497
Views
0
CrossRef citations to date
0
Altmetric
Author’s View

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

, , ORCID Icon & ORCID Icon
Article: 2276490 | Received 20 Oct 2023, Accepted 24 Oct 2023, Published online: 03 Nov 2023

References

  • Conlon KC, Miljkovic MD, Waldmann TA. Cytokines in the treatment of cancer. J Interferon Cytokine Res. 2019;39(1):6–3. doi:10.1089/jir.2018.0019.
  • Fabbi M, Carbotti G, Ferrini S. Dual roles of IL-27 in cancer biology and immunotherapy. Mediators Inflamm. 2017;2017:3958069. doi:10.1155/2017/3958069.
  • Svanberg R, Janum S, Patten PE, Ramsay AG, Niemann CU. Targeting the tumor microenvironment in chronic lymphocytic leukemia. Haematologica. 2021;106(9):2312–2324. doi:10.3324/haematol.2020.268037.
  • Wierz M, Janji B, Berchem G, Moussay E, Paggetti J High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia. Oncoimmunology. 2018;7(8):e1465167. doi:10.1080/2162402X.2018.1465167.
  • Wierz M, Pierson S, Guyonnet L, Viry E, Lequeux A, Oudin A, Niclou SP, Ollert M, Berchem G, Janji B, Guérin C. Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia. Blood. 2018;131(14):1617–1621. doi:10.1182/blood-2017-06-792267.
  • Cid LL, Leong JK, Botana IF, Paul Y, Wierz M, Floerchinger A, Gonder S, Pagano G, Chazotte M, Bestak K, Schifflers CT. High-dimensional single-cell definition of CLL T cells identifies galectin-9 as novel immunotherapy target. bioRxiv. 2022. doi:10.1101/2022.12.15.519719.
  • Mantovani A, Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444. doi:10.1038/nature07205.
  • Pagano G, Botana IF, Wierz M, Roessner PM, Ioannou N, Zhou X, Al-Hity G, Borne C, Gargiulo E, Gonder S, Qu B. Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia. Haematologica. 2023. doi:10.3324/haematol.2022.282474.
  • Zorzoli A, Di Carlo E, Cocco C, Ognio E, Ribatti D, Ferretti E, Dufour C, Locatelli F, Montagna D, Airoldi I, et al. Interleukin-27 inhibits the growth of pediatric acute myeloid leukemia in NOD/SCID/Il2rg−/− mice. Clin Cancer Res. 2012;18(6):1630–1640. doi:10.1158/1078-0432.CCR-11-2432.
  • Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, et al. Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration. Eur J Immunol. 2017;47(9):1562–1572. doi:10.1002/eji.201747124.