Nucleosides, Nucleotides & Nucleic Acids, Volume 33, Issue 4-6 (2014)

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Nucleosides, Nucleotides & Nucleic Acids, Volume 33, Issue 4-6 (2014)

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Proceedings of the 15th International Symposium on Purine and Pyrimidine Metabolism in Man

Miscellany

Proceedings of the 15th International Symposium on Purine and Pyrimidine Metabolism in Man
Pages: 163-164
Published online: 18 Jun 2014
CitationforProceedings of the 15th International Symposium on Purine and Pyrimidine Metabolism in Man | Full Text | PDF (128.1 KB)
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Novel Developments in Metabolic Disorders of Purine and Pyrimidine Metabolism and Therapeutic Applications of Their Analogs
Rosa J. Torres, Godefridus J. Peters & Juan G. Puig
Pages: 165-173
Published online: 18 Jun 2014
AbstractforNovel Developments in Metabolic Disorders of Purine and Pyrimidine Metabolism and Therapeutic Applications of Their Analogs | Full Text | References | PDF (187.9 KB)
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Efficacy and Safety of a Urate Lowering Regimen in Primary Gout
Rebeca Bailén, Nicolás M. González Senac, Mónica M. López, M. Luisa Llena, Marta Migoya, M. Teresa Rodríguez, Eugenio de Miguel, Rosa J. Torres & Juan G. Puig
Pages: 174-180
Published online: 18 Jun 2014
AbstractforEfficacy and Safety of a Urate Lowering Regimen in Primary Gout | Full Text | References | PDF (68 KB)
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Fenofibrate Increases Serum Creatinine in a Patient with Familial Nephropathy Associated to Hyperuricemia
G. Salgueiro, L. M. Beltrán, R. J. Torres & J. G. Puig
Pages: 181-184
Published online: 18 Jun 2014
AbstractforFenofibrate Increases Serum Creatinine in a Patient with Familial Nephropathy Associated to Hyperuricemia | Full Text | References | PDF (52.9 KB)
  • 148 Views
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Metabolic Syndrome in Primary Gout
Nicolás M. González-Senac, Rebeca Bailén, Rosa J. Torres, Eugenio de Miguel & Juan G. Puig
Pages: 185-191
Published online: 18 Jun 2014
AbstractforMetabolic Syndrome in Primary Gout | Full Text | References | PDF (102.8 KB)
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False In Vitro and In Vivo Elevations of Uric Acid Levels in Mouse Blood
Tamaki Watanabe, Naoko H. Tomioka, Shigekazu Watanabe, Masao Tsuchiya & Makoto Hosoyamada
Pages: 192-198
Published online: 18 Jun 2014
AbstractforFalse In Vitro and In Vivo Elevations of Uric Acid Levels in Mouse Blood | Full Text | References | PDF (227.8 KB)
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Proteomic Analysis to Examine the Role of Matrix Proteins in a Gouty Tophus from a Patient with Recurrent Gout
Kiyoko Kaneko, Hiro Iwamoto, Makoto Yasuda, Katsunori Inazawa, Noriko Yamaoka, Tomoko Fukuuchi, Yoshifuru Tamura, Shunya Uchida, Ken-ichi Mawatari, Kazuya Nakagomi, Yasukazu Yamada & Shin Fujimori
Pages: 199-207
Published online: 18 Jun 2014
AbstractforProteomic Analysis to Examine the Role of Matrix Proteins in a Gouty Tophus from a Patient with Recurrent Gout | Full Text | References | PDF (236.2 KB)
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Transcriptomic Approach to Lesch-Nyhan Disease
Luce Dauphinot, Lionel Mockel, Julie Cahu, H. A. Jinnah, Morgan Ledroit, Marie-Claude Potier & Irène Ceballos-Picot
Pages: 208-217
Published online: 18 Jun 2014
AbstractforTranscriptomic Approach to Lesch-Nyhan Disease | Full Text | References | PDF (199.8 KB)
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Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Deficiencies: HPRT1 Mutations in New Japanese Families and PRPP Concentration
Yasukazu Yamada, Noriko Nomura, Kenichiro Yamada, Reiko Kimura, Daisuke Fukushi, Nobuaki Wakamatsu, Yasufumi Matsuda, Takahiro Yamauchi, Takanori Ueda, Hiroshi Hasegawa, Makiko Nakamura, Kimiyoshi Ichida, Kiyoko Kaneko & Shin Fujimori
Pages: 218-222
Published online: 18 Jun 2014
AbstractforHypoxanthine Guanine Phosphoribosyltransferase (HPRT) Deficiencies: HPRT1 Mutations in New Japanese Families and PRPP Concentration | Full Text | References | PDF (55.9 KB)
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HPRT Deficiency in Spain: What Have We Learned in the Past 30 Years (1984–2013)?
R. J. Torres, C. Prior, M. G. Garcia, L. M. Beltran & J. G. Puig
Pages: 223-232
Published online: 18 Jun 2014
AbstractforHPRT Deficiency in Spain: What Have We Learned in the Past 30 Years (1984–2013)? | Full Text | References | PDF (384 KB)
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Thirteen Years Experience with Selective Screening for Disorders in Purine and Pyrimidine Metabolism
M. Castro, R. Carrillo, F. García, P. Sanz, I. Ferrer, P. Ruiz-Sala, A. I. Vega, L. Ruíz Desviat, B. Pérez, C. Pérez-Cerdá, B. Merinero & M. Ugarte
Pages: 233-240
Published online: 18 Jun 2014
AbstractforThirteen Years Experience with Selective Screening for Disorders in Purine and Pyrimidine Metabolism | Full Text | References | PDF (228 KB)
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2,8-Dihydroxyadenine Urolithiasis: A Not So Rare Inborn Error of Purine Metabolism
Irène Ceballos-Picot, Michel Daudon, Jérôme Harambat, Albert Bensman, Bertrand Knebelmann & Guillaume Bollée
Pages: 241-252
Published online: 18 Jun 2014
Abstractfor2,8-Dihydroxyadenine Urolithiasis: A Not So Rare Inborn Error of Purine Metabolism | Full Text | References | PDF (272.8 KB)
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Errata

Correction
Publisher's Note
Pages: 253-260
Published online: 18 Jun 2014
First Page PreviewforPublisher's Note | Full Text | PDF (196.2 KB)
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Free Access

Miscellany

Identification of a Hypouricemia Patient with SLC2A9 R380W, A Pathogenic Mutation for Renal Hypouricemia Type 2
Toshinori Chiba, Hirotaka Matsuo, Shushi Nagamori, Akiyoshi Nakayama, Yusuke Kawamura, Seiko Shimizu, Masayuki Sakiyama, Makoto Hosoyamada, Sayo Kawai, Rieko Okada, Nobuyuki Hamajima, Yoshikatsu Kanai & Nariyoshi Shinomiya
Pages: 261-265
Published online: 18 Jun 2014
AbstractforIdentification of a Hypouricemia Patient with SLC2A9 R380W, A Pathogenic Mutation for Renal Hypouricemia Type 2 | Full Text | References | PDF (210.9 KB)
  • 256 Views
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ABCG2 Dysfunction Increases the Risk of Renal Overload Hyperuricemia
Hirotaka Matsuo, Tappei Takada, Akiyoshi Nakayama, Toru Shimizu, Masayuki Sakiyama, Seiko Shimizu, Toshinori Chiba, Hiroshi Nakashima, Takahiro Nakamura, Yuzo Takada, Yutaka Sakurai, Tatsuo Hosoya, Nariyoshi Shinomiya & Kimiyoshi Ichida
Pages: 266-274
Published online: 18 Jun 2014
AbstractforABCG2 Dysfunction Increases the Risk of Renal Overload Hyperuricemia | Full Text | References | PDF (265.8 KB)
  • 398 Views
  • 31 CrossRef citations
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ABCG2 Dysfunction Increases Serum Uric Acid by Decreased Intestinal Urate Excretion
Tappei Takada, Kimiyoshi Ichida, Hirotaka Matsuo, Akiyoshi Nakayama, Keizo Murakami, Yoshihide Yamanashi, Hiroshi Kasuga, Nariyoshi Shinomiya & Hiroshi Suzuki
Pages: 275-281
Published online: 18 Jun 2014
AbstractforABCG2 Dysfunction Increases Serum Uric Acid by Decreased Intestinal Urate Excretion | Full Text | References | PDF (144.8 KB)
  • 582 Views
  • 52 CrossRef citations
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Mitochondrial Thymidine Kinase 2 but Not Deoxyguanosine Kinase Is Up-Regulated During the Stationary Growth Phase of Cultured Cells
Ren Sun, Staffan Eriksson & Liya Wang
Pages: 282-286
Published online: 18 Jun 2014
AbstractforMitochondrial Thymidine Kinase 2 but Not Deoxyguanosine Kinase Is Up-Regulated During the Stationary Growth Phase of Cultured Cells | Full Text | References | PDF (126.4 KB)
  • 105 Views
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Tomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation
N. B. Larsen, B. Munch-Petersen & J. Piškur
Pages: 287-290
Published online: 18 Jun 2014
AbstractforTomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation | Full Text | References | PDF (80.4 KB)
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Plants Salvage Deoxyribonucleosides in Mitochondria
Anders R. Clausen, Zeeshan Mutahir, Birgitte Munch-Petersen & Jure Piškur
Pages: 291-295
Published online: 18 Jun 2014
AbstractforPlants Salvage Deoxyribonucleosides in Mitochondria | Full Text | References | PDF (48.6 KB)
  • 131 Views
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Mycoplasma Pneumoniae Thymidine Phosphorylase
Liya Wang, Sebastian R. Schmidl & Jörg Stülke
Pages: 296-304
Published online: 18 Jun 2014
AbstractforMycoplasma Pneumoniae Thymidine Phosphorylase | Full Text | References | PDF (68.3 KB)
  • 136 Views
  • 4 CrossRef citations
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Immunohistochemical and Functional Analysis of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) and Ecto-5′-Nucleotidase (CD73) in Pig Aortic Valves
Ewa Kaniewska, Alicja Sielicka, Padmini Sarathchandra, Iwona Pelikant-Małecka, Mariola Olkowicz, Ewa M. Słomińska, Adrian H. Chester, Magdi H. Yacoub & Ryszad T. Smoleński
Pages: 305-312
Published online: 18 Jun 2014
AbstractforImmunohistochemical and Functional Analysis of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) and Ecto-5′-Nucleotidase (CD73) in Pig Aortic Valves | Full Text | References | PDF (302.5 KB)
  • 231 Views
  • 13 CrossRef citations
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Functional Analysis of Expression of Human Ecto-Nucleoside Triphosphate Diphosphohydrolase-1 and/or Ecto-5′-Nucleotidase in Pig Endothelial Cells
M. De Giorgi, I. Pelikant-Malecka, A. Sielicka, E. M. Slominska, R. Giovannoni, A. Cinti, M. G. Cerrito, M. Lavitrano & R. T. Smolenski
Pages: 313-318
Published online: 18 Jun 2014
AbstractforFunctional Analysis of Expression of Human Ecto-Nucleoside Triphosphate Diphosphohydrolase-1 and/or Ecto-5′-Nucleotidase in Pig Endothelial Cells | Full Text | References | PDF (236.9 KB)
  • 162 Views
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Effect of AMP-Deaminase 3 Knock-Out in Mice on Enzyme Activity in Heart and Other Organs
Iwona Rybakowska, Pawel Romaszko, Magdalena Zabielska, Jacek Turyn, Krystian Kaletha, Paul J. Barton, Ewa M. Slominska & Ryszard T. Smolenski
Pages: 319-322
Published online: 18 Jun 2014
AbstractforEffect of AMP-Deaminase 3 Knock-Out in Mice on Enzyme Activity in Heart and Other Organs | Full Text | References | PDF (72.4 KB)
  • 222 Views
  • 2 CrossRef citations
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Extracellular Nucleotide Catabolism in Aortoiliac Bifurcation of Atherosclerotic ApoE/LDLr Double Knock Out Mice
Barbara Kutryb-Zajac, Paulina Zukowska, Marta Toczek, Magdalena Zabielska, Marcin Lipinski, Iwona Rybakowska, Stefan Chlopicki, Ewa M. Slominska & Ryszard T. Smolenski
Pages: 323-328
Published online: 18 Jun 2014
AbstractforExtracellular Nucleotide Catabolism in Aortoiliac Bifurcation of Atherosclerotic ApoE/LDLr Double Knock Out Mice | Full Text | References | PDF (181.5 KB)
  • 139 Views
  • 12 CrossRef citations
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Extracellular Adenine Nucleotide Catabolism in Heart Valves
Marta Toczek, Barbara Kutryb-Zając, Małgorzata Kapczyńska, Marcin Lipiński, Ewa M. Słomińska & Ryszard T. Smoleński
Pages: 329-332
Published online: 18 Jun 2014
AbstractforExtracellular Adenine Nucleotide Catabolism in Heart Valves | Full Text | References | PDF (49.3 KB)
  • 78 Views
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Effect of 4-Pyridone-3-Carboxamide Ribonucleoside (4PYR)-Potential Cardiovascular Toxin in Perfused Rat Heart
Pawel Romaszko, Ewa M. Slominska & Ryszard T. Smolenski
Pages: 333-337
Published online: 18 Jun 2014
AbstractforEffect of 4-Pyridone-3-Carboxamide Ribonucleoside (4PYR)-Potential Cardiovascular Toxin in Perfused Rat Heart | Full Text | References | PDF (166.8 KB)
  • 66 Views
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4-Pyridone-3-Carboxamide-1β-D-Ribonucleoside Metabolism in Endothelial Cells and Its Impact on Cellular Energetic Balance
Iwona Pelikant-Małecka, Alicja Sielicka, Ewa Kaniewska, Ryszard T. Smoleński & Ewa M. Słomińska
Pages: 338-341
Published online: 18 Jun 2014
Abstractfor4-Pyridone-3-Carboxamide-1β-D-Ribonucleoside Metabolism in Endothelial Cells and Its Impact on Cellular Energetic Balance | Full Text | References | PDF (134.3 KB)
  • 132 Views
  • 10 CrossRef citations
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Effect of Nitrosative Stress on Extracellular Nucleotide Metabolism in Endothelial Cells
A. Sielicka, I. Pelikant-Malecka, E. Kaniewska, M. Olkowicz, Z. Pankrac, M. Swiatkowska-Freund, K. Preis, M. Gorska, E. M. Slominska & R. T. Smolenski
Pages: 342-346
Published online: 18 Jun 2014
AbstractforEffect of Nitrosative Stress on Extracellular Nucleotide Metabolism in Endothelial Cells | Full Text | References | PDF (79.6 KB)
  • 71 Views
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Activity of AMP-Regulated Protein Kinase and AMP-Deaminase in the Heart of Mice Fed High-Fat Diet
Iwona Rybakowska, Ewa M. Slominska, Paweł Romaszko, Marcin Lipiński, Paulina Żukowska & Ryszard T. Smolenski
Pages: 347-352
Published online: 18 Jun 2014
AbstractforActivity of AMP-Regulated Protein Kinase and AMP-Deaminase in the Heart of Mice Fed High-Fat Diet | Full Text | References | PDF (137.6 KB)
  • 118 Views
  • 4 CrossRef citations
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In Vitro and Cellular Effects of 4-Pyridone-3-Carboxamide Riboside on Enzymes of Nucleotide Metabolism
Ewa M. Slominska, Tomasz Borkowski, Iwona Rybakowska, Magdalena Abramowicz-Glinka, Czesława Orlewska & Ryszard T. Smolenski
Pages: 353-357
Published online: 18 Jun 2014
AbstractforIn Vitro and Cellular Effects of 4-Pyridone-3-Carboxamide Riboside on Enzymes of Nucleotide Metabolism | Full Text | References | PDF (196 KB)
  • 110 Views
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Research Article

Article
Novel Developments in the Use of Antimetabolites
Godefridus J. Peters
Pages: 358-374
Published online: 18 Jun 2014
AbstractforNovel Developments in the Use of Antimetabolites | Full Text | References | PDF (457.5 KB)
  • 1053 Views
  • 43 CrossRef citations
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Miscellany

Mechanisms of Action of Fludarabine Nucleoside Against Human Raji Lymphoma Cells
Richard I. Christopherson, Swetlana Mactier, Juhura G. Almazi, Philippa L. Kohnke, O. Giles Best & Stephen P. Mulligan
Pages: 375-383
Published online: 18 Jun 2014
AbstractforMechanisms of Action of Fludarabine Nucleoside Against Human Raji Lymphoma Cells | Full Text | References | PDF (252.1 KB)
  • 392 Views
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miR-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells
Mina Maftouh, Amir Avan, Niccola Funel, Adam E. Frampton, Hamid Fiuji, Serena Pelliccioni, Leandro Castellano, Valentina Galla, Godefridus J. Peters & Elisa Giovannetti
Pages: 384-393
Published online: 18 Jun 2014
AbstractformiR-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells | Full Text | References | PDF (239.9 KB)
  • 216 Views
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Original Articles

Article
The Pyrimidine Nucleoside Phosphorylase of Mycoplasma hyorhinis and How It May Affect Nucleoside-Based Therapy
J. Vande Voorde, S. Liekens, F. Gago & J. Balzarini
Pages: 394-402
Published online: 18 Jun 2014
AbstractforThe Pyrimidine Nucleoside Phosphorylase of Mycoplasma hyorhinis and How It May Affect Nucleoside-Based Therapy | Full Text | References | PDF (220.8 KB)
  • 143 Views
  • 3 CrossRef citations
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Miscellany

Selection of the Best Blood Compartment to Measure Cytidine Deaminase Activity to Stratify for Optimal Gemcitabine or Cytarabine Treatment
Godefridus J. Peters, Richard J. Honeywell, Marie Maulandi, Elisa Giovannetti, Nienke Losekoot, Marie-Christine Etienne-Grimaldi, Gerard Milano, Cindy Serdjebi, Joseph Ciccolini & for the EORTC-Pharmacology and Molecular Mechanism Group
Pages: 403-412
Published online: 18 Jun 2014
AbstractforSelection of the Best Blood Compartment to Measure Cytidine Deaminase Activity to Stratify for Optimal Gemcitabine or Cytarabine Treatment | Full Text | References | PDF (256.8 KB)
  • 196 Views
  • 17 CrossRef citations
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Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines
Maha El-Naggar, Eva Ebbing, Irene Bijnsdorp, Jaap van den Berg & Godefridus J. Peters
Pages: 413-421
Published online: 18 Jun 2014
AbstractforRadiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines | Full Text | References | PDF (339.7 KB)
  • 167 Views
  • 7 CrossRef citations
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Assessment of Mercaptopurine (6MP) Metabolites and 6MP Metabolic Key-Enzymes in Childhood Acute Lymphoblastic Leukemia
Anna Wojtuszkiewicz, Ana Barcelos, Boas Dubbelman, Ronney De Abreu, Connie Brouwer, Jos P. Bökkerink, Valerie de Haas, Hester de Groot-Kruseman, Gerrit Jansen, Gertjan L. Kaspers, Jacqueline Cloos & G. J. Peters
Pages: 422-433
Published online: 18 Jun 2014
AbstractforAssessment of Mercaptopurine (6MP) Metabolites and 6MP Metabolic Key-Enzymes in Childhood Acute Lymphoblastic Leukemia | Full Text | References | PDF (120.4 KB)
  • 245 Views
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Hyperuricemia in Hematologic Malignancies Is Caused by an Insufficient Urinary Excretion
Yoko Oka, Haruko Tashiro, Ryosuke Sirasaki, Tadashi Yamamoto, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji & Shin Fujimori
Pages: 434-438
Published online: 18 Jun 2014
AbstractforHyperuricemia in Hematologic Malignancies Is Caused by an Insufficient Urinary Excretion | Full Text | References | PDF (80.4 KB)
  • 110 Views
  • 8 CrossRef citations
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Determination and Profiling of Purines in Foods by Using HPLC AND LC-MS
K. Inazawa, A. Sato, Y. Kato, N. Yamaoka, T. Fukuuchi, M. Yasuda, K. Mawatari, K. Nakagomi & K. Kaneko
Pages: 439-444
Published online: 18 Jun 2014
AbstractforDetermination and Profiling of Purines in Foods by Using HPLC AND LC-MS | Full Text | References | PDF (184.8 KB)
  • 483 Views
  • 12 CrossRef citations
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Original Articles

Article
Characterizing Substrate Properties of Purine-Related Compounds with Purine Metabolism Enzymes for Enzymatic Peak-Shift HPLC Method
T. Fukuuchi, A. Morimura, M. Kawatani, K. Yamamoto, N. Yamaoka & K. Kaneko
Pages: 445-453
Published online: 18 Jun 2014
AbstractforCharacterizing Substrate Properties of Purine-Related Compounds with Purine Metabolism Enzymes for Enzymatic Peak-Shift HPLC Method | Full Text | References | PDF (165.9 KB)
  • 163 Views
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