365
Views
61
CrossRef citations to date
0
Altmetric
Research Article

Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles

, , , , , , , & show all
Pages 415-421 | Received 09 Sep 2005, Accepted 22 Sep 2005, Published online: 08 Oct 2008

References

  • Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam H, Aita VM, Owen J, deBlaquiere M, Frank J, et al. Alopecia universalis associated with a mutation in the human hairless gene. Science 1998; 279: 720–724
  • Chabri F, Bouris K, Jones T, Barrow D, Hann A, Allender C, Brain K, Birchall J. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br J Dermatol 2004; 150: 869–877
  • Cormier M, Johnson B, Ameri M, Nyam K, Libiran L, Zhang DD, Daddona P. Transdermal delivery of desmopressin using a coated microneedle array patch system. J Control Release 2004; 97: 503–511
  • Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: Protective immunization by parenteral, mucosal and gene innoculation. Proc Nat Acad Sci USA 1993; 90: 11478–11482
  • Hart IR, Vile RG. Targeted therapy for malignant melanoma. Curr Opin Oncol 1994; 6: 221–225
  • Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: A novel approach to transdermal drug delivery. J Pharm Sci 1998; 87: 922–925
  • Herndon TO, Gonzalez S, Gowrishankar TR, Rox Anderson R, Weaver JC. Transdermal microconduits by microscission for drug delivery and sample acquisition. BMC Med 2004; 2: 12
  • Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, Prausnitz MR. Lack of pain associated with microfabricated microneedles. Anesth Analg 2001; 92: 502–504
  • Kendall M, Mitchell T, Wrighton-Smith P. Intradermal ballistic delivery of micro-particles into excised human skin for pharmaceutical applications. J Biomech 2004; 37: 1733–1741
  • Lee WR, Shen SC, Wang KH, Hu CH, Fang JY. The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluoruracil. J Pharm Sci 2002; 91: 1613–1626
  • Li L, Hoffman RM. The feasibility of targeted selective gene therapy of the hair follicle. Nat Med 1995; 1: 705–706
  • Lin MTS, Pulkkinen L, Uitto J. Cutaneous gene therapy: Principles and prospects. Dermatol Clin 2000; 18: 177–188
  • Martanto W, Davis SP, Holiday NR, Wang J, Gill HS, Prausnitz MR. Transdermal delivery of insulin using microneedles in vivo. Pharm Res 2004; 21: 947–952
  • Matriano JA, Cormier M, Johnson J, Young WA, Buttery M, Nyam K, Daddona PE. Macroflux® microprojection array patch technology: A new and efficient approach for intracutaneous immunization. Pharm Res 2002; 19: 63–70
  • McAllister DV, Wang PM, Davis SP, Park JH, Canatella PJ, Allen MG, Prausnitz MR. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies. Proc Nat Acad Sci USA 2003; 100: 13755–13760
  • Menter A. Pathogenesis and genetics of psoriasis. Cutis 1998; 61: 8–10
  • Mikszta JA, Alarcon JB, Brittingham JM, Sutter DE, Pettis RJ, Harvey NG. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nat Med 2002; 8: 415–419
  • Panchagnula R, Stemmer K, Ritschel WA. Animal models for transdermal drug delivery. Methods Find Exp Clin Pharmacol 1997; 19: 335–341
  • Park JH, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. J Control Release 2005; 104: 51–66
  • Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA, et al. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Nat Acad Sci USA 1994; 91: 9519–9523
  • Sawamura D, Ina S, Itai K, Meng X, Kon A, Tamai K, Hanada K, Hashimoto I. In vivo gene introduction into keratinocytes using jet injection. Gene Ther 1999; 6: 1785–1787
  • Shi Z, Curiel DT, Tang DC. DNA-based non-invasive vaccination onto the skin. Vaccine 1999; 17: 2136–2141
  • Sivamani RK, Stoeber B, Wu GC, Zhai H, Liepmann D, Maibach H. Clinical microneedle injection of methyl nicotinate: Stratum corneum penetration. Skin Res Technol 2005; 11: 152–156
  • Tregear RT, Dirnhuber P. The mass of keratin removed from the stratum corneum by stripping with adhesive tape. J Investig Dermatol 1962; 38: 375–381
  • Uitto J, Pulkkinen L. The genodermatoses: Candidate diseases for gene therapy. Hum gene ther 2000; 11: 2267–2275
  • Wilke N, Mulcahy A, Ye SR, Morrissey A, Process optimization and characterization of silicon microneedles fabricated by wet etch technology. Microelectronics J (in press).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.