Transient mixed chimerism for allograft tolerance

References

• Owen RD. Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945; 102:400-1; PMID:17755278; http://dx.doi.org/10.1126/science.102.2651.400
   PubMed Web of Science ®Google Scholar
• Lillie FR. The theory of the free-martin. Science 1916; 43:611-13; PMID:17756274; http://dx.doi.org/10.1126/science.43.1113.611
   PubMedGoogle Scholar
• Anderson D, Billingham RE, Lampkin GH, Medawar PB. The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle. Heredity 1951; 5:379-97; http://dx.doi.org/10.1038/hdy.1951.38
   Web of Science ®Google Scholar
• Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172:603-6; PMID:13099277; http://dx.doi.org/10.1038/172603a0
   PubMed Web of Science ®Google Scholar
• Doria G. Identification of the immune system responsible for the specificity of actively acquired tolerance in mice. Proc Natl Acad Sci U S A 1963; 49:281-6; PMID:16591052; http://dx.doi.org/10.1073/pnas.49.3.281
   PubMed Web of Science ®Google Scholar
• Michie D, Woodruff MF, Zeiss IM. An investigation of immunological tolerance based on chimaera analysis. Immunology 1961; 4:413-24; PMID:14473459.
   PubMed Web of Science ®Google Scholar
• Main JM, Prehn RT. Successful skin homografts after the administration of high dosage x radiation and homologous bone marrow. J Natl Cancer Inst 1955; 15:1023-9; PMID:13233946.
   PubMed Web of Science ®Google Scholar
• Balner H. Persistence of tolerance towards donor-type antigens after temporary chimerism in rats. Transplantation 1964; 2:464-74; PMID:14181030; http://dx.doi.org/10.1097/00007890-196407000-00003
   PubMed Web of Science ®Google Scholar
• Slavin S, Strober S, Fuks Z, Kaplan HS. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: Long-term survival of allogeneic bone marrow and skin grafts. J Exp Med 1977; 146:34-48; PMID:17647; http://dx.doi.org/10.1084/jem.146.1.34
   PubMed Web of Science ®Google Scholar
• Strober S, Modry DL, Hoppe RT, Pennock JL, Bieber CP, Holm BI, Jamieson SW, Stinson EB, Schroder J, Suomalainen H, et al. Induction of specific unresponsiveness to heart allografts in mongrel dogs treated with total lymphoid irradiation and antithymocyte globulin. J Immunol 1984; 132:1013-8; PMID:6361129.
   PubMed Web of Science ®Google Scholar
• Smit JA, Hill RR, Myburgh JA, Browde S. Transplantation tolerance in primates after total lymphoid irradiation and allogeneic bone marrow injection. Iii. Lymphocyte responsiveness and suppressor cell activity. Transplantation 1980; 30:107-10; PMID:6451965; http://dx.doi.org/10.1097/00007890-198008000-00005
   PubMed Web of Science ®Google Scholar
• Cobbold SP, Martin G, Qin S, Waldmann H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 1986; 323:164-6; PMID:3528866; http://dx.doi.org/10.1038/323164a0
   PubMed Web of Science ®Google Scholar
• Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169:493-502; PMID:2562984; http://dx.doi.org/10.1084/jem.169.2.493
   PubMed Web of Science ®Google Scholar
• Kawai T, Cosimi AB, Colvin RB, Powelson J, Eason J, Kozlowski T, Sykes M, Monroy R, Tanaka M, Sachs DH. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59:256-62; PMID:7839449; http://dx.doi.org/10.1097/00007890-199501000-00018
   PubMed Web of Science ®Google Scholar
• Kimikawa M, Sachs DH, Colvin RB, Bartholomew A, Kawai T, Cosimi AB. Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys. Transplantation 1997; 64:709-16; PMID:9311707; http://dx.doi.org/10.1097/00007890-199709150-00008
   PubMed Web of Science ®Google Scholar
• Kawai T, Poncelet A, Sachs DH, Mauiyyedi S, Boskovic S, Wee SL, Ko DS, Bartholomew A, Kimikawa M, Hong HZ, et al. Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance. Transplantation 1999; 68:1767-75; PMID:10609955; http://dx.doi.org/10.1097/00007890-199912150-00022
   PubMed Web of Science ®Google Scholar
• Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith RN, Wee SL, Andrews D, Nadazdin O, Koyama I, Sykes M, et al. Cd154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4:1391-8; PMID:15307826; http://dx.doi.org/10.1111/j.1600-6143.2004.00523.x
   PubMed Web of Science ®Google Scholar
• Sykes M. Chimerism and central tolerance. Curr Opin Immunol 1996; 8:694-703; PMID:8902396; http://dx.doi.org/10.1016/S0952-7915(96)80088-4
   PubMed Web of Science ®Google Scholar
• Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M. Extrathymic t cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central t cell tolerance. J Exp Med 1998; 187:2037-44; PMID:9625763; http://dx.doi.org/10.1084/jem.187.12.2037
   PubMed Web of Science ®Google Scholar
• Cesana GC, DeRaffele G, Cohen S, Moroziewicz D, Mitcham J, Stoutenburg J, Cheung K, Hesdorffer C, Kim-Schulze S, Kaufman HL. Characterization of cd4+cd25+ regulatory t cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. J Clin Oncol 2006; 24:1169-77; PMID:16505437; http://dx.doi.org/10.1200/JCO.2005.03.6830
   PubMed Web of Science ®Google Scholar
• McDermott DF. The application of high-dose interleukin-2 for metastatic renal cell carcinoma. Med Oncol 2009; 1:13-7; http://dx.doi.org/10.1007/s12032-008-9152-1
   Web of Science ®Google Scholar
• Monk P, Lam E, Mortazavi A, Kendra K, Lesinski GB, Mace TA, Geyer S, Carson WE, 3rd, Tahiri S, Bhinder A, et al. A phase i study of high-dose interleukin-2 with sorafenib in patients with metastatic renal cell carcinoma and melanoma. J Immunother 2014; 37:180-6; PMID:24598448; http://dx.doi.org/10.1097/CJI.0000000000000023
   PubMed Web of Science ®Google Scholar
• Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, et al. Repeated injections of il-2 break renal allograft tolerance induced via mixed hematopoietic chimerism in monkeys. Am J Transplant 2015; 17:13382.
   Google Scholar
• Kawai T, Cosimi AB, Wee SL, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, et al. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys. Transplantation 2002; 73:1757-64; PMID:12084998; http://dx.doi.org/10.1097/00007890-200206150-00011
   PubMed Web of Science ®Google Scholar
• Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, et al. Tolerance of lung allografts achieved in nonhuman primates via mixed hematopoietic chimerism. Am J Transplant 2015; 15:2231-9; PMID:25904524; http://dx.doi.org/10.1111/ajt.13274
   PubMed Web of Science ®Google Scholar
• Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, et al. Depletion of cd8 memory t cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant 2007; 7:1055-61; PMID:17286617; http://dx.doi.org/10.1111/j.1600-6143.2006.01703.x
   PubMed Web of Science ®Google Scholar
• Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, et al. Overcoming memory t-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant 2012; 12:330-40; PMID:22053723; http://dx.doi.org/10.1111/j.1600-6143.2011.03795.x
   PubMed Web of Science ®Google Scholar
• Kawai T, Andrews D, Colvin RB, Sachs DH, Cosimi AB. Thromboembolic complications after treatment with monoclonal antibody against cd40 ligand. Nat Med 2000; 6:114; http://dx.doi.org/10.1038/72162
   Web of Science ®Google Scholar
• Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, et al. Use of ctla4ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant 2014; 14:2704-12; PMID:25394378; http://dx.doi.org/10.1111/ajt.12936
   PubMed Web of Science ®Google Scholar
• Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, et al. Hla-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-61; PMID:18216355; http://dx.doi.org/10.1056/NEJMoa071074
   PubMed Web of Science ®Google Scholar
• Kawai T, Sachs DH, Sykes M, Cosimi AB. Hla-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013; 9:1850-2; http://dx.doi.org/10.1056/NEJMc1213779
   Web of Science ®Google Scholar
• Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, et al. Long-term results in recipients of combined hla-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant 2014; 14:1599-611; PMID:24903438; http://dx.doi.org/10.1111/ajt.12731
   PubMed Web of Science ®Google Scholar
• Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAfee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999; 68:480-4; PMID:10480403; http://dx.doi.org/10.1097/00007890-199908270-00006
   PubMed Web of Science ®Google Scholar
• Farris AB, Taheri D, Kawai T, Fazlollahi L, Wong W, Tolkoff-Rubin N, Spitzer TR, Iafrate AJ, Preffer FI, Locascio SA, et al. Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts. Am J Transplant 2011; 11:1464-77; PMID:21668634; http://dx.doi.org/10.1111/j.1600-6143.2011.03572.x
   PubMed Web of Science ®Google Scholar