OncoImmunology, Volume 12, Issue 1 (2023)

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OncoImmunology, Volume 12, Issue 1 (2023)

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Original Research

Article
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo & Fernando Aranda
Article: 2147317
Published online: 15 Dec 2022
AbstractforIntracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3359 Views
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Open Access

Brief Report

Brief Report
Plasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors
Bao-Tram Thi Tran, Aurore Gelin, Sylvère Durand, Matthieu Texier, Amaury Daste, Clémence Toullec, Karim Benihoud, Ingrid Breuskin, Philippe Gorphe, Florence Garic, Catherine Brenner, Christophe Le Tourneau, Jérôme Fayette, Toshiro Niki, Muriel David, Pierre Busson & Caroline Even
Article: 2150472
Published online: 17 Dec 2022
AbstractforPlasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1182 Views
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Open Access

Original Research

Article
Overcoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles
Jun Deng & Hui Ke
Article: 2152635
Published online: 26 Dec 2022
AbstractforOvercoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 2179 Views
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Open Access
Article
Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy
Christoforos K. Vaxevanis, Marcus Bauer, Karthikeyan Subbarayan, Michael Friedrich, Chiara Massa, Katharina Biehl, Haifa Kathrin Al-Ali, Claudia Wickenhauser & Barbara Seliger
Article: 2152998
Published online: 15 Dec 2022
AbstractforBiglycan as a mediator of proinflammatory response and target for MDS and sAML therapy | Full Text | References | PDF (7.7 MB) | EPUB | Supplemental
  • 4491 Views
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Open Access

Author's View

Article
Cellular senescence enhances adaptive anticancer immunosurveillance
Ines Marin, Manuel Serrano & Federico Pietrocola
Article: 2154115
Published online: 15 Dec 2022
AbstractforCellular senescence enhances adaptive anticancer immunosurveillance | Full Text | References | PDF (379.3 KB) | EPUB
  • 2137 Views
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Open Access

Original Research

Article
Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition
Julia Koerner, Dennis Horvath, Franziska Oliveri, Jun Li & Michael Basler
Article: 2156091
Published online: 15 Dec 2022
AbstractforSuppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1521 Views
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Open Access
Article
ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer
Guanpeng Wang, Yeni Romero, Indhujah Thevarajan & Anna Zolkiewska
Article: 2158006
Published online: 16 Dec 2022
AbstractforADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2234 Views
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Open Access

Review

Review
Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors
Pierre-Antoine Laurent, Daphne Morel, Lydia Meziani, Stephane Depil & Eric Deutsch
Article: 2158013
Published online: 22 Dec 2022
AbstractforRadiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors | Full Text | References | PDF (4.1 MB) | EPUB
  • 2797 Views
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Open Access

Original Research

Article
Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frias, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Soren Buus, Allan Randrup Thomsen, Morten Nielsen, Kristoffer Staal Rohrberg, Kjeld Schmiegelow & Daniela De Zio
Article: 2158610
Published online: 17 Dec 2022
AbstractforThiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade | Full Text | References | PDF (14.1 MB) | EPUB | Supplemental
  • 1740 Views
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Open Access
Article
BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro
Gloria Esteso, María José Felgueres, Álvaro F. García-Jiménez, Christina Reyburn-Valés, Alberto Benguría, Enrique Vázquez, Hugh T. Reyburn, Nacho Aguiló, Carlos Martín, Eugenia Puentes, Ingrid Murillo, Esteban Rodríguez & Mar Valés-Gómez
Article: 2160094
Published online: 22 Dec 2022
AbstractforBCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 2447 Views
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Open Access

Brief Report

Brief Report
Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion
Zi-Hao Wang, Pei Zhang, Wen-Bei Peng, Lin-Lin Ye, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Si-Yu Zhang, Qian-Qian Xue, Hao-Lei Wang & Qiong Zhou
Article: 2160558
Published online: 22 Dec 2022
AbstractforAltered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 3217 Views
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Open Access

Original Research

Article
Prognostic and predictive value of Immunoscore and its correlation with ctDNA in stage II colorectal cancer
Fulong Wang, Shixun Lu, Di Cao, Juanjuan Qian, Cong Li, Rongxin Zhang, Feng Wang, Miaoqing Wu, Yifan Liu, Zhizhong Pan, Xiaojun Wu, Zhenhai Lu, Peirong Ding, Liren Li, Junzhong Lin, Aurélie Catteau, Jérôme Galon & Gong Chen
Article: 2161167
Published online: 05 Jan 2023
AbstractforPrognostic and predictive value of Immunoscore and its correlation with ctDNA in stage II colorectal cancer | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2008 Views
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Open Access
Article
In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer
Tao Xu, Philipp Karschnia, Bruno Loureiro Cadilha, Sertac Dede, Michael Lorenz, Niklas Seewaldt, Elene Nikolaishvili, Katharina Müller, Jens Blobner, Nico Teske, Julika J. Herold, Kai Rejeski, Sigrid Langer, Hannah Obeck, Theo Lorenzini, Matthias Mulazzani, Wenlong Zhang, Hellen Ishikawa-Ankerhold, Veit R. Buchholz, Marion Subklewe, Niklas Thon, Andreas Straube, Joerg-Christian Tonn, Sebastian Kobold & Louisa von Baumgarten
Article: 2163781
Published online: 13 Jan 2023
AbstractforIn vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 3361 Views
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Open Access
Article
Daratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease
Prabha Shrestha, Yana Astter, David A. Davis, Ting Zhou, Constance M. Yuan, Ramya Ramaswami, Hao-Wei Wang, Kathryn Lurain & Robert Yarchoan
Article: 2163784
Published online: 07 Jan 2023
AbstractforDaratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1728 Views
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Open Access

Brief Report

Brief Report
RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies
Camille Bigenwald, Yacine Haddad, Cassandra Thelemaque, Agathe Carrier, Roxanne Birebent, Pierre Ly, Caroline Flament, Imran Lahmar, Eric de Sousa, Markus Maeurer, Makoto Miyara, Tarek Assi, Cristina Castilla-Llorente, Christophe Willekens, Céline Fayemi, Julien Lazarovici, Aurélien Marabelle, Lisa Derosa, Vincent Ribrag & Laurence Zitvogel
Article: 2163785
Published online: 04 Jan 2023
AbstractforRBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1732 Views
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Open Access

Original Research

Article
Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas
Nicole L. Edmonds, Sarah E Gradecki, Priya Katyal, Kevin T Lynch, Anne M Stowman, Alejandro A Gru, Victor H Engelhard, Craig L Slingluff Jr. & Ileana S. Mauldin
Article: 2164476
Published online: 07 Jan 2023
AbstractforTertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas | Full Text | References | PDF (6.9 MB) | EPUB | Supplemental
  • 1807 Views
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Open Access
Article
The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice
Raghd Al Olabi, Abd El Aziz Hendy, Mohamad Basem Alkassab, Karla Alnajm, Manahel Elias, Mary Ibrahim, James R. Carlyle, Andrew P. Makrigiannis & Mir Munir A Rahim
Article: 2168233
Published online: 22 Jan 2023
AbstractforThe inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1707 Views
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Open Access
Article
The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma
E Orecchini, ML Belladonna, MT Pallotta, C Volpi, L Zizi, E Panfili, M Gargaro, F Fallarino, S Rossini, C Suvieri, A Macchiarulo, S Bicciato, G Mondanelli & C Orabona
Article: 2170095
Published online: 26 Jan 2023
AbstractforThe signaling function of IDO1 incites the malignant progression of mouse B16 melanoma | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1739 Views
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Open Access
Article
Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance
Guang Peng, Chao Wang, Hongru Wang, Min Qu, Keqin Dong, Yongwei Yu, Yuquan Jiang, Sishun Gan & Xu Gao
Article: 2173422
Published online: 06 Feb 2023
AbstractforGankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
  • 2192 Views
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Open Access
Article
Stereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients
Belinda Palermo, Marta Bottero, Mariangela Panetta, Adriana Faiella, Isabella Sperduti, Serena Masi, Giuseppe Frisullo, Maria Laura Foddai, Iole Cordone, Paola Nisticò & Giuseppe Sanguineti
Article: 2174721
Published online: 13 Feb 2023
AbstractforStereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients | Full Text | References | PDF (11.4 MB) | EPUB | Supplemental
  • 1626 Views
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Open Access

Editorial

Editorial
Arsenic trioxide as an inducer of immunogenic cell death
Oliver Kepp, Hui Pan, Peng Liu & Guido Kroemer
Article: 2174723
Published online: 06 Feb 2023
First Page PreviewforArsenic trioxide as an inducer of immunogenic cell death | Full Text | References | PDF (534 KB) | EPUB
  • 1343 Views
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Open Access
Editorial
Tumor-infiltrating lymphocytes for melanoma immunotherapy
Oliver Kepp, Peng Liu, Laurence Zitvogel & Guido Kroemer
Article: 2175506
Published online: 07 Feb 2023
First Page PreviewforTumor-infiltrating lymphocytes for melanoma immunotherapy | Full Text | References | PDF (182 KB) | EPUB
  • 1845 Views
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Open Access

Brief Report

Brief Report
CD25bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression
Ziqing Chen, Le Tong, Shi Yong Neo, Shuijie Li, Jiwei Gao, Susanne Schlisio & Andreas Lundqvist
Article: 2175517
Published online: 22 Mar 2023
AbstractforCD25bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2201 Views
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Open Access

Trial Watch

Article
Trial watch: Toll-like receptor ligands in cancer therapy
Julie Le Naour & Guido Kroemer
Article: 2180237
Published online: 17 Feb 2023
AbstractforTrial watch: Toll-like receptor ligands in cancer therapy | Full Text | References | PDF (349.1 KB) | EPUB
  • 2288 Views
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Open Access

Original Research

Article
Mesothelin-targeting T cells bearing a novel T cell receptor fusion construct (TRuC) exhibit potent antitumor efficacy against solid tumors
Jian Ding, Sarah Guyette, Brett Schrand, Jessica Geirut, Holly Horton, Guangwu Guo, Greg Delgoffe, Ashley Menk, Patrick A. Baeuerle, Robert Hofmeister & Robert Tighe
Article: 2182058
Published online: 24 Feb 2023
AbstractforMesothelin-targeting T cells bearing a novel T cell receptor fusion construct (TRuC) exhibit potent antitumor efficacy against solid tumors | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 4615 Views
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Open Access

Commentary

Article Commentary
Ferroptosis: friend or foe in cancer immunotherapy?
Robin Demuynck, Iuliia Efimova, Elena Catanzaro & Dmitri V Krysko
Article: 2182992
Published online: 23 Feb 2023
AbstractforFerroptosis: friend or foe in cancer immunotherapy? | Full Text | References | PDF (1.5 MB) | EPUB
  • 2479 Views
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Open Access

Original Research

Article
Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Anders Valind, Bronte Manouk Verhoeven, Jens Enoksson, Jenny Karlsson, Gustav Christensson, Adriana Mañas, Kristina Aaltonen, Caroline Jansson, Daniel Bexell, Ninib Baryawno, David Gisselsson & Catharina Hagerling
Article: 2184130
Published online: 01 Mar 2023
AbstractforMacrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2379 Views
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Open Access
Article
Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL
Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret & Jörg Faber
Article: 2184143
Published online: 01 Mar 2023
AbstractforAnalysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1796 Views
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Open Access
Article
Anti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth
Stéphanie Lacotte, Florence Slits, Beat Moeckli, Andrea Peloso, Stéphane Koenig, Matthieu Tihy, Sofia El Hajji, Quentin Gex, Laura Rubbia-Brandt & Christian Toso
Article: 2184991
Published online: 02 Mar 2023
AbstractforAnti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1913 Views
  • 1 CrossRef citations
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Open Access
Article
Rare immune-related adverse events in patients with melanoma: incidence, spectrum, and clinical presentations
Benjamin C. Park, Sathya Narayanan, Alexander Gavralidis, Fei Ye, Run Fan, Ryan J. Sullivan, Genevieve Boland, Kerry L Reynolds, Justin M. Balko, Matteo S. Carlino, Georgina V. Long, Leyre Zubiri, Alexander M. Menzies & Douglas B. Johnson
Article: 2188719
Published online: 08 Mar 2023
AbstractforRare immune-related adverse events in patients with melanoma: incidence, spectrum, and clinical presentations | Full Text | References | PDF (616.6 KB) | EPUB | Supplemental
  • 1833 Views
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Open Access

Brief Report

Brief Report
Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer
Vincent Carbonnier, Julie Le Naour, Thomas Bachelot, Erika Vacchelli, Fabrice André, Suzette Delaloge & Guido Kroemer
Article: 2189823
Published online: 21 Mar 2023
AbstractforRs867228 in FPR1 accelerates the manifestation of luminal B breast cancer | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1777 Views
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Open Access

Original Research

Article
ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer
Hae-Yun Jung, Dae-Keum Lee, Minwook Lee, Seung Hee Choi, Joo Dong Park, Eun-Su Ko, Jongwon Lee, Kyung-Soon Park & Hae-Yun Jung
Article: 2190671
Published online: 17 Mar 2023
AbstractforELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 1898 Views
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Open Access
Article
Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production
Oleg Kruglov, Kavita Vats, Vishal Soman, Vladimir A. Tyurin, Yulia Y. Tyurina, Jiefei Wang, Li’an Williams, Jiying Zhang, Cara Donahue Carey, Erik Jaklitsch, Uma R. Chandran, Hülya Bayir, Valerian E. Kagan & Yuri L. Bunimovich
Article: 2192098
Published online: 25 Mar 2023
AbstractforMelanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 2335 Views
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Open Access
Article
Targeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer
Tal Flieswasser, Astrid Van den Eynde, Laurie Freire Boullosa, Jöran Melis, Christophe Hermans, Céline Merlin, Ho Wa Lau, Jonas Van Audenaerde, Filip Lardon, Evelien Smits, Patrick Pauwels & Julie Jacobs
Article: 2192100
Published online: 23 Mar 2023
AbstractforTargeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2133 Views
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Open Access

Author's View

Article
Tissue-resident memory T cells in immune-related adverse events: friend or foe?
Robin Reschke & Thomas F Gajewski
Article: 2197358
Published online: 04 Apr 2023
AbstractforTissue-resident memory T cells in immune-related adverse events: friend or foe? | Full Text | References | PDF (607.8 KB) | EPUB
  • 1918 Views
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Open Access
Article
Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition
Laura Codarri Deak, Masao Hashimoto, Pablo Umaña & Christian Klein
Article: 2197360
Published online: 30 Mar 2023
AbstractforBeyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition | Full Text | References | PDF (640.8 KB) | EPUB
  • 3342 Views
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Open Access

Brief Report

Brief Report
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
Maite Alvarez, Carmen Molina, Saray Garasa, Maria C. Ochoa, Maria E Rodriguez-Ruiz, Gabriel Gomis, Assunta Cirella, Irene Olivera, Javier Glez-Vaz, Jose Gonzalez-Gomariz, carlos luri-Rey, arantza azpilikueta, Elixabet Bolaños, Alvaro Teijeira, Pedro Berraondo, Marisol Quintero & Ignacio Melero
Article: 2197370
Published online: 05 Apr 2023
AbstractforIntratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic | Full Text | References | PDF (773.9 KB) | EPUB | Supplemental
  • 2093 Views
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Open Access

Original Research

Article
Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression
Paul G. Pavicic Jr., Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero & Haider Mahdi
Article: 2198185
Published online: 10 Apr 2023
AbstractforImmunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2218 Views
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Open Access
Article
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok & Karin E. de Visser
Article: 2201147
Published online: 13 Apr 2023
AbstractforNeoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 2642 Views
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Open Access

Brief Report

Brief Report
Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome
Peng Zhang, Yan Zhao, Xin Xia, Song Mei, Yixuan Huang, Yingying Zhu, Shuting Yu & Xingming Chen
Article: 2203073
Published online: 18 Apr 2023
AbstractforExpression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 2028 Views
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Open Access

Original Research

Article
CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport
Cheng Tian, Huimin Yuan, Yi Lu, Henghui He, Qing Li, Senlin Li, Jian Yang, Mengheng Wang, Ruochen Xu, Qian Liu & Ming Xiang
Article: 2204015
Published online: 19 Apr 2023
AbstractforCARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 1881 Views
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Open Access

Brief Report

Brief Report
Early response evaluation of PD-1 blockade in NSCLC patients through FDG-PET-CT and T cell profiling of tumor-draining lymph nodes
Frank J. Borm, Jasper Smit, Joyce Bakker, Maurits Wondergem, Egbert F. Smit, Adrianus J. de Langen & Tanja D. de Gruijl
Article: 2204745
Published online: 26 Apr 2023
AbstractforEarly response evaluation of PD-1 blockade in NSCLC patients through FDG-PET-CT and T cell profiling of tumor-draining lymph nodes | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 2247 Views
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Open Access

Original Research

Article
Non-small cell lung cancer patients treated with Anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status
David Dora, Balazs Ligeti, Tamas Kovacs, Peter Revisnyei, Gabriella Galffy, Edit Dulka, Dániel Krizsán, Regina Kalcsevszki, Zsolt Megyesfalvi, Balazs Dome, Glen J. Weiss & Zoltan Lohinai
Article: 2204746
Published online: 12 May 2023
AbstractforNon-small cell lung cancer patients treated with Anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status | Full Text | References | PDF (15.4 MB) | EPUB | Supplemental
  • 2634 Views
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Open Access
Article
Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma
Jorge D. Oldan, Benjamin C. Giglio, Eric Smith, Weiling Zhao, Deeanna M. Bouchard, Marija Ivanovic, Yueh Z. Lee, Frances A. Collichio, Michael O. Meyers, Diana E. Wallack, Amber Abernethy-Leinwand, Patricia K. Long, Dimitri G. Trembath, Paul B. Googe, Madeline H. Kowalski, Anastasia Ivanova, Jennifer A. Ezzell, Nana Nikolaishvili-Feinberg, Nancy E. Thomas, Terence Z. Wong, David W. Ollila, Zibo Li & Stergios J. Moschos
Article: 2204753
Published online: 26 Apr 2023
AbstractforIncreased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 2122 Views
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Open Access
Article
Preexisting autoantibodies as predictor of immune related adverse events (irAEs) for advanced solid tumors treated with immune checkpoint inhibitors (ICIs)
A Daban, C Gonnin, L Phan, A Saldmann, C Granier, A Lillo-Lelouet, C Le Beller, J Pouchot, l Weiss, E Tartour, E Fabre, J Medioni, S Oudard, YA Vano, MA Dragon-Durey & A. Simonaggio
Article: 2204754
Published online: 11 May 2023
AbstractforPreexisting autoantibodies as predictor of immune related adverse events (irAEs) for advanced solid tumors treated with immune checkpoint inhibitors (ICIs) | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1550 Views
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Article
A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response
Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina
Article: 2205336
Published online: 24 Apr 2023
AbstractforA PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 3801 Views
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Article
Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer
Anna Sandström Gerdtsson, Mattis Knulst, Johan Botling, Artur Mezheyeuski, Patrick Micke & Sara Ek
Article: 2206725
Published online: 27 Apr 2023
AbstractforPhenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 3150 Views
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Article
Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selectively eliminate carcinoma cells
Isabel Britsch, Anne P. van Wijngaarden, Xiurong Ke, Mark. A.J.M. Hendriks, Douwe F. Samplonius, Emily M. Ploeg & Wijnand Helfrich
Article: 2207868
Published online: 10 May 2023
AbstractforNovel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selectively eliminate carcinoma cells | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 1555 Views
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Article
A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma
Azar Rezapour, Daniel Rydbeck, Fabian Byvald, Viktor Tasselius, Gustaf Danielsson, Eva Angenete & Ulf Yrlid
Article: 2209473
Published online: 10 May 2023
AbstractforA type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 1514 Views
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Article
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance
Naisheng Zheng, Tingting Wang, Qin Luo, Yi Liu, Junyao Yang, Yunlan Zhou, Guohua Xie, Yanhui Ma, Xiangliang Yuan & Lisong Shen
Article: 2210959
Published online: 13 May 2023
AbstractforM2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance | Full Text | References | PDF (7 MB) | EPUB | Supplemental
  • 2066 Views
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Article
T-cell dysfunction in natural killer/T-cell lymphoma
Xiaoyan Feng, Miaomiao Meng, Hongwen Li, Yuyang Gao, Wenting Song, Ruiqing Di, Zhaoming Li, Xudong Zhang & Mingzhi Zhang
Article: 2212532
Published online: 24 May 2023
AbstractforT-cell dysfunction in natural killer/T-cell lymphoma | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 1355 Views
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Editorial

Editorial
Prevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis
Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Article: 2212547
Published online: 15 May 2023
AbstractforPrevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis | Full Text | References | PDF (608.2 KB) | EPUB
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Original Research

Article
B cells require licensing by dendritic cells to serve as primary antigen-presenting cells for plasmid DNA
Ichwaku Rastogi & Douglas G. McNeel
Article: 2212550
Published online: 15 May 2023
AbstractforB cells require licensing by dendritic cells to serve as primary antigen-presenting cells for plasmid DNA | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 905 Views
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Article
Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells
Nabeel Kajihara, Yoshino Tanaka, Riko Takeuchi, Takuto Kobayashi, Masafumi Tanji, Tsukasa Ataka, Shiho Nakano, Taisho Yamada, Akinori Takaoka, Yoshinori Hasegawa, Ken-Ichiro Seino & Haruka Wada
Article: 2213132
Published online: 22 May 2023
AbstractforAugmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1412 Views
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Trial Watch

News
Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma
Benjamin Koh, Darren Jun Hao Tan, Wen Hui Lim, Jeffrey S L Wong, Cheng Han Ng, Kai En Chan, Meng Wang, Wei Peng Yong, Yock Young Dan, Louis Z Wang, Nigel Tan, Mark Muthiah, Alfred Kow, Nicholas L. Syn, Daniel Q. Huang & Thomas Yau
Article: 2214478
Published online: 03 Jun 2023
AbstractforTrial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 2729 Views
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Original Research

Article
CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants
Na Qiu, Akshaya Srikanth, Medhanie Mulaw, Umesh Tharehalli, Shanthiya Selvachandran, Martin Wagner, Thomas Seufferlein, Katja Stifter, André Lechel & Reinhold Schirmbeck
Article: 2215096
Published online: 26 May 2023
AbstractforCD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1440 Views
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Article
Acquired DNA damage repairs deficiency-driven immune evolution and involved immune factors of local versus distant metastases in non-small cell lung cancer
Wen-Fang Tang, Xiao-Jun Fan, Hua Bao, Rui Fu, Yi Liang, Min Wu, Chao Zhang, Jian Su, Yi-Long Wu & Wen-Zhao Zhong
Article: 2215112
Published online: 27 May 2023
AbstractforAcquired DNA damage repairs deficiency-driven immune evolution and involved immune factors of local versus distant metastases in non-small cell lung cancer | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1281 Views
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Article
FXR agonist GW4064 enhances anti-PD-L1 immunotherapy in colorectal cancer
Lu Lu, Yi-Xin Jiang, Xiao-Xia Liu, Jin-Mei Jin, Wen-Jie Gu, Xin Luan, Ying-Yun Guan & Li-Jun Zhang
Article: 2217024
Published online: 25 May 2023
AbstractforFXR agonist GW4064 enhances anti-PD-L1 immunotherapy in colorectal cancer | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 1509 Views
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Article
Studying TIGIT activity against tumors through the generation of knockout mice
Ahmed Rishiq, Reem Bsoul, Ophir Pick & Ofer Mandelboim
Article: 2217735
Published online: 29 May 2023
AbstractforStudying TIGIT activity against tumors through the generation of knockout mice | Full Text | References | PDF (4.3 MB) | EPUB
  • 1338 Views
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Article
23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function
Jill Fenaux, Xin Fang, Yao-ming Huang, Cristina Melero, Caroline Bonnans, Earth Light Lowe, Tiziana Palumbo, Cecilia Lay, Zuoan Yi, Aileen Zhou, Mauro Poggio, Wei-Jen Chung, Sophia R. Majeed, Dylan Glatt, Alice Chen, Maike Schmidt & Clarissa C. Lee
Article: 2217737
Published online: 05 Jun 2023
Abstractfor23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 2396 Views
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Article
Eribulin mesylate exerts antitumor effects via CD103
Kazumasa Oya, Yoshiyuki Nakamura, Rei Watanabe, Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Yutaka Matsumura, Hideaki Tahara, Naoko Okiyama, Manabu Fujimoto, Toshifumi Nomura & Yasuhiro Fujisawa
Article: 2218782
Published online: 27 May 2023
AbstractforEribulin mesylate exerts antitumor effects via CD103 | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1634 Views
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Article
Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
Iris Wyrobnik, Miryam Steinberg, Anat Gelfand, Ronen Rosenblum, Yara Eid Mutlak, Liron Sulimani, Shiri Procaccia, Yishai Ofran, Hila Novak-Kotzer & David Meiri
Article: 2219164
Published online: 11 Jun 2023
AbstractforDecreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 1706 Views
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Article
Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying a bispecific T cell engager against hepatocellular carcinoma
Xiangfei Yuan, Yang Lu, Yuanyuan Yang, Wencong Tian, Dongmei Fan, Ruoqi Liu, Xiaomin Lei, Yafei Xia, Lei Yang, Shu Yan & Dongsheng Xiong
Article: 2219544
Published online: 01 Jun 2023
AbstractforSystemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying a bispecific T cell engager against hepatocellular carcinoma | Full Text | References | PDF (23 MB) | EPUB | Supplemental
  • 1127 Views
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Review

Review Article
Trial watch: chemotherapy-induced immunogenic cell death in oncology
Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel & Abhishek D. Garg
Article: 2219591
Published online: 03 Jun 2023
AbstractforTrial watch: chemotherapy-induced immunogenic cell death in oncology | Full Text | References | PDF (934.7 KB) | EPUB
  • 3434 Views
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Original Research

Article
MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells
Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca & Lorenzo Moretta
Article: 2221081
Published online: 07 Jun 2023
AbstractforMicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1726 Views
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Review

Review Article
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference
Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R.V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch & Silvia C. Formenti
Article: 2222560
Published online: 21 Jun 2023
AbstractforUpdates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference | Full Text | References | PDF (491 KB) | EPUB
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Original Research

Article
Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1
Debayan Mukherjee, Erminia Romano, Richard Walshaw, Leo A. H. Zeef, Antonia Banyard, Stephen J. Kitcatt, Eleanor J. Cheadle, Karoliina Tuomela, Swati Pendharkar, Aws Al-Deka, Beatrice Salerno, Sophie Raby, Ian G. Mills, Jamie Honeychurch & Tim M. Illidge
Article: 2223094
Published online: 15 Jun 2023
AbstractforReprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1 | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 2627 Views
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Editorial

Editorial
Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
Marine Fidelle, Ai-Ling Tian, Laurence Zitvogel & Guido Kroemer
Article: 2224672
Published online: 29 Jun 2023
AbstractforBile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance | Full Text | References | PDF (311.7 KB) | EPUB
  • 1329 Views
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Editorial
Microbiota-associated immunotherapy resistance caused by deficient PD-L2 - RGMb signaling
Marine Fidelle, Isabelle Lebhar, Laurence Zitvogel & Guido Kroemer
Article: 2224679
Published online: 28 Jun 2023
AbstractforMicrobiota-associated immunotherapy resistance caused by deficient PD-L2 - RGMb signaling | Full Text | References | PDF (254.8 KB) | EPUB
  • 1179 Views
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Original Research

Article
Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer
Ernesto Lopez, Sofía Hidalgo, Eduardo Roa, Javiera Gómez, Carlos Hermansen Truan, Evy Sanders, Cristian Carrasco, Rodrigo Pacheco, Flavio Salazar-Onfray, Manuel Varas-Godoy, Vincenzo Borgna & Alvaro Lladser
Article: 2225291
Published online: 22 Jun 2023
AbstractforPreclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1587 Views
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Trial Watch

News
Trial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment
Mafalda Penetra, Luís G. Arnaut & Lígia C. Gomes-da-Silva
Article: 2226535
Published online: 18 Jun 2023
AbstractforTrial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1774 Views
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Open Access

Research paper

Article
A Chemically Defined TLR3 Agonist with Anticancer Activity
Julie Le Naour, Sylvain Thierry, Sarah Adriana Scuderi, Mathilde Boucard-Jourdin, Peng Liu, Marc Bonnin, Yuhong Pan, Clémence Perret, Liwei Zhao, Misha Mao, Chloé Renoux, María Pérez-Lanzón, Baptiste Martin, Oliver Kepp, Guido Kroemer & Bettina Werlé
Article: 2227510
Published online: 27 Jun 2023
AbstractforA Chemically Defined TLR3 Agonist with Anticancer Activity | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1536 Views
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Brief Report

Brief Report
Stem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironment
Linda Chen, Nancy Lee, Reith Sarkar, Nora Katabi, Yanyun Li, Luc Morris, Richard Wong, Eric Sherman, Jorge S. Reis-Filho, Travis Hollmann & Nadeem Riaz
Article: 2230666
Published online: 09 Jul 2023
AbstractforStem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironment | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1485 Views
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Original Research

Article
Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors
Paula Krone, Annabell Wolff, Julia Teichmann, Johanna Maennicke, Julia Henne, Leonie Engster, Inken Salewski, Wendy Bergmann, Christian Junghanss & Claudia Maletzki
Article: 2230669
Published online: 28 Jun 2023
AbstractforShort-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors | Full Text | References | PDF (6.9 MB) | EPUB | Supplemental
  • 1155 Views
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Article
Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues
Qikang Hu, Meredith L. Frank, Yang Gao, Liyan Ji, Muyun Peng, Chen Chen, Bin Wang, Yan Hu, Zeyu Wu, Jina Li, Lu Shu, Qiongzhi He, Yingqian Zhang, Xuefeng Xia, Jianjun Zhang, Xin Yi, Alexandre Reuben & Fenglei Yu
Article: 2233399
Published online: 20 Oct 2023
AbstractforSpatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1047 Views
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Article
An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin
Daniel Snell, Tea Gunde, Stefan Warmuth, Bithi Chatterjee, Matthias Brock, Christian Hess, Maria Johansson, Alexandre Simonin, Fabio Mario Spiga, Christopher Weinert, Niels Kirk, Nicole Bassler, Lucia Campos Carrascosa, Naomi Flückiger, Robin Heiz, Sandro Wagen, Noreen Giezendanner, Alessandra Alberti, Yasemin Yaman, Dana Mahler, Dania Diem, Peter Lichtlen & David Urech
Article: 2233401
Published online: 12 Jul 2023
AbstractforAn engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin | Full Text | References | PDF (3.2 MB) | EPUB
  • 1605 Views
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Article
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8+ T cells towards the center of human lung tumors
Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild, Emel Yilmaz, Jesper Säfholm, Mamdoh Al-Ameri, Evren Alici, Hans-Gustaf Ljunggren, Igor Schliemann, Ozan Aricak, Felix Haglund de Flon, Jakob Michaëlsson & Nicole Marquardt
Article: 2233402
Published online: 11 Jul 2023
AbstractforAccumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8+ T cells towards the center of human lung tumors | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1799 Views
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Article
Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition
Tom van den Ende, Aiarpi Ezdoglian, Lisanne M. Baas, Joyce Bakker, Sinéad M. Lougheed, Micaela Harrasser, Cynthia Waasdorp, Mark I. van Berge Henegouwen, Maarten C.C.M. Hulshof, Nadia Haj Mohammad, Richard van Hillegersberg, Stella Mook, Conny J. van der Laken, Nicole C.T. van Grieken, Sarah Derks, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven & Tanja D. de Gruijl
Article: 2233403
Published online: 17 Jul 2023
AbstractforLongitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1623 Views
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Article
Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis
Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig & Guido Kroemer
Article: 2237354
Published online: 21 Jul 2023
AbstractforFormyl peptide receptor-1 (FPR1) represses intestinal oncogenesis | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 1585 Views
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Article
A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin
Nanumi Han, Haruka Wada, Takuto Kobayashi, Ryo Otsuka & Ken-Ichiro Seino
Article: 2238499
Published online: 24 Jul 2023
AbstractforA mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 981 Views
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Article
CD11c+ and IRF8+ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy
Benita C. Y. Tse, Sarah Bergamin, Pascal Steffen, George Hruby, Nick Pavlakis, Stephen J. Clarke, Justin Evans, Alexander Engel, Andrew Kneebone & Mark P. Molloy
Article: 2238506
Published online: 20 Jul 2023
AbstractforCD11c+ and IRF8+ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 899 Views
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Article
Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells
Massimo Russo, Nicolò Panini, Paola Fabbrizio, Laura Formenti, Riccardo Becchetti, Cristina Matteo, Marina Meroni, Claudia Nastasi, Andrea Cappelleri, Roberta Frapolli, Giovanni Nardo, Eugenio Scanziani, Andrea Ponzetta, Maria Rosa Bani, Carmen Ghilardi & Raffaella Giavazzi
Article: 2239035
Published online: 01 Aug 2023
AbstractforChemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1242 Views
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Editorial

Editorial
Mammary carcinoma: toward a realistic mouse model of incurable cancers
Maria Pérez-Lanzón, Maria Chiara Maiuri, Carlos Lopez-Otin & Guido Kroemer
Article: 2240613
Published online: 03 Aug 2023
AbstractforMammary carcinoma: toward a realistic mouse model of incurable cancers | Full Text | References | PDF (1 MB) | EPUB
  • 785 Views
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Original Research

Article
In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies
Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, William T Tse, Svetlana Dambaeva, Sylvia Schneiderman, Philip M Iannaccone, Oren Becher, Douglas K Graham & Vasiliy Galat
Article: 2240670
Published online: 12 Sep 2023
AbstractforIn vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies | Full Text | References | PDF (9.6 MB) | EPUB | Supplemental
  • 1757 Views
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Open Access
Article
The yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1
Adeiye A. Pilgrim, Hunter C. Jonus, Andrew Ho, Anna C. Cole, Jenny Shim & Kelly C. Goldsmith
Article: 2240678
Published online: 05 Aug 2023
AbstractforThe yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1 | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1303 Views
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Article
Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer
Tatiana V. Kudling, James H.A. Clubb, Santeri Pakola, Dafne C.A. Quixabeira, Iris A.K. Lähdeniemi, Camilla Heiniö, Victor Arias, Riikka Havunen, Victor Cervera-Carrascon, Joao M. Santos, Eva Sutinen, Jari Räsänen, Kristian Borenius, Mikko I. Mäyränpää, Eero Aaltonen, Suvi Sorsa, Otto Hemminki, Anna Kanerva, Emmy W. Verschuren, Ilkka Ilonen & Akseli Hemminki
Article: 2241710
Published online: 02 Aug 2023
AbstractforEffective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 2039 Views
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Commentary

Histamine antagonists promote cancer immunosurveillance
Peng Liu, Guido Kroemer & Oliver Kepp
Article: 2242211
Published online: 05 Aug 2023
AbstractforHistamine antagonists promote cancer immunosurveillance | Full Text | References | PDF (540.9 KB) | EPUB
  • 1078 Views
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Original Research

Article
Group 2 innate lymphoid cells boost CD8+ T-cell activation in anti-tumor immune responses
Jing Wen, Shipeng Cheng, Ran Wang, Yuying Huang, Long Xu, Liyan Ma, Zhiyang Ling, Jinfu Xu, Deping Zhao, Yaguang Zhang & Bing Sun
Article: 2243112
Published online: 09 Aug 2023
AbstractforGroup 2 innate lymphoid cells boost CD8+ T-cell activation in anti-tumor immune responses | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1269 Views
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Review

Review Article
Light on life: immunoscore immune-checkpoint, a predictor of immunotherapy response
Assia Hijazi, Carlotta Antoniotti, Chiara Cremolini & Jérôme Galon
Article: 2243169
Published online: 05 Aug 2023
AbstractforLight on life: immunoscore immune-checkpoint, a predictor of immunotherapy response | Full Text | References | PDF (1.4 MB) | EPUB
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Open Access

Original Research

Article
L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes
Stephanie Schlichtner, Inna M. Yasinska, Elena Klenova, Maryam Abooali, Gurprit S. Lall, Steffen M. Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F. Gibbs, Elizaveta Fasler-Kan & Vadim V. Sumbayev
Article: 2244330
Published online: 10 Aug 2023
AbstractforL-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes | Full Text | References | PDF (10.1 MB) | EPUB | Supplemental
  • 1565 Views
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Open Access
Article
CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade
Sabrina N. Bossio, Carolina Abrate, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, María C. Ramello, Valentina Brunotto, Wilfrid Richer, Dario Rocha, Christine Sedlik, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Elmer Fernandez, Eva V. Acosta Rodríguez, Eliane Piaggio & Carolina L. Montes
Article: 2246319
Published online: 18 Aug 2023
AbstractforCD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 1412 Views
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Open Access
Article
TNBC-derived Gal3BP/Gal3 complex induces immunosuppression through CD45 receptor
Annat Raiter, Julia Lipovetsky, Asaf Stenbac, Ido Lubin & Rinat Yerushalmi
Article: 2246322
Published online: 14 Aug 2023
AbstractforTNBC-derived Gal3BP/Gal3 complex induces immunosuppression through CD45 receptor | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
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Open Access
Article
Melanoma patients with immune-related adverse events after immune checkpoint inhibitors are characterized by a distinct immunological phenotype of circulating T cells and M-MDSCs
Alisa Lepper, Rebekka Bitsch, Feyza Gül Özbay Kurt, Ihor Arkhypov, Samantha Lasser, Jochen Utikal & Viktor Umansky
Article: 2247303
Published online: 13 Aug 2023
AbstractforMelanoma patients with immune-related adverse events after immune checkpoint inhibitors are characterized by a distinct immunological phenotype of circulating T cells and M-MDSCs | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1339 Views
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Open Access
Article
CAR-T cells dual-target CD123 and NKG2DLs to eradicate AML cells and selectively target immunosuppressive cells
Xin Jin, Danni Xie, Rui Sun, Wenyi Lu, Xia Xiao, Yibing Yu, Juanxia Meng & Mingfeng Zhao
Article: 2248826
Published online: 26 Aug 2023
AbstractforCAR-T cells dual-target CD123 and NKG2DLs to eradicate AML cells and selectively target immunosuppressive cells | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 1988 Views
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Open Access

Brief Report

Brief Report
Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy
David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G. Soucy & Simon Turcotte
Article: 2253642
Published online: 14 Sep 2023
AbstractforHomogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
  • 745 Views
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Open Access

Original research

Article
Immune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell lung cancer patients
Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte & Stefano Ugel
Article: 2253644
Published online: 14 Sep 2023
AbstractforImmune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell lung cancer patients | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1384 Views
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Open Access

Brief report

Brief Report
Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody
Hayat Bähr-Mahmud, Ursula Ellinghaus, Christiane R. Stadler, Leyla Fischer, Claudia Lindemann, Anuhar Chaturvedi, Jan Diekmann, Stefan Wöll, Imke Biermann, Bernhard Hebich, Caroline Scharf, Manuela Siefke, Alexandra S. Roth, Martin Rao, Kerstin Brettschneider, Eva-Maria Ewen, Uğur Şahin & Özlem Türeci
Article: 2255041
Published online: 16 Oct 2023
AbstractforPreclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2874 Views
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Open Access

Review

Review Article
Non-pharmaceutical interventions to optimize cancer immunotherapy
Maximilian Boesch, Florent Baty, Frank Rassouli, Tobias Kowatsch, Markus Joerger, Martin Früh & Martin H. Brutsche
Article: 2255459
Published online: 28 Sep 2023
AbstractforNon-pharmaceutical interventions to optimize cancer immunotherapy | Full Text | References | PDF (972.1 KB) | EPUB
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Author’s View

Reply
Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer
Marion Thibaudin & Francois Ghiringhelli
Article: 2257098
Published online: 15 Sep 2023
AbstractforChemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer | Full Text | References | PDF (473.2 KB) | EPUB
  • 646 Views
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Open Access

Commentary

CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response
Maud Charpentier, Silvia Formenti & Sandra Demaria
Article: 2258011
Published online: 15 Sep 2023
AbstractforCD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response | Full Text | References | PDF (614.4 KB) | EPUB
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Open Access

Original research

Article
PB101, a VEGF- and PlGF-targeting decoy protein, enhances antitumor immunity and suppresses tumor progression and metastasis
Eun-Jin Go, Hannah Yang, Seung Joon Lee, Hyun Gul Yang, Jin A. Shin, Won Suk Lee, Hye Seong Lim, Hong Jae Chon & Chan Kim
Article: 2259212
Published online: 20 Sep 2023
AbstractforPB101, a VEGF- and PlGF-targeting decoy protein, enhances antitumor immunity and suppresses tumor progression and metastasis | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 981 Views
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Open Access
Article
Digital spatial profiling of melanoma shows CD95 expression in immune cells is associated with resistance to immunotherapy
Sandra Martinez-Morilla, Myrto Moutafi, Aileen I. Fernandez, Shlomit Jessel, Prajan Divakar, Pok Fai Wong, Rolando Garcia-Milian, Kurt A. Schalper, Harriet M. Kluger & David L. Rimm
Article: 2260618
Published online: 27 Sep 2023
AbstractforDigital spatial profiling of melanoma shows CD95 expression in immune cells is associated with resistance to immunotherapy | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 1509 Views
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Open Access
Article
Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection
Trevor S. Anderson, Amanda L. McCormick, Elizabeth A. Daugherity, Mariam Oladejo, Izuchukwu F. Okpalanwaka, Savanna L. Smith, Duke Appiah, Laurence M. Wood & Devin B. Lowe
Article: 2260620
Published online: 28 Sep 2023
AbstractforListeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1081 Views
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Open Access
Article
C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer
Chen Zhang, Kankan Cao, Moran Yang, Yiying Wang, Mengdi He, Jiaqi Lu, Yan Huang, Guodong Zhang & Haiou Liu
Article: 2261242
Published online: 30 Sep 2023
AbstractforC5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1665 Views
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Open Access
Article
Lag-3 expression and clinical outcomes in metastatic melanoma patients treated with combination anti-lag-3 + anti-PD-1-based immunotherapies
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long & Richard A. Scolyer
Article: 2261248
Published online: 04 Oct 2023
AbstractforLag-3 expression and clinical outcomes in metastatic melanoma patients treated with combination anti-lag-3 + anti-PD-1-based immunotherapies | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1309 Views
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Open Access
Article
Safety and effectiveness of combination versus monotherapy with immune checkpoint inhibitors in patients with preexisting autoimmune diseases
Pankti Reid, Sabina Sandigursky, Juhee Song, Maria A. Lopez-Olivo, Houssein Safa, Samuel Cytryn, Elizaveta Efuni, Maryam Buni, Anna Pavlick, Michelle Krogsgaard, Osama Abu-Shawer, Mehmet Altan, Jeffrey S. Weber, Osama E. Rahma, Maria E. Suarez-Almazor, Adi Diab & Noha Abdel-Wahab
Article: 2261264
Published online: 30 Oct 2023
AbstractforSafety and effectiveness of combination versus monotherapy with immune checkpoint inhibitors in patients with preexisting autoimmune diseases | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1123 Views
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Open Access
Article
Driver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients
Sandra García-Mulero, Roberto Fornelino, Marco Punta, Stefano Lise, Mar Varela, Luis P. del Carpio, Rafael Moreno, Marcel Costa-García, Dietmar Rieder, Zlatko Trajanoski, Alena Gros, Ramón Alemany, Josep María Piulats & Rebeca Sanz-Pamplona
Article: 2261278
Published online: 24 Oct 2023
AbstractforDriver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 1067 Views
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Open Access
Article
Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells
Constanza Rodriguez, Cintia L. Araujo Furlan, Jimena Tosello Boari, Sabrina N. Bossio, Santiago Boccardo, Laura Fozzatti, Fernando P. Canale, Cristian G. Beccaria, Nicolás G. Nuñez, Danilo G. Ceschin, Eliane Piaggio, Adriana Gruppi, Carolina L. Montes & Eva V. Acosta Rodríguez
Article: 2261326
Published online: 05 Oct 2023
AbstractforInterleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Open Access

Brief report

Brief Report
Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor
Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai & Hongkui Deng
Article: 2265703
Published online: 05 Oct 2023
AbstractforEnhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Open Access

Original research

Article
PD-L1 (CD274) promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma
Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J. Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M. Wirtz, Jennifer Landsberg, Dimo Dietrich & Markus Eckstein
Article: 2267744
Published online: 19 Oct 2023
AbstractforPD-L1 (CD274) promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1199 Views
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Open Access
Article
Dipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration
Yu Tian, Lingyi Kong, Yan Li, Zhiyun Liao, Xing Cai, Suke Deng, Xiao Yang, Bin Zhang, Yijun Wang, Zhanjie Zhang, Bian Wu, Lu Wen, Fang Huang, Yan Hu, Chao Wan, Yifei Liao, Yajie Sun & Kunyu Yang
Article: 2268257
Published online: 12 Oct 2023
AbstractforDipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 1077 Views
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Open Access
Article
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber & Anastasios D. Giannou
Article: 2269634
Published online: 20 Oct 2023
AbstractforCD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 1310 Views
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Author’s view

Reply
A mitochondrial checkpoint to adaptive anticancer immunity
Oliver Kepp, Peng Liu, Guido Kroemer & Lorenzo Galluzzi
Article: 2271693
Published online: 16 Oct 2023
AbstractforA mitochondrial checkpoint to adaptive anticancer immunity | Full Text | References | PDF (538.9 KB) | EPUB
  • 997 Views
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Open Access

Editorial

Editorial
Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors
Lucillia Bezu, Oliver Kepp & Guido Kroemer
Article: 2272352
Published online: 09 Nov 2023
AbstractforImmunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors | Full Text | References | PDF (236.6 KB) | EPUB
  • 816 Views
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Open Access

Original research

Article
Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC
Stefan Koeck, Arno Amann, Johan Kern, Marit Zwierzina, Edith Lorenz, Sieghart Sopper, Heinz Zwierzina, Finn Mildner, Martina Sykora, Susanne Sprung, Hubert Hackl, Florian Augustin, Hubert T. Maier, Andreas Pircher, Georg Pall, Dominik Wolf & Gabriele Gamerith
Article: 2274130
Published online: 28 Nov 2023
AbstractforWhole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 883 Views
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Open Access

Author‘s View

Reply
Next-generation CTLA-4 targeting molecules and combination therapy: promising strategies for improving cancer immunotherapy
Nils-Petter Rudqvist, Manushak Avagyan & Dhan Chand
Article: 2275333
Published online: 05 Nov 2023
AbstractforNext-generation CTLA-4 targeting molecules and combination therapy: promising strategies for improving cancer immunotherapy | Full Text | References | PDF (194 KB) | EPUB
  • 1524 Views
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Open Access

Original research

Article
Emergence of immune-related adverse events correlates with pathological complete response in patients receiving pembrolizumab for early triple-negative breast cancer
Maximilian Marhold, Simon Udovica, Anna Halstead, Mona Hirdler, Muna Ferner, Kerstin Wimmer, Zsuzsanna Bago-Horvath, Ruth Exner, Florian Fitzal, Kathrin Strasser-Weippl, Tim Robinson & Rupert Bartsch
Article: 2275846
Published online: 13 Nov 2023
AbstractforEmergence of immune-related adverse events correlates with pathological complete response in patients receiving pembrolizumab for early triple-negative breast cancer | Full Text | References | PDF (571.2 KB) | EPUB | Supplemental
  • 1327 Views
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Author’s View

Reply
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia
Iria Fernandez Botana, Giulia Pagano, Etienne Moussay & Jerome Paggetti
Article: 2276490
Published online: 03 Nov 2023
AbstractforInterleukin-27 tackles immunosuppression in chronic lymphocytic leukemia | Full Text | References | PDF (704.3 KB) | EPUB
  • 474 Views
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Open Access

Original research

Article
Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis
Baojun Wang, Bo Jiang, Lin Du, Wenyuan Chen, Qing Zhang, Wei Chen, Meng Ding, Wenmin Cao, Jie Gao, Yongming Deng, Yao Fu, Yan Li, Yonglong Xiao, Wenli Diao & Hongqian Guo
Article: 2279800
Published online: 20 Nov 2023
AbstractforTumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 1027 Views
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Open Access
Article
Piezo1 facilitates optimal T cell activation during tumor challenge
muta abiff, Mohammad Alshebremi, Melissa Bonner, Jay T. Myers, Byung-Gyu Kim, Suzanne L. Tomchuck, Alicia Santin, Daniel Kingsley, Sung Hee Choi & Alex Y. Huang
Article: 2281179
Published online: 22 Nov 2023
AbstractforPiezo1 facilitates optimal T cell activation during tumor challenge | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1401 Views
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Open Access
Article
A novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC
Huiting Wu, Chang Liu, Qiang Yuan, Yan Qiao, Yongwei Ding, Lina Duan, Wenjing Li, Mengjia Zhang, Xuhua Zhang, Yanan Jiang, Jing Lu, Ziming Dong, Tao Wang, Kangdong Liu & Jimin Zhao
Article: 2282250
Published online: 27 Nov 2023
AbstractforA novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC | Full Text | References | PDF (9.2 MB) | EPUB | Supplemental
  • 817 Views
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Author’s View

Reply
Cell type-specific induction of ferroptosis to boost antitumor immunity
Jiao Liu, Jingbo Li, Rui Kang & Daolin Tang
Article: 2282252
Published online: 20 Nov 2023
AbstractforCell type-specific induction of ferroptosis to boost antitumor immunity | Full Text | References | PDF (452.3 KB) | EPUB
  • 785 Views
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Open Access

Original research

Article
g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coenon, Caroline Multrier, Loïc Vaillant, Tianxiang Zhang & Martin Villalba
Article: 2283353
Published online: 22 Nov 2023
Abstractforg-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 702 Views
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Open Access
Article
Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p
Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger & Simon Jasinski-Bergner
Article: 2284483
Published online: 27 Nov 2023
AbstractforIdentification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 668 Views
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Open Access

Trial Watch

News
Trial watch: beta-blockers in cancer therapy
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer & Lucillia Bezu
Article: 2284486
Published online: 27 Nov 2023
AbstractforTrial watch: beta-blockers in cancer therapy | Full Text | References | PDF (918.6 KB) | EPUB
  • 1685 Views
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Author’s View

Reply
The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis
Ángela Bella, Ignacio Melero, Pedro Berraondo & Fernando Aranda
Article: 2285106
Published online: 20 Nov 2023
AbstractforThe significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis | Full Text | References | PDF (865.9 KB) | EPUB
  • 512 Views
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Open Access

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