Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease

References

• Fang EF, Xie C, Schenkel JA, et al. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev. 2020;64:101174. doi: 10.1016/J.ARR.2020.101174
   PubMed Web of Science ®Google Scholar
• Hou Y, Dan X, Babbar M, et al. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 2019;15:565–581. doi: 10.1038/S41582-019-0244-7
   PubMed Web of Science ®Google Scholar
• Mintun MA, Lo AC, Evans CD, Wessels AM, Ardayfio PA, Andersen SW, et al. Donanemab in early Alzheimer’s disease. New England Journal of Medicine 2021;384:1691–704. doi: 10.1056/NEJMOA2100708
   Google Scholar
• van Dyck C, Swanson C, Aisen P, et al. Lecanemab in early alzheimer’s disease. N Engl J Med. 2023;388(1):9–21. doi: 10.1056/NEJMC2301380
   PubMed Web of Science ®Google Scholar
• Lautrup S, Sinclair DA, Mattson MP, et al. NAD+ in brain aging and neurodegenerative disorders. Cell Metab. 2019;30:630. doi: 10.1016/J.CMET.2019.09.001
   PubMed Web of Science ®Google Scholar
• Aman Y, Schmauck-Medina T, Hansen M, et al. Autophagy in healthy aging and disease. Nat Aging. 2021;1:634–650. doi: 10.1038/S43587-021-00098-4
   PubMedGoogle Scholar
• Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell. 2011;146:682–695. doi: 10.1016/J.CELL.2011.07.030
   PubMed Web of Science ®Google Scholar
• Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61:654–666. doi: 10.1016/J.MOLCEL.2016.01.028
   PubMed Web of Science ®Google Scholar
• Palikaras K, Lionaki E, Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol. 2018;20:1013–1022. doi: 10.1038/S41556-018-0176-2
   PubMed Web of Science ®Google Scholar
• Lou G, Palikaras K, Lautrup S, et al. Mitophagy and neuroprotection. Trends Mol Med. 2020;26:8–20. doi: 10.1016/J.MOLMED.2019.07.002
   PubMed Web of Science ®Google Scholar
• Xie C, Zhuang XX, Niu Z, et al. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nat Biomed Eng. 2022;6:76. doi: 10.1038/S41551-021-00819-5
   PubMed Web of Science ®Google Scholar
• Fang EF, Hou Y, Palikaras K, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat neurosci. 2019;22(3):401–412. doi: 10.1038/s41593-018-0332-9
   PubMed Web of Science ®Google Scholar
• Kerr JS, Adriaanse BA, Greig NH, et al. Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms. Trends Neurosci. 2017;40:151. doi: 10.1016/J.TINS.2017.01.002
   PubMed Web of Science ®Google Scholar
• Menzies FM, Fleming A, Caricasole A, et al. Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities. Neuron. 2017;93(5):1015–1034. doi: 10.1016/J.NEURON.2017.01.022/ATTACHMENT/9A584587-3E18-4AF0-B0AF-D037F4A3B294/MMC1.PDF
   PubMed Web of Science ®Google Scholar
• Caponio D, Veverová K, Zhang S, et al. Compromised autophagy and mitophagy in brain ageing and Alzheimer’s diseases. Aging Brain. 2022;2:100056. doi: 10.1016/J.NBAS.2022.100056
   PubMedGoogle Scholar
• Du F, Yu Q, Yan S, et al. PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease. Brain. 2017;140:3233. doi: 10.1093/BRAIN/AWX258
   PubMed Web of Science ®Google Scholar
• Shi L, Baird AL, Westwood S, et al. A decade of blood biomarkers for alzheimer’s disease research: An evolving field, improving study designs, and the Challenge of Replication. J Alzheimers Dis. 2018;62(3):1181–1198. doi: 10.3233/JAD-170531
   PubMed Web of Science ®Google Scholar
• Nixon RA, Wegiel J, Kumar A, et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol. 2005;64:113–122. doi: 10.1093/JNEN/64.2.113
   PubMed Web of Science ®Google Scholar
• Yu WH, Cuervo AM, Kumar A, et al. Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer’s disease. The Journal Of Cell Biology. 2005;171(1):87. doi: 10.1083/JCB.200505082
   PubMedGoogle Scholar
• Martín-Maestro P, Gargini R, Perry G, et al. PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer’s disease. Hum Mol Genet. 2016;25(4):792. doi: 10.1093/HMG/DDV616
   PubMed Web of Science ®Google Scholar
• Ye X, Sun X, Starovoytov V, et al. Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer’s disease patient brains. Human Molecular Genetics. 2015;24(10):2938. doi: 10.1093/HMG/DDV056
   PubMed Web of Science ®Google Scholar
• Hou X, Watzlawik JO, Cook C, et al. Mitophagy alterations in Alzheimer’s disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer’s & Dementia. 2021;17(3):417. doi: 10.1002/ALZ.12198
   Web of Science ®Google Scholar
• Sohn HY, Kim SI, Park JY, et al. ApoE4 attenuates autophagy via FoxO3a repression in the brain. Sci Rep. 2021;11(1):1–10. doi: 10.1038/s41598-021-97117-6
   PubMed Web of Science ®Google Scholar
• Vaillant-Beuchot L, Mary A, Pardossi-Piquard R, et al. Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains. Acta Neuropathol. 2021;141:39–65. doi: 10.1007/S00401-020-02234-7
   PubMed Web of Science ®Google Scholar
• Bordi M, Berg MJ, Mohan PS, et al. Autophagy flux in CA1 neurons of Alzheimer hippocampus: increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 2016;12:2467. doi: 10.1080/15548627.2016.1239003
   PubMed Web of Science ®Google Scholar
• Qian S, He H, Xiong X, et al. Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson’s disease. CNS Neurosci Ther. 2023. doi: 10.1111/CNS.14532
   Web of Science ®Google Scholar
• Cossu D, Yokoyama K, Sechi LA, et al. Potential of PINK1 and PARKIN proteins as biomarkers for active multiple sclerosis: a Japanese cohort study. Front Immunol. 2021;12. doi: 10.3389/FIMMU.2021.681386
   Google Scholar
• Armstrong A, Mattsson N, Appelqvist H, et al. Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer’s disease. NeuroMol Med. 2014;16(1):150–160. doi: 10.1007/S12017-013-8269-3
   PubMed Web of Science ®Google Scholar
• Sjödin S, Brinkmalm G, Öhrfelt A, et al. Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease. Alzheimers Res Ther. 2019;11(1):11. doi: 10.1186/S13195-019-0533-9
   PubMed Web of Science ®Google Scholar
• Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med. 2006;27:495–502. doi: 10.1016/j.mam.2006.08.005
   PubMedGoogle Scholar
• Menzies FM, Moreau K, Puri C, et al. Measurement of autophagic activity in mammalian cells. Curr Protoc Cell Biol. 2012;54:.15.16.1–.15.16.25. doi: 10.1002/0471143030.CB1516S54
   Google Scholar
• Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021;17:1–382. DOI:10.1080/15548627.2020.1797280
   Google Scholar
• Sardiello M, Palmieri M, Di RA, et al. A gene network regulating lysosomal biogenesis and function. Science. 2009;325:473–477. doi: 10.1126/SCIENCE.1174447
   PubMed Web of Science ®Google Scholar
• Tiribuzi R, Crispoltoni L, Porcellati S, et al. miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer’s disease. Neurobiology Of Aging. 2014;35(2):345–356. doi: 10.1016/J.NEUROBIOLAGING.2013.08.003
   PubMed Web of Science ®Google Scholar
• Wang H, Wang R, Xu S, et al. Transcription factor eb is selectively reduced in the nuclear fractions of alzheimer’s and amyotrophic lateral sclerosis brains. Neurosci J. 2016;2016:1–8. doi: 10.1155/2016/4732837
   Google Scholar
• Martín-Maestro P, Sproul A, Martinez H, et al. Autophagy induction by Bexarotene promotes mitophagy in Presenilin 1 familial Alzheimer’s disease iPSC-derived neural stem cells. Mol Neurobiol. 2019;56:8220. doi: 10.1007/S12035-019-01665-Y
   PubMed Web of Science ®Google Scholar
• Sass F, Schlein C, Jaeckstein MY, et al. TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality. Mol Metab. 2021;47:101173. doi: 10.1016/J.MOLMET.2021.101173
   PubMed Web of Science ®Google Scholar
• Song JX, Malampati S, Zeng Y, et al. A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer’s disease models. Aging Cell. 2020 19;19(2). doi: 10.1111/ACEL.13069
   Web of Science ®Google Scholar
• Xiao Q, Yan P, Ma X, et al. Neuronal-targeted TFEB accelerates lysosomal degradation of app, reducing Aβ generation and amyloid plaque pathogenesis. J Neurosci. 2015;35:12137. doi: 10.1523/JNEUROSCI.0705-15.2015
   PubMed Web of Science ®Google Scholar
• Zhang YD, Zhao JJ. TFEB Participates in the Aβ-induced pathogenesis of alzheimer’s disease by regulating the autophagy-lysosome pathway. DNA Cell Biol. 2015;34(11):661–668. doi: 10.1089/DNA.2014.2738
   PubMed Web of Science ®Google Scholar
• Jack CR, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. The Lancet Neurology. 2013;12(2):207–216. doi: 10.1016/S1474-4422(12)70291-0
   PubMed Web of Science ®Google Scholar
• Glatigny M, Moriceau S, Rivagorda M, et al. Autophagy is required for memory formation and reverses age-related memory decline. Curr Biol. 2019;29(3):435–448.e8. doi: 10.1016/J.CUB.2018.12.021
   PubMed Web of Science ®Google Scholar
• McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the national institute on aging-alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia. 2011;7(3):263. doi: 10.1016/J.JALZ.2011.03.005
   PubMed Web of Science ®Google Scholar
• Gobom J, Parnetti L, Rosa-Neto P, et al. Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid. Clin Chem Lab Med. 2022;60(2):207–219. doi: 10.1515/CCLM-2021-0651/MACHINEREADABLECITATION/RIS
   PubMed Web of Science ®Google Scholar
• Scheltens P, Kuiper M, Ch Wolters E, et al. Atrophy of medial temporal lobes on MRI in probable Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. Journal of Neurology, Neurosurgery & Psychiatry. 1992;55(10):967–972. doi: 10.1136/JNNP.55.10.967
   PubMed Web of Science ®Google Scholar
• Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the national institute on aging-alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia. 2011;7(3):270. doi: 10.1016/J.JALZ.2011.03.008
   PubMed Web of Science ®Google Scholar
• Jessen F, Amariglio RE, Van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia. 2014;10(6):844. doi: 10.1016/J.JALZ.2014.01.001
   PubMed Web of Science ®Google Scholar
• Jack CR, Bennett DA, Blennow K, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia. 2018;14(4):535. doi: 10.1016/J.JALZ.2018.02.018
   PubMed Web of Science ®Google Scholar
• Štěpánková H, Nikolai T, Lukavský J, et al. Mini-mental state examination—Czech normative study. Ceska a Slovenska Neurologie a Neurochirurgie. 2015;78(3):292–299. doi: 10.14735/amcsnn201557
   Google Scholar
• Bezdicek O, Motak L, Axelrod BN, et al. Czech version of the trail making test: normative data and clinical utility. Arch Clin Neuropsychol. 2012;27:906–914. doi: 10.1093/ARCLIN/ACS084
   PubMed Web of Science ®Google Scholar
• Nikolai T, Stepankova H, Kopecek M, et al. The uniform data set, czech version: normative data in older adults from an international perspective. J Alzheimers Dis. 2018;61(3):1233. doi: 10.3233/JAD-170595
   PubMed Web of Science ®Google Scholar
• Bezdicek O, Rosická AM, Mana J, et al. The 30-item and 15-item boston naming test czech version: item response analysis and normative values for healthy older adults. J Clin Exp Neuropsychol. 2022;43(9):890–905. doi: 10.1080/13803395.2022.2029360
   Web of Science ®Google Scholar
• Nikolai T, Štěpánková H, Michalec J, et al. Verbal fluency tests—Czech normative study for older persons. Ceska a Slovenska Neurologie a Neurochirurgie. 2015;78(3):292–299. doi: 10.14735/amcsnn2015292
   Web of Science ®Google Scholar
• Mazancova AF, Nikolai T, Stepankova H, et al. The reliability of clock drawing test scoring systems modeled on the normative data in healthy aging and nonamnestic mild cognitive impairment. Assessment. 2017;24:945–957. doi: 10.1177/1073191116632586
   PubMed Web of Science ®Google Scholar
• Sheikh JI, Yesavage JA. Geriatric depression scale (gds): recent evidence and development of a shorter version. Clin Gerontologist. 1986;5(1–2):165–173. doi: 10.1300/J018V05N01_09
   Google Scholar
• Beck AT, Epstein N, Brown G, et al. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56:893–897. doi: 10.1037/0022-006X.56.6.893
   PubMed Web of Science ®Google Scholar
• Amlerova J, Laczó J, Nedelska Z, et al. Emotional prosody recognition is impaired in Alzheimer’s disease. Alzheimers Res Ther. 2022;14(1):14. doi: 10.1186/S13195-022-00989-7
   PubMed Web of Science ®Google Scholar
• Fischl B, Van Der Kouwe A, Destrieux C, Halgren E, Ségonne F, Salat DH, et al. Automatically parcellating the human cerebral cortex. Cerebral Cortex. 2004;14:11–22. doi: 10.1093/CERCOR/BHG087
   PubMed Web of Science ®Google Scholar
• Fischl B, Salat DH, Busa E, et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33:341–355. doi: 10.1016/S0896-6273(02)00569-X
   PubMed Web of Science ®Google Scholar
• Voevodskaya O, Simmons A, Nordenskjöld R, et al. The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer’s disease. Front Aging Neurosci. 2014;6:264. doi: 10.3389/FNAGI.2014.00264/BIBTEX
   PubMed Web of Science ®Google Scholar
• Schwarz CG, Gunter JL, Wiste HJ, et al. A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer’s disease severity. NeuroImage Clin. 2016;11:802. doi: 10.1016/J.NICL.2016.05.017
   PubMed Web of Science ®Google Scholar
• RStudio Team. Rstudio: integrated Development for R 2020.
   Google Scholar