2,101
Views
0
CrossRef citations to date
0
Altmetric
Original Articles: Clinical Oncology

Amivantamab compared with real-world therapies in patients with advanced non-small cell lung cancer EGFR Exon 20 insertion mutations after platinum-based chemotherapy

, , , , , , , , & show all
Pages 1689-1697 | Received 25 Jan 2023, Accepted 04 Aug 2023, Published online: 08 Nov 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660.
  • Ferlay J, Ervik M, Lam F, et al. Global cancer Observatory: cancer today. Lyon, France: International Agency for Research on Cancer 2020. [Internet]. 2020 [cited 2022 Jun 3]. Available from: https://gco.iarc.fr/today/home.
  • Collins LG, Haines C, Perkel R, et al. Lung cancer: diagnosis and management. afp. 2007;75:56–63.
  • Woodard GA, Jones KD, Jablons DM. Lung cancer staging and prognosis. In: Reckamp KL, editor. Lung Cancer: Treatment and Research [internet]. Cham: Springer International Publishing; 2016 p. 47–75.
  • Chansky K, Detterbeck FC, Nicholson AG, et al. The IASLC lung cancer staging project: external validation of the revision of the TNM stage groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 2017;12(7):1109–1121. doi: 10.1016/j.jtho.2017.04.011.
  • Zhang Y-L, Yuan J-Q, Wang K-F, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016;7(48):78985–78993. doi: 10.18632/oncotarget.12587.
  • Hsu W-H, Yang JC-H, Mok TS, et al. Overview of current systemic management of EGFR-mutant NSCLC. Ann Oncol. 2018;29(suppl_1):i3–i9. doi: 10.1093/annonc/mdx702.
  • Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol. 2012;13(1):e23-31–e31. doi: 10.1016/S1470-2045(11)70129-2.
  • Russo A, Franchina T, Ricciardi G, et al. Heterogeneous responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with uncommon EGFR mutations: new insights and future perspectives in this complex clinical scenario. Int J Mol Sci. 2019;20(6):1431. doi: 10.3390/ijms20061431.
  • Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene. 2009;28(Suppl 1):S24–S31. doi: 10.1038/onc.2009.198.
  • Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497–1500. doi: 10.1126/science.1099314.
  • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129–2139. doi: 10.1056/NEJMoa040938.
  • Harrison PT, Vyse S, Huang PH. Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer. Semin Cancer Biol. 2020;61:167–179. doi: 10.1016/j.semcancer.2019.09.015.
  • Takeda M, Sakai K, Hayashi H, et al. Clinical characteristics of non-small cell lung cancer harboring mutations in exon 20 of EGFR or HER2. Oncotarget. 2018;9(30):21132–21140. doi: 10.18632/oncotarget.24958.
  • Oxnard GR, Lo PC, Nishino M, et al. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 2013;8(2):179–184. doi: 10.1097/JTO.0b013e3182779d18.
  • Riess JW, Gandara DR, Frampton GM, et al. Diverse EGFR exon 20 insertions and Co-Occurring molecular alterations identified by comprehensive genomic profiling of NSCLC. J Thorac Oncol. 2018;13(10):1560–1568. doi: 10.1016/j.jtho.2018.06.019.
  • Arcila ME, Nafa K, Chaft JE, et al. EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics. Mol Cancer Ther. 2013;12(2):220–229. doi: 10.1158/1535-7163.MCT-12-0620.
  • Chen D, Song Z, Cheng G. Clinical efficacy of first-generation EGFR-TKIs in patients with advanced non-small-cell lung cancer harboring EGFR exon 20 mutations. Onco Targets Ther. 2016;9:4181–4186. doi: 10.2147/OTT.S108242.
  • Wu J-Y, Yu C-J, Chang Y-C, et al. Effectiveness of tyrosine kinase inhibitors on “uncommon” epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res. 2011;17(11):3812–3821. doi: 10.1158/1078-0432.CCR-10-3408.
  • Kate S, Chougule A, Joshi A, et al. Outcome of uncommon EGFR mutation positive newly diagnosed advanced non-small cell lung cancer patients: a single center retrospective analysis. Lung Cancer (Auckl). 2019;10:1–10. doi: 10.2147/LCTT.S181406.
  • Robichaux JP, Elamin YY, Tan Z, et al. Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer. Nat Med. 2018;24(5):638–646. doi: 10.1038/s41591-018-0007-9.
  • Piotrowska Z, Wang Y, Sequist LV, et al. ECOG-ACRIN 5162: a phase II study of osimertinib 160 mg in NSCLC with EGFR exon 20 insertions. J Clin Oncol. 2020;38(15_suppl):9513–9513. doi: 10.1200/JCO.2020.38.15_suppl.9513.
  • Floc’h N, Martin MJ, Riess JW, et al. Antitumor activity of osimertinib, an irreversible Mutant-Selective EGFR tyrosine kinase inhibitor, in NSCLC harboring EGFR exon 20 insertions. Mol Cancer Ther. 2018;17(5):885–896. doi: 10.1158/1535-7163.MCT-17-0758.
  • Lee Y, Kim TM, Kim D-W, et al. Preclinical modeling of osimertinib for NSCLC with EGFR exon 20 insertion mutations. J Thorac Oncol. 2019;14(9):1556–1566. doi: 10.1016/j.jtho.2019.05.006.
  • Yang Z, Yang N, Ou Q, et al. Investigating novel resistance mechanisms to third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer patients. Clin Cancer Res. 2018;24(13):3097–3107. doi: 10.1158/1078-0432.CCR-17-2310.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). Non-Small Cell Lung Cancer 2022 [Internet]. NCCN. 2022 [cited 2022 Jun 3]. Available from: https://www.nccn.org/guidelines.
  • Huang C-Y, Ju D-T, Chang C-F, et al. A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer. Biomedicine. 2017;7(4):23. doi: 10.1051/bmdcn/2017070423.
  • Choudhury NJ, Schoenfeld AJ, Flynn J, et al. Response to standard therapies and comprehensive genomic analysis for patients with lung adenocarcinoma with EGFR exon 20 insertions. Clin Cancer Res. 2021;27(10):2920–2927. doi: 10.1158/1078-0432.CCR-20-4650.
  • Yasuda H, Park E, Yun C-H, et al. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med. 2013;5(216):216ra177. doi: 10.1126/scitranslmed.3007205.
  • Park K, Haura EB, Leighl NB, et al. Amivantamab in EGFR exon 20 Insertion-Mutated Non-Small-Cell lung cancer progressing on platinum chemotherapy: initial results from the CHRYSALIS phase I study. J Clin Oncol. 2021;39(30):3391–3402. doi: 10.1200/JCO.21.00662.
  • Janssen Research & Development, LLC. A Phase 1, first-in-human, open-label, dose escalation study of JNJ-61186372, a human bispecific EGFR and cMet antibody, in subjects with advanced non-small cell lung cancer [Internet]. clinicaltrials.gov; 2022 [cited 2022 Jun 7]. Report No.: NCT02609776. Available from: https://clinicaltrials.gov/ct2/show/NCT02609776.
  • Minchom A, Viteri S, Bazhenova L, et al. Amivantamab compared with real-world therapies in patients with advanced non-small cell lung cancer harboring EGFR exon 20 insertion mutations who progressed after platinum-based chemotherapy. Lung Cancer. 2022;168:74–82. doi: 10.1016/j.lungcan.2022.03.005.
  • Haura EB, Cho BC, Lee JS, et al. JNJ-61186372 (JNJ-372), an EGFR-cMet bispecific antibody, in EGFR-driven advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2019;37(15_suppl):9009–9009. doi: 10.1200/JCO.2019.37.15_suppl.9009.
  • Goto K. Development of nationwide genomic screening project (LC-SCRUM-Japan) for the establishment of cancer precision medicine. Annals Oncol. 2017;28:ix5. doi: 10.1093/annonc/mdx570.001.
  • Hernán MA, Robins JM. Using big data to emulate a target trial when a randomized trial is not available. Am J Epidemiol. 2016;183(8):758–764. doi: 10.1093/aje/kwv254.
  • Morgan CJ. Reducing bias using propensity score matching. J Nucl Cardiol. 2018;25(2):404–406. doi: 10.1007/s12350-017-1012-y.
  • Remon J, Hendriks LEL, Cardona AF, et al. EGFR exon 20 insertions in advanced non-small cell lung cancer: a new history begins. Cancer Treat Rev. 2020;90:102105. doi: 10.1016/j.ctrv.2020.102105.
  • Cardona AF, Rojas L, Zatarain-Barrón ZL, et al. EGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP). Lung Cancer. 2018;125:265–272. doi: 10.1016/j.lungcan.2018.10.007.
  • Yang G, Li J, Xu H, et al. EGFR exon 20 insertion mutations in Chinese advanced non-small cell lung cancer patients: molecular heterogeneity and treatment outcome from nationwide real-world study. Lung Cancer. 2020;145:186–194. doi: 10.1016/j.lungcan.2020.03.014.
  • Hirose T, Ikegami M, Endo M, et al. Extensive functional evaluation of exon 20 insertion mutations of EGFR. Lung Cancer. 2021;152:135–142. doi: 10.1016/j.lungcan.2020.12.023.
  • Vyse S, Huang PH. Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer. Sig Transduct Target Ther. 2019;4(1):10. doi: 10.1038/s41392-019-0038-9.
  • Passaro A, Mok T, Peters S, et al. Recent advances on the role of EGFR tyrosine kinase inhibitors in the management of NSCLC with uncommon, non exon 20 insertions, EGFR mutations. J Thorac Oncol. 2021;16(5):764–773. doi: 10.1016/j.jtho.2020.12.002.
  • Johnson&Johnson. Treatment with RYBREVANT® (amivantamab-vmjw) plus chemotherapy resulted in statistically significant and clinically meaningful improvement in progression-free survival in patients with newly diagnosed EGFR exon 20 insertion mutation-positive non-small cell lung cancer. [cited Aug 2023]. Available from: https://www.jnj.com/treatment-with-rybrevant-amivantamab-vmjw-plus-chemotherapy-resulted-in-statistically-significant-and-clinically-meaningful-improvement-in-progression-free-survival-in-patients-with-newly-diagnosed-egfr-exon-20-insertion-mutation-positive-non-small-cell-lung-cancer