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Research Article

Amino acids 67 and 68 of transforming growth factor-β regulate binding to a glycosyl phosphatidyl inositol-linked membrane protein on vascular endothelial cells

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Pages 25-30 | Published online: 26 Sep 2009

  • Moses HL, Yang EY, Pietenpol JA, TGF-ß stimulation and inhibition of cell proliferation: new mechanistic insights. Cell (1990) 63: 245-7.
  • Roberts AB, Sporn MB, Physiological actions and clinical applications of transforming growth factor-ß (TGF-ß). Growth Factors (1993) 8: 1-9.
  • Massagué J, The transforming growth factor-ß family. Annu Rev Cell Biol (1990) 6: 597-641.
  • Isaka Y, Bret-s DK, Ikegaya K et al, Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med (1996) 2: 418-23.
  • Khalil N, Greenberg AH, The role of TGF-ß in pulmonary fibrosis. Ciba Found Symp (1991) 157: 194-207.
  • Peltonen J, Hsiao LL. Jaakkola S et al, Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-ß 1 mRNA. J Invest Dermatol (1991) 97: 240-8.
  • Reck LS, Chen TL, Hirabayashi SE et al, Accelerated healing of ulcer wounds in the rabbit ear by recombinant human transforming growth factor-ß1, Growth Factors (1990) 2: 273-82.
  • Sonis ST, Lindquist L, Van Vugt A et al, Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor ß3, Cancer Res (1994) 54: 1135-8.
  • Kuruvilla AP, Shah R, Hochwald GM et al. Protective effect of transforming growth factor ßl on experimental autoimmune diseases in mice. Proc Natl Acad Sd USA (1991) 88: 2918-21.
  • Massagué J, TGF-beta signal transduction. Annu Rev Biochem (1998) 57: 753-91.
  • McAllister KA, Baldwin MA, Thukkani AK et al, Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function. Hum Mol Genet (1995) 4: 1983-4.
  • Hahn SA, Hoque ATMS, Moskaluk CA et al, Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res (1996) 56: 490-4.
  • Markowitz S, Wang J, Myeroff L et al, Inactivation of the type II TGF-ß receptor in colon cancer cells with microsatellite instability. Science (1995) 268: 1336-8.
  • Thiagalingam S, Lengauer C, Leach FS et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet (1996) 13: 343-6.
  • MacGrogan D, Pegram M, Slamon D, Bookstein R, Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas. Oncogene (1997) 15: 1111-14.
  • Massagué J, Blain SW, Lo RS, TGF-ß signaling in growth control, cancer, and heritable disorders. Cell (2000) 103: 295-309.
  • Roberts AB, Sporn MB, The transforming growth factor-ßs. In: Peptide Growth Factors and Their Receptors, (ed MB Sporn, AB Roberts) Springer, Berlin, 1990 Vol. 1, 419-72.
  • Suardet L, Gaide AC, Calmes JM et al, Responsiveness of three newly established human colorectal cancer cell lines to transforming growth factors ßl and ß2. Cancer Res (1992) 52: 3705-12.
  • Cheifetz S, Weatherbee JA, Tsang MLS et al, The transforming growth factor-ß system, a complex pattern of cross-reactive ligands and receptors. Cell (1987) 48: 409-15.
  • Cheifetz S, Bellón T, Calés C et al, Endoglin is a component of the transforming growth factor-ß receptor system in human endothelial cells. J Biol Chem (1992) 267: 19027-30.
  • Cheifetz S, Massagué J, Isoform-specific transforming growth factor-ß binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C. J Biol Chem (1991) 266: 20767-72.
  • Morello JP, Plamondon J, Meyrick B et al, Transforming growth factor-ß receptor expression on endothelial cells: heterogeneity of type III receptor expression. J Cell Physiol (1995) 165: 201-11.
  • Dumont N, O'Connor-McCourt MD, Philip A, Transforming growth factor-ß receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosylphosphatidylinositol anchored TGF-ß binding proteins. Mol Cell Endecrinol (1995) 111: 57-66.
  • O'Connor-McCourt MD, Wakefield LM, Latent transforming growth factor beta in serum. A specific complex with a-2-macroglobulin. J Biol Chem (1987) 262: 14090-9.
  • Crookston KP, Webb DJ, Wolf BB, Gonias SL, Classification of a-2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J Biol Chem (1994) 269: 1533-40.
  • Daopin S, Piez KA, Ogawa Y, Davies DR, Crystal structure of transforming growth factor-ß2: an unusual fold for the superfamily. Science (1992) 257: 369-73.
  • Schlunegger MP, Grutter MG, An unusual feature revealed by the crystal structure at 2.2A resolution of human transforming growth factor-ß2. Nature (1992) 358: 430-4.
  • Archer SJ, Bax A, Roberts AB et al. Transforming growth factor ßl: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells. Biochemistry (1993) 32: 1152-63.
  • Hinck AP, Archer SJ, Qian SW et al, Transforming growth factor ßl: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor ß2. Biochemistry (1996) 35: 8517-34.
  • Burmester JK, Qian SW, Ohlsen D et al, Mutational analysis of a transforming growth factor-ß receptor binding site. Growth Factors (1998) 15: 231-42.
  • Qian SW, Burmester JK, Tsang MLS et al, Affinity of transforming growth factor-ß to the type II receptor is determined by the C-terminal region of the molecule. J Bial Chem (1996) 271: 30656-62.
  • Qian SW, Dumont N, O'Connor-McCourt MD et al, Distinct functional domains of TGF-beta bind receptors on endothelial cells. Growth Factors (1999) 17: 63-73.
  • Burmester JK, Qian SW, Roberts AB et al, Characterization of distinct functional domains of transforming growth factor-ß. Proc Natl Acad Sci USA (1993) 90: 8628-32.
  • Webb DJ, Atkins TL, Crookston KP et al, Transforming growth factor-ß isoform 2-specific high affinity binding to native a2-macroglobulin. Chimeras identify a sequence that determines affinity for native but not activated 2-macroglobulin. J Biol Chem (1994) 269: 30402-6.
  • Danielpour D, Dart LL, Flanders KC et al, Immunodctection and quantitation of the two forms of transforming growth factor-beta (TGF-ß1 and TGF-ß2) secreted by cells in culture. J Cell Physiol (1989) 138: 79-86.
  • Higuchi R, Krummel B, Saiki RK, A general method of in vitro preparation and specific mutagcnesis of DNA fragments: study of protein and DNA interactions. Nucl Acids Res (1988) 16: 7351-67.
  • Qian SW, Burmester JK, Merwin JR et al, Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor-ß on endothelial cells. Proc Natl Acad Sci USA (1992) 89: 6290-4.
  • Lee SJ, Nathans D, Proliferin secreted by cultured cells binds to manuose 6-phosphate receptors. J Biol Chem (1988) 263: 3521-7.
  • Frolik CA, Wakefield LM, Smith DM, Sporn MB, Characterization of a membrane receptor for transforming growth factor-ß in normal rat kidney fibroblasts. J Biol Chem (1984) 259: 10995-1000.
  • Massagué J, Like B, Cellular receptors for type ß transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines. J Biol Chem (1985) 260: 2636-45.
  • Geiser AG, Burmester JK, Webbink R et al, Inhibition of growth by transforming growth factor-ß following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses. 3 Biol Chem (1992) 267: 2588-93.
  • Tam BYY, Philip A, Transforming growth factor-ß receptor expression on human skin fibroblasts: dimeric complex formation of type I and type II receptors and identification of glycosyl phospbatidylinositol-anchored transforming growth faclor-ß binding proteins. } Cell Physiol (1998) 176: 553-64.
  • Qian SW, Burmester JK, Sun PD et al, Characterization of mutated transforming growth factor-ßs which possess unique biological properties. Biochemistry (1994) 33: 12298-304.
  • Huang SS, Liu Q, Johnson FE et al, Transforming growth factor ß peptide antagonists and their conversion to partial agonists. J Biol Chem (1997) 272: 27155-9.
  • Postlethwaite AE, Seyer JM, Identification of a chemotactic epitope in human transforming growth factor-ßl spanning amino acid residues 358-374. J Cell Physiol (1995) 164: 587-92.
  • Stefanova I, Corcoran ML, Horak EM et al, Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/S6lyn. 3 Biol Chem (1993) 208: 20725-8.
  • Lisant MP, Scherer PE, Vidugiriene J et al, Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J Cell Biol (1994) 126: 111-26.
  • Lopez-Casillas F, Wrana JL, Massagué J, Betaglycans presents ligand to the TGF-ß signaling receptor. Cell (1993) 73: 1435-44.
  • Hoodless PA, Wrana JL, Mechanism and function of signaling by the TGF-ß superfamily. Curr Topics Microbiol Immunol (1998) 228: 235-66.
  • Massagué J, Weis-Garcia F, Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv (1996) 27: 41-64.
  • Yamashita H, ten Dijke P, Franzen P et al, Formation of heterooligomeric complexes of type I and type II receptors for transforming growth factor-ß. J Biol Chem (1994) 269: 20171-8.
  • Feng XH, Filvaroff EH, Derynck R, Transforming growth factor-ß (TGF-ß)-induced down-regiuation of cyclin A expression requires a functional TGF-ß receptor complex. J Biol Chem (1995) 270: 24237-45.
  • Tedgui A, Mallat Z, Anti-inflammatory mechanisms in the vascular wall. Circ Res (2001) 88: 877-87.
  • McAllister KA, Grogg KM, Johnson DW et al, Endoglin, a TGF-ß binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet (1994) 8: 345-51.

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