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Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

, , ORCID Icon & ORCID Icon
Article: 2276490 | Received 20 Oct 2023, Accepted 24 Oct 2023, Published online: 03 Nov 2023
 

ABSTRACT

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EM and JP (C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-Télévie to IFB and GP (7.4501.18, 7.4529.19, 7.6518.20, and 7.6603.21).