What are the true benefits of robotic pancreaticoduodenectomy for patients with pancreatic cancer?

References

• National Institutes of Health. Cancer stat facts: pancreatic cancer. [Internet]. [cited 2023 Oct 20]. Available from: https://seer.cancer.gov/statfacts/html/pancreas.html
   Google Scholar
• Baker EH, Ross SW, Seshadri R, et al. Robotic pancreaticoduodenectomy for pancreatic adenocarcinoma: role in 2014 and beyond. J Gastrointest Oncol. 2015;6(4):396–405. doi: 10.3978/j.issn.2078-6891.2015.027
   PubMed Web of Science ®Google Scholar
• Russell TB, Labib PLZ, Aroori S. Five-year follow-up after pancreatoduodenectomy performed for malignancy: a single-centre study. Ann Hepato-Biliary-Pancreatic Surg. 2023;27(1):76–86. doi: 10.14701/ahbps.22-039
   PubMedGoogle Scholar
• Witt RG, Hirata Y, Prakash L. Comparative analysis of opioid use between robotic and open pancreatoduodenectomy. Hepatobiliary Pancreat Sci. 2023;30(4):523–531. doi: 10.1002/jhbp.1216
   PubMed Web of Science ®Google Scholar
• Cawich SO, Kluger MD, Francis W, et al. Review of minimally invasive pancreas surgery and opinion on its incorporation into low volume and resource poor centres. World J Gastrointest Surg. 2021;13(10):1122–1135. doi: 10.4240/wjgs.v13.i10.1122
   PubMed Web of Science ®Google Scholar
• Kendrick ML, Cusati D. Total laparoscopic pancreaticoduodenectomy: feasibility and outcome on early experience. Arch Surg. 2009;145(1):19–23. doi: 10.1001/archsurg.2009.243
   Google Scholar
• Wang M, Meng L, Cai Y, et al. Learning curve for Laparoscopic Pancreaticoduodenectomy: a CUSUM analysis. J Gastrointest Surg. 2016;20(5):924–935. doi: 10.1007/s11605-016-3105-3
   PubMed Web of Science ®Google Scholar
• Moekotte AL, Rawashdeh A, Asbun HJ, et al. Safe implementation of minimally invasive pancreas resection: a systematic review. HPB. 2020;22(5):637–648. doi: 10.1016/j.hpb.2019.11.005
   PubMed Web of Science ®Google Scholar
• van Oosten AF, Ding D, Habib JR, et al. Perioperative outcomes of Robotic Pancreaticoduodenectomy: a propensity-matched analysis to open and Laparoscopic Pancreaticoduodenectomy. J Gastrointest Surg. 2021;25(7):1795–1804. doi: 10.1007/s11605-020-04869-z
   PubMed Web of Science ®Google Scholar
• Ouyang L, Zhang J, Feng Q, et al. Robotic versus Laparoscopic Pancreaticoduodenectomy: an up-to-date system review and meta-analysis. Front Oncol. 2022;12:1–10. doi: 10.3389/fonc.2022.834382
   Web of Science ®Google Scholar
• Melvin WS, Needleman BJ, Krause KR, et al. Robotic resection of pancreatic neuroendocrine tumor. J Laparoendosc Adv Surg Tech - Part A. 2003;13(1):33–36. doi: 10.1089/109264203321235449
   PubMed Web of Science ®Google Scholar
• Boggi U, Signori S, De Lio N, et al. Feasibility of robotic pancreaticoduodenectomy. Br J Surg. 2013;100(7):917–925. doi: 10.1002/bjs.9135
   PubMed Web of Science ®Google Scholar
• Zeh HJ, Bartlett DL, Moser AJ. Robotic-assisted major pancreatic resection. Adv Surg. 2011;45(1):323–340. doi: 10.1016/j.yasu.2011.04.001
   PubMedGoogle Scholar
• Strijker M, Van Santvoort HC, Besselink MG, et al. Robot-assisted pancreatic surgery: a systematic review of the literature. HPB. 2013;15(1):1–10. doi: 10.1111/j.1477-2574.2012.00589.x
   PubMed Web of Science ®Google Scholar
• Chan OCY, Tang CN, Lai ECH, et al. Robotic hepatobiliary and pancreatic surgery: a cohort study. J Hepatobiliary Pancreat Sci. 2011;18:471–480. doi: 10.1007/s00534-011-0389-2
   PubMed Web of Science ®Google Scholar
• Kauffmann EF, Napoli N, Ginesini M, et al. Tips and tricks for robotic pancreatoduodenectomy with superior mesenteric/portal vein resection and reconstruction. Surg Endosc. 2023;37(4):3233–3245. doi: 10.1007/s00464-022-09860-0
   PubMed Web of Science ®Google Scholar
• Shi Y, Jin J, Qiu W, et al. Short-term outcomes after robot-assisted vs open pancreaticoduodenectomy after the learning curve. JAMA Surg. 2020;155(5):389–394. doi: 10.1001/jamasurg.2020.0021
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhao Z, Zhang X, et al. Perioperative and oncological outcomes of robotic versus open pancreaticoduodenectomy in low-risk surgical candidates: a multicenter propensity score-matched study. Ann Surg. 2023;277(4):E864–E871. doi: 10.1097/SLA.0000000000005160
   PubMed Web of Science ®Google Scholar
• Song Y, Li Z, Cui H, et al. Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades. World J Surg Oncol. 2023;21(1):1–13. doi: 10.1186/s12957-023-03145-z
   PubMed Web of Science ®Google Scholar
• Kalabin A, Mani VR, Kruse RL. New perspectives on robotic pancreaticoduodenectomy: an analysis of the national cancer database. World J Gastrointest Endosc. 2023;15(1):60–71. doi: 10.4240/wjgs.v15.i1.60
   Google Scholar
• Zureikat AH, Postlewait LM, Liu Y, et al. A multi-institutional comparison of perioperative outcomes of robotic and open pancreaticoduodenectomy. Ann Surg. 2016;264(4):640–649. doi: 10.1097/SLA.0000000000001869
   PubMed Web of Science ®Google Scholar
• Wang SE, Shyr BU, Chen SC, et al. Comparison between robotic and open pancreaticoduodenectomy with modified blumgart pancreaticojejunostomy: a propensity score–matched study. Surg (United States). 2018;164(6):1162–1167. doi: 10.1016/j.surg.2018.06.031
   Google Scholar
• Fu Y, Qiu J, Yu Y, et al. Meta-analysis of robotic versus open pancreaticoduodenectomy in all patients and pancreatic cancer patients. Front Surg. 2022;9:1–11. doi: 10.3389/fsurg.2022.989065
   Google Scholar
• De GN, Zwart MJW, Van HJ, et al. Early experience with robotic pancreatoduodenectomy versus open pancreatoduodenectomy: nationwide propensity-score-matched analysis. Br J Surg. 2024;111(2):1–10. doi: 10.1093/bjs/znae043
   Web of Science ®Google Scholar
• Peng L, Lin S, Li Y, et al. Systematic review and meta-analysis of robotic versus open pancreaticoduodenectomy. Surg Endosc. 2017;31(8):3085–3097. doi: 10.1007/s00464-016-5371-2
   PubMed Web of Science ®Google Scholar
• Mulchandani J, Shetty N, Kulkarni A, et al. Short-term and pathologic outcomes of robotic versus open pancreatoduodenectomy for periampullary and pancreatic head malignancy: an early experience. J Robot Surg. 2022;16(4):859–866. doi: 10.1007/s11701-021-01309-1
   PubMed Web of Science ®Google Scholar
• Klotz R, Dörr-Harim C, Bruckner T, et al. Evaluation of robotic versus open partial pancreatoduodenectomy—study protocol for a randomised controlled pilot trial (EUROPA, DRKS00020407). Trials. 2021;22(1):1–10. doi: 10.1186/s13063-020-04933-8
   PubMedGoogle Scholar
• Klotz R, Mihaljevic AL, Kulu Y, et al. Robotic versus open partial pancreatoduodenectomy (EUROPA): a randomised controlled stage 2b trial. Lancet Reg Heal - Eur. 2024;39:100864. doi: 10.1016/j.lanepe.2024.100864
   PubMedGoogle Scholar
• Bergström M, Azadani A, Falk P, et al. Stress response and well-being after open, laparoscopic, and NOTES transgastric uterine horn resection in a randomized porcine model. Surg Endosc. 2014;28(8):2421–2427. doi: 10.1007/s00464-014-3491-0
   PubMed Web of Science ®Google Scholar
• Veenhof AAFA, Vlug MS, Van Der Pas MHGM, et al. Surgical stress response and postoperative immune function after laparoscopy or open surgery with fast track or standard perioperative care: a randomized trial. Ann Surg. 2012;255(2):216–221. doi: 10.1097/SLA.0b013e31824336e2
   PubMed Web of Science ®Google Scholar
• Karanika S, Karantanos T, Theodoropoulos GE. Immune response after laparoscopic colectomy for cancer: a review. Gastroenterol Rep. 2013;1(2):85–94. doi: 10.1093/gastro/got014
   Google Scholar
• Shyr BU, Shyr BS, Chen SC, et al. Robotic and open pancreaticoduodenectomy: results from taipei veterans general hospital in Taiwan. Updates Surg. 2021;73(3):939–946. doi: 10.1007/s13304-020-00899-z
   PubMed Web of Science ®Google Scholar
• Rashid OM, Mullinax JE, Pimiento JM, et al. Robotic whipple procedure for pancreatic cancer: the moffitt cancer center pathway. Cancer Cont. 2015;22(3):340–351. doi: 10.1177/107327481502200313
   PubMed Web of Science ®Google Scholar
• Vining CC, Kuchta K, Schuitevoerder D, et al. Risk factors for complications in patients undergoing pancreaticoduodenectomy: a NSQIP analysis with propensity score matching. J Surg Oncol. 2020;122(2):183–194. doi: 10.1002/jso.25942
   PubMed Web of Science ®Google Scholar
• Fong ZV, Lwin TM, Aliaj A. Four-day Robotic Whipple: early discharge after Robotic Pancreatoduodenectomy. J Am Coll Oof Surg. 2023;236(6):1172–1179. doi: 10.1097/XCS.0000000000000560
   PubMed Web of Science ®Google Scholar
• Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the international study group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surg (United States). 2017;161:584–591.
   Google Scholar
• Cai J, Ramanathan R, Zenati MS, et al. Robotic pancreaticoduodenectomy is associated with decreased clinically relevant pancreatic fistulas: a propensity-matched analysis. J Gastrointest Surg. 2020;24(5):1111–1118. doi: 10.1007/s11605-019-04274-1
   PubMed Web of Science ®Google Scholar
• Meyyappan T, Wilson GC, Zeh HJ. Robotic approach mitigates the effect of major complicatioons on survival after pancreaticoduodenectomy for periampullary cancer. Surg Endosc. 2023;37(2):1181–1187. doi: 10.1007/s00464-022-09638-4
   PubMed Web of Science ®Google Scholar
• Nickel F, Wise P, Muller PC, et al. Short-term outcomes of robotic versus open pancreatoduodenectomy - propensity score-matched analysis. Ann Surg. 2023; Epub ahead. 279(4):665–670. doi: 10.1097/SLA.0000000000005981
   PubMedGoogle Scholar
• Aiolfi A, Lombardo F, Bonitta G, et al. Systematic review and updated network meta-analysis comparing open, laparoscopic, and robotic pancreaticoduodenectomy. Updates Surg. 2021;73(3):909–922. doi: 10.1007/s13304-020-00916-1
   PubMed Web of Science ®Google Scholar
• Zhang W, Huang Z, Zhang J, et al. Safety and efficacy of robot-assisted versus open pancreaticoduodenectomy: a meta-analysis of multiple worldwide centers. Updates Surg. 2021;73(3):893–907. doi: 10.1007/s13304-020-00912-5
   PubMed Web of Science ®Google Scholar
• Buchs NC, Addeo P, Bianco FM, et al. Robotic versus open pancreaticoduodenectomy: a comparative study at a single institution. World J Surg. 2011;35(12):2739–2746. doi: 10.1007/s00268-011-1276-3
   PubMed Web of Science ®Google Scholar
• Ielpo B, Caruso R, Duran H, et al. Robotic versus standard open pancreatectomy: a propensity score-matched analysis comparison. Updates Surg. 2019;71(1):137–144. doi: 10.1007/s13304-018-0529-1
   PubMed Web of Science ®Google Scholar
• Bin JJ, Qin K, Yang Y, et al. Robotic pancreatectomy for solid pseudopapillary tumors in the pancreatic head: a propensity score-matched comparison and analysis from a single center. Asian J Surg. 2020;43(1):354–361. doi: 10.1016/j.asjsur.2019.05.016
   PubMed Web of Science ®Google Scholar
• Lai ECH, Yang GPC, Tang CN. Robot-assisted laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy – a comparative study. Int J Surg. 2012;10(9):475–479. doi: 10.1016/j.ijsu.2012.06.003
   PubMed Web of Science ®Google Scholar
• Marino MV, Podda M, Gomez Ruiz M, et al. Robotic-assisted versus open pancreaticoduodenectomy: the results of a case-matched comparison. J Robot Surg. 2020;14(3):493–502. doi: 10.1007/s11701-019-01018-w
   PubMed Web of Science ®Google Scholar
• Tummers WS, Groen JV, Sibinga Mulder BG, et al. Impact of resection margin status on recurrence and survival in pancreatic cancer surgery. Br J Surg. 2019;106(8):1055–1065. doi: 10.1002/bjs.11115
   PubMed Web of Science ®Google Scholar
• Da Dong X, Felsenreich DM, Gogna S, et al. Robotic pancreaticoduodenectomy provides better histopathological outcomes as compared to its open counterpart: a meta-analysis. Sci Rep. 2021;11(1):1–20. doi: 10.1038/s41598-021-83391-x
   PubMed Web of Science ®Google Scholar
• Verbeke CS, Menon KV. Redefining resection margin status in pancreatic cancer. HPB. 2009;11(4):282–289. doi: 10.1111/j.1477-2574.2009.00055.x
   PubMed Web of Science ®Google Scholar
• Menon KV, Gomez D, Smith AM, et al. Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds pathology protocol (LEEPP). HPB. 2009;11:18–24. doi: 10.1111/j.1477-2574.2008.00013.x
   PubMed Web of Science ®Google Scholar
• Gebauer F, Tachezy M, Vashist YK, et al. Resection margin clearance in pancreatic cancer after implementation of the Leeds pathology protocol (LEEPP): clinically relevant or just academic? World J Surg. 2015;39(2):493–499. doi: 10.1007/s00268-014-2808-4
   PubMed Web of Science ®Google Scholar
• You MS, Lee SH, Choi YH, et al. Lymph node ratio as valuable predictor in pancreatic cancer treated with R0 resection and adjuvant treatment. BMC Cancer. 2019;19(1):1–8. doi: 10.1186/s12885-019-6193-0
   PubMed Web of Science ®Google Scholar
• Schwarz RE, Smith DD. Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database. Ann Surg Oncol. 2006;13(9):1189–1200. doi: 10.1245/s10434-006-9016-x
   PubMed Web of Science ®Google Scholar
• Mantzavinou A, Uppara M, Chan J, et al. Robotic versus open pancreaticoduodenectomy, comparing therapeutic indexes; a systematic review. Int J Surg. 2022;101:106633. doi: 10.1016/j.ijsu.2022.106633
   PubMed Web of Science ®Google Scholar
• Baimas-George M, Watson M, Murphy KJ, et al. Robotic pancreaticoduodenectomy may offer improved oncologic outcomes over open surgery: a propensity-matched single-institution study. Surg Endosc. 2020;34(8):3644–3649. doi: 10.1007/s00464-020-07564-x
   PubMed Web of Science ®Google Scholar
• Rosemurgy A, Ross SB, Espeut A. Survival and robotic approach for Pancreaticoduodenectomy: a propensity score-match study. J Am Coll Surg. 2022;234(4):677–684. doi: 10.1097/XCS.0000000000000137
   PubMed Web of Science ®Google Scholar
• Napoli N, Kauffmann EF, Vistoli F, et al. State of the art of robotic pancreatoduodenectomy. Updates Surg. 2021;73(3):873–880. doi: 10.1007/s13304-021-01058-8
   PubMed Web of Science ®Google Scholar
• Zwart M, van den Broek B, de Graaf N, et al. The feasibility, proficiency, and mastery learning curves in 635 robotic pancreatoduodenectomies following a multicenter training program “standing on the Shoulders of Giants. Ann Surg. 2023;278(6):e1232–e1241. doi: 10.1097/SLA.0000000000005928
   PubMed Web of Science ®Google Scholar