Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage

References

• Qi L, Luo Q, Zhang Y, et al. Advances in toxicological research of the anticancer drug cisplatin. Chem Res Toxicol. 2019;32:1469–1486. doi:10.1021/acs.chemrestox.9b00204
   PubMed Web of Science ®Google Scholar
• Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. 2003;22:7265–7279. doi:10.1038/sj.onc.1206933
   PubMed Web of Science ®Google Scholar
• Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005;4:307–320. doi:10.1038/nrd1691
   PubMed Web of Science ®Google Scholar
• Breglio AM, Rusheen AE, Shide ED, et al. Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun. 2017;8:1654. doi:10.1038/s41467-017-01837-1
   PubMed Web of Science ®Google Scholar
• Meijer AJM, Li KH, Brooks B, et al. The cumulative incidence of cisplatin-induced hearing loss in young children is higher and develops at an early stage during therapy compared with older children based on 2052 audiological assessments. Cancer. 2022;128:169–179. doi:10.1002/cncr.33848
   PubMed Web of Science ®Google Scholar
• Fetoni AR, Ruggiero A, Lucidi D, et al. Audiological monitoring in children treated with platinum chemotherapy. Audiol Neurootol. 2016;21:203–211. doi:10.1159/000442435
   PubMed Web of Science ®Google Scholar
• Rybak LP, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Semin Hear. 2019;40:197–204. doi:10.1055/s-0039-1684048
   PubMedGoogle Scholar
• Sheth S, Mukherjea D, Rybak LP, et al. Mechanisms of cisplatin-induced ototoxicity and otoprotection. Front Cell Neurosci. 2017;11:338. doi:10.3389/fncel.2017.00338
   PubMed Web of Science ®Google Scholar
• García-Berrocal JR, Nevado J, Ramírez-Camacho R, et al. The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear. Br J Pharmacol. 2007;152:1012–1020. doi:10.1038/sj.bjp.0707405
   PubMed Web of Science ®Google Scholar
• Tan WJT, Song L. Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hear Res. 2023;434:108783. doi:10.1016/j.heares.2023.108783
   PubMed Web of Science ®Google Scholar
• Lu MC, Ji JA, Jiang ZY, et al. The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update. Med Res Rev. 2016;36:924–963. doi:10.1002/med.21396
   PubMed Web of Science ®Google Scholar
• Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89–116. doi:10.1146/annurev.pharmtox.46.120604.141046
   PubMed Web of Science ®Google Scholar
• Wu F, Hu R, Huang X, et al. CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress. Biomed Pharmacother. 2023;166:115399. doi:10.1016/j.biopha.2023.115399
   PubMed Web of Science ®Google Scholar
• Aboraya DM, El Baz A, Risha EF, et al. Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats. Saudi J Biol Sci. 2022;29:3157–3166. doi:10.1016/j.sjbs.2022.01.052
   PubMed Web of Science ®Google Scholar
• Jia Y, Guo H, Cheng X, et al. Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway. Food Funct. 2022;13:4205–4215. doi:10.1039/D2FO00298A
   PubMed Web of Science ®Google Scholar
• Chen X, Wei W, Li Y, et al. Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2019;308:269–278. doi:10.1016/j.cbi.2019.05.040
   PubMed Web of Science ®Google Scholar
• Kara M, Türkön H, Karaca T, et al. Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model. Int J Pediatr Otorhinolaryngol. 2016;85:12–18. doi:10.1016/j.ijporl.2016.03.019
   PubMed Web of Science ®Google Scholar
• He J, Yin S, Wang J, et al. Effectiveness of different approaches for establishing cisplatin-induced cochlear lesions in mice. Acta Otolaryngol. 2009;129:1359–1367. doi:10.3109/00016480902856604
   PubMed Web of Science ®Google Scholar
• He W, Wu F, Xiong H, et al. Promoting TFEB nuclear localization with curcumin analog C1 attenuates sensory hair cell injury and delays age-related hearing loss in C57BL/6 mice. Neurotoxicology. 2023;95:218–231. doi:10.1016/j.neuro.2023.02.004
   PubMed Web of Science ®Google Scholar
• Park C, Thein P, Kalinec G, et al. HEI-OC1 cells as a model for investigating prestin function. Hear Res. 2016;335:9–17. doi:10.1016/j.heares.2016.02.001
   PubMed Web of Science ®Google Scholar
• Wu F, Hill K, Fang Q, et al. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ. Cell Mol Life Sci. 2022;79:249. doi:10.1007/s00018-022-04268-4
   PubMed Web of Science ®Google Scholar
• Lai R, Fang Q, Wu F, et al. Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3 K/Akt survival signaling pathway. Front Cell Neurosci. 2023;17:1199656. doi:10.3389/fncel.2023.1199656
   PubMed Web of Science ®Google Scholar
• Fang QJ, Wu F, Chai R, et al. Cochlear surface preparation in the adult mouse. J Vis Exp. 2019;153.
   Web of Science ®Google Scholar
• Li D, Zhao H, Xu P, et al. Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs. Front Pharmacol. 2022;13:887833. doi:10.3389/fphar.2022.887833
   PubMed Web of Science ®Google Scholar
• Nan B, Zhao Z, Jiang K, et al. Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo. Acta Pharm Sin B. 2022;12:167–181. doi:10.1016/j.apsb.2021.07.002
   PubMed Web of Science ®Google Scholar
• Cao R, Zhao Y, Zhou Z, et al. Enhancement of the water solubility and antioxidant activity of hesperidin by chitooligosaccharide. J Sci Food Agric. 2018;98:2422–2427. doi:10.1002/jsfa.8734
   PubMed Web of Science ®Google Scholar
• Wang H, Lin H, Kang W, et al. miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress. BMC Pharmacol Toxicol. 2023;24:16. doi:10.1186/s40360-023-00654-1
   PubMed Web of Science ®Google Scholar
• Gu J, Wang X, Chen Y, et al. An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity. J Nanobiotechnology. 2022;20:268. doi:10.1186/s12951-022-01485-8
   PubMed Web of Science ®Google Scholar
• He Y, Zheng Z, Liu C, et al. Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1–PI3K/AKT pathway. Acta Pharm Sin B. 2022;12:1305–1321. doi:10.1016/j.apsb.2021.11.002
   PubMed Web of Science ®Google Scholar
• Fernandez K, Wafa T, Fitzgerald TS, et al. An optimized, clinically relevant mouse model of cisplatin-induced ototoxicity. Hear Res. 2019;375:66–74. doi:10.1016/j.heares.2019.02.006
   PubMed Web of Science ®Google Scholar
• Xia L, Chen Z, Yin S. Ototoxicity of cisplatin administered to guinea pigs via the round window membrane. J Toxicol Sci. 2012;37:823–830. doi:10.2131/jts.37.157
   PubMed Web of Science ®Google Scholar
• Nacher-Soler G, Lenglet S, Coelho M, et al. Local cisplatin delivery in mouse reliably models sensorineural ototoxicity without systemic adverse effects. Front Cell Neurosci. 2021;15:701783. doi:10.3389/fncel.2021.701783
   PubMed Web of Science ®Google Scholar
• Qi J, Huang W, Lu Y, et al. Stem cell-based hair cell regeneration and therapy in the inner ear. Neurosci Bull. 2023;40:113–126.
   PubMed Web of Science ®Google Scholar
• Weng B, Zhang X, Chu X, et al. Nrf2-Keap1-ARE-NQO1 signaling attenuates hyperoxia-induced lung cell injury by inhibiting apoptosis. Mol Med Rep. 2021;23.
   Web of Science ®Google Scholar
• Gentilin E, Simoni E, Candito M, et al. Cisplatin-induced ototoxicity: updates on molecular targets. Trends Mol Med. 2019;25:1123–1132. doi:10.1016/j.molmed.2019.08.002
   PubMed Web of Science ®Google Scholar
• Tang Q, Wang X, Jin H, et al. Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies. Eur J Pharm Biopharm. 2021;163:60–71. doi:10.1016/j.ejpb.2021.03.008
   PubMed Web of Science ®Google Scholar
• Gao Y, Wu F, He W, et al. Reactive oxygen species-related disruptions to cochlear hair cell and stria vascularis consequently leading to radiation-induced sensorineural hearing loss. Antioxid Redox Signal. 2024;40:470–491. doi:10.1089/ars.2022.0161
   PubMed Web of Science ®Google Scholar
• Wu F, Xiong H, Sha S. Noise-induced loss of sensory hair cells is mediated by ROS/AMPKα pathway. Redox Biol. 2020;29:101406. doi:10.1016/j.redox.2019.101406
   PubMed Web of Science ®Google Scholar
• Kim YR, Baek JI, Kim SH, et al. Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Redox Biol. 2019;20:544–555. doi:10.1016/j.redox.2018.11.013
   PubMed Web of Science ®Google Scholar
• Fujimoto C, Yamasoba T. Mitochondria-targeted antioxidants for treatment of hearing loss: a systematic review. Antioxidants (Basel). 2019;8:109.
   PubMedGoogle Scholar
• Marullo R, Werner E, Degtyareva N, et al. Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS One. 2013;8:e81162. doi:10.1371/journal.pone.0081162
   PubMed Web of Science ®Google Scholar
• He G, He G, Zhou R, et al. Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo. Biochem Biophys Res Commun. 2016;469:1075–1082. doi:10.1016/j.bbrc.2015.12.100
   PubMed Web of Science ®Google Scholar
• Omar HA, Mohamed WR, Arafa el SA, et al. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacol Rep. 2016;68:349–356. doi:10.1016/j.pharep.2015.09.007
   PubMed Web of Science ®Google Scholar
• Saleh N, Allam T, Korany RMS, et al. Protective and therapeutic efficacy of hesperidin versus cisplatin against Ehrlich ascites carcinoma-induced renal damage in mice. Pharmaceuticals. 2022;15. doi:10.3390/ph15030294
   Web of Science ®Google Scholar
• Kong W, Ling X, Chen Y, et al. Hesperetin reverses P-glycoprotein-mediated cisplatin resistance in DDP-resistant human lung cancer cells via modulation of the nuclear factor-κB signaling pathway. Int J Mol Med. 2020;45:1213–1224.
   PubMed Web of Science ®Google Scholar