 Views
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Open Access

Review

Review Article
Update on new biologics for intractable eosinophilic asthma: impact of reslizumab
Jagdeep Sahota & Douglas S Robinson
Pages: 1173-1181
Published online: 08 May 2018
AbstractforUpdate on new biologics for intractable eosinophilic asthma: impact of reslizumab | Full Text | References | PDF (424.7 KB)
  • 95 Views
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Open Access

Original Research

Article
Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation
Han Wang, Yao Wang, Wentao Guo, Bin Du, Xiaobing Huang, Riping Wu, Baoyu Yang, Xiaoyan Lin & Yilan Wu
Pages: 1183-1193
Published online: 09 May 2018
AbstractforInsight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation | Full Text | References | PDF (5.9 MB)
  • 82 Views
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Open Access
Article
Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
Jisheng Ran, Chiyuan Ma, Kai Xu, Langhai Xu, Yuzhe He, Safwat Adel Abdo Moqbel, Pengfei Hu, Lifeng Jiang, Weiping Chen, Jiapeng Bao, Yan Xiong & Lidong Wu
Pages: 1195-1204
Published online: 09 May 2018
AbstractforSchisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways | Full Text | References | PDF (7.1 MB)
  • 122 Views
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Open Access
Article
Semen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats
Si Cao, Baoping Zheng, Tao Chen, Xinfeng Chang, Bao Yin, Zhihua Huang, Ping Shuai & Limin Han
Pages: 1205-1213
Published online: 11 May 2018
AbstractforSemen Brassicae ameliorates hepatic fibrosis by regulating transforming growth factor-β1/Smad, nuclear factor-κB, and AKT signaling pathways in rats | Full Text | References | PDF (6.3 MB)
  • 81 Views
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Open Access

Review

Review Article
Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials
Marco Solmi, Giorgio Pigato, John M Kane & Christoph U Correll
Pages: 1215-1238
Published online: 14 May 2018
AbstractforTreatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (759.7 KB)
  • 383 Views
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Open Access
Review Article
Computer-aided design of amino acid-based therapeutics: a review
Tayebeh Farhadi & Seyed MohammadReza Hashemian
Pages: 1239-1254
Published online: 14 May 2018
AbstractforComputer-aided design of amino acid-based therapeutics: a review | Full Text | References | PDF (1.1 MB)
  • 248 Views
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Open Access

Original Research

Article
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy
Mingyan Zhang, Zhibin Yan, Lili Bu, Chunmei An, Dan Wang, Xin Liu, Jianfeng Zhang, Wenle Yang, Bochuan Deng, Junqiu Xie & Bangzhi Zhang
Pages: 1255-1268
Published online: 15 May 2018
AbstractforRapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy | Full Text | References | PDF (18.1 MB)
  • 147 Views
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Open Access
Article
Efficacy of intra-meibomian gland injection of the anti-VEGF agent bevacizumab for the treatment of meibomian gland dysfunction with lid-margin vascularity
Xiaodan Jiang, Yuexin Wang, Huibin Lv, Yan Liu, Mingzhou Zhang & Xuemin Li
Pages: 1269-1279
Published online: 16 May 2018
AbstractforEfficacy of intra-meibomian gland injection of the anti-VEGF agent bevacizumab for the treatment of meibomian gland dysfunction with lid-margin vascularity | Full Text | References | PDF (6 MB)
  • 81 Views
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Open Access
Article
Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
Rong Wang, Jing Wang, Fuxing Song, Shengnan Li & Yongfang Yuan
Pages: 1281-1292
Published online: 17 May 2018
AbstractforTanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway | Full Text | References | PDF (5.5 MB)
  • 124 Views
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Open Access
Article
Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway
Lei Wang, Zhiyuan Chen, Yang Liu, Yang Du & Xiuheng Liu
Pages: 1293-1301
Published online: 21 May 2018
AbstractforOzone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway | Full Text | References | PDF (3.5 MB)
  • 83 Views
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Open Access
Article
Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line
Dong Yang, Xiling Zhang, Wencun Zhang & Thamaraiselvan Rengarajan
Pages: 1303-1310
Published online: 18 May 2018
AbstractforVicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line | Full Text | References | PDF (979.4 KB)
  • 149 Views
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Open Access
Article
Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state
Chongli Xu, Caihong Liang, Weixin Sun, Jiandong Chen & Xiaohu Chen
Pages: 1311-1319
Published online: 18 May 2018
AbstractforGlycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state | Full Text | References | PDF (1.6 MB)
  • 101 Views
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Open Access
Article
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
Rui Wang, Yang Li, Xu-Dong Huai, Qing-Xuan Zheng, Wei Wang, Hui-Jing Li & Qi-Yong Huai
Pages: 1321-1336
Published online: 21 May 2018
AbstractforDesign and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties | Full Text | References | PDF (1.6 MB)
  • 101 Views
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Open Access
Article
Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
Meilin Liu, Xiaolong Chen, Henan Liu & Yu Di
Pages: 1337-1346
Published online: 21 May 2018
AbstractforExpression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice | Full Text | References | PDF (2.5 MB)
  • 83 Views
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Open Access
Article
Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats
Şaban Cem Sezen, Aysegul Kucuk, Abdullah Özer, Yiğit Kılıç, Barış Mardin, Metin Alkan, Fatmanur Duruk Erkent, Mustafa Arslan, Yusuf Ünal, Gürsel Levent Oktar & Murat Tosun
Pages: 1347-1352
Published online: 22 May 2018
AbstractforAssessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats | Full Text | References | PDF (3.7 MB)
  • 121 Views
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Open Access
Article
Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease
Lei Pi, Di Che, Haifeng Long, Zhenzhen Fang, Jiawen Li, Shuyi Lin, Yunfeng Liu, Meiai Li, Lijuan Bao, Wenli Li, Yuan Zhang, Qiulian Deng, Techang Liu, Li Zhang & Xiaoqiong Gu
Pages: 1353-1362
Published online: 23 May 2018
AbstractforImmature platelets and antiplatelet therapy response to aspirin in Kawasaki disease | Full Text | References | PDF (918.9 KB)
  • 88 Views
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Open Access
Article
REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma
Cuilin Li, Hecun Zou, Zhifei Wang, Xinyue Tang, Xitang Fan, Ke Zhang, Jianqiu Liu & Zhi Li
Pages: 1363-1371
Published online: 22 May 2018
AbstractforREST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma | Full Text | References | PDF (5.3 MB)
  • 84 Views
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Open Access
Article
Antihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice
Noraisyah Zulkawi, Kam Heng Ng, Nur Rizi Zamberi, Swee Keong Yeap, Dilan A Satharasinghe, Sheau Wei Tan, Wan Yong Ho, Nur Yuhasliza Abd Rashid, Mohd Izwan Md Lazim, Anisah Jamaluddin, Noorjahan Banu Alitheen & Kamariah Long
Pages: 1373-1383
Published online: 23 May 2018
AbstractforAntihyperglycemic and anti-inflammatory effects of fermented food paste in high-fat diet and streptozotocin-challenged mice | Full Text | References | PDF (7.3 MB)
  • 201 Views
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Open Access
Article
Effects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities
Haixin Li, Ying Huang, Xian Wu, Ting Wu, Ying Cao, Qimei Wang, Yuchang Qiu, Weiming Fu, Qun Zhang & Jianxin Pang
Pages: 1385-1398
Published online: 23 May 2018
AbstractforEffects of hemocoagulase agkistrodon on the coagulation factors and its procoagulant activities | Full Text | References | PDF (2 MB)
  • 127 Views
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Open Access
Article
The anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles
Nan Li, Zhenzhen Han, Lin Li, Bing Zhang, Zhidong Liu & Jiawei Li
Pages: 1399-1411
Published online: 23 May 2018
AbstractforThe anti-cataract molecular mechanism study in selenium cataract rats for baicalin ophthalmic nanoparticles | Full Text | References | PDF (2 MB)
  • 139 Views
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Open Access
Article
Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet
Soyoung Lee, Kyu-Yeol Nam, Jaeseong Oh, SeungHwan Lee, Sang-Min Cho, Youn-Woong Choi, Joo-Youn Cho, Beom-Jin Lee & Jang Hee Hong
Pages: 1413-1420
Published online: 23 May 2018
AbstractforEvaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet | Full Text | References | PDF (570.5 KB)
  • 223 Views
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Open Access
Article
The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry
Ennio Giulio Favalli, Andrea Becciolini, Martina Biggioggero, Ilaria Bertoldi, Chiara Crotti, Maria Gabriella Raimondo & Antonio Marchesoni
Pages: 1421-1429
Published online: 24 May 2018
AbstractforThe role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry | Full Text | References | PDF (721 KB)
  • 81 Views
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Open Access
Article
In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents
Arif Malik, Mahwish Arooj, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Tassadaq Hussain Jafar, Sulayman Waquar, Siew Hua Gan, Sarfraz Ahmad & Muhammad Usman Mirza
Pages: 1431-1443
Published online: 24 May 2018
AbstractforIn silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents | Full Text | References | PDF (3.3 MB)
  • 203 Views
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Open Access
Article
nab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial
Cesare Gridelli, Tianlei Chen, Amy Ko, Mary E O’Brien, Teng Jin Ong, Mark A Socinski & Pieter E Postmus
Pages: 1445-1451
Published online: 24 May 2018
Abstractfornab-Paclitaxel/carboplatin in elderly patients with advanced squamous non-small cell lung cancer: a retrospective analysis of a Phase III trial | Full Text | References | PDF (1.1 MB)
  • 88 Views
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Open Access
Article
Sustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production
Yu Li & Zhan-Zhao Zhang
Pages: 1453-1466
Published online: 24 May 2018
AbstractforSustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production | Full Text | References | PDF (3.7 MB)
  • 247 Views
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Open Access
Article
Synthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging
Chi-Wei Chang, Chun-Nan Yeh, Yi-Hsiu Chung, Yong-Ren Chen, Shi-Wei Tien, Tsung-Wen Chen, Shiou-Shiow Farn, Ying-Cheng Huang & Chung-Shan Yu
Pages: 1467-1478
Published online: 24 May 2018
AbstractforSynthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging | Full Text | References | PDF (1.4 MB)
  • 81 Views
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Review

Review Article
Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system
Zhifeng Zhong, Jing Han, Jizhou Zhang, Qing Xiao, Juan Hu & Lidian Chen
Pages: 1479-1489
Published online: 24 May 2018
AbstractforPharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system | Full Text | References | PDF (945.7 KB)
  • 622 Views
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Original Research

Article
Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study
Behzat Can, Remzi Atilgan, Sehmus Pala, Tuncay Kuloğlu, Sule Kiray & Nevin Ilhan
Pages: 1491-1500
Published online: 25 May 2018
AbstractforExamination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study | Full Text | References | PDF (6.8 MB)
  • 127 Views
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Review

Review Article
Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy
Domenica Lorusso, Elisa Tripodi, Giuseppa Maltese, Stefano Lepori, Ilaria Sabatucci, Giorgio Bogani & Francesco Raspagliesi
Pages: 1501-1509
Published online: 29 May 2018
AbstractforSpotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy | Full Text | References | PDF (363.3 KB)
  • 138 Views
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Original Research

Article
5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
Sobhi M Gomha, Mastoura M Edrees, Zeinab A Muhammad & Ahmed AM El-Reedy
Pages: 1511-1523
Published online: 30 May 2018
Abstractfor5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents | Full Text | References | PDF (1.3 MB)
  • 312 Views
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Article
Incidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib
Fang Zhao, Bo Yang, Juan Wang, Rui Zhang, Jing Liu, Fenglei Yin, Weixing Xu & Chunyuan He
Pages: 1525-1531
Published online: 30 May 2018
AbstractforIncidence and risk of cardiac toxicities in patients with relapsed and refractory multiple myeloma treated with carfilzomib | Full Text | References | PDF (830.2 KB)
  • 81 Views
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Open Access
Article
Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery
Quanjing Mei, Peipei Luo, Yi Zuo, Jidong Li, Qin Zou, Yubao Li, Dianming Jiang & Yaning Wang
Pages: 1533-1544
Published online: 31 May 2018
AbstractforFormulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery | Full Text | References | PDF (12.5 MB)
  • 111 Views
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Review

Review Article
2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents
Georgeta Serban, Oana Stanasel, Eugenia Serban & Sanda Bota
Pages: 1545-1566
Published online: 31 May 2018
Abstractfor2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents | Full Text | References | PDF (2.6 MB)
  • 1148 Views
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Open Access

Original Research

Article
Optimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension
Csaba Bartos, Orsolya Jójárt-Laczkovich, Gábor Katona, Mária Budai-Szűcs, Rita Ambrus, Alexandra Bocsik, Ilona Gróf, Mária Anna Deli & Piroska Szabó-Révész
Pages: 1567-1580
Published online: 31 May 2018
AbstractforOptimization of a combined wet milling process in order to produce poly(vinyl alcohol) stabilized nanosuspension | Full Text | References | PDF (2.7 MB)
  • 192 Views
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Open Access
Article
AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells
Chang Zhang, Yue Jiang, Jia Liu, Meina Jin, Nan Qin, Ying Chen, Wenyan Niu & Hongquan Duan
Pages: 1581-1587
Published online: 01 Jun 2018
AbstractforAMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells | Full Text | References | PDF (1 MB)
  • 80 Views
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Open Access

Review

Review Article
Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy
Claudia Friedl & Emanuel Zitt
Pages: 1589-1598
Published online: 01 Jun 2018
AbstractforRole of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy | Full Text | References | PDF (347.2 KB)
  • 225 Views
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Open Access

Original Research

Article
Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers
Mira P Patel, Vincent Siu, Abel Silva-Garcia, Qing Xu, Zhe Li & Donna Oksenberg
Pages: 1599-1607
Published online: 01 Jun 2018
AbstractforDevelopment and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers | Full Text | References | PDF (1.5 MB)
  • 131 Views
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Open Access
Article
RETRACTED ARTICLE: Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats
Guanglei Fu, Hua Wang, Youli Cai, Hui Zhao & Wenjun Fu
Pages: 1609-1619
Published online: 12 Jun 2018
AbstractforRETRACTED ARTICLE: Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats | PDF (1.4 MB)
  • 38 Views
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Open Access
Article
GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity
Song Guo, Zhichao Li, Li Yan, Yijuan Sun & Yun Feng
Pages: 1621-1631
Published online: 07 Jun 2018
AbstractforGnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity | Full Text | References | PDF (6.2 MB)
  • 176 Views
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Review

Review Article
The role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives
Nataša Toplak, Štefan Blazina & Tadej Avčin
Pages: 1633-1643
Published online: 08 Jun 2018
AbstractforThe role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives | Full Text | References | PDF (2.1 MB)
  • 123 Views
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Original Research

Article
Risk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies
Jiang-Dong Sui, Ying Wang, Yue Wan & Yong-Zhong Wu
Pages: 1645-1657
Published online: 08 Jun 2018
AbstractforRisk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies | Full Text | References | PDF (1.1 MB)
  • 70 Views
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Open Access
Article
Burden of heart failure on patients from China: results from a cross-sectional survey
James DS Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz & Frederico J Calado
Pages: 1659-1668
Published online: 08 Jun 2018
AbstractforBurden of heart failure on patients from China: results from a cross-sectional survey | Full Text | References | PDF (2.2 MB)
  • 167 Views
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Article
Burden of heart failure on caregivers in China: results from a cross-sectional survey
James DS Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz & Frederico J Calado
Pages: 1669-1678
Published online: 08 Jun 2018
AbstractforBurden of heart failure on caregivers in China: results from a cross-sectional survey | Full Text | References | PDF (4 MB)
  • 237 Views
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Article
Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation
Xiaofei Wu, Yan Tang, Xiaohua Zhang, Chenchen Wu & Lingti Kong
Pages: 1679-1684
Published online: 11 Jun 2018
AbstractforPharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation | Full Text | References | PDF (516.5 KB)
  • 110 Views
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Article
Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis
Dan Liu, Xiaodan Li, Yonggang Zhang, Joey Sum-Wing Kwong, Ling Li, Yiyi Zhang, Chang Xu, Qianrui Li, Xin Sun, Haoming Tian & Sheyu Li
Pages: 1685-1695
Published online: 11 Jun 2018
AbstractforChloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis | Full Text | References | PDF (1.7 MB)
  • 171 Views
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Article
Atrial natriuretic peptide modified oleate adenosine prodrug lipid nanocarriers for the treatment of myocardial infarction: in vitro and in vivo evaluation
Jianjun Yu, Wei Li & Dongmei Yu
Pages: 1697-1706
Published online: 11 Jun 2018
AbstractforAtrial natriuretic peptide modified oleate adenosine prodrug lipid nanocarriers for the treatment of myocardial infarction: in vitro and in vivo evaluation | Full Text | References | PDF (879.4 KB)
  • 125 Views
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Article
Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic
Jung Sunwoo, Yu Kyong Kim, Yewon Choi, Kyung-Sang Yu, Heesook Nam, Young Lag Cho, Seonghae Yoon & Jae-Yong Chung
Pages: 1707-1714
Published online: 11 Jun 2018
AbstractforEffect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic | Full Text | References | PDF (558.5 KB)
  • 73 Views
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Article
Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study
Wan Nuraini Wan Hasan, Norzana Abd Ghafar, Kok-Yong Chin & Soelaiman Ima-Nirwana
Pages: 1715-1726
Published online: 13 Jun 2018
AbstractforAnnatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study | Full Text | References | PDF (4.2 MB)
  • 129 Views
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Article
Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro
Jennifer Bourn & Maria Cekanova
Pages: 1727-1742
Published online: 13 Jun 2018
AbstractforCyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro | Full Text | References | PDF (2.7 MB)
  • 100 Views
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Article
Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells
Hongen Lei, Huixi Li, Long Tian, Meng Li, Zhongcheng Xin, Xiaodong Zhang & Ruili Guan
Pages: 1743-1751
Published online: 13 Jun 2018
AbstractforIcariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells | Full Text | References | PDF (1.5 MB)
  • 90 Views
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Review

Review Article
Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism
Barbara Lisowska, Dariusz Kosson & Karolina Domaracka
Pages: 1753-1758
Published online: 18 Jun 2018
AbstractforLights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism | Full Text | References | PDF (554.1 KB)
  • 220 Views
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Review Article
Linezolid: a review of its properties, function, and use in critical care
Seyed Mohammad Reza Hashemian, Tayebeh Farhadi & Mojdeh Ganjparvar
Pages: 1759-1767
Published online: 18 Jun 2018
AbstractforLinezolid: a review of its properties, function, and use in critical care | Full Text | References | PDF (402.3 KB)
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Article
Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer
Rossella De Luca, Livio Blasi, Massimiliano Alù, Valerio Gristina & Giuseppe Cicero
Pages: 1769-1775
Published online: 19 Jun 2018
AbstractforClinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer | Full Text | References | PDF (606.7 KB)
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Case Report

Case Report
Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study
Dariusz Onichimowski, Krzysztof Nosek, Radosław Goraj, Rakesh Jalali, Aleksandra Wińska, Aleksandra Pawlos & Bułat Tuyakov
Pages: 1777-1783
Published online: 20 Jun 2018
AbstractforUse of levosimendan in the treatment of cerebral vascular vasospasm: a case study | Full Text | References | PDF (611.4 KB)
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Original Research

Article
Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
Amira EM Abdallah & Galal H Elgemeie
Pages: 1785-1798
Published online: 20 Jun 2018
AbstractforDesign, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs | Full Text | References | PDF (5.2 MB)
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Article
Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects
Jesse Hall, Michael Gillen, Sha Liu, Jeffrey N Miner, Shakti Valdez, Zancong Shen & Caroline Lee
Pages: 1799-1807
Published online: 20 Jun 2018
AbstractforPharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects | Full Text | References | PDF (1.2 MB)
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Review

Review Article
Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair
Barbara Lisowska, Dariusz Kosson & Karolina Domaracka
Pages: 1809-1814
Published online: 21 Jun 2018
AbstractforPositives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair | Full Text | References | PDF (226.4 KB)
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Original Research

Article
Short-versus long-term dual antiplatelet therapy after second-generation drug-eluting stent implantation: a systematic review and meta-analysis of randomized controlled trials
Hongqing Li, Wenqin Guo, Weiran Dai & Lang Li
Pages: 1815-1825
Published online: 22 Jun 2018
AbstractforShort-versus long-term dual antiplatelet therapy after second-generation drug-eluting stent implantation: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (1.2 MB)
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Article
Sevoflurane anesthesia during pregnancy in mice induces hearing impairment in the offspring
Xia Shen, Yanan Xiao, Wen Li, Kaizheng Chen & Huiqian Yu
Pages: 1827-1836
Published online: 22 Jun 2018
AbstractforSevoflurane anesthesia during pregnancy in mice induces hearing impairment in the offspring | Full Text | References | PDF (1.9 MB)
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Article
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
Jiao Feng, Kan Chen, Yujing Xia, Liwei Wu, Jingjing Li, Sainan Li, Wenwen Wang, Xiya Lu, Tong Liu & Chuanyong Guo
Pages: 1837-1853
Published online: 22 Jun 2018
AbstractforSalidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways | Full Text | References | PDF (8.8 MB)
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Article
Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model
Bo Ram Choi, Hye Kyung Kim, Kiran Kumar Soni, Keshab Kumar Karna, Sung Won Lee, Insuk So & Jong Kwan Park
Pages: 1855-1863
Published online: 22 Jun 2018
AbstractforAdditive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model | Full Text | References | PDF (1.5 MB)
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Article
RETRACTED ARTICLE: Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling
Shenglan Gong, Jin Zhang, Zhouke Guo & Wenjun Fu
Pages: 1865-1879
Published online: 25 Jun 2018
AbstractforRETRACTED ARTICLE: Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling | PDF (5.7 MB)
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Article
Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines
Marcel Nel, Anna M Joubert, Wolfgang Dohle, Barry VL Potter & Anne E Theron
Pages: 1881-1904
Published online: 25 Jun 2018
AbstractforModes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines | Full Text | References | PDF (8.3 MB)
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Article
The mechanism of botulinum A on Raynaud syndrome
Yanwen Zhou, Ying Liu, Yunhua Hao, Ya Feng, Lizhen Pan, Wuchao Liu, Bing Li, Libin Xiao, Lingjing Jin & Zhiyu Nie
Pages: 1905-1915
Published online: 26 Jun 2018
AbstractforThe mechanism of botulinum A on Raynaud syndrome | Full Text | References | PDF (2.8 MB)
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Article
Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis
Petra Hartmann, Edina Butt, Ágnes Fehér, Ágnes Lilla Szilágyi, Kurszán Dávid Jász, Boglárka Balázs, Mónika Bakonyi, Szilvia Berkó, Gábor Erős, Mihály Boros, Gyöngyi Horváth, Endre Varga & Erzsébet Csányi
Pages: 1917-1930
Published online: 27 Jun 2018
AbstractforElectroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis | Full Text | References | PDF (1.4 MB)
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Article
Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells
Liyu Qian & Yu Zhu
Pages: 1931-1939
Published online: 27 Jun 2018
AbstractforComputer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells | Full Text | References | PDF (2.3 MB)
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Article
Mechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma
Ling Yu Pan, Yan Quan Han, Yong Zhong Wang, Qian Qian Chen, Ying Wu & Yuan Sun
Pages: 1941-1951
Published online: 27 Jun 2018
AbstractforMechanism of Yanghe Pingchuan granules treatment for airway remodeling in asthma | Full Text | References | PDF (2.1 MB)
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Review

Review Article
Daptomycin: a comparison of two intravenous formulations
Celeste Frankenfeld, Sachin Mittal, Yanira Melendez, Luke Mendez-Vigo, Kenneth C Lamp, Kaitlin N Keller & Shellie R Bertolami
Pages: 1953-1958
Published online: 29 Jun 2018
AbstractforDaptomycin: a comparison of two intravenous formulations | Full Text | References | PDF (227.9 KB)
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Original Research

Article
Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation
Sinem Yaprak Karavana, Zeynep Ay Şenyiğit, Çağrı Çalışkan, Gülnur Sevin, Derya İlem Özdemir, Yalçın Erzurumlu, Sait Şen & Esra Baloğlu
Pages: 1959-1975
Published online: 02 Jul 2018
AbstractforGemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation | Full Text | References | PDF (2 MB)
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Article
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits
Tijana Drobnjak, Hamutal Meiri, Maurizio Mandalá, Berthold Huppertz & Sveinbjörn Gizurarson
Pages: 1977-1983
Published online: 03 Jul 2018
AbstractforPharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbits | Full Text | References | PDF (502.2 KB)
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Review

Review Article
Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy
Mihaela Popescu, Cătălina Bogdan, Adela Pintea, Dumitriţa Rugină & Corina Ionescu
Pages: 1985-1996
Published online: 03 Jul 2018
AbstractforAntiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy | Full Text | References | PDF (752.2 KB)
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Original Research

Article
The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation
Hong Ruan, Youcheng Yu, Xuehua Guo, Qian Jiang & Ying Luo
Pages: 1997-2003
Published online: 04 Jul 2018
AbstractforThe possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation | Full Text | References | PDF (1.6 MB)
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Review

Review Article
Efficacy and safety of adalimumab in the treatment of non-infectious uveitis: a meta-analysis and systematic review
Shuai Ming, Kunpeng Xie, Huijuan He, Ya Li & Bo Lei
Pages: 2005-2016
Published online: 04 Jul 2018
AbstractforEfficacy and safety of adalimumab in the treatment of non-infectious uveitis: a meta-analysis and systematic review | Full Text | References | PDF (621.1 KB)
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Article
Comparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations
Wei Xiang, Ya Qing Sun & Hui Chin Teoh
Pages: 2017-2024
Published online: 04 Jul 2018
AbstractforComparison of nocturnal symptoms in advanced Parkinson’s disease patients with sleep disturbances: pramipexole sustained release versus immediate release formulations | Full Text | References | PDF (462.5 KB)
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Article
Comparisons of therapeutic efficacy and safety of ipilimumab plus GM-CSF versus ipilimumab alone in patients with cancer: a meta-analysis of outcomes
Peng Chen, Fuchao Chen & Benhong Zhou
Pages: 2025-2038
Published online: 04 Jul 2018
AbstractforComparisons of therapeutic efficacy and safety of ipilimumab plus GM-CSF versus ipilimumab alone in patients with cancer: a meta-analysis of outcomes | Full Text | References | PDF (1.2 MB)
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Article
Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during intervention in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis
Weiran Dai, Ziliang Ye, Lang Li & Qiang Su
Pages: 2039-2049
Published online: 04 Jul 2018
AbstractforEffect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during intervention in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
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Article
Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg & Xin-Fu Zhou
Pages: 2051-2069
Published online: 05 Jul 2018
AbstractforSelf-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement | Full Text | References | PDF (2 MB)
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Article
Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials
Na Xu, Zhouqing Chen, Chongshun Zhao, Tao Xue, Xin Wu, Xiaoou Sun & Zhong Wang
Pages: 2071-2084
Published online: 06 Jul 2018
AbstractforDifferent doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials | Full Text | References | PDF (1,012.2 KB)
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Article
Safety and efficacy of durvalumab (MEDI4736) in various solid tumors
Hui Yang, Kai Shen, Chenjing Zhu, Qingfang Li, Yunuo Zhao & Xuelei Ma
Pages: 2085-2096
Published online: 06 Jul 2018
AbstractforSafety and efficacy of durvalumab (MEDI4736) in various solid tumors | Full Text | References | PDF (635.3 KB)
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Article
Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors
Haiyan Chen, An Lu, Xiaoyi Zhang, Lin Gui, Yaonan Wang, Jianhui Wu, Hua Feng, Shiqi Peng & Ming Zhao
Pages: 2097-2110
Published online: 09 Jul 2018
AbstractforDesign and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors | Full Text | References | PDF (2.7 MB)
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Article
Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model
Ankit Parikh, Krishna Kathawala, Jintao Li, Chi Chen, Zhengnan Shan, Xia Cao, Yan-Jiang Wang, Sanjay Garg & Xin-Fu Zhou
Pages: 2111-2128
Published online: 09 Jul 2018
AbstractforSelf-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model | Full Text | References | PDF (3 MB)
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Article
Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate
Andi Bai, Chao Wu, Xuan Liu, Huiling Lv, Xiaoyan Xu, Yue Cao, Wenjing Shang, Lili Hu & Ying Liu
Pages: 2129-2138
Published online: 10 Jul 2018
AbstractforDevelopment of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate | Full Text | References | PDF (5 MB)
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Article
Effect of green tea catechins on the pharmacokinetics of digoxin in humans
Tae-Eun Kim, Kwang-Hee Shin, Jeong-Eun Park, Min-Gul Kim, Yeo-Min Yun, Dong-Hee Choi, Kyoung Ja Kwon & Jongmin Lee
Pages: 2139-2147
Published online: 10 Jul 2018
AbstractforEffect of green tea catechins on the pharmacokinetics of digoxin in humans | Full Text | References | PDF (584.4 KB)
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Article
Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib
Wendu Duan & Yan Liu
Pages: 2149-2161
Published online: 11 Jul 2018
AbstractforTargeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib | Full Text | References | PDF (4.7 MB)
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Case Report

Case Report
A case report of toxic epidermal necrolysis associated with AZD-9291
Jie Wang, XianYe Cheng, Yan Lu & BingRong Zhou
Pages: 2163-2167
Published online: 11 Jul 2018
AbstractforA case report of toxic epidermal necrolysis associated with AZD-9291 | Full Text | References | PDF (558.3 KB)
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Letter

Letter
Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?
Umit Yasar
Pages: 2169-2172
Published online: 11 Jul 2018
First Page PreviewforDoes celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2? | Full Text | References | PDF (317.7 KB)
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Article
Efficacy and safety of apatinib combined with chemotherapy for the treatment of advanced gastric cancer in the Chinese population: a systematic review and meta-analysis
Honggang Cheng, Aixia Sun, Qingbo Guo & Yucai Zhang
Pages: 2173-2183
Published online: 11 Jul 2018
AbstractforEfficacy and safety of apatinib combined with chemotherapy for the treatment of advanced gastric cancer in the Chinese population: a systematic review and meta-analysis | Full Text | References | PDF (1.4 MB)
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Article
Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90
Roberta Gaziano, Elena Campione, Federico Iacovelli, Daniele Marino, Francesca Pica, Paolo Di Francesco, Stefano Aquaro, Francesco Menichini, Mattia Falconi & Luca Bianchi
Pages: 2185-2193
Published online: 12 Jul 2018
AbstractforAntifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90 | Full Text | References | PDF (6.2 MB)
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Article
Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy
Nianxiu Tian, Yanbin Gao, Xiaolei Wang, Xiaoming Wu, Dawei Zou, Zhiyao Zhu, ZheJi Han, Tao Wang & Yimin Shi
Pages: 2195-2211
Published online: 13 Jul 2018
AbstractforEmodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy | Full Text | References | PDF (7.5 MB)
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Article
Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis
Ying-Bin Hu, Xin-Yu Liu & Wei Zhan
Pages: 2213-2221
Published online: 16 Jul 2018
AbstractforFarnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis | Full Text | References | PDF (2.1 MB)
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Article
Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells
Jianfeng Huang, Xiaopeng Yuan, Qingfeng Pang, Haowen Zhang, Jiahua Yu, Bo Yang, Leyuan Zhou, Fuzheng Zhang & Fenju Liu
Pages: 2223-2231
Published online: 16 Jul 2018
AbstractforRadiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells | Full Text | References | PDF (1.6 MB)
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Article
The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis
Wen-bin Liu, Wen-tao Zhao, Peng Shen & Fu-jiang Zhang
Pages: 2233-2240
Published online: 17 Jul 2018
AbstractforThe effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis | Full Text | References | PDF (763.6 KB)
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Article
Development of novel rosuvastatin nanostructured lipid carriers for oral delivery in an animal model
Jun Li, Min Yang & Wenrong Xu
Pages: 2241-2248
Published online: 20 Jul 2018
AbstractforDevelopment of novel rosuvastatin nanostructured lipid carriers for oral delivery in an animal model | Full Text | References | PDF (1.5 MB)
  • 169 Views
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Article
Pharmacodynamic considerations of collateral sensitivity in design of antibiotic treatment regimen
Klas I Udekwu & Howard Weiss
Pages: 2249-2257
Published online: 23 Jul 2018
AbstractforPharmacodynamic considerations of collateral sensitivity in design of antibiotic treatment regimen | Full Text | References | PDF (1.3 MB)
  • 159 Views
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Article
Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach
Osama AA Ahmed & Waleed Y Rizq
Pages: 2259-2265
Published online: 23 Jul 2018
AbstractforFinasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach | Full Text | References | PDF (1.4 MB)
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Article
Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats
Renjin Lin, Jinti Lin, Shihen Li, Jian Ding, Hongqiang Wu, Guangheng Xiang, Shi Li, Yijia Huang, Dingsheng Lin, Weiyang Gao, Jianzhong Kong, Huazi Xu & Kailiang Zhou
Pages: 2267-2276
Published online: 23 Jul 2018
AbstractforEffects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats | Full Text | References | PDF (7 MB)
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Article
Corticosteroids as adjunctive therapy with antibiotics in the treatment of children with septic arthritis: a meta-analysis
Ya-fei Qin, Zhi-jun Li & Hui Li
Pages: 2277-2284
Published online: 23 Jul 2018
AbstractforCorticosteroids as adjunctive therapy with antibiotics in the treatment of children with septic arthritis: a meta-analysis | Full Text | References | PDF (780.7 KB)
  • 125 Views
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Article
HA/HSA co-modified erlotinib–albumin nanoparticles for lung cancer treatment
Yuzhou Shen & Wentao Li
Pages: 2285-2292
Published online: 23 Jul 2018
AbstractforHA/HSA co-modified erlotinib–albumin nanoparticles for lung cancer treatment | Full Text | References | PDF (1.3 MB)
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Review

Review Article
Inotuzumab ozogamicin: a CD22 mAb–drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia
Ilana R Yurkiewicz, Lori Muffly & Michaela Liedtke
Pages: 2293-2300
Published online: 24 Jul 2018
AbstractforInotuzumab ozogamicin: a CD22 mAb–drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia | Full Text | References | PDF (399.8 KB)
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Original Research

Article
Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers
Yewon Choi, SeungHwan Lee, In-Jin Jang & Kyung-Sang Yu
Pages: 2301-2309
Published online: 24 Jul 2018
AbstractforPharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers | Full Text | References | PDF (665.1 KB)
  • 105 Views
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Article
Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey
James DS Jackson, Sarah E Cotton, Sara Bruce Wirta, Catia C Proenca, Milun Zhang, Raquel Lahoz, Bogdan Balas & Frederico J Calado
Pages: 2311-2321
Published online: 26 Jul 2018
AbstractforCare pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey | Full Text | References | PDF (2.5 MB)
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Review

Review Article
Role of janus kinase inhibitors in the treatment of alopecia areata
Korn Triyangkulsri & Poonkiat Suchonwanit
Pages: 2323-2335
Published online: 27 Jul 2018
AbstractforRole of janus kinase inhibitors in the treatment of alopecia areata | Full Text | References | PDF (2.3 MB)
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Original Research

Article
Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)
Melissa Bello-Pérez, Alberto Falcó, Vicente Galiano, Julio Coll, Luis Perez & José Antonio Encinar
Pages: 2337-2359
Published online: 30 Jul 2018
AbstractforDiscovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV) | Full Text | References | PDF (4.8 MB)
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Article
Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance
Kamontip Chaikomon, Supreecha Chattong, Theerasak Chaiya, Danai Tiwawech, Yongsak Sritana-Anant, Amornpun Sereemaspun & Krissanapong Manotham
Pages: 2361-2369
Published online: 01 Aug 2018
AbstractforDoxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance | Full Text | References | PDF (5.9 MB)
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Review

Review Article
Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap
Xiaoli Zhang, Yuqing Chen, Liyu Fan, Jiaqi Ye, Junsheng Fan, Xinjie Xu, Danming You, Sihan Liu, Xin Chen & Peng Luo
Pages: 2371-2379
Published online: 01 Aug 2018
AbstractforPharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap | Full Text | References | PDF (1.5 MB)
  • 207 Views
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Clinical Trial Report

Article
Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers
Chungam Choi, Byung Won Yoo, Choon Ok Kim, Taegon Hong, Byung Hak Jin, Kwang-Seok Seo, Ja Yun Jang & Min Soo Park
Pages: 2381-2387
Published online: 01 Aug 2018
AbstractforComparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers | Full Text | References | PDF (923.8 KB)
  • 115 Views
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Original Research

Article
Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice
Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Yong-Yi Xu, Hai-Tao Yue & Jin Sun
Pages: 2389-2402
Published online: 01 Aug 2018
AbstractforZafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice | Full Text | References | PDF (7.3 MB)
  • 87 Views
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Article
Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism
Yonggang Zhang, Tingrui Ge, Ping Xiang, Haibing Mao, Shumin Tang, Aimin Li, Lin Lin & Yinting Wei
Pages: 2403-2411
Published online: 01 Aug 2018
AbstractforTherapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism | Full Text | References | PDF (7.5 MB)
  • 79 Views
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Article
Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition
Zheng Sun, Lingling Zheng, Xujun Liu, Wenlong Xing & Xinhai Liu
Pages: 2413-2421
Published online: 06 Aug 2018
AbstractforSinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition | Full Text | References | PDF (7.4 MB)
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Methodology

Article
Monitoring antiangiogenesis of bevacizumab in zebrafish
Jing Zhang, Beili Gao, Wenchao Zhang, Zijun Qian & Yi Xiang
Pages: 2423-2430
Published online: 06 Aug 2018
AbstractforMonitoring antiangiogenesis of bevacizumab in zebrafish | Full Text | References | PDF (4 MB)
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Original Research

Article
Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice
Xiaolei Wang, Yanbin Gao, Nianxiu Tian, Dawei Zou, Yimin Shi & Nan Zhang
Pages: 2431-2442
Published online: 06 Aug 2018
AbstractforAstragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice | Full Text | References | PDF (5.9 MB)
  • 134 Views
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Article
Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches
Muhammad Tahir Aqeel, Nisar ur-Rahman, Arif-ullah Khan, Zaman Ashraf, Muhammad Latif, Hummera Rafique & Usman Rasheed
Pages: 2443-2453
Published online: 09 Aug 2018
AbstractforAntihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches | Full Text | References | PDF (2.2 MB)
  • 299 Views
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Article
Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer
Lilan Yi, Wei Zhang, Hongman Zhang, Jie Shen, Jingwen Zou, Peng Luo & Jian Zhang
Pages: 2455-2466
Published online: 07 Aug 2018
AbstractforSystematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer | Full Text | References | PDF (1.5 MB)
  • 107 Views
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Article
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus
Euna Cho, Eun Jin Ryu, Fen Jiang, Ung Bae Jeon, Mong Cho, Cy Hyun Kim, Miyoung Kim, Nam Deuk Kim & Tae-Ho Hwang
Pages: 2467-2474
Published online: 08 Aug 2018
AbstractforPreclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus | Full Text | References | PDF (2.6 MB)
  • 103 Views
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Article
No pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects
Jung-Ryul Kim, Seokuee Kim, Wooseong Huh & Jae-Wook Ko
Pages: 2475-2483
Published online: 10 Aug 2018
AbstractforNo pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects | Full Text | References | PDF (1.1 MB)
  • 181 Views
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Article
Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study
Gisèle Pickering, Nicolas Macian, Noémie Delage, Pascale Picard, Jean-Michel Cardot, Sophia Sickout-Arondo, Fatiha Giron, Christian Dualé, Bruno Pereira & Fabienne Marcaillou
Pages: 2485-2496
Published online: 10 Aug 2018
AbstractforMilnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study | Full Text | References | PDF (1.2 MB)
  • 99 Views
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Article
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
Jiang Fang, Handong Wang, Jian Zhou, Wei Dai, Yihao Zhu, Yuan Zhou, Xiaoliang Wang & Mengliang Zhou
Pages: 2497-2508
Published online: 10 Aug 2018
AbstractforBaicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway | Full Text | References | PDF (5.8 MB)
  • 163 Views
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Article
Enhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: characterization and in vivo investigation on nephrotic syndrome rats
Guojuan Zhang & Jianfang Zhang
Pages: 2509-2518
Published online: 14 Aug 2018
AbstractforEnhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: characterization and in vivo investigation on nephrotic syndrome rats | Full Text | References | PDF (7.4 MB)
  • 156 Views
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Review

Review Article
Current research for a vaccine against Lassa hemorrhagic fever virus
Bryce M Warner, David Safronetz & Derek R Stein
Pages: 2519-2527
Published online: 14 Aug 2018
AbstractforCurrent research for a vaccine against Lassa hemorrhagic fever virus | Full Text | References | PDF (947.1 KB)
  • 294 Views
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Original Research

Article
Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer
Tivadar Bíró, Gabriella Horvát, Mária Budai-Szűcs, Erzsébet Csányi, Edit Urbán, Andrea Facskó, Piroska Szabó-Révész, Ildikó Csóka & Zoltán Aigner
Pages: 2529-2537
Published online: 15 Aug 2018
AbstractforDevelopment of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer | Full Text | References | PDF (648.5 KB)
  • 167 Views
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Review

Review Article
Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date
Zachary A King, Kevin N Sheth, W Taylor Kimberly & J Marc Simard
Pages: 2539-2552
Published online: 15 Aug 2018
AbstractforProfile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date | Full Text | References | PDF (2.2 MB)
  • 159 Views
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Review Article
MEK inhibitors for the treatment of NRAS mutant melanoma
Saro Sarkisian & Diwakar Davar
Pages: 2553-2565
Published online: 20 Aug 2018
AbstractforMEK inhibitors for the treatment of NRAS mutant melanoma | Full Text | References | PDF (308.8 KB)
  • 214 Views
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Original Research

Article
Genetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells
Yanzi Guo, Yonghao Huang, Shuhong Tian, Xueli Xie, Guilan Xing & Jian Fu
Pages: 2567-2575
Published online: 20 Aug 2018
AbstractforGenetically engineered drug rhCNB induces apoptosis and cell cycle arrest in both gastric cancer cells and hepatoma cells | Full Text | References | PDF (2.2 MB)
  • 73 Views
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Review

Review Article
Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib
Günter Krause, Floyd Hassenrück & Michael Hallek
Pages: 2577-2590
Published online: 21 Aug 2018
AbstractforCopanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib | Full Text | References | PDF (1.3 MB)
  • 229 Views
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Original Research

Article
Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial
Ziliang Ye, Haili Lu, Qiang Su, Manyun Long, Lang Li & On behalf of the PENENMIPCICI investigators
Pages: 2591-2599
Published online: 22 Aug 2018
AbstractforEfficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial | Full Text | References | PDF (735.9 KB)
  • 81 Views
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Article
Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis
Hong Zhou & Haixin Qian
Pages: 2601-2609
Published online: 22 Aug 2018
AbstractforPreparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis | Full Text | References | PDF (9.5 MB)
  • 220 Views
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Article
A randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients
Giuseppe Derosa, Giovanni Gaudio, Gianfranco Pasini, Angela D’Angelo & Pamela Maffioli
Pages: 2611-2616
Published online: 24 Aug 2018
AbstractforA randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients | Full Text | References | PDF (342 KB)
  • 57 Views
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Article
Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector
Jahangir Khan, Sajid Bashir, Muhammad Asif Khan, Mohammad Amin Mohammad & Mohammad Isreb
Pages: 2617-2626
Published online: 29 Aug 2018
AbstractforFabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector | Full Text | References | PDF (1.4 MB)
  • 125 Views
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Article
Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast
Tanveer A Wani, Ahmed H Bakheit, Mohammed Nazam Ansari, Abdul-Rahman A Al-Majed, Bakr M Al-Qahtani & Seema Zargar
Pages: 2627-2634
Published online: 28 Aug 2018
AbstractforSpectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast | Full Text | References | PDF (2 MB)
  • 195 Views
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Methodology

Article
Efficient drug delivery of β-estradiol encapsulated in Zn-metal–organic framework nanostructures by microwave-assisted coprecipitation method
Mehdi Ranjbar, Abbas Pardakhty, Arezou Amanatfard & Ali Asadipour
Pages: 2635-2643
Published online: 28 Aug 2018
AbstractforEfficient drug delivery of β-estradiol encapsulated in Zn-metal–organic framework nanostructures by microwave-assisted coprecipitation method | Full Text | References | PDF (2.5 MB)
  • 179 Views
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Original Research

Article
A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities
Yue Liu, Yanlan Wang, Jieyu Xing, Yumei Li, Jiayu Liu & Zhong Wang
Pages: 2645-2654
Published online: 29 Aug 2018
AbstractforA novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities | Full Text | References | PDF (1.8 MB)
  • 92 Views
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Article
Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma
Yuan-yuan Zhao, Ying Tian, Lin Liu, Jian-hua Zhan, Xue Hou, Xi Chen, Ting Zhou, Yan Huang & Li Zhang
Pages: 2655-2663
Published online: 29 Aug 2018
AbstractforInhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma | Full Text | References | PDF (1.5 MB)
  • 85 Views
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Review

Review Article
Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy
Andrea Romigi, Giuseppe Vitrani, Temistocle Lo Giudice, Diego Centonze & Valentina Franco
Pages: 2665-2675
Published online: 30 Aug 2018
AbstractforProfile of pitolisant in the management of narcolepsy: design, development, and place in therapy | Full Text | References | PDF (536.9 KB)
  • 314 Views
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Original Research

Article
Asenapine pharmacokinetics and tolerability in a pediatric population
Peter Dogterom, Robert Riesenberg, Rik de Greef, Justin Dennie, Martin Johnson, Venkatesh Pilla Reddy, André MM Miltenburg, Robert L Findling, Abhijeet Jakate, Timothy J Carrothers & Matthew D Troyer
Pages: 2677-2693
Published online: 30 Aug 2018
AbstractforAsenapine pharmacokinetics and tolerability in a pediatric population | Full Text | References | PDF (2 MB)
  • 99 Views
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Article
The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats
Jia-Chuan Li, Xiao-Fei Shen, Jun-Ao Shao, Meng-Min Tao, Jian Gu, Jingyu Li & Ning Huang
Pages: 2695-2706
Published online: 31 Aug 2018
AbstractforThe total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats | Full Text | References | PDF (4.4 MB)
  • 116 Views
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Article
Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway
Xiao-Dong Li, Yu-Peng Wu, Shao-Hao Chen, Ying-Chun Liang, Ting-Ting Lin, Tian Lin, Yong Wei, Xue-Yi Xue, Qing-Shui Zheng & Ning Xu
Pages: 2707-2713
Published online: 03 Sep 2018
AbstractforFasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway | Full Text | References | PDF (2.5 MB)
  • 83 Views
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Article
17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy
Qingquan Wei, Xiuwei Liang, Ye Peng, Donghui Yu, Ruiling Zhang, Huizi Jin, Jiaqi Fan, Wenting Cai, Chengda Ren & Jing Yu
Pages: 2715-2730
Published online: 04 Sep 2018
Abstractfor17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy | Full Text | References | PDF (5.6 MB)
  • 119 Views
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Article
Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells
Yi Zhang, Hui Guo, Brian Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Ting Li, Pei-Li Zhu, Kai-Wing Tse, Si-Yuan Pan & Zhi-Ling Yu
Pages: 2731-2748
Published online: 04 Sep 2018
AbstractforDingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells | Full Text | References | PDF (3.2 MB)
  • 136 Views
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Review

Review Article
Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence
Kenichi Morikawa, Akihisa Nakamura, Tomoe Shimazaki & Naoya Sakamoto
Pages: 2749-2756
Published online: 05 Sep 2018
AbstractforSafety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence | Full Text | References | PDF (722.9 KB)
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Original Research

Article
Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?
David A Brott, Michael J Goodman, Richard P Hermann, Michael Merz, Roser Calvo, Nadereh Poorkhalkali & Alexandre Kiazand
Pages: 2757-2773
Published online: 06 Sep 2018
AbstractforAre laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations? | Full Text | References | PDF (5.9 MB)
  • 84 Views
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Article
Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms
Morton Scheinberg, Henrique Pott Júnior, Eduardo de Almeida Macêdo, Monalisa Fernanda Bocchi de Oliveira, Christina Ecclissato & Roberto Bleuel Amazonas
Pages: 2775-2783
Published online: 06 Sep 2018
AbstractforEfficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms | Full Text | References | PDF (697.7 KB)
  • 151 Views
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Article
Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats
Xiao Lei, Limei Zhang, Zonglin Li & Jigang Ren
Pages: 2785-2793
Published online: 06 Sep 2018
AbstractforAstragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats | Full Text | References | PDF (1.6 MB)
  • 92 Views
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Article
The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules
Nadine Pavloff, Terry A Hauser, Chris Williams, Sara Louis Isbell, Ben Cadieux & Mark Johnson
Pages: 2795-2804
Published online: 06 Sep 2018
AbstractforThe effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules | Full Text | References | PDF (497.1 KB)
  • 101 Views
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Article
Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth
Franck Gallardo, Bernard Mariamé, Remi Gence & Anne-Francoise Tilkin-Mariamé
Pages: 2805-2814
Published online: 07 Sep 2018
AbstractforMacrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth | Full Text | References | PDF (1.9 MB)
  • 275 Views
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Article
Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells
Bohong Guo, Cancheng Liao, Xiaohong Liu & Jun Yi
Pages: 2815-2826
Published online: 07 Sep 2018
AbstractforPreliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells | Full Text | References | PDF (3.1 MB)
  • 118 Views
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Review

Review Article
Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin & Ren Zhang
Pages: 2827-2840
Published online: 07 Sep 2018
AbstractforAlpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy | Full Text | References | PDF (802.2 KB)
  • 189 Views
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Original Research

Article
Anti-HER2 functionalized graphene oxide as survivin-siRNA delivery carrier inhibits breast carcinoma growth in vitro and in vivo
Xiaoli Wang, Qi Sun, Chunying Cui, Jing Li & Yifan Wang
Pages: 2841-2855
Published online: 07 Sep 2018
AbstractforAnti-HER2 functionalized graphene oxide as survivin-siRNA delivery carrier inhibits breast carcinoma growth in vitro and in vivo | Full Text | References | PDF (2.6 MB)
  • 92 Views
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Review

Review Article
Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives
Francesco Facchinetti, Paola Bordi, Alessandro Leonetti, Sebastiano Buti & Marcello Tiseo
Pages: 2857-2873
Published online: 10 Sep 2018
AbstractforProfile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives | Full Text | References | PDF (684.8 KB)
  • 107 Views
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Original Research

Article
Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties
Evgenia N Olsufyeva, Andrey E Shchekotikhin, Elena N Bychkova, Eleonora R Pereverzeva, Ivan D Treshalin, Elena P Mirchink, Elena B Isakova, Mikhail G Chernobrovkin, Roman S Kozlov, Andrey V Dekhnich & Maria N Preobrazhenskaya
Pages: 2875-2885
Published online: 10 Sep 2018
AbstractforEremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties | Full Text | References | PDF (736.6 KB)
  • 90 Views
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Article
Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2
Jiayu Li, Rong Dong, Jiali Yu, Sun Yi, Jingjing Da, Fuxun Yu & Yan Zha
Pages: 2887-2896
Published online: 11 Sep 2018
AbstractforInhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2 | Full Text | References | PDF (3.7 MB)
  • 214 Views
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Article
Geraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells
Yue Huang, Xiao-Lin Yang, Yi-Hua Ni & Zheng-Min Xu
Pages: 2897-2903
Published online: 11 Sep 2018
AbstractforGeraniol suppresses proinflammatory mediators in phorbol 12-myristate 13-acetate with A23187-induced HMC-1 cells | Full Text | References | PDF (1.5 MB)
  • 160 Views
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Review

Review Article
Chemopreventive activity of sulforaphane
Xin Jiang, Ye Liu, Lixin Ma, Rui Ji, Yaqin Qu, Ying Xin & Guoyue Lv
Pages: 2905-2913
Published online: 11 Sep 2018
AbstractforChemopreventive activity of sulforaphane | Full Text | References | PDF (302.6 KB)
  • 263 Views
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Article
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease
Venkata Raveendra Pothineni, Mansi B Parekh, Mustafeez Mujtaba Babar, Aditya Ambati, Peter Maguire, Mohammed Inayathullah, Kwang-Min Kim, Lobat Tayebi, Hari-Hara SK Potula & Jayakumar Rajadas
Pages: 2915-2921
Published online: 11 Sep 2018
AbstractforIn vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease | Full Text | References | PDF (843.5 KB)
  • 101 Views
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Article
Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction
Szilvia Berkó, Stella Zsikó, Gábor Deák, Attila Gácsi, Anita Kovács, Mária Budai-Szűcs, László Pajor, Zoltán Bajory & Erzsébet Csányi
Pages: 2923-2931
Published online: 12 Sep 2018
AbstractforPapaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction | Full Text | References | PDF (2.5 MB)
  • 165 Views
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Review

Review Article
GlycoPEGylated recombinant factor IX for hemophilia B in context
Elena Santagostino & Maria Elisa Mancuso
Pages: 2933-2943
Published online: 11 Sep 2018
AbstractforGlycoPEGylated recombinant factor IX for hemophilia B in context | Full Text | References | PDF (1.6 MB)
  • 95 Views
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Article
Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy
Yu Hong, Ning Deng, Han-Na Jin, Zheng-Zheng Xuan, Yi-Xiao Qian, Zhi-yong Wu & Wei Xie
Pages: 2945-2958
Published online: 11 Sep 2018
AbstractforSaikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy | Full Text | References | PDF (4.9 MB)
  • 96 Views
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Article
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor
Ling Chen, Jing Zhong, Saiqun Li, Weihua Li, Bowen Wang, Yuqing Deng & Jin Yuan
Pages: 2959-2969
Published online: 12 Sep 2018
AbstractforThe long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor | Full Text | References | PDF (6.9 MB)
  • 92 Views
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Article
Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit
Xiaolei Wang, Yanbin Gao, Nianxiu Tian, Zhiyao Zhu, Tao Wang, Jiayi Xu, Bingjie Wu & Nan Zhang
Pages: 2971-2980
Published online: 12 Sep 2018
AbstractforAstragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit | Full Text | References | PDF (7.1 MB)
  • 83 Views
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Article
Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin”
Hend Mohamed Anter, Irhan Ibrahim Abu Hashim, Walaa Awadin & Mahasen Mohamed Meshali
Pages: 2981-3001
Published online: 13 Sep 2018
AbstractforNovel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical “Apocynin” | Full Text | References | PDF (4.8 MB)
  • 190 Views
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Article
The role of hypoxia-inducible factor stabilizers in the treatment of anemia in patients with chronic kidney disease
Hongzhen Zhong, Tianbiao Zhou, Hongyan Li & Zhiqing Zhong
Pages: 3003-3011
Published online: 18 Sep 2018
AbstractforThe role of hypoxia-inducible factor stabilizers in the treatment of anemia in patients with chronic kidney disease | Full Text | References | PDF (5 MB)
  • 125 Views
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Article
Risk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials
Yongping Liu, Jun Meng & Guichan Wang
Pages: 3013-3019
Published online: 17 Sep 2018
AbstractforRisk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials | Full Text | References | PDF (734.5 KB)
  • 91 Views
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Article
Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway
Zichang Zhao, Wei Shen, Hanbin Zhu, Lin Lin, Gening Jiang, Yongzhe Zhu, Hongyuan Song & Liang Wu
Pages: 3021-3031
Published online: 17 Sep 2018
AbstractforZoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway | Full Text | References | PDF (3.9 MB)
  • 80 Views
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Article
Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats
Chia-Hsien Chen, Wei-Chuan Chen, Chun-Yi Lin, Chih-Hwa Chen, Yang-Hwei Tsuang & Yi-Jie Kuo
Pages: 3033-3041
Published online: 18 Sep 2018
AbstractforSintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats | Full Text | References | PDF (3.1 MB)
  • 72 Views
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Article
Fatal adverse events with molecular targeted agents in the treatment of advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials
Xiaofei Li, Jia Wan, Zhenping Wu, Juncai Tu, Yongtao Hu, Shuang Wu & Lianqing Lou
Pages: 3043-3049
Published online: 18 Sep 2018
AbstractforFatal adverse events with molecular targeted agents in the treatment of advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials | Full Text | References | PDF (797.5 KB)
  • 60 Views
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Article
Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration
Sibghatullah Sangi, Nagaraja SreeHarsha, Abdulhakim Bawadekji & Mouhanad Al Ali
Pages: 3051-3060
Published online: 18 Sep 2018
AbstractforChemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration | Full Text | References | PDF (2 MB)
  • 108 Views
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Article
Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction
Işın Güneş, Nuran Süngü, Aydan Kılıçarslan, Volkan Şıvgın, Metin Alkan, Ayşegül Küçük, Hakan Boyunağa, Yusuf Ünal & Mustafa Arslan
Pages: 3061-3070
Published online: 20 Sep 2018
AbstractforEffects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction | Full Text | References | PDF (3 MB)
  • 68 Views
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Article
Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites
Ahmed Mahmoud Abdelhaleem Ali, Ahmed Khames, Majed Mansour Alrobaian, Mohammad Hamaidi & Mohammed AS Abourehab
Pages: 3071-3084
Published online: 21 Sep 2018
AbstractforGlucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites | Full Text | References | PDF (2.2 MB)
  • 204 Views
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Article
Comparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer
Si Li, Wei Wei, Yi Jiang, Qiuyun Li, Qinghua Huang, Huawei Yang & Jianlun Liu
Pages: 3085-3093
Published online: 21 Sep 2018
AbstractforComparison of the efficacy and survival analysis of neoadjuvant chemotherapy for Her-2-positive breast cancer | Full Text | References | PDF (854.7 KB)
  • 108 Views
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Article
A targeted therapy for melanoma by graphene oxide composite with microRNA carrier
Can Liu, Huiqing Xie, Jingang Yu, Xiaoqing Chen, Shijie Tang, Lichun Sun, Xiang Chen, Defei Peng, Xiangyan Zhang & Jianda Zhou
Pages: 3095-3106
Published online: 21 Sep 2018
AbstractforA targeted therapy for melanoma by graphene oxide composite with microRNA carrier | Full Text | References | PDF (3.2 MB)
  • 107 Views
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Article
Murrangatin suppresses angiogenesis induced by tumor cell–derived media and inhibits AKT activation in zebrafish and endothelial cells
Weiqing Long, Mingjun Wang, Xiongming Luo, Guixian Huang & Jianwen Chen
Pages: 3107-3115
Published online: 24 Sep 2018
AbstractforMurrangatin suppresses angiogenesis induced by tumor cell–derived media and inhibits AKT activation in zebrafish and endothelial cells | Full Text | References | PDF (3.6 MB)
  • 81 Views
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Review

Review Article
Current development of biodegradable polymeric materials for biomedical applications
Richard Song, Maxwell Murphy, Chenshuang Li, Kang Ting, Chia Soo & Zhong Zheng
Pages: 3117-3145
Published online: 24 Sep 2018
AbstractforCurrent development of biodegradable polymeric materials for biomedical applications | Full Text | References | PDF (971.8 KB)
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Review Article
Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy
Sasigarn A Bowden & Brian L Foster
Pages: 3147-3161
Published online: 24 Sep 2018
AbstractforProfile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy | Full Text | References | PDF (7.5 MB)
  • 263 Views
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Review Article
Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis
Feng-Chih Kuo, Pao-Yen Lin, Jun-Wen Wang, Po-Chun Lin, Mel S Lee & Antonia F Chen
Pages: 3163-3170
Published online: 24 Sep 2018
AbstractforIntravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis | Full Text | References | PDF (603.6 KB)
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Article
Colorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers
Zhiyu Wang, Yaning Wei, Guotao Fang, Dan Hong, Lin An, Ting Jiao, Yan Shi & Aimin Zang
Pages: 3171-3180
Published online: 24 Sep 2018
AbstractforColorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers | Full Text | References | PDF (3.8 MB)
  • 123 Views
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Review Article
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
Matej Sova & Luciano Saso
Pages: 3181-3197
Published online: 25 Sep 2018
AbstractforDesign and development of Nrf2 modulators for cancer chemoprevention and therapy: a review | Full Text | References | PDF (1.5 MB)
  • 241 Views
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Article
Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid–polymer hybrid nanoparticles
Jia Liu, Hao Cheng, Le Han, Zhun Qiang, Xinwei Zhang, Wei Gao, Kun Zhao & Yangrong Song
Pages: 3199-3209
Published online: 25 Sep 2018
AbstractforSynergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid–polymer hybrid nanoparticles | Full Text | References | PDF (1 MB)
  • 448 Views
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Article
RETRACTED ARTICLE: Lycium barbarum polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway
Fenglian Yang, Yuxia Wei, Biyun Liao, Guijiang Wei, Haimei Qin, Xiaoxia Pang & Junli Wang
Pages: 3211-3219
Published online: 26 Sep 2018
AbstractforRETRACTED ARTICLE: Lycium barbarum polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway | PDF (1.9 MB)
  • 28 Views
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Article
Lactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model
Anna Tomusiak-Plebanek, Piotr Heczko, Beata Skowron, Agnieszka Baranowska, Krzysztof Okoń, Piotr J Thor & Magdalena Strus
Pages: 3221-3233
Published online: 28 Sep 2018
AbstractforLactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model | Full Text | References | PDF (3.3 MB)
  • 252 Views
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Review Article
Copper-64: a real theranostic agent
Bianca Gutfilen, Sergio AL Souza & Gianluca Valentini
Pages: 3235-3245
Published online: 02 Oct 2018
AbstractforCopper-64: a real theranostic agent | Full Text | References | PDF (734.9 KB)
  • 299 Views
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Article
Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway
Yihao Zhu, Jiang Fang, Handong Wang, Maoxing Fei, Ting Tang, Kaichao Liu, Wenhao Niu & Yali Zhou
Pages: 3247-3261
Published online: 02 Oct 2018
AbstractforBaicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway | Full Text | References | PDF (10.1 MB)
  • 107 Views
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Article
Effect of butorphanol on opioid-induced cough: a meta-analysis of randomized controlled trials
Jian Zhang, Shuai Miao, Qing Tu, Mengzhu Shi, Lan Zou, Su Liu & Guanglei Wang
Pages: 3263-3268
Published online: 02 Oct 2018
AbstractforEffect of butorphanol on opioid-induced cough: a meta-analysis of randomized controlled trials | Full Text | References | PDF (663.9 KB)
  • 83 Views
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Article
α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo
Changshun Chen, Chen Zhu, Xiang Hu, Qiuli Yu, Qianjin Zheng, Shengxiang Tao & Lihong Fan
Pages: 3269-3287
Published online: 02 Oct 2018
Abstractforα-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo | Full Text | References | PDF (8.8 MB)
  • 135 Views
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Review

Review Article
Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride
Yaguang Wang, Yafen Gao & Jun Ma
Pages: 3289-3299
Published online: 05 Oct 2018
AbstractforPleiotropic effects and pharmacological properties of penehyclidine hydrochloride | Full Text | References | PDF (1,017.2 KB)
  • 108 Views
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Article
Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment
Dan Xu, Shu-Ting Lu, Yu-Shuang Li, Aju Baidya, Hao Mei, Yong He & Bo Wu
Pages: 3301-3309
Published online: 05 Oct 2018
AbstractforEvaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment | Full Text | References | PDF (11.3 MB)
  • 81 Views
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Review Article
Pretreatment with lidocaine reduces both incidence and severity of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
Bingchen Lang, Lingli Zhang, Chunsong Yang, Yunzhu Lin, Wensheng Zhang & Fengshan Li
Pages: 3311-3319
Published online: 04 Oct 2018
AbstractforPretreatment with lidocaine reduces both incidence and severity of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials | Full Text | References | PDF (652.8 KB)
  • 93 Views
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Article
Gastric cancer combination therapy: synthesis of a hyaluronic acid and cisplatin containing lipid prodrug coloaded with sorafenib in a nanoparticulate system to exhibit enhanced anticancer efficacy and reduced toxicity
Feng Yang, Aimei Li, Han Liu & Hairong Zhang
Pages: 3321-3333
Published online: 04 Oct 2018
AbstractforGastric cancer combination therapy: synthesis of a hyaluronic acid and cisplatin containing lipid prodrug coloaded with sorafenib in a nanoparticulate system to exhibit enhanced anticancer efficacy and reduced toxicity | Full Text | References | PDF (999 KB)
  • 168 Views
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Article
Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway
Lihong Chen, Jinhua Wang, Jianbo Wu, Qiaomei Zheng & Jifen Hu
Pages: 3335-3342
Published online: 04 Oct 2018
AbstractforIndirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway | Full Text | References | PDF (1.7 MB)
  • 215 Views
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Article
Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system
Wei Zhang, Kimberly R Jordan, Brian Schulte & Enkhtsetseg Purev
Pages: 3343-3356
Published online: 05 Oct 2018
AbstractforCharacterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system | Full Text | References | PDF (1.9 MB)
  • 287 Views
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Article
RETRACTED ARTICLE: Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9
Xuchun Che, Rong Lu, Zheng Fu, Yajun Sun, Zhi-feng Zhu, Jin-ping Li, Song Wang, Jing Jia, Qing Wang & Zhi Yao
Pages: 3357-3368
Published online: 09 Oct 2018
AbstractforRETRACTED ARTICLE: Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9 | PDF (6.7 MB)
  • 25 Views
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Article
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study
Mitsuhiro Abe, Kenji Tsushima, Masashi Sakayori, Kenichi Suzuki, Jun Ikari, Jiro Terada & Koichiro Tatsumi
Pages: 3369-3375
Published online: 09 Oct 2018
AbstractforUtility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study | Full Text | References | PDF (659 KB)
  • 105 Views
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Article
Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers
Seong Shin Kwak, Eun Seok Lee, Ho Yub Yoon, Chang Hyun Kim, Yoon Tae Goo, Myung Joo Kang, Sangkil Lee, Bong Sang Lee, Hong Ryeol Jeon, Chang Hyun Oh & Young Wook Choi
Pages: 3377-3392
Published online: 09 Oct 2018
AbstractforImmediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers | Full Text | References | PDF (2.4 MB)
  • 214 Views
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Article
Synthesis and anticancer activity of dimeric podophyllotoxin derivatives
Cheng-Ting Zi, Liu Yang, Feng-Qing Xu, Fa-Wu Dong, Dan Yang, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang & Jiang-Miao Hu
Pages: 3393-3406
Published online: 09 Oct 2018
AbstractforSynthesis and anticancer activity of dimeric podophyllotoxin derivatives | Full Text | References | PDF (608.3 KB)
  • 183 Views
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Article
Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure
Jin Ma, Chunxia Yin, Shiyu Ma, Huiliang Qiu, Chaoyang Zheng, Qiuxiong Chen, Chunhua Ding & Weihui Lv
Pages: 3407-3418
Published online: 10 Oct 2018
AbstractforShensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure | Full Text | References | PDF (4.6 MB)
  • 169 Views
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Article
All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies
Yi Liu, Xiaoqing Ma, Jing Guo, Zhen Lin, Miao Zhou, Wenjuan Bi, Jinsong Liu, Jingxiao Wang, Haiping Lu & Gang Wu
Pages: 3419-3430
Published online: 10 Oct 2018
AbstractforAll-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies | Full Text | References | PDF (2.2 MB)
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Review Article
Inhibition of sialidase activity as a therapeutic approach
Victor Yu Glanz, Veronika A Myasoedova, Andrey V Grechko & Alexander N Orekhov
Pages: 3431-3437
Published online: 10 Oct 2018
AbstractforInhibition of sialidase activity as a therapeutic approach | Full Text | References | PDF (534.9 KB)
  • 229 Views
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Article
miR-708-5p promotes fibroblast-like synoviocytes’ cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway
Jie Wu, Wenqiang Fan, Ling Ma & Xiuqin Geng
Pages: 3439-3447
Published online: 10 Oct 2018
AbstractformiR-708-5p promotes fibroblast-like synoviocytes’ cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway | Full Text | References | PDF (1.9 MB)
  • 103 Views
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Article
Dose-proportional pharmacokinetic properties of GLA5PR GLARS-NF1 controlled-release pregabalin in healthy Korean volunteers: a randomized, open, single-dose, parallel study
Kwang-Hee Shin, Ji-Young Jeon, Kyungho Jang, Tae-Eun Kim & Min-Gul Kim
Pages: 3449-3457
Published online: 11 Oct 2018
AbstractforDose-proportional pharmacokinetic properties of GLA5PR GLARS-NF1 controlled-release pregabalin in healthy Korean volunteers: a randomized, open, single-dose, parallel study | Full Text | References | PDF (1.1 MB)
  • 119 Views
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Article
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway
Wencheng Ding, Teng Ji, Wei Xiong, Tian Li, Demin Pu & Rong Liu
Pages: 3459-3469
Published online: 15 Oct 2018
AbstractforRealgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway | Full Text | References | PDF (2.6 MB)
  • 76 Views
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Review Article
The efficacy and safety of aflibercept and conbercept in diabetic macular edema
Siwei Cai, Qianhui Yang, Xiaorong Li & Yan Zhang
Pages: 3471-3483
Published online: 15 Oct 2018
AbstractforThe efficacy and safety of aflibercept and conbercept in diabetic macular edema | Full Text | References | PDF (374.6 KB)
  • 182 Views
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Review Article
The retinoprotective role of phenytoin
Silvia Bartollino, Flavia Chiosi, Silvio di Staso, Maurizio Uva, Arduino Pascotto, Michele Rinaldi, Jan M Keppel Hesselink & Ciro Costagliola
Pages: 3485-3489
Published online: 16 Oct 2018
AbstractforThe retinoprotective role of phenytoin | Full Text | References | PDF (213.3 KB)
  • 130 Views
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Article
Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin
Jun Li, Min Yang & Wen-Rong Xu
Pages: 3491-3499
Published online: 23 Oct 2018
AbstractforEnhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin | Full Text | References | PDF (2.6 MB)
  • 160 Views
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Article
Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation
Heba A Abou-Taleb, Rasha A Khallaf & Jelan A Abdel-Aleem
Pages: 3501-3516
Published online: 17 Oct 2018
AbstractforIntranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation | Full Text | References | PDF (7.5 MB)
  • 494 Views
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Article
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy
Na Du, Zhiping Xu, Mingyue Gao, Peng Liu, Bo Sun & Xia Cao
Pages: 3517-3524
Published online: 18 Oct 2018
AbstractforCombination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy | Full Text | References | PDF (1.8 MB)
  • 106 Views
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Article
Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats
Farah M Abdulkhaleq, Tawfiq M Alhussainy, Mujtaba M Badr, Asad A Abu Khalil, Omar Gammoh, Bayan Y Ghanim & Nidal A Qinna
Pages: 3525-3533
Published online: 18 Oct 2018
AbstractforAntioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats | Full Text | References | PDF (537.1 KB)
  • 310 Views
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Review Article
Glutathione S-transferase π: a potential role in antitumor therapy
Shu-Chen Dong, Huan-Huan Sha, Xiao-Yue Xu, Tian-Mu Hu, Rui Lou, Huizi Li, Jian-Zhong Wu, Chen Dan & Jifeng Feng
Pages: 3535-3547
Published online: 23 Oct 2018
AbstractforGlutathione S-transferase π: a potential role in antitumor therapy | Full Text | References | PDF (3.3 MB)
  • 206 Views
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Review Article
Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma
Holly L Pacenta & Margaret E Macy
Pages: 3549-3561
Published online: 23 Oct 2018
AbstractforEntrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma | Full Text | References | PDF (1.9 MB)
  • 163 Views
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Article
Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression
Wuguo Tian, Shuai Hao, Bo Gao, Yan Jiang, Xiaohua Zhang, Shu Zhang, Lingji Guo, Jianjie Zhao, Gang Zhang, Yi Chen, Zhirong Li & Donglin Luo
Pages: 3563-3571
Published online: 29 Oct 2018
AbstractforLobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression | Full Text | References | PDF (957.3 KB)
  • 77 Views
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Article
Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte
Yang Dai, Ziwei Wang, Minxue Quan, Yanni Lv, Yunman Li, Hong-Bo Xin & Yisong Qian
Pages: 3573-3582
Published online: 25 Oct 2018
AbstractforAsiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte | Full Text | References | PDF (2.3 MB)
  • 100 Views
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Article
Effect and safety of antithrombotic therapies for secondary prevention after acute coronary syndrome: a network meta-analysis
Fanrui Mo, Juan Li, Yuluan Yan, Weifeng Wu & Shayi Lai
Pages: 3583-3594
Published online: 25 Oct 2018
AbstractforEffect and safety of antithrombotic therapies for secondary prevention after acute coronary syndrome: a network meta-analysis | Full Text | References | PDF (536.8 KB)
  • 58 Views
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Article
Asiatic acid ameliorates CCl4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways
Jie Fan, Qingshan Chen, Liwen Wei, Xiaoming Zhou, Rong Wang & Hai Zhang
Pages: 3595-3605
Published online: 26 Oct 2018
AbstractforAsiatic acid ameliorates CCl4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways | Full Text | References | PDF (3.6 MB)
  • 145 Views
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Article
Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects
Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Eun Hee Kim, Dong Heon Yang, Hae Won Lee & Young-Ran Yoon
Pages: 3607-3615
Published online: 26 Oct 2018
AbstractforPharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects | Full Text | References | PDF (474.9 KB)
  • 131 Views
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Article
Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling
Yangyang Shan, Shiwei Sun, Fan Yang, Nan Shang & Hongtao Liu
Pages: 3617-3624
Published online: 30 Oct 2018
AbstractforDexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling | Full Text | References | PDF (3.1 MB)
  • 97 Views
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Review

Review Article
Clinical effectiveness of ranibizumab and conbercept for neovascular age-related macular degeneration: a meta-analysis
Luping Wang, Canwei Zhang & Rui Hua
Pages: 3625-3633
Published online: 29 Oct 2018
AbstractforClinical effectiveness of ranibizumab and conbercept for neovascular age-related macular degeneration: a meta-analysis | Full Text | References | PDF (927 KB)
  • 78 Views
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Review Article
Darunavir–cobicistat–emtricitabine–tenofovir alafenamide: safety and efficacy of a protease inhibitor in the modern era
Nicola Squillace, Giorgio Bozzi, Elisa Colella, Andrea Gori & Alessandra Bandera
Pages: 3635-3643
Published online: 29 Oct 2018
AbstractforDarunavir–cobicistat–emtricitabine–tenofovir alafenamide: safety and efficacy of a protease inhibitor in the modern era | Full Text | References | PDF (374.2 KB)
  • 85 Views
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Article
Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations
Ei Mon Phyo Lwin, Catherine Leggett, Usha Ritchie, Cobus Gerber, Yunmei Song, William Hague, Sean Turner, Richard Upton & Sanjay Garg
Pages: 3645-3651
Published online: 29 Oct 2018
AbstractforTransfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations | Full Text | References | PDF (1.4 MB)
  • 138 Views
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Article
Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation
Ralf Regenthal, Margarita Voskanian, Frank Baumann, Jens Teichert, Christian Brätter, Achim Aigner & Getu Abraham
Pages: 3653-3664
Published online: 01 Nov 2018
AbstractforPharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation | Full Text | References | PDF (2 MB)
  • 189 Views
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Article
Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial
Bin Miao, Feng-Wu Li, Shu-Wen Zhang, Hong Wang, Wen-Jie Qi & Chao Wang
Pages: 3665-3673
Published online: 31 Oct 2018
AbstractforEfficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial | Full Text | References | PDF (309.1 KB)
  • 71 Views
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Article
Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway
Teng Li, Yuanyuan Zhong, Tao Tang, Jiekun Luo, Hanjin Cui, Rong Fan, Yang Wang & Dongsheng Wang
Pages: 3675-3684
Published online: 01 Nov 2018
AbstractforFormononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway | Full Text | References | PDF (3.1 MB)
  • 104 Views
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Article
Meta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury
Jing Zhang, Ying Guo, Qi Jin, Li Bian & Ping Lin
Pages: 3685-3690
Published online: 31 Oct 2018
AbstractforMeta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury | Full Text | References | PDF (543.2 KB)
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Article
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells
Xiaolei Liang, Ruirui Wang, Wenshan Dou, Li Zhao, Lanxia Zhou, Junfang Zhu, Kairong Wang & Jiexi Yan
Pages: 3691-3703
Published online: 31 Oct 2018
AbstractforArminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells | Full Text | References | PDF (5.2 MB)
  • 113 Views
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Article
Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo
Mingxing Wang, Bo Wu, Sapana N Shah, Peijuan Lu & Qilong Lu
Pages: 3705-3715
Published online: 31 Oct 2018
AbstractforSaponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo | Full Text | References | PDF (4.3 MB)
  • 127 Views
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Article
Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography
Yinbing Zhang, Haifeng Liu, Yingqian Zhang, Qiong Wu, Yanyan Zhang, Jie Zhang, Xiangshan Zhou, He Jiao, Feng Fan, Qi Xue, Xin Wang & Zhihui Zhong
Pages: 3717-3730
Published online: 01 Nov 2018
AbstractforEfficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography | Full Text | References | PDF (4 MB)
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Review

Review Article
Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy
Katya C Corado, Margaret R Caplan & Eric S Daar
Pages: 3731-3740
Published online: 01 Nov 2018
AbstractforTwo-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy | Full Text | References | PDF (287.5 KB)
  • 114 Views
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Original Research

Article
Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
Noor Atatreh, Mohammad A Ghattas, Sanaa K Bardaweel, Sara Al Rawashdeh & Mohammad Al Sorkhy
Pages: 3741-3752
Published online: 02 Nov 2018
AbstractforIdentification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening | Full Text | References | PDF (3.3 MB)
  • 193 Views
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Article
Hydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia
Samar Genedy, Ahmed Khames, Amal Hussein & Hatem Sarhan
Pages: 3753-3766
Published online: 05 Nov 2018
AbstractforHydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia | Full Text | References | PDF (4.9 MB)
  • 324 Views
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Article
Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial
Eun Ju Cho, Su Jong Yu, So Young Kwon, Ji-Hoon Kim, Do Young Kim, Won Kim, June Sung Lee, Jin Woo Lee, Youn Jae Lee, Hee Bok Chae & Jung-Hwan Yoon
Pages: 3767-3774
Published online: 02 Nov 2018
AbstractforConcomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial | Full Text | References | PDF (360 KB)
  • 73 Views
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Article
Effect of intrathecal dexmedetomidine on preventing shivering in cesarean section after spinal anesthesia: a meta-analysis and trial sequential analysis
Shuai Miao, Mengzhu Shi, Lan Zou & Guanglei Wang
Pages: 3775-3783
Published online: 02 Nov 2018
AbstractforEffect of intrathecal dexmedetomidine on preventing shivering in cesarean section after spinal anesthesia: a meta-analysis and trial sequential analysis | Full Text | References | PDF (1.1 MB)
  • 232 Views
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Article
Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat
Mansour Amraei, Mahmoud Mohamadpour, Mohammad Reza Hafezi Ahmadi, Monireh Azizi, Ahmad Daemi, Mohammad Omidi & Ehsan Shirzadpour
Pages: 3785-3795
Published online: 05 Nov 2018
AbstractforHistopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat | Full Text | References | PDF (1.5 MB)
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Corrigendum

Correction
The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum]
Page: 3797
Published online: 05 Nov 2018
CitationforThe effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum] | Full Text | PDF (142.5 KB)
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Original Research

Article
Comparative pharmacokinetics of an adalimumab biosimilar SB5 administered via autoinjector or prefilled syringe in healthy subjects
Donghoon Shin, Younju Lee, Deokyoon Jeong & Rod Ellis-Pegler
Pages: 3799-3805
Published online: 05 Nov 2018
AbstractforComparative pharmacokinetics of an adalimumab biosimilar SB5 administered via autoinjector or prefilled syringe in healthy subjects | Full Text | References | PDF (405.6 KB)
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Review

Review Article
An insight into new strategies to combat antifungal drug resistance
Yan-Hua Zheng, Yue-Yun Ma, Yi Ding, Xie-Qun Chen & Guang-Xun Gao
Pages: 3807-3816
Published online: 05 Nov 2018
AbstractforAn insight into new strategies to combat antifungal drug resistance | Full Text | References | PDF (289.2 KB)
  • 246 Views
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Original Research

Article
The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome
Hong Jiao & Huan Ren
Pages: 3817-3824
Published online: 06 Nov 2018
AbstractforThe effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome | Full Text | References | PDF (1.9 MB)
  • 79 Views
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Article
The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials
Wei-Te Lei, Hsin Hui Lin, Mu-Chieh Tsai, Hua-His Hung, Yu-Jyun Cheng, Shu-Jung Liu, Chien Yu Lin & Tzu-Lin Yeh
Pages: 3825-3845
Published online: 08 Nov 2018
AbstractforThe effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (1.2 MB)
  • 189 Views
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Article
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury
Hong-Mei Zhang, Wei Chen, Rui-Ning Liu & Yan Zhao
Pages: 3847-3854
Published online: 08 Nov 2018
AbstractforNotch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury | Full Text | References | PDF (1.5 MB)
  • 90 Views
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Article
A new strategy for taste masking of azithromycin antibiotic: development, characterization, and evaluation of azithromycin titanium nanohybrid for masking of bitter taste using physisorption and panel testing studies
Fazli Amin, Shahzeb Khan, Syed Muhammad Hassan Shah, Haroon Rahim, Zahid Hussain, Muhammad Sohail, Riaz Ullah, Mansour S Alsaid & Abdelaaty A Shahat
Pages: 3855-3866
Published online: 08 Nov 2018
AbstractforA new strategy for taste masking of azithromycin antibiotic: development, characterization, and evaluation of azithromycin titanium nanohybrid for masking of bitter taste using physisorption and panel testing studies | Full Text | References | PDF (2.3 MB)
  • 940 Views
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Article
The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats
Peiyang Gao, Ziyi Zhao, Chuantao Zhang, Chunxia Wang, Kunlan Long, Liuxue Guo & Baixue Li
Pages: 3867-3878
Published online: 13 Nov 2018
AbstractforThe therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats | Full Text | References | PDF (12.4 MB)
  • 137 Views
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Review

Review Article
Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis
Isabel M Haugh, Allie K Preston, Dario N Kivelevitch & Alan M Menter
Pages: 3879-3883
Published online: 12 Nov 2018
AbstractforRisankizumab: an anti-IL-23 antibody for the treatment of psoriasis | Full Text | References | PDF (612.4 KB)
  • 309 Views
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Review Article
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia
Stephanie Vairy, Julia Lopes Garcia, Pierre Teira & Henrique Bittencourt
Pages: 3885-3898
Published online: 12 Nov 2018
AbstractforCTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia | Full Text | References | PDF (1.5 MB)
  • 415 Views
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Original Research

Article
A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells
Guoxiang Li, Qifeng Yin, Huanhuan Ji, Yujuan Wang, Huihui Liu, Liangqian Jiang, Feng Zhu & Bing Li
Pages: 3899-3912
Published online: 13 Nov 2018
AbstractforA study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells | Full Text | References | PDF (5.2 MB)
  • 94 Views
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Article
Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells
Zhen Tan, Xiuli Zhang, Ting Kang, Lian Zhang & Siyu Chen
Pages: 3913-3927
Published online: 14 Nov 2018
AbstractforArsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells | Full Text | References | PDF (4.8 MB)
  • 114 Views
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Article
Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysis
Lei Cheng, Keyan Zhang & Zhenyong Zhang
Pages: 3929-3935
Published online: 14 Nov 2018
AbstractforEffectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysis | Full Text | References | PDF (534.6 KB)
  • 119 Views
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Article
Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles
Noha Attia, Mohamed Mashal, Cristina Soto-Sánchez, Gema Martínez-Navarrete, Eduardo Fernández, Santiago Grijalvo, Ramón Eritja, Gustavo Puras & Jose Luis Pedraz
Pages: 3937-3949
Published online: 16 Nov 2018
AbstractforGene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles | Full Text | References | PDF (6 MB)
  • 99 Views
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Article
Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis
Hongqiang Wu, Jian Ding, Lei Wang, Jinti Lin, Shihen Li, Guangheng Xiang, Liangfu Jiang, Huazi Xu, Weiyang Gao & Kailiang Zhou
Pages: 3951-3960
Published online: 16 Nov 2018
AbstractforValproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis | Full Text | References | PDF (8.7 MB)
  • 107 Views
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Article
Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
Wanjun Yan, Xingcong Ma, Xiaoyao Zhao & Shuqun Zhang
Pages: 3961-3972
Published online: 16 Nov 2018
AbstractforBaicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro | Full Text | References | PDF (5.8 MB)
  • 370 Views
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Article
Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells
Shimei Qi, Zunyong Feng, Qiang Li, Zhilin Qi & Yao Zhang
Pages: 3973-3984
Published online: 16 Nov 2018
AbstractforInhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells | Full Text | References | PDF (4.9 MB)
  • 106 Views
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Article
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
Jibo Han, Xiaowen Shi, Zhanxiong Zheng, Bin Zhang, Fengjie Shi, Liqin Jiang & Jianjiang Xu
Pages: 3985-3997
Published online: 22 Nov 2018
AbstractforSchisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway | Full Text | References | PDF (3 MB)
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Review

Review Article
Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
Sima Kianpour Rad, Aditya Arya, Hamed Karimian, Priya Madhavan, Farzana Rizwan, Shajan Koshy & Girish Prabhu
Pages: 3999-4021
Published online: 22 Nov 2018
AbstractforMechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease | Full Text | References | PDF (7.9 MB)
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Original Research

Article
Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HIF-1α/CXCR4 pathway
Haiyan Zhu, Xuxia Wang, Yuanyuan Han, Wenjuan Zhang, Wei Xin, Xiaotao Zheng & Jun Zhang
Pages: 4023-4031
Published online: 22 Nov 2018
AbstractforIcariin promotes the migration of bone marrow stromal cells via the SDF-1α/HIF-1α/CXCR4 pathway | Full Text | References | PDF (3.1 MB)
  • 92 Views
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Article
Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
Shan Feng, Bingxun Qiu, Li Zou, Ke Liu, Xiaoyu Xu & Huifeng Zhu
Pages: 4033-4046
Published online: 23 Nov 2018
AbstractforSchisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver | Full Text | References | PDF (2.6 MB)
  • 62 Views
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Article
Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers
Jie Huang, Cheng-xiao Fu, Xiao-yan Yang, Chan Cui, Shuang Yang, Yun Kuang, Cheng-xian Guo, Pei Hu, Qi Pei & Guo-ping Yang
Pages: 4047-4057
Published online: 26 Nov 2018
AbstractforPharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers | Full Text | References | PDF (713.6 KB)
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Review

Review Article
Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis
Stamatia Chorepsima, Konstantinos S Kechagias, Georgios Kalimeris, Nikolaos A Triarides & Matthew E Falagas
Pages: 4059-4066
Published online: 27 Nov 2018
AbstractforSpotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis | Full Text | References | PDF (274.6 KB)
  • 93 Views
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Original Research

Article
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
Jingfan Deng, Jiao Feng, Tong Liu, Xiya Lu, Wenwen Wang, Ning Liu, Yang Lv, Qing Liu, Chuanyong Guo & Yingqun Zhou
Pages: 4067-4082
Published online: 29 Nov 2018
AbstractforBeraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways | Full Text | References | PDF (11.4 MB)
  • 93 Views
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Article
The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside combined with Adriamycin on MCF-7 breast cancer cells
Jianfen Shen, Youzhi Zhang, Hui Shen, Hua Pan, Longsheng Xu, Linna Yuan & Zhiying Ding
Pages: 4083-4094
Published online: 30 Nov 2018
AbstractforThe synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside combined with Adriamycin on MCF-7 breast cancer cells | Full Text | References | PDF (2.4 MB)
  • 65 Views
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Article
Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats
Qiaoding Dai, Di Zhou, Liping Xu & Xinwei Song
Pages: 4095-4105
Published online: 03 Dec 2018
AbstractforCurcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats | Full Text | References | PDF (4.4 MB)
  • 494 Views
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Article
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
Mao Mu, Shi Zuo, Rong-Min Wu, Kai-Sheng Deng, Shuang Lu, Juan-Juan Zhu, Gao-Liang Zou, Jing Yang, Ming-Liang Cheng & Xue-Ke Zhao
Pages: 4107-4115
Published online: 03 Dec 2018
AbstractforFerulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway | Full Text | References | PDF (1.7 MB)
  • 354 Views
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Article
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury
Yuan Zhou, Han-dong Wang, Xiao-ming Zhou, Jiang Fang, Lin Zhu & Ke Ding
Pages: 4117-4127
Published online: 04 Dec 2018
AbstractforN-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury | Full Text | References | PDF (4.2 MB)
  • 176 Views
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Article
The role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts
Hana Polachek, Nir Debotton, Valeria Feinshtein, Mazal Rubin, Zvi Ben-Zvi, Gershon Holcberg, Riad Agbaria & Arik Dahan
Pages: 4129-4138
Published online: 04 Dec 2018
AbstractforThe role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts | Full Text | References | PDF (689.9 KB)
  • 81 Views
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Article
Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2
Tomasz Kostrzewa, Kamlesh K Sahu, Magdalena Gorska-Ponikowska, Jack A Tuszynski & Alicja Kuban-Jankowska
Pages: 4139-4147
Published online: 05 Dec 2018
AbstractforSynthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2 | Full Text | References | PDF (1.6 MB)
  • 159 Views
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Article
Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway
Wenting Cai, Donghui Yu, Jiaqi Fan, Xiuwei Liang, Huizi Jin, Chang Liu, Meijiang Zhu, Tianyi Shen, Ruiling Zhang, Weinan Hu, Qingquan Wei & Jing Yu
Pages: 4149-4161
Published online: 06 Dec 2018
AbstractforQuercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway | Full Text | References | PDF (4.3 MB)
  • 120 Views
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Article
SREBP-2, a new target of metformin?
Fengxia Zhang, Wenxiu Sun, Jianbo Chen, Lusheng Jiang, Ping Yang, Yufang Huang, Aihua Gong, Shudong Liu & Shizhan Ma
Pages: 4163-4170
Published online: 06 Dec 2018
AbstractforSREBP-2, a new target of metformin? | Full Text | References | PDF (1 MB)
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Article
Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights
Mohamed M Ibrahim, Abdulla M Abuelmatty, Gehan H Mohamed, Mohsen A Nasr, Amal K Hussein, Mohy El Deen Ebaed & Hatem A Sarhan
Pages: 4171-4179
Published online: 07 Dec 2018
AbstractforBest tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights | Full Text | References | PDF (386.9 KB)
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Article
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
Yun Jiang, Zhancheng Wang, Xu Chen, Wei Wang & Xiaowei Wang
Pages: 4181-4189
Published online: 10 Dec 2018
AbstractforADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress | Full Text | References | PDF (3.1 MB)
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Letter

Letter
Comment on the intravenous tranexamic acid use in revision total joint arthroplasty
Jieyu He & Youshuo Liu
Pages: 4191-4194
Published online: 10 Dec 2018
First Page PreviewforComment on the intravenous tranexamic acid use in revision total joint arthroplasty | Full Text | References | PDF (196.8 KB)
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Review

Review Article
Recent development in the strategies projected for chikungunya vaccine in humans
Manu Goyal, Anil Chauhan, Vishavdeep Goyal, Nishant Jaiswal, Shreya Singh & Meenu Singh
Pages: 4195-4206
Published online: 10 Dec 2018
AbstractforRecent development in the strategies projected for chikungunya vaccine in humans | Full Text | References | PDF (478.7 KB)
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Original Research

Article
Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy
Peng Zhang, Zhongyu Ren, Zhiqiang Chen, Jinyong Zhu, Jing Liang, Rujia Liao & Jian Wen
Pages: 4207-4216
Published online: 10 Dec 2018
AbstractforIron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy | Full Text | References | PDF (2 MB)
  • 257 Views
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Article
Comparison of efficacy and safety between two different irbesartan, generic vs branded, in the treatment of Korean patients with mild-to-moderate hypertension: an 8-week, multicenter, randomized, open-label, Phase IV clinical study
Seung Hwan Han, Gyu Chul Oh, Hyuck Moon Kwon, Chang Gyu Park, In Jai Kim, Gyo-Seung Hwang, Byung Su Yoo, Seong Hoon Park, Kwang Je Lee & Hyo-soo Kim
Pages: 4217-4229
Published online: 19 Dec 2018
AbstractforComparison of efficacy and safety between two different irbesartan, generic vs branded, in the treatment of Korean patients with mild-to-moderate hypertension: an 8-week, multicenter, randomized, open-label, Phase IV clinical study | Full Text | References | PDF (660.1 KB)
  • 97 Views
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Article
Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system
Xiangju Zhao, Ying Sun & Zhaoguo Li
Pages: 4231-4240
Published online: 13 Dec 2018
AbstractforTopical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system | Full Text | References | PDF (939.5 KB)
  • 144 Views
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Article
Gamma linolenic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced hepatocellular carcinoma
Hong Cui, Feng Han, Ling Zhang, Li Wang & Mukesh Kumar
Pages: 4241-4252
Published online: 13 Dec 2018
AbstractforGamma linolenic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced hepatocellular carcinoma | Full Text | References | PDF (1.4 MB)
  • 89 Views
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Short Report

Brief Report
MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1
Binchan He, Shen Geng, Wei Zhou, Yuwen Rui, Xianmin Mu, Chen Zhang, Qiang You & Xin Su
Pages: 4253-4260
Published online: 13 Dec 2018
AbstractforMMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1 | Full Text | References | PDF (1.3 MB)
  • 85 Views
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Original Research

Article
3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke
Ningyuan Chen, Zhibing Zhou, Ji Li, Bocheng Li, Jihua Feng, Dan He, Yifeng Luo, Xiaowen Zheng, Jiefeng Luo & Jianfeng Zhang
Pages: 4261-4271
Published online: 14 Dec 2018
Abstractfor3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke | Full Text | References | PDF (3.7 MB)
  • 137 Views
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