Nucleosides, Nucleotides & Nucleic Acids, Volume 39, Issue 1-3 (2020)

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Nucleosides, Nucleotides & Nucleic Acids, Volume 39, Issue 1-3 (2020)

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Special Issue: Issue in Honor of the 70th Birthday of Prof. Akira Matsuda

Articles

Article
Preface to Nucleosides, Nucleotides & Nucleic Acids issue honoring the 70th birthday of Professor Akira Matsuda
Noriaki Minakawa
Pages: 1-51
Published online: 25 Jan 2020
First Page PreviewforPreface to Nucleosides, Nucleotides & Nucleic Acids issue honoring the 70th birthday of Professor Akira Matsuda | Full Text | PDF (3.4 MB) | EPUB
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Article
Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase
Uma S. Singh & Chung K. Chu
Pages: 52-68
Published online: 20 Apr 2020
AbstractforSynthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase | Full Text | References | PDF (1.6 MB) | EPUB
  • 313 Views
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Article
Synthesis and hybridization properties of iridium(III) polypyridyl complex-conjugated oligonucleotide
Yuta Ito, Koichi Mizuno, Kohei Domoto & Yoshiyuki Hari
Pages: 69-81
Published online: 25 Jan 2020
AbstractforSynthesis and hybridization properties of iridium(III) polypyridyl complex-conjugated oligonucleotide | Full Text | References | PDF (1.5 MB) | EPUB
  • 142 Views
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Article
Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers
Asmaa Abdelrahman, Alaa S. Gouda, Per T. Jørgensen & Jesper Wengel
Pages: 82-96
Published online: 01 Nov 2019
AbstractforNovel assemblies based on oligonucleotides containing intercalating nucleic acid monomers | Full Text | References | PDF (2.5 MB) | EPUB
  • 290 Views
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Article
Cooperative recognition of a repetitive sequence through consecutive formation of triplex and duplex structures
Yusuke Kitamura, Koki Nagai, Tomohiro Furuzono, Yousuke Katsuda & Toshihiro Ihara
Pages: 97-108
Published online: 22 Oct 2019
AbstractforCooperative recognition of a repetitive sequence through consecutive formation of triplex and duplex structures | Full Text | References | PDF (1.6 MB) | EPUB
  • 104 Views
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Article
Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides
Tsuyoshi Yamamoto, Motoki Sawamura, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika & Mariko Harada-Shiba
Pages: 109-118
Published online: 16 Oct 2019
AbstractforEffect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides | Full Text | References | PDF (1.2 MB) | EPUB
  • 268 Views
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Article
Selective cross-linking behavior of oligodeoxyribonucleotides containing 2'-O-[N-(4,5',8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutant H-ras DNA
Asako Yamayoshi, Maiko Higuchi, Yui Sakai, Akio Kobori, Tsuyoshi Yamamoto, Takayuki Shibata & Akira Murakami
Pages: 119-130
Published online: 24 Oct 2019
AbstractforSelective cross-linking behavior of oligodeoxyribonucleotides containing 2'-O-[N-(4,5',8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutant H-ras DNA | Full Text | References | PDF (1.8 MB) | EPUB
  • 82 Views
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Article
Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base
Yoshihiro Moai, Hidekazu Hiroaki, Saoshi Obika & Tetsuya Kodama
Pages: 131-140
Published online: 12 Oct 2019
AbstractforSynthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base | Full Text | References | PDF (1.3 MB) | EPUB
  • 242 Views
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Article
A nanocarrier for the mitochondrial delivery of nucleic acids to cardiomyocytes
Yuma Yamada, Naoki Fujishita & Hideyoshi Harashima
Pages: 141-155
Published online: 09 Oct 2019
AbstractforA nanocarrier for the mitochondrial delivery of nucleic acids to cardiomyocytes | Full Text | References | PDF (1.7 MB) | EPUB
  • 401 Views
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Article
Cationic copolymer-chaperoned short-armed 10–23 DNAzymes
Orakan Hanpanich, Hitonari Miyaguchi, He Huang, Naohiko Shimada & Atsushi Maruyama
Pages: 156-169
Published online: 12 Oct 2019
AbstractforCationic copolymer-chaperoned short-armed 10–23 DNAzymes | Full Text | References | PDF (1.4 MB) | EPUB
  • 275 Views
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Article
Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms
Masataka Tsuda, Kaito Kitamasu, Seiji Hosokawa, Toshiaki Nakano & Hiroshi Ide
Pages: 170-184
Published online: 12 Oct 2019
AbstractforRepair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Limits of using oligonucleotides for allele-selective inhibition at trinucleotide repeat sequences – targeting the CAG repeat within ataxin-1
Jiaxin Hu & David R. Corey
Pages: 185-194
Published online: 24 Oct 2019
AbstractforLimits of using oligonucleotides for allele-selective inhibition at trinucleotide repeat sequences – targeting the CAG repeat within ataxin-1 | Full Text | References | PDF (1.3 MB) | EPUB
  • 260 Views
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Article
Translational control by secondary-structure formation in mRNA in a eukaryotic system
Daisuke Kawaguchi, Saaya Shimizu, Naoko Abe, Fumitaka Hashiya, Fumiaki Tomoike, Yasuaki Kimura & Hiroshi Abe
Pages: 195-203
Published online: 30 Sep 2019
AbstractforTranslational control by secondary-structure formation in mRNA in a eukaryotic system | Full Text | References | PDF (1,005.9 KB) | EPUB | Supplemental
  • 319 Views
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Article
Intracellular metabolism and potential cardiotoxicity of a β-D-2’-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication
Sijia Tao, Longhu Zhou, Hongwang Zhang, Shaoman Zhou, Sheida Amiralaei, Jadd Shelton, Maryam Ehteshami, Yong Jiang, Franck Amblard, Steven J. Coats & Raymond F. Schinazi
Pages: 204-224
Published online: 09 Oct 2019
AbstractforIntracellular metabolism and potential cardiotoxicity of a β-D-2’-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication | Full Text | References | PDF (1.7 MB) | EPUB
  • 218 Views
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Article
Inhibition of breast cancer cell proliferation with anti-microRNA oligonucleotides flanked by interstrand cross-linked duplexes
Sho Okumura, Yu Hirano & Yasuo Komatsu
Pages: 225-235
Published online: 04 Oct 2019
AbstractforInhibition of breast cancer cell proliferation with anti-microRNA oligonucleotides flanked by interstrand cross-linked duplexes | Full Text | References | PDF (1.5 MB) | EPUB
  • 144 Views
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Article
Practical and reliable synthesis of 2′,3′,5′,5″-tetradeuterated uridine derivatives
Noriko Miyamoto, Hiroki Ohno, Yoshiaki Kitamura, Kwihwan Park, Yoshinari Sawama, Hironao Sajiki & Yukio Kitade
Pages: 236-244
Published online: 24 Oct 2019
AbstractforPractical and reliable synthesis of 2′,3′,5′,5″-tetradeuterated uridine derivatives | Full Text | References | PDF (886.1 KB) | EPUB
  • 425 Views
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Article
Structure–activity relationship of pseudoknot-type hammerhead ribozyme reveals key structural elements for enhanced catalytic activity†
Mituhiro Yamada & Yoshiyuki Tanaka
Pages: 245-257
Published online: 03 Oct 2019
AbstractforStructure–activity relationship of pseudoknot-type hammerhead ribozyme reveals key structural elements for enhanced catalytic activity† | Full Text | References | PDF (2.7 MB) | EPUB
  • 160 Views
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Article
Development of gapmer antisense oligonucleotide with deoxyribonucleic guanidine (DNG) modifications
Naoshi Kojima, Ajaya R. Shrestha, Takuya Akisawa, Haishun Piao, Hideki Kizawa, Yoshihiro Ohmiya & Ryoji Kurita
Pages: 258-269
Published online: 26 Sep 2019
AbstractforDevelopment of gapmer antisense oligonucleotide with deoxyribonucleic guanidine (DNG) modifications | Full Text | References | PDF (1.5 MB) | EPUB
  • 337 Views
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Article
A highly constrained nucleic acid analog based on α-l-threosamine
Kunihiko Morihiro & Akimitsu Okamoto
Pages: 270-279
Published online: 17 Sep 2019
AbstractforA highly constrained nucleic acid analog based on α-l-threosamine | Full Text | References | PDF (1.1 MB) | EPUB
  • 277 Views
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Article
Synthesis and characterization of 4′-C-guanidinomethyl-2′-O-methyl-modified RNA oligomers
Azusa Uematsu, Ryohei Kajino, Yusuke Maeda & Yoshihito Ueno
Pages: 280-291
Published online: 18 Sep 2019
AbstractforSynthesis and characterization of 4′-C-guanidinomethyl-2′-O-methyl-modified RNA oligomers | Full Text | References | PDF (1.2 MB) | EPUB
  • 183 Views
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Article
Design of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity
Makoto Koizumi, Yasuhide Hirota, Makiko Nakayama, Masakazu Tamura, Wataru Obuchi, Akiko Kurimoto, Hiroshi Tsuchida & Hiroaki Maeda
Pages: 292-309
Published online: 11 Sep 2019
AbstractforDesign of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 338 Views
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Article
Effects of metal ions on thermal stabilities of DNA duplexes containing homo- and heterochiral mismatched base pairs: comparison of internal and terminal substitutions
Tatsuya Funai, Nahomi Adachi, Megumi Aotani, Shun-ichi Wada & Hidehito Urata
Pages: 310-321
Published online: 12 Sep 2019
AbstractforEffects of metal ions on thermal stabilities of DNA duplexes containing homo- and heterochiral mismatched base pairs: comparison of internal and terminal substitutions | Full Text | References | PDF (1 MB)
  • 181 Views
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Article
Survey of ribose ring pucker of signaling nucleosides and nucleotides
Veronica Salmaso & Kenneth A. Jacobson
Pages: 322-341
Published online: 28 Aug 2019
AbstractforSurvey of ribose ring pucker of signaling nucleosides and nucleotides | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 326 Views
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Article
Synthesis of D-like and L-like 5′-fluoro-5′-deoxy-1′,6′-isoneplanocins and their antiviral activity including Ebola
Chong Liu, Qi Chen & Stewart Schneller
Pages: 342-348
Published online: 26 Aug 2019
AbstractforSynthesis of D-like and L-like 5′-fluoro-5′-deoxy-1′,6′-isoneplanocins and their antiviral activity including Ebola | Full Text | References | PDF (653.3 KB) | EPUB
  • 165 Views
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Article
Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
Kazuki Yamamoto, Toyotaka Sato, Yuta Hikiji, Akira Katsuyama, Takanori Matsumaru, Fumika Yakushiji, Shin-Ichi Yokota & Satoshi Ichikawa
Pages: 349-364
Published online: 30 Sep 2019
AbstractforSynthesis and biological evaluation of a MraY selective analogue of tunicamycins | Full Text | References | PDF (1.8 MB) | EPUB
  • 221 Views
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Article
Synthesis of 2′-aminouridine derivatives as an organocatalyst for Diels-Alder reaction
Hideaki Wakamatsu, Moeko Itoh, Yoshihiro Natori & Yuichi Yoshimura
Pages: 365-383
Published online: 30 Jul 2019
AbstractforSynthesis of 2′-aminouridine derivatives as an organocatalyst for Diels-Alder reaction | Full Text | References | PDF (1.8 MB) | EPUB
  • 280 Views
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Article
Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs
Juan C. Salinas, Punit P. Seth & Stephen Hanessian
Pages: 384-406
Published online: 05 Aug 2019
AbstractforDesign And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs | Full Text | References | PDF (2.8 MB) | EPUB
  • 315 Views
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Article
Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT
Irmina Diala, Yasuo Shiohama, Takashi Fujita, Yojiro Kotake, Constantinos Demonacos, Marija Krstic-Demonacos, Gianpiero Di Leva & Masayuki Fujii
Pages: 407-425
Published online: 20 Apr 2020
AbstractforTelomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT | Full Text | References | PDF (1.8 MB)
  • 198 Views
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Article
An alternative method for the synthesis of 2′-halogeno-1′,2′-unsaturated uridine derivatives through syn-elimination of pivalic acid of 2′-halogeno- 2′-deoxy-1′-pivaloyloxyuracil nucleoside: preparation of its 2′-C-branched nucleosides
Kazuhiro Haraguchi, Eisen Gen, Hiroki Kumamoto, Yoshiharu Itoh & Hiromichi Tanaka
Pages: 426-438
Published online: 20 Aug 2019
AbstractforAn alternative method for the synthesis of 2′-halogeno-1′,2′-unsaturated uridine derivatives through syn-elimination of pivalic acid of 2′-halogeno- 2′-deoxy-1′-pivaloyloxyuracil nucleoside: preparation of its 2′-C-branched nucleosides | Full Text | References | PDF (1.3 MB) | EPUB
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Review

Review
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis
Hironobu Yasui, Daisuke Iizuka, Wakako Hiraoka, Mikinori Kuwabara, Akira Matsuda & Osamu Inanami
Pages: 439-452
Published online: 27 Sep 2019
AbstractforNucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 375 Views
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Corrections

Correction
Correction
Pages: 453-461
Published online: 20 Apr 2020
CitationforCorrection | Full Text | PDF (93.3 KB) | EPUB
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Correction
Correction
Pages: 462-470
Published online: 20 Apr 2020
CitationforCorrection | Full Text | PDF (94 KB) | EPUB
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Correction
Correction
Pages: 471-492
Published online: 20 Apr 2020
CitationforCorrection | Full Text | PDF (93.8 KB) | EPUB
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