Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles

References

• Jin J, Yang L, Chen F, et al. Drug delivery system based on nanobubbles. Interdiscip Mater. 2022;1:471–494. doi: 10.1002/idm2.12050
   Google Scholar
• Zullino S, Argenziano M, Stura I, et al. From micro- to nano-multifunctional theranostic platform: effective ultrasound imaging is not just a matter of scale. Mol Imaging. 2018;17:153601211877821. doi: 10.1177/1536012118778216
   Web of Science ®Google Scholar
• Nitai AS, Mahmud R, Habib A, et al. A systematic review on nanobubbles in drug delivery: mechanism and applications. Biomed J Sci Tech Res. 2022;43(5):35041–35045.
   Google Scholar
• Combination of ultrasound and nanobubbles enables the removal of tumors without surgery. News-Medical.net. 2022. [cited 2023 June 6]. Available from: https://www.news-medical.net/news/20221121
   Google Scholar
• Liu S, Oshita S, Thuyet DQ, et al. Antioxidant activity of hydrogen nanobubbles in water with different reactive oxygen species both in vivo and in vitro. Langmuir. 2018;34:11878–11885. doi: 10.1021/acs.langmuir.8b02440
   PubMed Web of Science ®Google Scholar
• Sayadi LR, Banyard DA, Ziegler ME, et al. Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery. Int Wound J. 2018;15:363–374. doi: 10.1111/iwj.12873
   PubMed Web of Science ®Google Scholar
• Kida H, Feril LB, Irie Y, et al. Influence of nanobubble size distribution on ultrasound-mediated plasmid DNA and messenger RNA gene delivery. Front Pharmacol. 2022;13:855495. doi: 10.3389/fphar.2022.855495
   PubMed Web of Science ®Google Scholar
• Nittayacharn P, Yuan HX, Hernandez C, et al. Enhancing tumor drug distribution with ultrasound-triggered nanobubbles. J Pharm Sci. 2019;108(9):3091–3098. doi: 10.1016/j.xphs.2019.05.004
   PubMed Web of Science ®Google Scholar
• Batchelor DVB, Armistead FJ, Ingram N, et al. The influence of nanobubble size and stability on ultrasound enhanced drug delivery. Langmuir. 2022;38(45):13943–13954. doi: 10.1021/acs.langmuir.2c02303
   PubMed Web of Science ®Google Scholar
• Ristow M, Zarse K, Oberbach A, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Nat Acad Sci. 2009;106:8665–8670. doi: 10.1073/pnas.0903485106
   PubMed Web of Science ®Google Scholar
• Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008;87:142–149. doi: 10.1093/ajcn/87.1.142
   PubMed Web of Science ®Google Scholar
• Rana A, Samtiya M, Dhewa T, et al. Health benefits of polyphenols: a concise review. J Food Biochem. 2022;46(10):e14264. doi: 10.1111/jfbc.14264
   PubMed Web of Science ®Google Scholar
• Rajha HN, Paule A, Aragonès G, et al. Recent advances in research on polyphenols: effects on microbiota, metabolism, and health. Mol Nutr Food Res. 2022;66(1):e2100670. doi: 10.1002/mnfr.202100670
   PubMed Web of Science ®Google Scholar
• Spencer JP, Ria-Evans C, William RJ. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Bio Chem. 2003;278:34783–34793. doi: 10.1074/jbc.M305063200
   PubMed Web of Science ®Google Scholar
• Pallauf K, Rimbach G. Autophagy, polyphenols and healthy ageing. Ageing Res Rev. 2013;12:237–252. doi: 10.1016/j.arr.2012.03.008
   PubMed Web of Science ®Google Scholar
• Sharma A, Kaur M, Katnoria J, et al. Polyphenols in food: cancer prevention and apoptosis induction. Curr Med Chem. 2018;25:4740–4757. doi: 10.2174/0929867324666171006144208
   PubMed Web of Science ®Google Scholar
• Munin A, Edwards-Levy F. Encapsulation of natural polyphenolic compounds; a review. Pharmaceutics. 2011;3:793–829. doi: 10.3390/pharmaceutics3040793
   PubMedGoogle Scholar
• Fang Z, Bhandri B. Encapsulation of polyphenols – a review. Trends Food Sci Technol. 2010;21:510–523. doi: 10.1016/j.tifs.2010.08.003
   Web of Science ®Google Scholar
• Duda-Chodak A, Tarko T, Satora P, et al. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur J Nutr. 2015;54:325–341. doi: 10.1007/s00394-015-0852-y
   PubMed Web of Science ®Google Scholar
• Parkar SG, Trower TM, Stevenson DE. Fecal microbial metabolism of polyphenols and its effects on human gut microbiota. Anaerobe. 2013;23:12–19. doi: 10.1016/j.anaerobe.2013.07.009
   PubMed Web of Science ®Google Scholar
• Svegliati-Baron G, Patricio B, Liuci G, et al. Gut-pancreas-liver axis as a target for treatment of NAFLD/NASH. Int J Mol Sci. 2020;21(16):5820. doi: 10.3390/ijms21165820
   PubMed Web of Science ®Google Scholar
• Albillos A, Gottardi A, Rescigno M. The gut-liver axis in liver disease: pathophysiological basis for therapy. J Hepatol. 2020;72:558–577. doi: 10.1016/j.jhep.2019.10.003
   PubMed Web of Science ®Google Scholar
• Fung TC. The microbiota-immune axis as a central mediator of gut-brain communication. Neurobiol Dis. 2020;136:104714. doi: 10.1016/j.nbd.2019.104714
   PubMed Web of Science ®Google Scholar
• Mayer EA, Nance K, Chen S. The gut-brain-axis. Annu Rev Med. 2022;73:439–453. doi: 10.1146/annurev-med-042320-014032
   PubMed Web of Science ®Google Scholar
• Bliss ES, Whiteside E. The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol. 2018;9:900. doi: 10.3389/fphys.2018.00900
   PubMed Web of Science ®Google Scholar
• Buhman H, Roux CW, Bueter MN. The gut-brain axis in obesity. Best Pract Res Clin Gastroenterol. 2014;28:559–571. doi: 10.1016/j.bpg.2014.07.003
   PubMed Web of Science ®Google Scholar
• Lotstedt B, Strazar M, Xavier RJ, et al. Spatial host-microbiome sequencing. bioRxiv. 2022. doi:10.1038/s41587-023-01988-1
   Google Scholar
• Li VSW. Modelling intestinal inflammation and infection using ‘mini-gut’ organoids. Nat Rev Gastroenterol Hepatol. 2021;18:89–90. doi: 10.1038/s41575-020-00391-4
   PubMed Web of Science ®Google Scholar
• Kraljević Pavelić S, Simović Medica J, Gumbarević D, et al. Critical review on zeolite clinoptilolite safety and medical applications in vivo. Front Pharmacol. 2018;9:1350. doi: 10.3389/fphar.2018.01350
   PubMed Web of Science ®Google Scholar
• Gescher A. Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents? J Chemother. 2004;16:3–6. doi: 10.1179/joc.2004.16.Supplement-1.3
   PubMed Web of Science ®Google Scholar
• Derakhshankhah H, Jafari S, Sarvari S, et al. Biomedical application of zeolitic nanoparticles with an emphasis on medical interventions. Int J Nanomed. 2020;15:363–386. doi: 10.2147/IJN.S234573
   PubMed Web of Science ®Google Scholar
• Sankarasubramanian J, Ahmad R, Avuthu N, et al. Gut microbiota and metabolic specificity in ulcerative colitis and Crohn's disease. Front Med. 2020;7:606298. doi: 10.3389/fmed.2020.606298
   Web of Science ®Google Scholar
• Lu H, Xiang L, Cui X, et al. Molecular weight dependence of synthetic glycopolymers on flocculation and dewatering of fine particles. Langmuir. 2016;32:11615–11622. doi: 10.1021/acs.langmuir.6b03072
   PubMed Web of Science ®Google Scholar
• Nacini T, Khaleel Basha S, Sadiq AMM, et al. Development and characterization of alginate / chitosan nanoparticulate system for hydrophobic drug encapsulation. J Drug Deliv Sci Technol. 2019;52:65–72. doi: 10.1016/j.jddst.2019.04.002
   Web of Science ®Google Scholar
• Jakobek L. Interactions of polyphenols with carbohydrates, lipids and proteins. Food Chem. 2015;175:556–567. doi: 10.1016/j.foodchem.2014.12.013
   PubMed Web of Science ®Google Scholar
• Kanner J. Polyphenols by generating H2O2, affect cell redox signaling, inhibit PTPs and activate Nrf2 axis for adaptation and cell surviving: in vitro, in vivo and human health. Antioxidants. 2020;9(9):797. doi: 10.3390/antiox9090797
   Web of Science ®Google Scholar
• Bunesova V, Lacroix C, Schwab C. Mucin cross-feeding of infant bifidobacteria and eubacterium hallii. Microb Ecol. 2018;75:228–238. doi: 10.1007/s00248-017-1037-4
   PubMed Web of Science ®Google Scholar
• Greiner TU, Backhed F. Microbial regulation of GLP-1 and L-cell biology. Mol Metab. 2016;5:753–758. doi: 10.1016/j.molmet.2016.05.012
   PubMed Web of Science ®Google Scholar
• Gerard C, Vidal H. Impact of gut microbiota on host glycemic control. Front Endocrinol. 2019;10:29. doi: 10.3389/fendo.2019.00029
   PubMed Web of Science ®Google Scholar
• Claus SP. Will gut microbiota help design the next generation of GLP-1-based therapies for type 2 diabetes? Cell Metab. 2017;26:6–7. doi: 10.1016/j.cmet.2017.06.009
   PubMed Web of Science ®Google Scholar
• Jackson DN, Theiss A. Gut bacteria signaling to mitochondria in intestinal inflammation and cancer. Gut Microbes. 2020;11:285–304. doi: 10.1080/19490976.2019.1592421
   PubMed Web of Science ®Google Scholar
• Wojciechowska O, Costabile A, Kujawska M. The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles. Nanoscale Adv. 2023;5(23):6349–6364. doi: 10.1039/D3NA00696D
   PubMed Web of Science ®Google Scholar
• Cui X, Wang X, Chang X, et al. A new capacity of gut microbiota: fermentation of engineered inorganic carbon nanomaterials into endogenous organic metabolites. Proc Natl Acad Sci U S A. 2023;120(20):e2218739120. doi: 10.1073/pnas.2218739120
   PubMed Web of Science ®Google Scholar
• Ahmed S, Bhattacharya T, Annu A, editors. Handbook of nanotechnology in nutraceuticals. CRC Press; Taylor &Francis; 2023.
   Google Scholar
• Cas MD, Ghidoni R. Dietary curcumin: correlation between bioavailability and health potential. Nutrients. 2019;11:2147. doi: 10.3390/nu11092147
   PubMed Web of Science ®Google Scholar
• Huminiecki L. Evidence for multilevel chemopreventive activities of natural phenols from functional genomic studies of curcumin, resveratrol, genistein, quercetin, and luteolin. Int J Mol Sci. 2022;23:14957. doi: 10.3390/ijms232314957
   PubMed Web of Science ®Google Scholar
• Liang J, Yan H, Wang X, et al. Encapsulation of epigallocatechin gallate in zein/chitosan nanoparticles for controlled applications in food systems. Food Chem. 2017;231:19–24. doi: 10.1016/j.foodchem.2017.02.106
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang C, Qi Z, et al. Pea protein based nanocarriers for lipophilic polyphenols: spectroscopic analysis, characterization, chemical stability, antioxidant and molecular docking. Food Res Int. 2022;160:111713. doi: 10.1016/j.foodres.2022.111713
   PubMed Web of Science ®Google Scholar
• Dong R, Huang Z, Ma W, et al. Fabrication of nanocomplexes for anthocyanins delivery by ovalbumin and differently dense sulphate half-ester polysaccharides nanocarriers: enhanced stability, bio-accessibility, and antioxidant properties. Food Chem. 2024;432:137263. doi: 10.1016/j.foodchem.2023.137263
   PubMed Web of Science ®Google Scholar
• Maqsoudlou A, Assadpour E, Mohebodini H, et al. Improving the efficiency of natural antioxidant compounds via different nanocarriers. Adv Colloid Interface Sci. 2020;278:102122. doi: 10.1016/j.cis.2020.102122
   PubMed Web of Science ®Google Scholar
• Viana-Mendieta P, Sanchez ML, Benavides J. Rational selection of bioactive principles for wound healing applications: growth factors and antioxidants. Int Wound J. 2022;19:100–113. doi: 10.1111/iwj.13602
   PubMed Web of Science ®Google Scholar
• Chen AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21:e2900.
   Web of Science ®Google Scholar
• Shobal G, Joseph T, Majeed M, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Panta Med. 1998;64:353–356. doi: 10.1055/s-2006-957450
   PubMed Web of Science ®Google Scholar
• Wang R, Sun W, Liu J, et al. Preparation of curcumin nanocrystalline injection and evaluation of its in vivo and in vitro properties. J China Pharm Univ. 2022;6:54–59.
   Google Scholar
• Valentini G, Parize AL. Investigation of the interaction between curcumin and hydroxypropyl methylcellulose acetate succinate in solid and solution media. J Mol Liq. 2023;376:121446. doi: 10.1016/j.molliq.2023.121446
   Web of Science ®Google Scholar
• Morimoto T, Sunagawa Y, Katanasaka Y, et al. Drinkable preparation of theracurmin exhibits high absorption efficiency—a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull. 2013;36:1708–1714. doi: 10.1248/bpb.b13-00150
   PubMed Web of Science ®Google Scholar
• Wang F, Yang Y, Ju X, et al. Polyelectrolyte complex nanoparticles from chitosan and acylated rape seed cruciferrin protein for curcumin delivery. J Agric Food Chem. 2018;66:2689–2693.
   Web of Science ®Google Scholar
• Schibbor C, Kocher A, Benham D, et al. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014;58:516–527. doi: 10.1002/mnfr.201300724
   PubMed Web of Science ®Google Scholar
• Peng S, Li Z, Zou L, et al. Enhancement of curcumin bioavailability by encapsulation in sophorolipid-coated nanoparticles: an in vitro and in vivo study. J Agric Food Chem. 2018;66:1488–1497. doi: 10.1021/acs.jafc.7b05478
   PubMed Web of Science ®Google Scholar
• Gota VS, Maru GB, Soni TG, et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010;58:2095–2099. doi: 10.1021/jf9024807
   PubMed Web of Science ®Google Scholar
• Jude S, Amaraj A, Kunnumakkara AB, et al. Development of validated methods and quantification of curcuminoids and curcumin metabolites and their pharmacokinetic study of oral administration of complete natural turmeric formulation (Cureit™) in human plasma via UPLC/ESI-Q-TOF-MS spectrometry. Molecules. 2018;23:2415. doi: 10.3390/molecules23102415
   PubMed Web of Science ®Google Scholar
• Antony B, Merina B, Lyer V, et al. A pilot cross-over study to evaluate human oral bioavailability of BCM-95 CG (BiocurcumaxTM): a novel bioenhanced preparation of curcumin. Indian J Pharm Sci. 2008;70(4):445–449. doi: 10.4103/0250-474X.44591
   PubMed Web of Science ®Google Scholar
• Pasupathy R, Pandian P, Selvamuthukumar S. Nanobubbles: a novel targeted drug delivery system. Braz J Pharm Sci. 2022;58:e19608. doi: 10.1590/s2175-97902022e19604
   Web of Science ®Google Scholar
• Lu S, Zhao P, Deng Y, et al. Mechanistic insights and therapeutic delivery through micro/nanobubble-assisted ultrasound. Pharmaceutics. 2022;14(3):480. doi: 10.3390/pharmaceutics14030480
   PubMed Web of Science ®Google Scholar
• Wu M, Zhao H, Guo L, et al. Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer. Drug Deliv. 2018;25:226–240. doi: 10.1080/10717544.2017.1422300
   PubMed Web of Science ®Google Scholar
• Yan Y, Chen Y, Liu Z, et al. Brain delivery of curcumin through low-intensity ultrasound-induced blood–brain barrier opening via lipid-PLGA nanobubbles. Int J Nanomed. 2021;16:7433–7447. doi: 10.2147/IJN.S327737
   PubMed Web of Science ®Google Scholar
• Abdulmalek S, Nasef M, Awad D, et al. Protective effect of natural antioxidant, curcumin nanoparticles, and zinc oxide nanoparticles against type 2 diabetes-promoted hippocampal neurotoxicity in rats. Pharmaceutics. 2021;13(11):1937. doi: 10.3390/pharmaceutics13111937
   PubMed Web of Science ®Google Scholar
• Zha W, Bai Y, Xu L, et al. Curcumin attenuates testicular injury in rats with streptozotocin-induced diabetes. Biomed Res Int. 2018;2018:7468019.
   PubMed Web of Science ®Google Scholar
• Shengnuo F, Yuqiu Z, Xuan L, et al. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug Deliv. 2018;25(1):1091–1102. doi: 10.1080/10717544.2018.1461955
   PubMed Web of Science ®Google Scholar
• Othman MS, Hafez MM, Abdel AE. The potential role of zinc oxide nanoparticles in MicroRNAs dysregulation in STZ-induced type 2 diabetes in rats. Biol Trace Elem Res. 2020;197(2):606–618. doi: 10.1007/s12011-019-02012-x
   PubMed Web of Science ®Google Scholar
• Swati CA, Rinku DU, Kishore MP. In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles. Nanomedicine (Lond). 2016;11(13):1671–1687. doi: 10.2217/nnm-2016-0119
   PubMed Web of Science ®Google Scholar
• Farooqi AA, Pinheiro M, Granja A, et al. EGCG mediated targeting of deregulated signaling pathways and non-coding RNAs in different cancers: focus on JAK/STAT, Wnt/β-catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL mediated signaling pathways. Cancers (Basel). 2020;12:951. doi: 10.3390/cancers12040951
   PubMed Web of Science ®Google Scholar
• Holczer M, Besze B, Zambo V, et al. Epigallocatechin-3-gallate (EGCG) promotes autophagy dependent survival via influencing the balance of mTOR -AMPK pathways upon endoplasmic reticulum stress. Oxid Med Cell Longevity. 2018;2018. Article ID 6721530.
   PubMed Web of Science ®Google Scholar
• Van Aller GS, Carson JD, Tang W, et al. Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun. 2011;406(2):194–199. doi: 10.1016/j.bbrc.2011.02.010
   PubMed Web of Science ®Google Scholar
• Huang CH, Tsai SJ, Wang YJ, et al. EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. Mol Nutr Food Res. 2009;53:1156–1165. doi: 10.1002/mnfr.200800592
   PubMed Web of Science ®Google Scholar
• Teng H, Chen L. Polyphenols and bioavailability: an update. Crit Rev Food Sci Nutr. 2019;59:2040–2051. doi: 10.1080/10408398.2018.1437023
   PubMed Web of Science ®Google Scholar
• Liang J, Yan H, Yang HJ, et al. Synthesis and controlled – release properties of chitosan/ β-lactoglobulin nanoparticles as carriers for oral administration of epigallocatchin gallate. Food Sci Biotechnol. 2016;25:1585–1590.
   Web of Science ®Google Scholar
• Yang R, Tian J, Liu Y, et al. One-step fabrication of phytoferritin-chitosan-epigallocatechin shell-core nanoparticles by thermal treatment. Food Hydrocolloids. 2018;80:24–32. doi: 10.1016/j.foodhyd.2018.01.014
   Web of Science ®Google Scholar
• Hsieh DS, Lu HC, Chen CC, et al. The preparation and characterization of gold-conjugated polyphenol nanoparticles as a novel delivery system. Int J Nanomed. 2012;7:1623–1633.
   PubMed Web of Science ®Google Scholar
• Hsieh DS, Wang H, Tan S-W, et al. The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles. Biomaterials. 2011;32:7633–7640. doi: 10.1016/j.biomaterials.2011.06.073
   PubMed Web of Science ®Google Scholar
• Haghi A, Raussi H, Hashemzadeh H, et al. Designing a high-performance smart drug delivery system for the synergetic co-absorption of DOX and EGCG on ZIF-8. RSC Adv. 2020;10:44533–44544. doi: 10.1039/D0RA08123J
   PubMed Web of Science ®Google Scholar
• Yu J, Yang H, Li K, et al. Development of epigallocatechin-3-gallate-encapsulated nanohydroxyapatite/mesoporous silica for therapeutic management of dentin surface. ACS Appl Mater Interfaces. 2017;9:25796–25807. doi: 10.1021/acsami.7b06597
   PubMed Web of Science ®Google Scholar
• Manea AM, Vasile BS, Meghea A. Antioxidant and antimicrobial activities of green tea extract loaded into nanostructured lipid carriers. C R Chim. 2014;17:331–341. doi: 10.1016/j.crci.2013.07.015
   Web of Science ®Google Scholar
• Frias I, Neves AR, Pinheiro M, et al. Design, development and characterization of lipid nanocarriers-based epigallocatechin-gallate delivery system for preventive and therapeutic supplementation. Drug Des Devel Ther. 2016;10:3519–3528. doi: 10.2147/DDDT.S109589
   PubMed Web of Science ®Google Scholar
• Bancil AS, Sandall AM, Ross M, et al. Food additive emulsifiers and their impact on gut microbiome, permeability and inflammation: mechanistic insights in inflammatory bowel disease. J Crohn's Colitis. 2021;15(6):1068–1079. doi: 10.1093/ecco-jcc/jjaa254
   Google Scholar
• Nielsen CK, Kjems J, Mygind T, et al. Effects of TWEEN 80 on growth and biofilm formation in laboratory media. Front Microbiol. 2016;7:1878. doi: 10.3389/fmicb.2016.01878
   PubMed Web of Science ®Google Scholar
• Bhushani JA, Karthik P, Anandharamakrishnan C. Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins. Food Hydrocolloids. 2016;56:372–382. doi: 10.1016/j.foodhyd.2015.12.035
   Web of Science ®Google Scholar
• Tsai YJ, Chen BH. Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effects on prostate cancer cells PC-3. Int J Nanomedicine. 2016;11:1907–1926.
   PubMed Web of Science ®Google Scholar
• Ding J, Liang T, Min Q, et al. “Stealth and fully-laden” drug carriers: self-assembled nanogels encapsulated with epigallocatechin gallate and sirna for drug-resistant breast cancer therapy. ACS Appl Mater Interfaces. 2018;10:9938–9948. doi: 10.1021/acsami.7b19577
   PubMed Web of Science ®Google Scholar
• Piran F, Khoshkov Z, Hosseini SE, et al. Controlling the antioxidant activity of green tea extract through encapsulation in chitosan-citrate nanogel. J Food Qual. 2020;10(12). Article ID 7935420.
   Google Scholar
• Wang H, Zhang H, Gao Z, et al. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol. 2022;12:854885. doi: 10.3389/fcimb.2022.854885
   PubMed Web of Science ®Google Scholar
• Cho AS, Jeon SM, Kim MJ, et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol. 2010;48:937–943. doi: 10.1016/j.fct.2010.01.003
   PubMed Web of Science ®Google Scholar
• Niu B, Chen H, Wu W, et al. Co-encapsulation of chlorogenic acid and cinnamalaldehyde essential oil in pickering emulsion stabilized by chitosan nanoparticles. Food Chem. 2022;14:100312.
   Web of Science ®Google Scholar
• DiSanto MC, D'Antoni CC, Dominguez-Rubio AP, et al. Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications − a review. Biomed Pharmacother. 2021;142:111970. doi: 10.1016/j.biopha.2021.111970
   PubMed Web of Science ®Google Scholar
• Goncalves B, Moeenfard M, Rocha F, et al. Microencapsulation of a natural antioxidant from coffee—chlorogenic acid (3-caffeoylquinic acid). Food Bioprocess Technol. 2017;10:1521–1530. doi: 10.1007/s11947-017-1919-y
   Web of Science ®Google Scholar
• Feng Y, Sun C, Yuan Y, et al. Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. Int J Pharm. 2016;501:342–349. doi: 10.1016/j.ijpharm.2016.01.081
   PubMed Web of Science ®Google Scholar
• Csaki KF. Synthetic surfactant food additives can cause intestinal barrier dysfunction. Med Hypotheses. 2011;76:676–681. doi: 10.1016/j.mehy.2011.01.030
   PubMed Web of Science ®Google Scholar
• Halmos EP, Mack A, Gibson PK. Review article: emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49:41–50. doi: 10.1111/apt.15045
   PubMed Web of Science ®Google Scholar
• Sikalidis AK, Kelleher AH, Kristo AS. Mediterranean diet. Encyclopedia. 2021;1:371–387. doi: 10.3390/encyclopedia1020031
   Google Scholar
• Li Q, Huang Y, Du Y, et al. Food-grade olive oil pickering emulsions stabilized by starch/β-cyclodextrin complex nanoparticles: improved storage stability and regulatory effects on gut microbiota. LWT. 2022;155:112950. doi: 10.1016/j.lwt.2021.112950
   Web of Science ®Google Scholar
• Nieto G, Lorenzo JM. Use of olive oil as fat replacer in meat emulsions. Curr Opin Food Sci. 2021;40:179–186. doi: 10.1016/j.cofs.2021.04.007
   Web of Science ®Google Scholar
• Bidooki SH, Alejo T, Sánchez-Marco J, et al. Squalene loaded nanoparticles effectively protect hepatic AML12 cell lines against oxidative and endoplasmic reticulum stress in a TXNDC5-dependent way. Antioxidants. 2022;11:581. doi: 10.3390/antiox11030581
   Web of Science ®Google Scholar
• Valentino A, Conte R, De Luca I, et al. Thermo-responsive gel containing hydroxytyrosol-chitosan nanoparticles (Hyt@tgel) counteracts the increase of osteoarthritis biomarkers in human chondrocytes. Antioxidants. 2022;11:1210. doi: 10.3390/antiox11061210
   Web of Science ®Google Scholar
• Huguet-Casquero A, Moreno-Sastre M, López-Méndez TB, et al. Encapsulation of oleuropein in nanostructured lipid carriers: biocompatibility and antioxidant efficacy in lung epithelial cells. Pharmaceutics. 2020;12:429. doi: 10.3390/pharmaceutics12050429
   PubMed Web of Science ®Google Scholar
• Guo X, Huang Z, Chen J, et al. Synergistic delivery of resveratrol and ultrasmall copper-based nanoparticles by aptamer-functionalized ultrasound nanobubbles for the treatment of nonalcoholic fatty liver disease. Front Physiol. 2022;13:2022.950141.
   PubMed Web of Science ®Google Scholar
• Mastinu A, Kumar A, Maccarinelli G, et al. Zeolite clinoptilolite: therapeutic virtues of an ancient mineral. Molecules. 2019;24:1517. doi: 10.3390/molecules24081517
   PubMed Web of Science ®Google Scholar
• Kraljević Pavelić S, Micek V, Bobinac D, et al. Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Exp Biol Med (Maywood). 2021;246:529–537. doi: 10.1177/1535370220968752
   PubMed Web of Science ®Google Scholar
• Kraljević Pavelić S, Krpan D, Žuvić M, et al. Clinical parameters in osteoporosis patients supplemented with PMA-zeolite at the end of 5-year double-blinded clinical trial. Front Med. 2022;9:870962. doi: 10.3389/fmed.2022.870962
   Web of Science ®Google Scholar
• Hao J, Stavljenić Milašin I, Batu Eken Z, et al. Effects of zeolite as a drug delivery system on cancer therapy: a systematic review. Molecules. 2021;26(20):6196. doi: 10.3390/molecules26206196
   PubMed Web of Science ®Google Scholar
• Jiang B, Yang Z, Shi H, et al. Potentiation of curcumin-loaded zeolite Y nanoparticles/PCL-gelatin electrospun nanofibers for postsurgical glioblastoma treatment. J Drug Deliv Sci Technol. 2023;80:104105. doi: 10.1016/j.jddst.2022.104105
   Web of Science ®Google Scholar
• Liu J, Liu S, Wu Y, et al. Curcumin doped zeolitic imidazolate framework nanoplatforms as multifunctional nanocarriers for tumor chemo/immunotherapy. Biomater Sci. 2022;10:2384–2393. doi: 10.1039/D2BM00149G
   PubMed Web of Science ®Google Scholar
• Chen X, Tong R, Liu B, et al. Duo of (-)-epigallocatechin-3-gallate and doxorubicin loaded by polydopamine coating ZIF-8 in the regulation of autophagy for chemo-photothermal synergistic therapy. Biomater Sci. 2020;8:1380–1393. doi: 10.1039/C9BM01614G
   PubMed Web of Science ®Google Scholar
• Tamanai-Shacoori Z, Chandad F, Rébillard A, et al. Silver-zeolite combined to polyphenol-rich extracts of Ascophyllum nodosum: potential active role in prevention of periodontal diseases. PLoS One. 2014;9:e105475. doi: 10.1371/journal.pone.0105475
   PubMed Web of Science ®Google Scholar
• Yaneva Z, Ivanova D, Popov N. Clinoptilolite microparticles as carriers of catechin-rich acacia catechu extracts: microencapsulation and in vitro release study. Molecules. 2021;26:1655. doi: 10.3390/molecules26061655
   PubMed Web of Science ®Google Scholar
• Tondar M, Parsa MJ, Yousefpour Y, et al. Feasibility of clinoptilolite application as a microporous carrier for pH-controlled oral delivery of aspirin. Acta Chim Slov. 2014;61:688–693.
   PubMed Web of Science ®Google Scholar
• Kraljević Pavelić S, Micek V, Filošević A, et al. Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo. Microp Mesop Mater. 2017;249:146–156. doi: 10.1016/j.micromeso.2017.04.062
   Web of Science ®Google Scholar
• Pogorelov AG, Panait AI, Gulin AA, et al. Natural clinoptilolite nanoparticles coated with phosphatidylcholine. Dokl Biochem Biophys. 2022;505:156–159. doi: 10.1134/S160767292204007X
   PubMed Web of Science ®Google Scholar
• Kim C, Shim J, Han S, et al. The skin-permeation-enhancing effect of phosphatidylcholine: caffeine as a model active ingredient. J Cosmet Sci. 2002;53(6):363–374.
   PubMed Web of Science ®Google Scholar