Abstract
The ruthenium(II) complex [Ru([Citation9]aneS 3)(phpz)Cl 2] (1) ([Citation9]aneS 3=trithiacyclononane, phpz=5-(2- hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole]) was readily isolated by reacting [Ru([Citation9]aneS 3)(DMSO)Cl 2] with one equivalent of the ligand phpz. A combination of MS, FT–IR and solution NMR studies (1-D and 2-D) was employed to determine the structural formula of the complex 1, in which phpz coordinates in a monodentate mode to Ru(II) by a simple replacement of the leaving group DMSO of the precursor. The cytotoxic properties of 1 in vitro were investigated by determination of the half-maximal growth inhibition on the human prostate (PC-3) and breast cancer cells (MDA-MB-231).
Funding
We acknowledge Fundação para a Ciência e a Tecnologia (FCT), the European Union, QREN, FEDER, COMPETE, for funding QOPNA (Organic Chemistry Research Unit) (project PEst-C/QUI/UI0062/2013; FCOMP-01-0124-FEDER-037296). The FCT and the European Social Fund, through the Programa Operacional Potencial Humano (POPH), are acknowledged for J.M.’s Ph.D. grant (SFRH/BD/44791/2008).
Supplemental data
Supplemental data for this article can be accessed http://dx.doi.org/10.1080/2164232X.2013.873992.