The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis

ABSTRACT

Our recent research has unveiled the potential of locoregional immunotherapy. Cytokine-armored viral vectors, such as modified vaccinia virus Ankara vector encoding single-chain interleukin-12 (MVA.scIL-12), can target the omentum and elicit a robust tumor-specific immune response, all the while minimizing toxicity.

KEYWORDS:

• Adoptive cell transfer
• locoregional immunotherapy
• omentum
• peritoneal carcinomatosis
• virotherapy

Disclosure statement

P.B. and F.A. received research funding from Bavarian Nordic. I.M. reports receiving commercial research grants from AstraZeneca, BMS, Highlight Therapeutics, Alligator, Pfizer Genmab and Roche; has received speakers bureau honoraria from MSD; and is a consultant or advisory board member for BMS, Roche, AstraZeneca, Genmab, Pharmamar, F-Star, Bioncotech, Bayer, Numab, Pieris, Gossamer, Alligator and Merck Serono. A.B. has no conflict of interest to declare.

Additional information

Funding

Authors are supported by Bavarian Nordic, Instituto de Salud Carlos III (PI22/00147, PI20/00002, PI23/00203) co-financed by Fondos Feder, Gobierno de Navarra Proyecto ARNMUNE Ref.: 0011–1411-2023. F.A. receives a Miguel Servet I (CP19/00114) contract from ISCIII (Instituto de Salud Carlos III) co-financed by FSE (Fondo Social Europeo). A.B. is the recipient of PFIS fellowship from ISCIII (FI20/00058). Work produced with the support of a 2022 Leonardo Grant for Researchers and Cultural Creators (BBVA Foundation).