Nucleosides, Nucleotides & Nucleic Acids, Volume 35, Issue 10-12 (2016)

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Nucleosides, Nucleotides & Nucleic Acids, Volume 35, Issue 10-12 (2016)

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Proceedings of the 16th International Symposium on Purine and Pyrimidine Metabolism in Man (PP15)

Miscellany

Advances in purine and pyrimidine metabolism in health and diseases
Michio Hirano & Godefridus J. Peters
Pages: 495-501
Published online: 01 Dec 2016
AbstractforAdvances in purine and pyrimidine metabolism in health and diseases | Full Text | References | PDF (292.8 KB)
  • 291 Views
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Summary of the 2015 Purine and Pyrimidine Society/Purine Metabolic Patients Association H. Anne Simmonds Memorial Lecture
Michael A. Becker
Pages: 502-506
Published online: 01 Dec 2016
First Page PreviewforSummary of the 2015 Purine and Pyrimidine Society/Purine Metabolic Patients Association H. Anne Simmonds Memorial Lecture | Full Text | References | PDF (274.8 KB)
  • 65 Views
  • 1 CrossRef citations
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A review of the implication of hypoxanthine excess in the physiopathology of Lesch–Nyhan disease
R. J. Torres, C. Prior, M. G. Garcia & J. G. Puig
Pages: 507-516
Published online: 01 Dec 2016
AbstractforA review of the implication of hypoxanthine excess in the physiopathology of Lesch–Nyhan disease | Full Text | References | PDF (426.8 KB)
  • 395 Views
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Ultrasonography in the diagnosis of asymptomatic hyperuricemia and gout
J. G. Puig, L. M. Beltrán, C. Mejía-Chew, D. Tevar & R. J. Torres
Pages: 517-523
Published online: 01 Dec 2016
AbstractforUltrasonography in the diagnosis of asymptomatic hyperuricemia and gout | Full Text | References | PDF (366.4 KB)
  • 255 Views
  • 12 CrossRef citations
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Development of new forms of self-injurious behavior following total dental extraction in Lesch–Nyhan disease
Livia Gisbert de la Cuadra, Rosa J. Torres, Luis M. Beltrán, Arantxa Sánchez & Juan G. Puig
Pages: 524-528
Published online: 01 Dec 2016
AbstractforDevelopment of new forms of self-injurious behavior following total dental extraction in Lesch–Nyhan disease | Full Text | References | PDF (342 KB)
  • 131 Views
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Prevalence of URAT1 allelic variants in the Roma population
Blanka Stiburkova, Dana Gabrikova, Pavel Čepek, Pavel Šimek, Pavol Kristian, Elizabeth Cordoba-Lanus & Felix Claverie-Martin
Pages: 529-535
Published online: 01 Dec 2016
AbstractforPrevalence of URAT1 allelic variants in the Roma population | Full Text | References | PDF (359.9 KB)
  • 192 Views
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Original Articles

Article
Expression of a human NPT1/SLC17A1 missense variant which increases urate export
Masayuki Sakiyama, Hirotaka Matsuo, Shushi Nagamori, Wei Ling, Yusuke Kawamura, Akiyoshi Nakayama, Toshihide Higashino, Toshinori Chiba, Kimiyoshi Ichida, Yoshikatsu Kanai & Nariyoshi Shinomiya
Pages: 536-542
Published online: 01 Dec 2016
AbstractforExpression of a human NPT1/SLC17A1 missense variant which increases urate export | Full Text | References | PDF (401.4 KB)
  • 248 Views
  • 8 CrossRef citations
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Miscellany

Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury
Makoto Hosoyamada, Yu Tsurumi, Hidenori Hirano, Naoko H. Tomioka, Yuko Sekine, Takayuki Morisaki & Shunya Uchida
Pages: 543-549
Published online: 01 Dec 2016
AbstractforUrat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury | Full Text | References | PDF (442.3 KB)
  • 340 Views
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Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease
Michito Nagura, Yoshifuru Tamura, Takanori Kumagai, Makoto Hosoyamada & Shunya Uchida
Pages: 550-558
Published online: 01 Dec 2016
AbstractforUric acid metabolism of kidney and intestine in a rat model of chronic kidney disease | Full Text | References | PDF (474 KB)
  • 327 Views
  • 22 CrossRef citations
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Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice
K. Inazawa, S. Yamaguchi, M. Hosoyamada, T. Fukuuchi, N. H. Tomioka, N. Yamaoka & K. Kaneko
Pages: 559-565
Published online: 01 Dec 2016
AbstractforUrinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice | Full Text | References | PDF (452 KB)
  • 260 Views
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Reviews

Review
Orotate (orotic acid): An essential and versatile molecule
M. Löffler, E.A. Carrey & E. Zameitat
Pages: 566-577
Published online: 01 Dec 2016
AbstractforOrotate (orotic acid): An essential and versatile molecule | Full Text | References | PDF (454.8 KB)
  • 1010 Views
  • 45 CrossRef citations
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Miscellany

Mitochondrial purine and pyrimidine metabolism and beyond
Liya Wang
Pages: 578-594
Published online: 01 Dec 2016
AbstractforMitochondrial purine and pyrimidine metabolism and beyond | Full Text | References | PDF (525.8 KB)
  • 2108 Views
  • 64 CrossRef citations
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Role of genomic factors beyond thymidylate synthase in the prediction of response to 5-fluorouracil
Godefridus J. Peters, K. Smid, E. Meijer, C.J. van Groeningen & L.G. Leon
Pages: 595-603
Published online: 01 Dec 2016
AbstractforRole of genomic factors beyond thymidylate synthase in the prediction of response to 5-fluorouracil | Full Text | References | PDF (421.1 KB)
  • 99 Views
  • 2 CrossRef citations
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Stably transfected adherent cancer cell models with decreased expression of 5′-nucleotidase cN-II
Gabriel Bricard, Emeline Cros-Perrial, Christelle Machon, Charles Dumontet & Lars Petter Jordheim
Pages: 604-612
Published online: 01 Dec 2016
AbstractforStably transfected adherent cancer cell models with decreased expression of 5′-nucleotidase cN-II | Full Text | References | PDF (385.1 KB)
  • 92 Views
  • 6 CrossRef citations
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Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines
R. Meinsma & A.B.P. van Kuilenburg
Pages: 613-618
Published online: 01 Dec 2016
AbstractforPurification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines | Full Text | References | PDF (376.4 KB)
  • 252 Views
  • 6 CrossRef citations
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The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines
Dzjemma Sarkisjan, Jaap van den Berg, Evelyn Smit, Young B. Lee, Deog J. Kim & Godefridus J. Peters
Pages: 619-630
Published online: 01 Dec 2016
AbstractforThe radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines | Full Text | References | PDF (696.8 KB)
  • 186 Views
  • 4 CrossRef citations
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Extended exposure to substrate regulates the human equilibrative nucleoside transporter 1 (hENT1)
Maliha Zafar, Zlatina Naydenova & Imogen R. Coe
Pages: 631-642
Published online: 01 Dec 2016
AbstractforExtended exposure to substrate regulates the human equilibrative nucleoside transporter 1 (hENT1) | Full Text | References | PDF (556.8 KB)
  • 211 Views
  • 2 CrossRef citations
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A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1
Elisa Giovannetti, Leticia G. Leon, Valentina E. Gómez, Paolo A. Zucali, Filippo Minutolo & Godefridus J. Peters
Pages: 643-651
Published online: 01 Dec 2016
AbstractforA specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1 | Full Text | References | PDF (460.5 KB)
  • 220 Views
  • 12 CrossRef citations
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Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA
Richard J. Honeywell, Dzjemma Sarkisjan, Ietje Kathmann, Michael H. Kristensen & Godefridus J. Peters
Pages: 652-662
Published online: 01 Dec 2016
AbstractforSensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA | Full Text | References | PDF (501.9 KB)
  • 320 Views
  • 3 CrossRef citations
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Evaluation of cellular purine transport and metabolism in the Caco-2 cell using comprehensive high-performance liquid chromatography method for analysis of purines
T. Fukuuchi, M. Kobayashi, N. Yamaoka & K. Kaneko
Pages: 663-669
Published online: 01 Dec 2016
AbstractforEvaluation of cellular purine transport and metabolism in the Caco-2 cell using comprehensive high-performance liquid chromatography method for analysis of purines | Full Text | References | PDF (509.8 KB)
  • 233 Views
  • 2 CrossRef citations
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Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine
N. Yamada, C. Iwamoto, H. Kano, N. Yamaoka, T. Fukuuchi, K. Kaneko & Y. Asami
Pages: 670-676
Published online: 01 Dec 2016
AbstractforEvaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine | Full Text | References | PDF (406.3 KB)
  • 689 Views
  • 42 CrossRef citations
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Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 Family
Zeeshan Mutahir, Louise Slot Christiansen, Anders R. Clausen, Martin W. Berchtold, Zoran Gojkovic, Birgitte Munch-Petersen, Wolfgang Knecht & Jure Piškur
Pages: 677-690
Published online: 01 Dec 2016
AbstractforGene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 Family | Full Text | References | PDF (512.9 KB)
  • 148 Views
  • 0 CrossRef citations
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Expression of tomato thymidine kinase 1 by means of the baculovirus expression vector system
Juan Manuel Orozco Rodriguez, Mohamad Nesrini, Louise Slot Christiansen & Wolfgang Knecht
Pages: 691-698
Published online: 01 Dec 2016
AbstractforExpression of tomato thymidine kinase 1 by means of the baculovirus expression vector system | Full Text | References | PDF (353.3 KB) | Supplemental
  • 94 Views
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Isolation of a novel protein, P12—from adult Drosophila melanogaster that inhibits deoxyribonucleoside and protein kinase activities and activates 3′-5′- exonuclease activity
Louise Slot Christiansen, Gabriella van Zanten, Dvora Berenstein, Marianne Lauridsen, Søren Kjærulff, Leif Søndergaard & Birgitte Munch-Petersen
Pages: 699-706
Published online: 01 Dec 2016
AbstractforIsolation of a novel protein, P12—from adult Drosophila melanogaster that inhibits deoxyribonucleoside and protein kinase activities and activates 3′-5′- exonuclease activity | Full Text | References | PDF (440.4 KB)
  • 128 Views
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Changes in cardiac nucleotide metabolism in Huntington's disease
Marta Toczek, Barbara Kutryb-Zajac, Paulina Zukowska, Ewa M. Slominska, Mark Isalan, Michal Mielcarek & Ryszard T. Smolenski
Pages: 707-712
Published online: 01 Dec 2016
AbstractforChanges in cardiac nucleotide metabolism in Huntington's disease | Full Text | References | PDF (400.7 KB)
  • 173 Views
  • 12 CrossRef citations
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Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium
Ewa Kaniewska-Bednarczuk, Michał Mielcarek, Adrian H. Chester, Ewa M. Slominska, Magdi H Yacoub & Ryszard T. Smolenski
Pages: 713-719
Published online: 01 Dec 2016
AbstractforOxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium | Full Text | References | PDF (416.7 KB)
  • 162 Views
  • 6 CrossRef citations
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Effects of 4-Pyridone-3-carboxamide-1β-D-ribonucleoside on adenine nucleotide catabolism in the aortic wall; Implications for atherosclerosis in ApoE-/-LDLR-/- mice
Magdalena Zabielska, Barbara Kutryb-Zajac, Paulina Żukowska, Ewa Slominska & Ryszard Smoleński
Pages: 720-725
Published online: 01 Dec 2016
AbstractforEffects of 4-Pyridone-3-carboxamide-1β-D-ribonucleoside on adenine nucleotide catabolism in the aortic wall; Implications for atherosclerosis in ApoE-/-LDLR-/- mice | Full Text | References | PDF (362.9 KB)
  • 96 Views
  • 2 CrossRef citations
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Polymorphism in exon 6 of the human NT5E gene is associated with aortic valve calcification
Zdzislaw Kochan, Joanna Karbowska, Patrycja Gogga, Barbara Kutryb-Zajac, Ewa M. Slominska & Ryszard T. Smolenski
Pages: 726-731
Published online: 01 Dec 2016
AbstractforPolymorphism in exon 6 of the human NT5E gene is associated with aortic valve calcification | Full Text | References | PDF (387.1 KB)
  • 138 Views
  • 7 CrossRef citations
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Influence of 4-pyridone-3-carboxamide-1Β-D-ribonucleoside (4PYR) on activities of extracellular enzymes in endothelial human cells
I. Pelikant-Małecka, A. Sielicka, E. Kaniewska, R. T. Smoleński & E. M. Słomińska
Pages: 732-736
Published online: 01 Dec 2016
AbstractforInfluence of 4-pyridone-3-carboxamide-1Β-D-ribonucleoside (4PYR) on activities of extracellular enzymes in endothelial human cells | Full Text | References | PDF (443.7 KB)
  • 84 Views
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