Recent advancements in curcumin extraction, chemical/bio-synthesis, purification, and food applications

References

• Abu-Lafi, S., M. Akkawi, Q. Abu-Remeleh, M. Qutob, and P. Lutgen. 2019. Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential. Pharmacy & Pharmacology International Journal 7 (1):22–6. doi: 10.15406/ppij.2019.07.00228.
   Google Scholar
• ActiNovo’s liposomal curcumin supplement. 2023. Accessed July 5, 2023. https://www.actinovo.com/liposomal-curcumin-turmeric.
   Google Scholar
• Antony, B. 2011. U.S. Patent No. 7,879,373. Washington, DC: U.S. Patent and Trademark Office.
   Google Scholar
• Bose, T. K., S. Nandy, and D. Sengupta. 2018. Effect of plant growth regulators on curcumin content in Curcuma longa L. and its relation to plant nutrition. Journal of Plant Nutrition 41 (2):174–82. doi: 10.1080/01904167.2017.1393475.
   Google Scholar
• Carvalho Henriques, M., M. A. F. Faustino, and S. Santos Braga. 2020. Curcumin innovative delivery forms: Paving the ‘Yellow Brick Road’ of antitumoral phytotherapy. Applied Sciences 10 (24):8990. doi: 10.3390/app10248990.
   Google Scholar
• CAVACURMIN®: highly bioavailable curcumin. 2023. Accessed July 5, 2023. https://www.wacker.com/cms/en-us/products/brands/cavacurmin/cavacurmin.html.
   Google Scholar
• Chen, X., X. Li, B. Zhang, and Z. Xu. 2013. Transcriptome analysis reveals the molecular mechanisms underlying the accumulation of phenylpropanoid-derived chemicals in Curcuma longa. Journal of Agricultural and Food Chemistry 61 (6):1413–21. doi: 10.1021/jf305532e.
   Google Scholar
• Chen, X., Y. Liu, Z. Hu, X. Zhang, and M. Zhang. 2017. Isolation and purification of curcumin from Curcuma longa L. by preparative supercritical fluid chromatography. Journal of Separation Science 40 (22):4409–16. doi: 10.1002/jssc.201700920.
   Google Scholar
• Chen, X., Y. Liu, Z. Hu, X. Zhang, and M. Zhang. 2018. Purification of curcumin by anti-solvent crystallization from a crude ethanol extract of turmeric. Industrial Crops and Products 116:72–8. doi: 10.1016/j.indcrop.2018.02.048.
   Google Scholar
• Chen, Y., M. Li, X. Zhao, and M. Zhu. 2017. Preparative separation of curcuminoids from turmeric using supercritical fluid chromatography. Journal of Chromatography A 1492:22–9. doi: 10.1016/j.chroma.2017.03.015.
   Google Scholar
• Chen, Y., M. Li, X. Zhao, and M. Zhu. 2018. One-step purification of curcumin from crude extract of turmeric using ethanol as an antisolvent. Separation Science and Technology 53 (9):1363–9. doi: 10.1080/01496395.2018.1467826.
   Google Scholar
• Cheng, Y., F. Xue, S. Yu, S. Du, and Y. Yang. 2021. Subcritical water extraction of natural products. Molecules 26 (13):4004. doi: 10.3390/molecules26134004.
   PubMed Web of Science ®Google Scholar
• Ciuca, M. D., and R. C. Racovita. 2023. Curcumin: Overview of extraction methods, health benefits, and encapsulation and delivery using microemulsions and nanoemulsions. International Journal of Molecular Sciences 24 (10):8874. doi: 10.3390/ijms24108874.
   PubMed Web of Science ®Google Scholar
• Doldolova, K., M. Bener, M. Lalikoğlu, Y. S. Aşçı, R. Arat, and R. Apak. 2021. Optimization and modeling of microwave-assisted extraction of curcumin and antioxidant compounds from turmeric by using natural deep eutectic solvents. Food Chemistry 353:129337. doi: 10.1016/j.foodchem.2021.129337.
   PubMed Web of Science ®Google Scholar
• Fu, W. J., J. Liu, M. Zhang, J. Q. Li, J. F. Hu, L. R. Xu, and G. H. Dai. 2018. Isolation, purification and identification of the active compound of turmeric and its potential application to control cucumber powdery mildew. The Journal of Agricultural Science 156 (3):358–66. doi: 10.1017/S0021859618000345.
   Web of Science ®Google Scholar
• Ghosh, S., S. B. Patil, M. L. Ahire, R. Kitture, D. D. Gurav, A. M. Jabgunde, and S. N. Kale. 2016. Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents. International Journal of Nanomedicine 11:483–96. doi: 10.2147/IJN.S96522.
   Google Scholar
• Giori, A., and F. Franceschi. 2020. U.S. Patent No. 10,603,329. Washington, DC: U.S. Patent and Trademark Office.
   Google Scholar
• Gligor, O., A. Mocan, C. Moldovan, M. Locatelli, G. Crișan, and I. C. F. R. Ferreira. 2019. Enzyme-assisted extractions of polyphenols – A comprehensive review. Trends in Food Science & Technology 88:302–15. doi: 10.1016/j.tifs.2019.03.029.
   Web of Science ®Google Scholar
• Goel, A., S. Jhurani, and B. B. Aggarwal. 2008. Multi‐targeted therapy by curcumin: How spicy is it? Molecular Nutrition & Food Research 52 (9):1010–30. doi: 10.1002/mnfr.200700354.
   PubMed Web of Science ®Google Scholar
• Gökdemir, B., N. Baylan, and S. Çehreli. 2020. Application of a novel ionic liquid as an alternative green solvent for the extraction of curcumin from turmeric with response surface methodology: Determination and optimization study. Analytical Letters 53 (13):2111–21. doi: 10.1080/00032719.2020.1730394.
   Web of Science ®Google Scholar
• Gong, J., X. Li, Y. Wang, and J. Xu. 2018. Post-translational modifications of chalcone synthase are involved in its regulation of flavonoid biosynthesis in Arabidopsis. Plant, Cell & Environment 41 (3):682–92. doi: 10.1111/pce.13139.
   Google Scholar
• Inoue, K., C. Nomura, S. Ito, A. Nagatsu, T. Hino, and H. Oka. 2008. Purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography. Journal of Agricultural and Food Chemistry 56 (20):9328–36. doi: 10.1021/jf801815n.
   PubMed Web of Science ®Google Scholar
• Jessop, P. G., D. J. Heldebrant, X. Li, C. A. Eckert, and C. L. Liotta. 2005. Reversible nonpolar-to-polar solvent. Nature 436 (7054):1102. doi: 10.1038/4361102a.
   PubMed Web of Science ®Google Scholar
• Jha, A. K., and N. Sit. 2022. Extraction of bioactive compounds from plant materials using combination of various novel methods: A review. Trends in Food Science & Technology 119:579–91. doi: 10.1016/j.tifs.2021.11.019.
   Web of Science ®Google Scholar
• Jiang, T., R. Ghosh, and C. Charcosset. 2021. Extraction, purification and applications of curcumin from plant materials–A comprehensive review. Trends in Food Science & Technology 112:419–30. doi: 10.1016/j.tifs.2021.04.015.
   Web of Science ®Google Scholar
• Kita, T., S. Imai, H. Sawada, H. Kumagai, and H. Seto. 2008. The biosynthetic pathway of curcuminoid in turmeric (Curcuma longa) as revealed by 13C-labeled precursors. Bioscience, Biotechnology, and Biochemistry 72 (7):1789–98. doi: 10.1271/bbb.80075.
   PubMed Web of Science ®Google Scholar
• Kurmudle, N., L. D. Kagliwal, S. B. Bankar, and R. S. Singhal. 2013. Enzyme-assisted extraction for enhanced yields of turmeric oleoresin and its constituents. Food Bioscience 3:36–41. doi: 10.1016/j.fbio.2013.06.001.
   Web of Science ®Google Scholar
• Kwon, H. L., and M. S. Chung. 2015. Pilot-scale subcritical solvent extraction of curcuminoids from Curcuma longa L. Food Chemistry 185:58–64. doi: 10.1016/j.foodchem.2015.03.114.
   PubMed Web of Science ®Google Scholar
• Le-Tan, H., and H. Jaeger. 2022. Impact of cell disintegration techniques on curcumin recovery. Food Engineering Reviews 14 (4):655–72. doi: 10.1007/s12393-022-09319-x.
   Web of Science ®Google Scholar
• Le-Tan, H., T. Fauster, J. Vladic, T. Gerhardt, K. Haas, and H. Jaeger. 2021. Application of emerging cell disintegration techniques for the accelerated recovery of curcuminoids from Curcuma longa. Applied Sciences 11 (17):8238. doi: 10.3390/app11178238.
   Google Scholar
• Le-Tan, H., T. Fauster, K. Haas, and H. Jaeger. 2022. Aqueous extraction of curcuminoids from Curcuma longa: Effect of cell disintegration pre-treatment and extraction condition. Food and Bioprocess Technology 15 (6):1359–73. doi: 10.1007/s11947-022-02820-5.
   Web of Science ®Google Scholar
• Li, J., Z. Wang, S. Yao, and H. Song. 2020. Aqueous solubilization and extraction of curcumin enhanced by imidazolium, quaternary ammonium, and tropine ionic liquids, and insight of ionic liquids-curcumin interaction. Journal of Molecular Liquids 317:113906. doi: 10.1016/j.molliq.2020.113906.
   Web of Science ®Google Scholar
• LIPOSOMAL CURCUMIN. 2023. Accessed July 5, 2023. https://www.valimenta.com/product/liposomal-curcumin/.
   Google Scholar
• Madhavi, D., and D. Kagan. 2014. Bioavailability of a sustained release formulation of curcumin. Integrative Medicine: A Clinician’s Journal 13 (3):24.
   Google Scholar
• Majeed, M., V. Badmaev, and R. Rajendran. 1999. U.S. Patent No. 5,861,415. Washington, DC: U.S. Patent and Trademark Office.
   Google Scholar
• Martinez-Correa, H. A., J. T. Paula, A. C. A. V. Kayano, C. L. Queiroga, P. M. Magalhães, F. T. M. Costa, and F. A. Cabral. 2017. Composition and antimalarial activity of extracts of Curcuma longa L. obtained by a combination of extraction processes using supercritical CO2, ethanol and water as solvents. The Journal of Supercritical Fluids 119:122–9. doi: 10.1016/j.supflu.2016.08.017.
   Web of Science ®Google Scholar
• Mary, C. P. V., S. Vijayakumar, and R. Shankar. 2018. Metal chelating ability and antioxidant properties of curcumin-metal complexes–A DFT approach. Journal of Molecular Graphics & Modelling 79:1–14. doi: 10.1016/j.jmgm.2017.10.022.
   PubMed Web of Science ®Google Scholar
• Mollayi, S., S. Tamhidi, H. Hashempour, and A. J. A. C. Ghassempour. 2015. Recycling preparative high performance liquid chromatography for the separation of curcumin from curcuminoids in Curcuma longa L. Acta Chromatographica 27 (2):387–98. doi: 10.1556/AChrom.27.2015.2.13.
   Web of Science ®Google Scholar
• Mottahedin, P., A. Haghighi Asl, and M. Khajenoori. 2017. Extraction of curcumin and essential oil from Curcuma longa L. by subcritical water via response surface methodology. Journal of Food Processing and Preservation 41 (4):e13095. doi: 10.1111/jfpp.13095.
   Web of Science ®Google Scholar
• Nagargoje, A. A., S. V. Akolkar, M. M. Siddiqui, D. D. Subhedar, J. N. Sangshetti, V. M. Khedkar, and B. B. Shingate. 2020. Quinoline based monocarbonyl curcumin analogs as potential antifungal and antioxidant agents: Synthesis, bioevaluation and molecular docking study. Chemistry & Biodiversity 17 (2):e1900624. doi: 10.1002/cbdv.201900624.
   PubMed Web of Science ®Google Scholar
• Nelson, K. M., J. L. Dahlin, J. Bisson, J. Graham, G. F. Pauli, and M. A. Walters. 2017. The essential medicinal chemistry of curcumin: Miniperspective. Journal of Medicinal Chemistry 60 (5):1620–37. doi: 10.1021/acs.jmedchem.6b00975.
   PubMed Web of Science ®Google Scholar
• Neves, M. I. L., M. M. Strieder, R. Vardanega, E. K. Silva, and M. A. A. Meireles. 2020. Biorefinery of turmeric (Curcuma longa L.) using non-thermal and clean emerging technologies: An update on the curcumin recovery step. RSC Advances 10 (1):112–21. doi: 10.1039/C9RA08265D.
   Web of Science ®Google Scholar
• Oomen, W. W., P. Begines, N. R. Mustafa, E. G. Wilson, R. Verpoorte, and Y. H. Choi. 2020. Natural deep eutectic solvent extraction of flavonoids of Scutellaria baicalensis as a replacement for conventional organic solvents. Molecules 25 (3):617. doi: 10.3390/molecules25030617.
   PubMed Web of Science ®Google Scholar
• Orellana-Paucar, A. M., and M. G. Machado-Orellana. 2022. Pharmacological profile, bioactivities, and safety of turmeric oil. Molecules 27 (16):5055. doi: 10.3390/molecules27165055.
   PubMed Web of Science ®Google Scholar
• Osorio-Tobón, J. F. 2020. Recent advances and comparisons of conventional and alternative extraction techniques of phenolic compounds. Journal of Food Science and Technology 57 (12):4299–315. doi: 10.1007/s13197-020-04433-2.
   PubMed Web of Science ®Google Scholar
• Pabon, H. J. J. 1964. A synthesis of curcumin and related compounds. Recueil Des Travaux Chimiques Des Pays-Bas 83 (4):379–86. doi: 10.1002/recl.19640830407.
   Google Scholar
• Priyadarsini, K. I. 2014. The chemistry of curcumin: From extraction to therapeutic agent. Molecules 19 (12):20091–112. doi: 10.3390/molecules191220091.
   PubMed Web of Science ®Google Scholar
• Rao, E. V., and P. Sudheer. 2011. Revisiting curcumin chemistry part I: A new strategy for the synthesis of curcuminoids. Indian Journal of Pharmaceutical Sciences 73 (3):262. doi: 10.4103/0250-474X.93508.
   PubMed Web of Science ®Google Scholar
• Sagnou, M., F. N. Novikov, E. S. Ivanova, P. Alexiou, V. S. Stroylov, I. Y. Titov, V. V. Tatarskiy, M. S. Vagida, M. Pelecanou, A. A. Shtil, et al. 2020. Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin. European Journal of Medicinal Chemistry 198:112331. doi: 10.1016/j.ejmech.2020.112331.
   PubMed Web of Science ®Google Scholar
• Sahne, F., M. Mohammadi, G. D. Najafpour, and A. A. Moghadamnia. 2017. Enzyme-assisted ionic liquid extraction of bioactive compound from turmeric (Curcuma longa L.): Isolation, purification and analysis of curcumin. Industrial Crops and Products 95:686–94. doi: 10.1016/j.indcrop.2016.11.037.
   Web of Science ®Google Scholar
• Sasaki, H., Y. Sunagawa, K. Takahashi, A. Imaizumi, H. Fukuda, T. Hashimoto, H. Wada, Y. Katanasaka, H. Kakeya, M. Fujita, et al. 2011. Innovative preparation of curcumin for improved oral bioavailability. Biological & Pharmaceutical Bulletin 34 (5):660–5. doi: 10.1248/bpb.34.660.
   PubMed Web of Science ®Google Scholar
• Sharma, A., A. Ray, and R. S. Singhal. 2023. Co-extraction of turmeric (Curcuma longa L.) and dried coconut shreds by supercritical fluid extraction (SFE): Chemical and bioactivity profile. Journal of Cleaner Production 382:135313. doi: 10.1016/j.jclepro.2022.135313.
   Web of Science ®Google Scholar
• Sharma, P., P. Kashyap, and A. Dhakane. 2023. Exploring the antioxidant potential of fermented turmeric pulp: Effect of extraction methods and microencapsulation. Preparative Biochemistry & Biotechnology 53 (8):968–77. doi: 10.1080/10826068.2022.2163256.
   PubMed Web of Science ®Google Scholar
• Shirsath, S. R., S. S. Sable, S. G. Gaikwad, and P. R. Gogate. 2021. Ultrasound assisted curcumin recovery from Curcuma aromatica: Understanding the effect of different operating parameters. Chemical Engineering and Processing-Process Intensification 169:108604. doi: 10.1016/j.cep.2021.108604.
   Web of Science ®Google Scholar
• Shirsath, S. R., S. S. Sable, S. G. Gaikwad, S. H. Sonawane, D. R. Saini, and P. R. Gogate. 2017. Intensification of extraction of curcumin from Curcuma amada using ultrasound assisted approach: Effect of different operating parameters. Ultrasonics Sonochemistry 38:437–45. doi: 10.1016/j.ultsonch.2017.03.040.
   PubMed Web of Science ®Google Scholar
• Siddiqui, R. A., S. Hassan, K. A. Harvey, T. Rasool, T. Das, P. Mukerji, and S. DeMichele. 2009. Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice. The British Journal of Nutrition 102 (7):967–75. doi: 10.1017/S0007114509345250.
   PubMed Web of Science ®Google Scholar
• Singh, K., S. Srichairatanakool, T. Chewonarin, A. Prommaban, R. S. Samakradhamrongthai, M. A. Brennan, C. S. Brennan, and N. Utama-Ang. 2022. Impact of green extraction on curcuminoid content, antioxidant activities and anti-cancer efficiency (in vitro) from turmeric rhizomes (Curcuma longa L.). Foods 11 (22):3633. doi: 10.3390/foods11223633.
   PubMed Web of Science ®Google Scholar
• Sontsa-Donhoung, A.-M., M. Bahdjolbe, D. Nwaga. 2022. Selecting endophytes for rhizome production, curcumin content, biocontrol potential, and antioxidant activities of turmeric (Curcuma longa). BioMed Research international 2022:8321734. doi: 10.1155/2022/8321734.
   PubMed Web of Science ®Google Scholar
• Srivastava, B. B. L., A. S. Ripanda, and H. M. Mwanga. 2022. Ethnomedicinal, phytochemistry and antiviral potential of turmeric (Curcuma longa). Compounds 2 (3):200–21. doi: 10.3390/compounds2030017.
   Google Scholar
• Stohs, S. J., O. Chen, S. D. Ray, J. Ji, L. R. Bucci, and H. G. Preuss. 2020. Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: A review. Molecules 25 (6):1397. doi: 10.3390/molecules25061397.
   PubMed Web of Science ®Google Scholar
• Sureshbabu, A., E. Smirnova, A. Karthikeyan, M. Moniruzzaman, S. Kalaiselvi, K. Nam, G. L. Goff, and T. Min. 2023. The impact of curcumin on livestock and poultry animal’s performance and management of insect pests. Frontiers in Veterinary Science 10:1048067. doi: 10.3389/fvets.2023.1048067.
   PubMed Web of Science ®Google Scholar
• Tavares, K., E. Kirk, S. Motomura-Wages, J. Calpito, J.-P. Bingham, A. A. Ahmad, K. Flanagan, J. Uyeda, M. B. Kantar, and T. J. K. Radovich. 2022. Genotypic and environmental influence on fresh rhizome yield of turmeric (Curcuma longa L.). Agronomy 12 (11):2703. doi: 10.3390/agronomy12112703.
   Google Scholar
• Urošević, M., L. Nikolić, I. Gajić, V. Nikolić, A. Dinić, and V. Miljković. 2022. Curcumin: Biological activities and modern pharmaceutical forms. Antibiotics 11 (2):135. doi: 10.3390/antibiotics11020135.
   Web of Science ®Google Scholar
• Utaipan, T., P. Boonyanuphong, T. Chuprajob, A. Suksamrarn, and W. Chunglok. 2020. A trienone analog of curcumin, 1,7-bis (3-hydroxyphenyl)-1,4,6-heptatrien-3-one, possesses ROS-and caspase-mediated apoptosis in human oral squamous cell carcinoma cells in vitro. Applied Biological Chemistry 63 (1):11. doi: 10.1186/s13765-020-0491-8.
   Web of Science ®Google Scholar
• Valizadeh Kiamahalleh, M., G. Najafpour-Darzi, M. Rahimnejad, A. A. Moghadamnia, and M. Valizadeh Kiamahalleh. 2016. High performance curcumin subcritical water extraction from turmeric (Curcuma longa L.). Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1022:191–8. doi: 10.1016/j.jchromb.2016.04.021.
   PubMed Web of Science ®Google Scholar
• Vichakshana, G. A. D., S. C. Foo, and W. S. Choo. 2023. Impact of high-pressure homogenization pretreatment on recovery of curcumin from turmeric by different combinations of extraction and drying methods. Innovative Food Science & Emerging Technologies 83:103249. doi: 10.1016/j.ifset.2022.103249.
   Web of Science ®Google Scholar
• Wang, C., H. Yang, and J. Li. 2021. Combination of microwave, ultrasonic, enzyme assisted method for curcumin species extraction from turmeric (Curcuma longa L.) and evaluation of their antioxidant activity. eFood 2 (2):73–80. doi: 10.2991/efood.k.210329.001.
   Google Scholar
• Wang, L., P. Gulati, D. Santra, D. Rose, and Y. Zhang. 2018. Nanoparticles prepared by proso millet protein as novel curcumin delivery system. Food Chemistry 240:1039–46. doi: 10.1016/j.foodchem.2017.08.036.
   PubMed Web of Science ®Google Scholar
• Wang, L., R. J. Mu, Y. Li, L. Lin, Z. Lin, and J. Pang. 2019. Characterization and antibacterial activity evaluation of curcumin loaded konjac glucomannan and zein nanofibril films. LWT 113:108293. doi: 10.1016/j.lwt.2019.108293.
   Web of Science ®Google Scholar
• Wen, L., Z. Zhang, D.-W. Sun, S. P. Sivagnanam, and B. K. Tiwari. 2020. Combination of emerging technologies for the extraction of bioactive compounds. Critical Reviews in Food Science and Nutrition 60 (11):1826–41. doi: 10.1080/10408398.2019.1602823.
   PubMed Web of Science ®Google Scholar
• Widmann, A.-K., M. A. Wahl, D. R. Kammerer, and R. Daniels. 2022. Supercritical fluid extraction with CO2 of Curcuma longa L. in comparison to conventional solvent extraction. Pharmaceutics 14 (9):1943. doi: 10.3390/pharmaceutics14091943.
   PubMed Web of Science ®Google Scholar
• Yixuan, L., M. A. Qaria, S. Sivasamy, S. Jianzhong, and Z. Daochen. 2021. Curcumin production and bioavailability: A comprehensive review of curcumin extraction, synthesis, biotransformation and delivery systems. Industrial Crops and Products 172:114050. doi: 10.1016/j.indcrop.2021.114050.
   Web of Science ®Google Scholar
• Zhang, J., C. Wen, H. Zhang, Y. Duan, and H. Ma. 2020. Recent advances in the extraction of bioactive compounds with subcritical water: A review. Trends in Food Science & Technology 95:183–95. doi: 10.1016/j.tifs.2019.11.018.
   Web of Science ®Google Scholar
• Zia, S., M. R. Khan, M. A. Shabbir, A. Aslam Maan, M. K. I. Khan, M. Nadeem, A. A. Khalil, A. Din, and R. M. Aadil. 2022. An inclusive overview of advanced thermal and nonthermal extraction techniques for bioactive compounds in food and food-related matrices. Food Reviews International 38 (6):1166–96. doi: 10.1080/87559129.2020.1772283.
   Web of Science ®Google Scholar