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Original research

Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC

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Article: 2274130 | Received 16 Apr 2023, Accepted 18 Oct 2023, Published online: 28 Nov 2023

References

  • Labani-Motlagh A, Ashja-Mahdavi M, Loskog A. The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses. Front Immunol. 2020 May 15;11:940. doi:10.3389/fimmu.2020.00940. PMID: 32499786; PMCID: PMC7243284.
  • An Y, Liu F, Chen Y, Yang Q. Crosstalk between cancer-associated fibroblasts and immune cells in cancer. J Cell Mol Med. 2020;24(1):13–10. doi:10.1111/jcmm.14745.
  • Galbo PM Jr., Zang X, Zheng D. Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance. Clinical Cancer Research. 2021;27(9):2636–2647. doi:10.1158/1078-0432.CCR-20-4226.
  • Koeck S, Kern J, Zwierzina M, Gamerith G, Lorenz E, Sopper S, Zwierzina H, Amann A. The influence of stromal cells and tumor-microenvironment-derived cytokines and chemokines on CD3+CD8+ tumor infiltrating lymphocyte subpopulations. Oncoimmunology. 2017 May 8;6(6):e1323617. PMID: 28680763; PMCID: PMC5486171. 10.1080/2162402X.2017.1323617.
  • Mueller S, Mackay L. Tissue-resident memory T cells: local specialists in immune defence. Nat Rev Immunol. 2016;16(2):79–89. doi:https://doi.org/10.1038/nri.2015.3.
  • Sato Y, Silina K, van den Broek M, Hirahara K, Yanagita M. The roles of tertiary lymphoid structures in chronic diseases. Nat Rev Nephrol 19, 525–537 (2023). 10.1038/s41581-023-00706-z.
  • Guo FF, Cui JW. The role of tumor-infiltrating B cells in tumor immunity. J Oncol. 2019;2592419. Published 2019 Sep 24. doi:10.1155/2019/2592419.
  • Kohli K, Pillarisetty VG, Kim TS. Key chemokines direct migration of immune cells in solid tumors. Cancer Gene Ther. 2022;29(1):10–21. doi:https://doi.org/10.1038/s41417-021-00303-x.
  • Mendez-Enriquez E, García-Zepeda EA. The multiple faces of CCL13 in immunity and inflammation. Inflammopharmacology. 2013 Dec;21(6):397–406. Epub 2013 Jul 12. PMID: 23846739. doi:10.1007/s10787-013-0177-5.
  • Hojo S, Koizumi K, Tsuneyama K, Arita Y, Cui Z, Shinohara K, Minami T, Hashimoto I, Nakayama T, Sakurai H, et al. High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res. 2007 May 15;67(10):4725–4731. doi:10.1158/0008-5472.CAN-06-3424. PMID: 17510400.
  • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014;511(7511):543–550. doi:10.1038/nature13385.
  • Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, et al. An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell. 2018;173:400–416. doi:10.1016/j.cell.2018.02.052.
  • Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009 Nov 5;462(7269):108–112. doi:10.1038/nature08460.
  • Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 2013 Jan 16;14(1):7. doi:10.1186/1471-2105-14-7).
  • Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4(1):2612. doi:10.1038/ncomms3612.
  • Racle J, de Jonge K, Baumgaertner P, Speiser DE, Gfeller D. Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data. Elife. 2017;6:e26476. doi:10.7554/eLife.26476.
  • Sturm G, Finotello F, Petitprez F, Zhang JD, Baumbach J, Fridman WH, List M, Aneichyk T. Comprehensive evaluation of transcriptome-based cell-type Quantification methods for immuno-oncology. Bioinformatics. 2019;35(14):i436–i445. doi:10.1093/bioinformatics/btz363.
  • Salcher S, Sturm G, Horvath L, Untergasser G, Kuempers C, Fotakis G, Panizzolo E, Martowicz A, Trebo M, Pall G, et al. High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer. Cancer Cell. 2022 Dec 12;40(12):1503–1520.e8. doi:10.1016/j.ccell.2022.10.008. Epub 2022 Nov 10. PMID: 36368318; PMCID: PMC9767679.
  • Koeck S, Zwierzina M, Huber JM, Bitsche M, Lorenz E, Gamerith G, Dudas J, Kelm JM, Zwierzina H, Amann A, et al. Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology. 2016 May;221(5):604–617. Epub 2016 Feb 1. PMID: 26876590. doi:10.1016/j.imbio.2015.12.010.
  • Gamerith G, Rainer J, Huber JM, Hackl H, Trajanoski Z, Koeck S, Lorenz E, Kern J, Kofler R, Kelm JM, et al. 3D-cultivation of NSCLC cell lines induce gene expression alterations of key cancer-associated pathways and mimic in-vivo conditions. Oncotarget. 2017 Nov 6;8(68):112647–112661. doi:10.18632/oncotarget.22636. PMID: 29348853; PMCID: PMC5762538.
  • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545–15550. doi:10.1073/pnas.0506580102.
  • Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 2018 Aug;24(8):1277–1289. Epub 2018 Jul 9. PMID: 29988129. doi:10.1038/s41591-018-0096-5.
  • Hu H, Piotrowska Z, Hare PJ, Chen H, Mulvey HE, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, et al. Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. Cancer Cell. 2021;39(11):1531–47.e10. doi:10.1016/j.ccell.2021.09.003.
  • Min KW, Kim DH, Noh YK, Son BK, Kwon MJ, Moon J-Y. Cancer-associated fibroblasts are associated with poor prognosis in solid type of lung adenocarcinoma in a machine learning analysis. Sci Rep. 2021;11(1):16779. doi:https://doi.org/10.1038/s41598-021-96344-1.
  • Michaud D, Steward CR, Mirlekar B, Pylayeva‐Gupta Y. Regulatory B cells in cancer. Immunol Rev. 2021 Jan;299(1):74–92. doi:10.1111/imr.12939. Epub 2020 Dec 23. PMID: 33368346; PMCID: PMC7965344.
  • Rosser EC, Mauri C. Regulatory B cells: origin, phenotype, and function. Immunity. 2015 Apr 21;42(4):607–612. PMID: 25902480. doi:10.1016/j.immuni.2015.04.005.
  • Garaud S, Dieu-Nosjean MC, Willard-Gallo K. T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy. Nat Commun. 2022;13(1):2259. doi:https://doi.org/10.1038/s41467-022-29753-z.
  • Germain C, Devi-Marulkar P, Knockaert S, Biton J, Kaplon H, Letaïef L, Goc J, Seguin-Givelet A, Gossot D, Girard N, et al. Tertiary lymphoid structure-B cells narrow Regulatory T cells impact in lung cancer patients. Front Immunol. 2021 Mar 8;12:626776. PMID: 33763071; PMCID: PMC7983944. 10.3389/fimmu.2021.626776.